On November 7, 2000, despite the ardent pleas of clergy from across the spectrum of religious traditions, South Carolina voters repealed a constitutional amendment to pave the way for a state lottery. In a state known for intense evangelical religiosity, this outcome raises several important questions about the political influence of religion and religious leaders. In this article we offer a history of the religious aspects of the lottery debate in South Carolina and an empirical look at the relationships between religious factors and support for the lottery among South Carolina voters. Specifically, we explore the extent to which involvement in evangelical Protestantism, political salience of religion, and clergy cues affected public support for a state lottery Data for the empirical analysis are drawn from an October 3, 2000 poll of 450 South Carolinians who had voted in two previous elections.