The object of the research was to investigate: (1) the effectiveness of the learning Cycle 4Es combined with Drill and Practice and conventional learning models on the students’ learning achievement; (2) the effect of the ability in Mathematics on the students’ learning achievement; and (3) the interaction between the Learning Cycle 4Es combined with Drill and Practice and conventional learning models and the ability in Mathematics on the students’ learning achievement on solubility and solubility product. The samples of research consisted of 2 classes, experimental class and control class. Data analysis study used two way variance analysis (ANAVA) with unequal cells and Kruskal Wallis tests. The results of the research showed that (1) there was an effectiveness of the Learning Cycle 4Es combined with Drill and Practice and conventional learning models on the learning achievement in the knowledge and skill aspect, but there was not any effectiveness on the attitude aspects; (2) there was an influence of mathematics ability on learning achievement aspects of knowledge, but there was not any influence on attitude and skills aspect; (3) there was an interaction between the Learning Cycle 4Es combined with Drill and Practice and conventional learning model and the ability in Mathematics on learning achievement aspects of knowledge, but there was not an interaction on attitudes and skills aspect.