Learning Disabled Children Research Articles

Childhood Learning Disabilities

Learning disability is commonly encountered in General Practice affecting between 1 and 2% of the Western world. Patients with learning disabilities have two and a half times as many associated medical problems. It often leads to functional impairment and increased need for lifelong support involving medical services. The care of patients with learning disabilities requires a holistic approach with awareness of the services available and knowledge of the barriers to health care faced by this patient group. This article aims to outline the definitions of learning disabilities and screening and diagnosis of these conditions in primary care, causes, principles of management and the difficulties and barriers in care delivery for these patients.

Development and validation of an attention-deficit/hyperactivity disorder (ADHD) executive function and behavior rating screening battery

Attention problems are ubiquitous in clinical practice, commonly found in many childhood learning and behavior disorders. Practitioners need cost- and time-effective methods for determining whether children have attention problems due to attention-deficit/hyperactivity disorder (ADHD) or numerous other conditions. This study examined the utility of a 15-minute ADHD screening battery designed to differentiate ADHD (including inattentive, IT, and combined, CT, subtypes), specific learning disability (SLD), and typical child samples. Results for the 368 children (age 6 to 12 years) revealed that the Trail Making Test–Part B (Time/Errors), Hale–Denckla Cancellation Test (Time/Correct), and Child Attention Profile (Inattention/Overactivity) teacher ratings discriminated between typical and ADHD groups (87% correct classification; sensitivity = .64; specificity = .92) and differentiated between IT, CT, and SLD groups (80% correct classification; IT sensitivity = .82, and specificity = .96; CT sensitivity = .84, and specificity = .82). Discriminant function and Bonferroni post hoc results revealed different neuropsychological and behavioral patterns among groups.

Semi-dominant X-chromosome linked learning disability with progressive ataxia, spasticity and dystonia associated with the novel MECP2 variant p.V122A: Akin to the new MECP2 duplication syndrome?

A novel X-chromosome linked phenotype is reported. Three affected males had learning disability in early childhood and subsequently developed progressive ataxia, dystonia, and spasticity with death at ages 9, 14 and 19 years. Two female obligate carriers had learning difficulties with psychosis in one case. A third, possible carrier had learning difficulties and epilepsy. A family study indicates that this inherited syndrome is most likely due to an unreported MECP2 variant, p.V122A, located in the methyl binding domain of the MECP2 protein. The clinical features are similar to those present in the newly reported MECP2 duplication syndrome. Non-progressive neuropsychiatric symptoms in female relatives of a male child with learning disability, ataxia and progressive spasticity may constitute a clue to inherited, MECP2 pathogenesis.

Perceived Support Among Iranian Mothers of Children with Learning Disability

This qualitative phenomenological study explores the lived experiences of perceived support by Iranian mothers who have children with learning disability. Twelve open interviews with six mothers of learning-disabled children (7-12 years of age) were audiotape-recorded with participants' consent. The interviews were transcribed and data were analyzed using Van Manen methodology. Two major themes emerged from 138 thematic sentences. The mothers'experiences could be interpreted as a sense of being in the light or being in the shade of support, with variations for different participants. The results indicate a need for more specialized and individually adjusted support for mothers in Iran.

Dysfunctional neural network of spatial working memory contributes to developmental dyscalculia

