Leak-off and formation integrity test data from the central part of the Bavarian Foreland Molasse Basin have been investigated in detail to infer information about the stress regime of the Cenozoic basin fill. The detailed analysis of leak-off test data from the Bavarian Foreland Molasse Basin and lithology-dependent analysis of leak-off test and formation integrity data is the first of its kind in a published study. Only test data from shale-rich sequences have been considered. All data yield minimum principal stresses that are smaller than an estimated vertical stress range. In combination with critical stress and frictional equilibrium theory, the data indicate that the stress regime in the greater Munich area and possibly the far-field stress regime of the Bavarian Foreland Molasse Basin are most likely of an extensional nature (normal-faulting stress regime). Under the assumption of frictional equilibrium, a friction coefficient between 0.2 and 0.4 best explains failure in shale-dominated sections of the central part of the Bavarian Foreland Molasse Basin and can be used to estimate the minimum horizontal stress SHmin. However, even in the spatially restricted domain of the greater Munich area the stress regime might vary towards a strike-slip stress regime; most likely in the vicinity of fault zones and/or due to variations in mechanical rock strength. The results of this study have great impact and relevance to improved planning of drilling campaigns, future numerical modelling and the general understanding of the evolution of the Bavarian Foreland Molasse Basin. Additional leak-off tests and extended leak-off tests are recommended to fully unravel the spatial variation and geologic control factors of the stress regime of the entire Bavarian Foreland Molasse Basin.