In order to prevent radiation-related disasters for radiation workers, the higher the average radiation exposure dose for each industry, the stronger the regulatory level of nuclear and radiation safety regulatory agencies is for its purpose and relevance. Therefore, nuclear regulatory agencies must apply radiation safety-related licensing and technical standards for nuclear power facilities differently for each type of nuclear business operator depending on the degree of risk of exposure to radiation. From the perspective of a nuclear regulatory agency with limited administrative and financial resources, this study was conducted to efficiently prioritize the regulated sectors of nuclear power operators and promote scientification of regulatory administration by incorporating evidence-based administration. Using the results of the 「2021 Nuclear Safety Survey」 conducted on 2,000 radiation workers, we investigated how radiation workers' satisfaction with nuclear regulation policy changes depending on the activities of nuclear regulatory agencies between independent, mediating, and dependent variables. Direct effects and indirect effects were measured and tested. Four exogenous factors, including the accident response human management system (ERHMS), accident response material management system (ERMMS), in-house safety culture (CISC), and recurrence prevention safety education system (RPSES) for radiation workers subject to nuclear regulation by the nuclear regulatory administrative agency. The regulatory agency activity satisfaction (RAAS), which is a mediating factor, and the endogenous factor 'nuclear energy and radiation safety' regulatory policy satisfaction (NRPS) were set as independent variables, mediators, and dependent variables, respectively. We examined whether the reliability, validity, and correlation between survey items and measurement variables were significant through reliability analysis, correlation analysis, and factor analysis. As a result of multiple regression analysis and structural equation modeling (SEM) mediation effect analysis, the 'activities of regulatory agencies' regarding the accident response human and material management system, in-house safety culture, and accident recurrence prevention education system are related to the nuclear and radiation safety regulatory policy of radiation workers. It was confirmed that it was an influential factor that made a significant difference in satisfaction. When comparing the sizes of standardization coefficients, the sizes of factors affecting satisfaction with nuclear regulation policy are: in-house safety culture (β=0.395), accident response human management system (β=0.080), accident response material management system (β=0.077), Relapse prevention safety education system (β=0.042) appeared in that order. The implications of this study are that the direction of the nuclear safety regulation policy of regulatory agencies that carry out nuclear regulation administration with limited administrative and financial resources is related to the in-house safety culture (CISC) and accident response human management system of nuclear power operators to prevent nuclear and radiation safety accidents. It can be said that it has been verified through quantitative research that strengthening nuclear safety through reinforcement is more effective and efficient