The underlying neural mechanisms of developmental dyscalculia (DD) are still far from being clearly understood. Even the behavioral processes that generate or influence this heterogeneous disorder are a matter of controversy. To date, the few studies examining functional brain activation in children with DD mainly focus on number and counting related tasks, whereas studies on more general cognitive domains that are involved in arithmetical development, such as working memory are virtually absent. There are several studies showing a close relationship between DD and spatial working memory [Camos, V. (2008). Low working memory capacity impedes both efficiency and learning of number transcoding in children. Journal of Experimental Child Psychology, 99(1), 37-57; McLean, J. F., & Hitch, G. J. (1999). Working memory impairments in children with specific arithmetic learning difficulties. Journal of Experimental Child Psychology, 74(3), 240-260; Rosselli, M., Matute, E., Pinto, N., & Ardila, A. (2006). Memory abilities in children with subtypes of dyscalculia. Developmental Neuropsychology, 30(3), 801-818; Siegel, L. S., & Ryan, E. B. (1989). The development of working memory in normally achieving and subtypes of learning disabled children. Child Development, 60(4), 973-980]. The relationship between these two mechanisms is still matter of debate, but this study follows the assumption that poor spatial working memory capacity may hinder the acquisition of spatial number representations in children with DD [Geary, D. C. (1993). Mathematical disabilities: Cognitive, neuropsychological, and genetic components. Psychological Bulletin, 114(2), 345-362; von Aster, M., & Shalev, R. S. (2007). Number development and developmental dyscalculia. Developmental Medicine and Child Neurology, 49(11), 868-873]. Using functional MRI the current study compares brain activity associated with spatial working memory processes in 8-10-year-old children with DD and normally achieving controls. Both groups showed significant spatial working memory related activity in a network including occipital and parietal regions. Children with DD showed weaker neural activation compared to the control group during a spatial working memory task in the right intraparietal sulcus (IPS), the right insula and the right inferior frontal lobe. Performance tests outside the scanner showed impaired working memory proficiency in children with DD. Bringing behavioral performance and neural activity together we found significant correlations of right IPS activity with performance on the verbal digit span forward and the spatial Corsi Block Tapping test. Our findings demonstrate for the first time an involvement of spatial working memory processes in the neural underpinnings of DD. These poor spatial working memory processes may inhibit the formation of spatial number representations (mental numberline) as well as the storage and retrieval of arithmetical facts.

Poor Reading in French Elementary School: The Interplay of Cognitive, Behavioral, and Socioeconomic Factors

: Reading impairment is the major learning disability in childhood. Most previous studies were done on English-speaking populations. Yet, it has been argued that the English writing system exacerbates phonological deficits because of its exceptionally high inconsistency between spelling and sound. Thus, cross-language studies are needed to explore the universal versus language-specific factors underlying reading impairment. The goal of the present research was to study biological, socioeconomic, cognitive, and behavioral factors underlying poor reading in French-speaking second grade children. : A total of 1062 children from 20 different schools in the city of Paris participated in the study. After an initial test phase, children with a suspected impairment in reading acquisition were assessed individually. Subsequently, 100 poor readers and 50 controls were matched for sex, age, school, and neighborhood socioeconomic status (SES). They underwent comprehensive medical, cognitive, and behavioral assessment complemented by individual socioeconomic data. : The average prevalence of reading impairment was around 12% in our sample. It was highly influenced by neighborhood SES, varying from 3.3% in high SES to 24.2% in low SES areas. Among the individual SES variables, low maternal education significantly distinguished poor from typical readers. Multiple regression analyses showed that reading outcome was best predicted by phonological awareness skills and attention deficits. : The majority of poor readers come from low SES areas. As in the English literature, the most robust predictor for reading impairment is phonological awareness. In addition, behavioral problems, such as attention deficits, seem to aggravate reading deficits for children with weak phonological awareness skills.

