Microleakage can result in failure of endodontic treatment. An important characteristic of endodontic sealer is sealing ability. The aim of this experimental study was to compare the apical leakage of teeth obturated with single-cone and warm vertical condensation techniques using three different sealers (Cortisomol, AH Plus, Apexit Plus). Materials and Methods: Sixty extracted human lower premolar teeth were selected and randomly assigned to six groups (n = 10), according to the root canal sealer and technique used for obturation: (A) Single-cone technique with Cortisomol; (B) Single-cone technique with AH Plus; (C) Single-cone technique with Apexit Plus; (D) Warm vertical condensation technique with Cortisomol; (E) Warm vertical condensation technique with AH Plus; (F) Warm vertical condensation technique with Apexit Plus. The teeth were immersed in India ink for seven days and clarified using methyl salicylate. The extent of apical dye penetration was measured with a measuroscope in all aspects of the canal. Results: The mean penetration length of dye in Cortisomol, AH Plus and Apexit Plus samples were 0.85, 0.98 and 0.58 mm, respectively. The differences between three groups were not significant (p > 0.05); also, the mean dye penetration in obturating with single-cone and warm vertical condensation techniques using Cortisomol, AH Plus, Apexit Plus was not significantly different. Conclusion: Cortisomol, AH Plus, Apexit Plus were similarly effective in prevention of apical microleakage. Differences in the mean dye penetration between the groups which were obturated with Single-cone and warm vertical condensation were not statistically significant. Key words: Microleakage, single-cone, warm vertical condensation, Cortisomol, AH Plus, Apexit Plus
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