This article describes the development and implementation of wellness initiatives within a large Canadian academic mental health hospital, based on the Mental Health Commission of Canada's workplace standards for mental health. To support the implementation of an organizational framework for physician wellness, a needs assessment of Centre for Addiction and Mental Health physicians (N = 181) was conducted between 21 November and 5 December 2017, including measuring physician burnout rates using two items on the Maslach Burnout Inventory tool. Based on findings, and the organizational wellness framework, a multi-pronged wellness approach was developed, improving physician supports at the individual, team and organizational levels. Eighty-four survey responses (46% response rate) were gathered across eight clinical divisions, with 59% of respondents stating that they were negatively impacted by emotionally stressful events at work within the past year. Themes emerging from open-ended questions included the importance of a culture of safety and wellbeing, leadership accountability and availability of formal supports and processes. In response to survey findings, and our organizational framework, the following six initiatives were implemented: (i) a peer support program, (ii) an office of professionalism, (iii) individual and group mentorship opportunities, (iv) communities of practice, (v) enhanced training and leadership development opportunities, and (vi) efforts to optimize use of electronic health records to enhance efficiency of practice. It is possible to implement a multifaceted organizational approach to physician wellness, engaging physicians and continuously adapting in response to physician input. Future robust evaluation of these strategies can inform organizational roadmaps to improve physician wellness.