The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway

Recently, genetic studies have implicated KIAA0319 in developmental dyslexia, the most common of the childhood learning disorders. The first functional data indicated that the KIAA0319 protein is expressed on the plasma membrane and may be involved in neuronal migration. Further analysis of the subcellular distribution of the overexpressed protein in mammalian cells indicates that KIAA0319 can colocalize with the early endosomal marker early endosome antigen 1 (EEA1) in large intracellular vesicles, suggesting that it is endocytosed. Antibody internalization assays with full-length KIAA0319 and deletion constructs confirmed that KIAA0319 is internalized and showed the importance of the cytoplasmic juxtamembranal region in this process. The present study has identified the medium subunit (μ2) of adaptor protein 2 (AP-2) as a binding partner of KIAA0319 in a yeast two-hybrid screen. Using Rab5 mutants or depletion of the μ-subunit of AP-2 or clathrin heavy chain by RNA interference, we demonstrate that KIAA0319 follows a clathrin-mediated endocytic pathway. We also identify tyrosine-995 of KIAA0319 as a critical amino acid required for the interaction with AP-2 and subsequent internalization. These results suggest the surface expression of KIAA0319 is regulated by endocytosis, supporting the idea that the internalization and recycling of the protein may be involved in fine tuning its role in neuronal migration.

Attitudes toward Inclusion of Children with Special Needs in Regular Schools (A Case Study from Parents' Perspective).

The purpose of this case study was to find out the attitudes of parents towards mainstreaming children with special needs into 2 regular private elementary schools in Sidon-Lebanon. A total of 15 parents were interviewed out of 35 whose children have learning disabilities. Sampling was purposeful where the subjects were chosen to facilitate reaching a range of data related to the targeted theme. Data collected was analyzed within the intention to detect; (a) attitude of parents towards various aspects of inclusion namely, cooperation, academic improvement and social adaptation of special and regular students and modification of teaching methods, (b) attitudes related to information on types of inclusion, types of special needs to be included and level at which inclusion is recommended. Respondents showed a positive attitude towards the various aspects of inclusion, types and levels of inclusion. Results were discussed in terms of relevant research outcome in Lebanon and other countries and in relation to implication for future research and practice. Attitudes towards Inclusion of children with special needs in regular schools (A case study from parents' perspective). Key words: Inclusion, inclusive education, learning disabled child, special education, educational change, case studies.

Troubles d’acquisition de la lecture en cours élémentaire : facteurs cognitifs, sociaux et comportementaux dans un échantillon de 1062 enfants

Background Reading impairment is the major learning disability in children. While research on illiteracy has mainly been conducted from a sociological perspective, research on dyslexia has typically been studied from a cognitive-linguistic perspective. Studies that jointly investigate sociological, behavioral and cognitive factors in predicting reading outcome are rare and limited to English-speaking populations. The goal of the present study was to screen second grade children with reading impairment in French urban elementary schools and to pin down the factors that explain the various facets of reading failure and success. Methods A total of 1062 children from 20 different schools in the city of Paris participated in the study. Different aspects of reading were assessed individually for children with a suspected impairment in reading acquisition. Subsequently, 131 poor readers and 50 typically developing readers were matched for sex, age, and school. For these children, medical, cognitive, behavioral and individual socioeconomic data were obtained. Group differences were examined and multiple regression analyses were conducted to examine how much variance in reading was explained by the various variables. Results The prevalence of poor reading skills in grade 2 was highly influenced by neighborhood socioeconomic status (SES) (ranging from 3.3% in high SES to 20.5% in low SES areas). Among the SES variables, employment of the father was a significant predictor of poor reading. Among the cognitive variables, phonological awareness and rapid naming were the most significant factors, much more than verbal or nonverbal intelligence. Among the behavioral variables, attention was an important factor but not externalized symptoms. Multiple regression analyses showed that reading outcome was best predicted by phonological awareness skills and attention deficits. Conclusion The majority of children with reading disability come from low SES areas. As in the English literature, the most robust predictor for reading impairment is phonological awareness, even when SES is taken into account. In addition, attention deficits seemed to aggravate reading impairments for children with weak phonological awareness skills. Successful early prevention should focus on reinforcing phonological awareness, recoding and attention skills.

Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort

Anesthetic drugs administered to immature animals may cause neurohistopathologic changes and alterations in behavior. The authors studied association between anesthetic exposure before age 4 yr and the development of reading, written language, and math learning disabilities (LD). This was a population-based, retrospective birth cohort study. The educational and medical records of all children born to mothers residing in five townships of Olmsted County, Minnesota, from 1976 to 1982 and who remained in the community at 5 yr of age were reviewed to identify children with LD. Cox proportional hazards regression was used to calculate hazard ratios for anesthetic exposure as a predictor of LD, adjusting for gestational age at birth, sex, and birth weight. Of the 5,357 children in this cohort, 593 received general anesthesia before age 4 yr. Compared with those not receiving anesthesia (n = 4,764), a single exposure to anesthesia (n = 449) was not associated with an increased risk of LD (hazard ratio = 1.0; 95% confidence interval, 0.79-1.27). However, children receiving two anesthetics (n = 100) or three or more anesthetics (n = 44) were at increased risk for LD (hazard ratio = 1.59; 95% confidence interval, 1.06-2.37, and hazard ratio = 2.60; 95% confidence interval, 1.60-4.24, respectively). The risk for LD increased with longer cumulative duration of anesthesia exposure (expressed as a continuous variable) (P = 0.016). Exposure to anesthesia was a significant risk factor for the later development of LD in children receiving multiple, but not single anesthetics. These data cannot reveal whether anesthesia itself may contribute to LD or whether the need for anesthesia is a marker for other unidentified factors that contribute to LD.

Mathematical learning disabilities in children with 22q11.2 deletion syndrome: A review

Mathematical learning disabilities (MLD) occur frequently in children with specific genetic disorders, like Turner syndrome, fragile X syndrome and neurofibromatosis. This review focuses on MLD in children with chromosome 22q11.2 deletion syndrome (22q11DS). This syndrome is the most common known microdeletion syndrome with a prevalence of at least 1:4000 to 1:6000 live births. Although the clinical presentation of 22q11DS is quite variable, its major characteristics include velopharyngeal abnormalities, congenital cardiac anomalies, mild facial dysmorphism and learning difficulties. Children with 22q11DS show considerable difficulties in mathematics, despite relatively normal reading performance. While fact retrieval seems to be preserved, impairments in procedural calculation and word problem solving are particularly prominent. Children with 22q11DS also have substantial difficulties in understanding and representing numerical quantities, possibly related to poor visuospatial attention, which all might stem from their underlying abnormalities in the inferior parietal cortex. This review ends with a discussion on how research on genetic disorders might aid our understanding of MLD in general.

A review of mathematical learning disabilities in children with fragile X syndrome

The prevalence rate of mathematical learning disabilities (MLD) among children with fragile X syndrome who do not meet criteria for intellectual and developmental disabilities (approximately 50% of female children) exceeds the rate reported in the general population. The purpose of this article is two-fold: (1) to review the findings on MLD in persons with fragile X syndrome; and (2) to discuss fragile X syndrome as a possible model for understanding pathways to MLD.

Student nurses supporting children with learning disabilities

Summary: At Glasgow Caledonian University, nursing students are given the opportunity to gain practice experience by providing care and support to children with learning disabilities within the individual child’s home-setting during the summer holiday period. Three families of children with learning disabilities took part in a pilot study. The Study attempts to understand and explain the effects, if any, of such practice experiences for the families concerned. Hermeneutic analysis of interview texts utilising a Gadamerian approach reveals an initial understanding of the realities of life for the families concerned. The emergent picture is one of mothers being trapped within their own homes by and with their learning disabled children. Nursing student placements are viewed by families as liberating.

Cognitive training: Improving problem-solving transfer skills of learning disabled students

AbstractThe effectiveness of cognitive training with the Cognitive Training for Children Programme (Klauer & Phye, 1994) and other forms of the Klauer training programmes has been recently reviewed (Klauer & Phye, 2008). Numerous meta-analyses confirm the wide spread effectiveness of training inductive reasoning skills with different ability groups at varying ages in various settings. The majority of these studies were conducted in Germany. The present study was designed to determine the effectiveness of the English form of the Cognitive Training for Children Programme (Klauer & Phye, 1994) in a clinical setting. Theoretically, focus was on the impact of meaningful practice with inductive reasoning strategies on the growth of problem-solving transfer ability of learning disabled children. Future research efforts involving an integration of dynamic assessment techniques, and the cognitive analysis of practice using the Cognitive Training for Children Programme is recommended.

