Leaf Capsule Research Articles

Impact of Iron Tablet and Moringa Leaf Capsule Supplementation on Hemoglobin Levels in Anemic Pregnant Women in Pariaman City, 2016

Background: Iron deficiency anemia is a prevalent global nutritional problem, particularly affecting pregnant women in developing countries. This study aimed to evaluate the effects of iron tablet supplementation and Moringa leaf capsules on hemoglobin (Hb) levels in anemic pregnant women in Pariaman City, Indonesia. Method: A total of 60 pregnant women were divided into two groups: one receiving iron tablets and the other Moringa leaf capsules for four weeks. Hemoglobin levels were measured before and after the intervention. Findings: In the iron supplementation group, the average Hb level increased from 9.05 g/dL to 9.46 g/dL, with a significant improvement (p = 0.001). Similarly, the Moringa capsule group showed an Hb increase from 8.99 g/dL to 9.27 g/dL (p = 0.019). While iron tablets resulted in a greater increase in Hb, Moringa capsules, rich in natural iron, also demonstrated significant effectiveness. The study concludes that both iron supplements and Moringa capsules are effective in increasing Hb levels, with Moringa capsules being a potential natural alternative for combating anemia in pregnant women. However, optimizing the dosage of Moringa could further enhance its efficacy. Factors such as adherence, diet, and knowledge of iron absorption enhancers and inhibitors play crucial roles in the success of the interventions.

Comprehensive Chemical Profiling and Mechanistic Insight into Anticancer Activity of Annona muricata Leaves Extract.

The aqueous extract of Annona muricata L. leaves was thoroughly analyzed using the UPLC-MS/MS, in addition to a new approach of examination of the extract's impact on cancer of EAC(Ehrlich ascites carcinoma) in albino male mice. The aim was to investigate the diversity of the phytochemical constituents of the aqueous leaf capsule extract and their impacts on EAC as anticancer agents. The UPLC-ESI-MS/MS screening resulted in 410 tentatively identified metabolites. Among them, 384 compounds were tentatively identified in a previous study, besides a number of 26 compounds belonging to acetogenins, phenolics, flavonoids, alkaloids, and other miscellaneous compounds, which were exclusively identified in the aqueous extract of the leaf capsule. Interestingly, a new compound was tentatively characterized as galloyl-quinic acid-rutinoside. This study also demonstrated that treating EAC mice with an extract from A. muricata leaves significantly improved the abnormalities in the expression of pro-apoptotic (Bax and caspase-3) and anti-apoptotic (Bcl-2) genes. Furthermore, the extract showed good protection against induced Ehrlich hepatocarcinoma, according to the microscopical, histological, and immune-histochemical analyses of the liver tissues and tumor mass.

Differences in the Effect of Giving Fe Tablets and Capsules Moringa Leaves on Hepcidin and Ferritin Levels in Anemic Pregnancy Rats

<p><em>Anemia is a condition characterized by a decrease in Hemoglobin (HB), a serious global public health problem especially affecting children and pregnant women. This study aimed t</em><em>o </em><em>determine differences in the effect of </em><em>giving </em><em>Fe tablets and </em><em>capsules </em><em>of Moringa lea</em><em>ves</em><em> on</em><em> </em><em>hepcidin </em><em>and ferritin </em><em>level</em><em>s </em><em>in anaemic pregnan</em><em>cy</em><em> rats. This research was an experimental study with a randomized post-test-only control group design. This research was conducted at the Animal House of the Faculty of Medicine, Andalas University to maintain and treat experimental animals. Ferritin and Hepcidin examinations were carried out at the biomedical laboratory of the Faculty of Medicine, Andalas University. The sample in this study were female white rats (Rattus Novergicus) which met the inclusion and exclusion criteria, the data were analyzed using One Way Anova. The results of this study indicated that the mean hepcidin levels in the Fe (P1) and Moringa leaf capsule (P2) groups were 181.902 ± 20.31 and 216.362 ± 29.90 with a p-value of 0.006 . The mean ferritin levels in the Fe(P1) and Moringa leaf capsule (P2) groups were 1.928 ± 0.263 and 2.308 ± 0.320 with a p-value of 0.004. The conclusion in this study was that there was an effect on hepcidin levels after being given Fe tablets (P1) and Moringa leaf capsules (P2) to anemic pregnant rats and there was an effect on ferritin levels after being given Fe tablets (P1) and Moringa leaf capsules (P2) to anemic pregnant rats</em></p><p> </p><p><strong><em>Keyword: Anemic, Ferritin, Fe Tablets, Hepcidin, Moringa Leaf Capsules</em></strong></p>

