Polycystic ovarian syndrome (PCOS) is a common hormonal disorder in reproductive-age women, characterized by irregular periods, excess androgen levels, and ovarian cysts, often leading to infertility. While incurable, symptoms can be managed through lifestyle changes and treatments. Its exact cause is unknown, but genetic and metabolic factors are implicated. A comprehensive evaluation assessed various health markers including insulin resistance, glycemic index, lipid profile, blood pressure, BMI, and waist-to-hip ratio in PCOS women at Nnewi Anambra State Nigeria’s gynecology clinic, likely aiming to understand metabolic health, cardiovascular risks, and overall well-being. In this cross-sectional study conducted at a hospital, 45 participants diagnosed with PCOS were compared to 45 participants without PCOS, all aged between 18 and 50. Biochemical parameters were assessed using the enzyme-linked immunoassay technique. Data was expressed as Mean ± standard deviation. The differences in parameters studied between the PCOS group (test) and the control group were evaluated using an independent t-test. Statistical significance was set at a p-value of <0.05. Results showed that significantly lower differences exist in the mean serum levels of LDL-C (1.23±0.73) and Insulin resistance (15.13±8.13), in women with PCOS compared with the control (1.96±0.43) and (18.46±10.20)(p<0.05) respectively. A higher significant difference exists in the BMI (32.42±8.72) and WHR (0.71±0.14) of the test group (women with PCOS) compared with the control group (26.79±6.35) and (0.60±.178) respectively. The study found that women with PCOS attending the gynecology clinic at Nnamdi Azikiwe University Teaching Hospital in Nnewi, Anambra state exhibited obesity, without dyslipidemia as indicated by notably elevated mean values of the body mass index.