An update from the British Psychological Society Child Learning Disabilities Network

An update from the British Psychological Society Child Learning Disabilities Network

260. Positive vs. Negative reinforcement in neurofeedback applied to learning disabled children

260. Positive vs. Negative reinforcement in neurofeedback applied to learning disabled children

Identification of novel dyslexia candidate genes through the analysis of a chromosomal deletion

Dyslexia is the most common childhood learning disorder and it is a significantly heritable trait. At least nine chromosomal loci have been linked to dyslexia, and additional susceptibility loci on other chromosomes have been suggested. Within two of these loci, DYX1C1 (15q21) and ROBO1 (3p12) have recently been proposed as dyslexia candidate genes through the molecular analysis of translocation breakpoints in dyslexic individuals carrying balanced chromosomal translocations. Moreover, genetic association studies have indicated a cluster of five dyslexia candidate genes in another linkage region on chromosome 6p22, although there is currently no consensus about which of these five genes contributes to the genetic susceptibility for dyslexia. In this article, we report the identification of four new dyslexia candidate genes (PCNT, DIP2A, S100B, and PRMT2) on chromosome region 21q22.3 by FISH and SNP microarray analyses of a very small deletion in this region, which cosegregates with dyslexia in a father and his three sons.

The development of a child learning disability screening questionnaire: a pilot study

The identification of learning disability in children can be problematic, especially for those with significant intellectual impairment (Hamilton 2006, Siminoff et al 2006). However, early diagnosis can be crucial in terms of the child’s learning and everyday functioning (Herbert 2006), with early intervention helping to improve difficulties in communication and self-care skills (Chadwick et al 2005). In addition, diagnosis can help parents and others make sense of the child’s behaviours and difficulties, guide intervention and identify support needs (Goodman and Linn 2003).

Brainstem Timing Deficits in Children with Learning Impairment May Result from Corticofugal Origins

A substantial proportion of children with language-based learning problems [learning disabilities (LD)] display abnormal encoding of speech at rostral levels of the auditory brainstem (i.e. midbrain) as measured by the auditory brainstem response (ABR). Of interest here is whether these timing deficits originate at the rostral brainstem or whether they reflect deficient sensory encoding at lower levels of the auditory pathway. We describe the early brainstem response to speech (waves I and III) in typically developing 8- to 12-year-old children and children with LD. We then focus on the early brainstem responses in children with LD found to show abnormal components of the rostral speech-evoked ABR (waves V and A). We found that wave I was not reliably evoked using our speech stimulus and recording parameters in either typically developing children or those with LD. Wave III was reliably evoked in the large majority of subjects in both groups and its timing did not differ between them. These data are consistent with the view that the auditory deficits in the majority of LD children with abnormal speech-evoked ABR originate from corticofugal modulation of subcortical activity.

A Friendly Technique to Study the Child Neurocognitive Development in the School Environment

Learning disabilities (LD) is experienced by 10% of the school aged children and are important causes of school evasion. Modern techniques of brain imaging allow neuroscientist a better comprehension of human cognition and to study neurocognitive development. The most popular among these techniques is fMRI, but it requires special facilities and is unfriendly to the children. The development of the microcomputers turned EEG recording very portable and allows it to be used at the school associated with very friendly computer games (CG) specially designed to study children neurocognitive development. Here, we describe an EEG brain mapping technique developed for such a purpose. The study of the brain activity during word and phrase reading by normal and learning disabled children is presented as an example of its application. The developed CGs were very effective in distinguishing children with a normal school development from those experiencing difficulties in reading.