The Potential of Paulownia fortunei L. for the Phytoremediation of Pb

Pb endangers forest ecological health; phytoremediation is an effective Pb remediation technology. Woody plants with Pb tolerance provided a mechanism for the phytoremediation of Pb. Paulownia fortunei (L.), a fast-growing woody plant, has a good tolerance to Pb. However, its tolerance mechanism is unclear. The results in this study revealed that P. fortunei seedlings can withstand 400 mg·L−1 Pb stress. The quantification of Pb in different P. fortunei tissues showed an increasing trend of accumulation in root > leaf > stem; the transport coefficient and enrichment coefficient decreased with an increase in Pb concentration. The tolerance of P. fortunei to Pb may be related to cell partition and immobilization by the cell wall. Microstructural analysis performed using scanning electron microscopy showed that the absorbed Pb is mainly distributed in cell wall components, and when the concentration of Pb increases, it can be transferred to soluble parts and organelles. The Fourier transform infrared spectrometry results showed that excess hydroxyl groups occurred under Pb stress in the outer epidermis cell walls of roots and leaves adsorbing heavy metals. When the concentration of Pb was over 400 mg·L−1, the growth of P. fortunei was inhibited, the root cell wall was deformed, the plasmolysis occurred in the cauline cell, and the internal leaf capsule was ruptured. Furthermore, antioxidant enzyme activity was significantly reduced. Therefore, P. fortunei can transfer the underground part of Pb to the aboveground part up to the concentration of 400 mg·L−1. This study provides a theoretical basis and technical reference for fully utilizing woody plant resources to restore the ecological environment of forests.

Effect of moringa leaf capsules and fe administration to increase hemoglobin levels, weight, and upper arm circumference (LILA) in trimester II pregnant women with chronic energy deficiency (KEK)

Moringa leaves are nutrient-rich plants that increase hemoglobin (Hb) levels, nutritional intake, and nutritional status. Therefore, this research aims to determine the effect of administering Moringa leaf capsules and Fe to increase hemoglobin levels, body weight, and upper arm circumference (LILA) in second-trimester pregnant women suffering from chronic energy deficiency (KEK). It was carried out for 2 months in the working area of the Banabungi Public Health Center, Buton Regency, Indonesia. The method adopted was an experimental design using a double-blind randomized controlled trial with a pre and post-test as well as a control group pattern. The samples were 34 second-trimester pregnant women suffering from KEK and divided into 2 groups, namely Moringa capsules + Fe (n=17) and Fe (n=17). The data were analyzed using the Chisquare, Paired, and Independent T-Test. The analysis was conducted based on the characteristics of the majority of the samples aged from 20 to 35 years, gravida, higher education, work, and income less than the minimum wage with a p-value > 0.05. The results showed a significant increase in hemoglobin levels in the Moringa leaf capsule group + Fe from 9.47 ± 2.11 to 11.67 ± 1.32 p = 0.001.

The Effect of Moringa Leaf Capsule on the Hemoglobin Levels in Young Women at Smp Sabbihisma Padang

In adolescents, the iron not only functions as energy metabolism in the body but also helps to improve learning achievement. Iron deficiency can lead to fatigue, and the concentration, memory and learning abilities can be disrupted. It can also lead to anemia, especially in young women. The purpose of this study was to determine the effect of leaf moringa capsules on the hemoglobin levels in adolescent girls in Sabbihisma Junior High School. This research used a quasi method of pretest and posttest experiment with control group design. The sample of the study were 32 people, 16 cases (moringa leaf capsule) and 16 control groups. Data collection was done through observation and laboratory examination of hemoglobin levels before and after treatment. The data were tested with paired sample t-test. The results showed that there was a significant difference in female hemoglobin levels in the case group with p = 0,000, while the control group was not significant with p = 0,091.

