Human activities widely exhibit a power-law distribution. Considering stock trading as a typical human activity in the financial domain, the first aim of this paper is to validate whether the well-known power-law distribution can be observed in this activity. Interestingly, this paper determines that the number of accumulated lead–lag days between stock pairs meets the power-law distribution in both the U.S. and Chinese stock markets based on 10 years of trading data. Based on this finding this paper adopts the power-law distribution to formally define the lead–lag effect, detect stock pairs with the lead–lag effect, and then design a pure lead–lag investment strategy as well as enhancement investment strategies by integrating the lead–lag strategy into classic alpha-factor strategies. Tests conducted on 20 different alpha-factor strategies demonstrate that both perform better than the selected benchmark strategy and that the lead–lag strategy provides useful signals that significantly improve the performance of basic alpha-factor strategies. Our results therefore indicate that the lead–lag effect may provide effective information for designing more profitable investment strategies.