You have accessJournal of UrologySurgical Technology & Simulation: Instrumentation & Technology I1 Apr 2016MP23-12 INTRAOPERATIVE RADIATION THERAPY DURING GENITOURINARY SURGERY: THE IMPORTANCE OF SPECIMEN MARGIN STATUS IN IMPROVING SURVIVAL Meera Chappidi, Max Kates, Zeyad Schwen, Nikolai Sopko, Phuoc Tran, Nita Ahuja, Stephanie Terezakis, Phillip Pierorazio, and Trinity Bivalacqua Meera ChappidiMeera Chappidi More articles by this author , Max KatesMax Kates More articles by this author , Zeyad SchwenZeyad Schwen More articles by this author , Nikolai SopkoNikolai Sopko More articles by this author , Phuoc TranPhuoc Tran More articles by this author , Nita AhujaNita Ahuja More articles by this author , Stephanie TerezakisStephanie Terezakis More articles by this author , Phillip PierorazioPhillip Pierorazio More articles by this author , and Trinity BivalacquaTrinity Bivalacqua More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.734AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Intraoperative radiation therapy (IORT) is used to provide effective local control (LC) for patients with locally advanced or recurrent tumors. Since 2006, our institution has performed IORT for pelvic and retroperitoneal soft tissue malignancies. We sought to assess outcomes of IORT cases in which there was genitourinary (GU) involvement. METHODS We retrospectively reviewed patients from 2006-2015 who underwent IORT with GU involvement. Case selection for IORT included those in which pre-op EBRT could not obtain LC without excessive toxicity or pre-op imaging suggested difficulty obtaining negative surgical margins due to proximity to vital structures, bladder, or bowel. To provide IORT, the area at risk for local recurrence is measured following tumor resection and an appropriately sized Freiburg flap is created with linear, connected silicone rubbers balls to provide a uniform radiation dose (10-16 Gy) to the targeted area while using lead shields to protect surrounding structures. The primary endpoint was overall survival (OS) with secondary endpoints of recurrence free survival (RFS, defined as local recurrence in the surgical bed), 90-day readmission rate and Clavien grade IV or V complication rates. RESULTS Of the 158 patients who underwent IORT, 87 cases (55.1%) involved GU surgery. The most common procedures were 33 (37.9%) radical cystectomies and 21 (24.1%) radical nephrectomies. With a median follow-up time of 21.6 months, the 2-year OS was 71% [95% confidence interval (CI) 57-81%]. OS for patients with positive and negative margins was 54% [CI 29-73%] vs. 81% [CI 62-91%] (p=0.04) respectively. The 2-year RFS for patients with negative margins was 73% [CI 55-85%]. In a multivariate model controlling for age and receipt of neoadjuvant chemotherapy, margin status was the only predictor of OS [HR=2.10 (1.32-9.95)]. The 90-day readmission rate was 44.2% and 90-day rate of Clavien IV complications was 16.3% with no deaths in the cohort. CONCLUSIONS IORT is a safe and feasible treatment for high-risk patients undergoing complex surgery for sarcomas and other soft tissue malignancies with GU involvement. While IORT can improve LC, it does not serve as a substitute for adequate surgical control as surgical margin is still an important predictor of survival. Effort should be taken to achieve a negative margin in order to maximize the LC achieved with IORT. As this mode of cancer therapy expands into other sectors of urologic oncology, future studies will need to address the benefits of this cancer therapy versus additional local toxicity. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e266 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Meera Chappidi More articles by this author Max Kates More articles by this author Zeyad Schwen More articles by this author Nikolai Sopko More articles by this author Phuoc Tran More articles by this author Nita Ahuja More articles by this author Stephanie Terezakis More articles by this author Phillip Pierorazio More articles by this author Trinity Bivalacqua More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...