The Effect of Moringa-Based Supplementation on Fetal Birth Weight in Jeneponto Regency

Background: Low birth weight (LBW) is one of the main causes of morbidity and mortality besides preterm birth. Proper interventions during pregnancy can prevent an adverse pregnancy outcome. This study aims to see the effect of Moringa leaf capsule on birth weight.Methods: This study was double blind randomized controlled trial (DB-RCT) which consisted of three groups namely, Moringa powder (PG), Moringa extract (EG), and iron-folate (IG) groups. The intervention was given for 12 weeks. The samples were 453 pregnant women in six sub-districts in Jeneponto Regency. Data on birth weight and placental weight were measured by trained midwives. The weight of the placenta was measured to determine the placental ratio to birth weight. In addition, some socio-economic variables such as age, gestational age, eating frequency, smoking, and Hb levels were measured in this study. Logistic and linear regression were conducted in this study.Result: The Moringa leaf supplementation groups (PG and EG) delivered child with better weight than iron supplementation (3240.03±453.82, 3161.91±527.70, 3100.89±412.15, respectively). The placenta to birth weight ratio (PBWR) showed that IG group became lowest, merely 16.19%. The most influenced factor to LBW is the unhappiness of the women with her pregnancy (OR = 26.3, 95% CI = 1.227 - 566.474, p = 0.037).Conclusion: Moringa powder supplementation can be used as an alternative in improving new born baby weight. Pregnant women need to be happy and avoid stress to prevent LBW.

THE EFFECT OF MORINGA OLEIFERA LEAVES ON CHANGE IN BLOOD PROFILE IN POSTPARTUM MOTHERS

Background: Postpartum anemia among mothers is a health problem in Indonesia. Consuming Moringa Oleifera is assumed as one of the efforts to deal with anemia. However, lack of the study conducted in the working in the working area of health center of Tlogosari Wetan.Objective: This study was conducted to examine the effect of Moringa Oleifera on blood profile in postpartum mothers.Methods: The study was quasy experimental study with pretest posttest control group design. The sample in this study were all postpartum mothers in the working area of the health center of Tlogosari Wetan. It was 30 respondents recruited by purposive sampling, divided into intervention group (15 respondents) who received Moringa leaf capsule and iron tablet; and control group (15 respondents) were given iron tablet. Data were analyzed using Independent t-test.Results: Findings showed a significant difference in the mean of hemoglobin level (Intervention group 11.9467; control group 11.0600), hematocrit (Intervention group 38.3867; Control group 33.8133), thrombocyte (Intervention group 3.02536; Control group 2.35805), and erythrocyte (Intervention group 4.30137; Control group 3.78206) with p-value < 0.05.Conclusion: there was a significant effect of Moringa Oleifera on changes in blood profile (hemoglobin, hematocrit, erythrocyte, thrombocyte) in postpartum mothers in the working area of the health center of Tlogosari Wetan. Thus, it is suggested that Moringa leaves could be used to prevent anemia in postpartum mothers.

Zero effect of multiple dosage of olive leaf supplements on urinary biomarkers of oxidative stress in healthy humans

Objective We determined the effect of dietary supplementation with an olive leaf capsule or liquid extract on oxidative status of young and healthy male and female subjects. Methods This was a single-center, randomized, single-blinded, prospective pilot comparison of the effect of dietary supplementation with olive leaf extracts. Healthy young adult male and female subjects ( n = 45) were randomized into three groups and received daily doses of control, capsule, or liquid extract of olive leaf. Urinary F 2α-isoprostane, 8-hydroxy-2′-deoxyguanosine, and Folin-Ciocalteu total reducing power were measured to assess the impact of supplementation. Results Baseline values (mean ± standard deviation) of the biomarkers were 0.24 ± 0.13 μg, 9.16 ± 2.94 μg, and 424.9 ± 121.4 mg of gallic acid equivalents per gram of creatinine, respectively, for the control group. Using these markers, supplementation with liquid or capsule did not alter oxidative status compared with the control group. Possible reasons for the lack of an observed correlation are presented. Conclusion Dietary supplementation with olive leaf extract did not alter the oxidative status of healthy young adults.