Latin Research Articles

Plasmodium vivax genomic surveillance in the Peruvian Amazon with Pv AmpliSeq assay.

Plasmodium vivax is the most predominant malaria species in Latin America, constituting 71.5% of malaria cases in 2021. With several countries aiming for malaria elimination, it is crucial to prioritize effectiveness of national control programs by optimizing the utilization of available resources and strategically implementing necessary changes. To support this, there is a need for innovative approaches such as genomic surveillance tools that can investigate changes in transmission intensity, imported cases and sources of reintroduction, and can detect molecular markers associated with drug resistance. Here, we apply a modified highly-multiplexed deep sequencing assay: Pv AmpliSeq v2 Peru. The tool targets a newly developed 41-SNP Peru barcode for parasite population analysis within Peru, the 33-SNP vivaxGEN-geo panel for country-level classification, and 11 putative drug resistance genes. It was applied to 230 samples from the Peruvian Amazon (2007-2020), generating baseline surveillance data. We observed a heterogenous P. vivax population with high diversity and gene flow in peri-urban areas of Maynas province (Loreto region) with a temporal drift using all SNPs detected by the assay (nSNP = 2909). In comparison, in an indigenous isolated area, the parasite population was genetically differentiated (FST = 0.07-0.09) with moderate diversity and high relatedness between isolates in the community. In a remote border community, a clonal P. vivax cluster was identified, with distinct haplotypes in drug resistant genes and ama1, more similar to Brazilian isolates, likely representing an introduction of P. vivax from Brazil at that time. To test its applicability for Latin America, we evaluated the SNP Peru barcode in P. vivax genomes from the region and demonstrated the capacity to capture local population clustering at within-country level. Together this data shows that P. vivax transmission is heterogeneous in different settings within the Peruvian Amazon. Genetic analysis is a key component for regional malaria control, offering valuable insights that should be incorporated into routine surveillance.

Specific depletion of myeloid-derived suppressor cells by the chemotherapeutic agent 5-Fluorouracil enhances protective immune response in Paracoccidioidomycosis.

Paracoccidioidomycosis (PCM), a systemic mycosis in Latin America, is regulated by suppressive mechanisms mediated by tolerogenic plasmacytoid-dendritic-cells and regulatory T-cells. Our recent studies revealed that myeloid-derived suppressor cells (MDSCs), are important mediators in PCM. Their suppressive activity on Th1/Th17 immunity was shown to be mediated by inhibitory effect of IL-10, IDO-1 and PD-L1. Studies revealed the chemotherapeutic drug 5-Fluorouracil (5-FU) as a selective MDSC apoptosis-inducing agent, but its in vivo effect on infectious processes remains poorly investigated. MDSCs and other leukocytes were evaluated in the lungs of 5-FU-treated mice after four, six, and eight weeks of P. brasiliensis infection. Disease severity and immunological response were evaluated in MDSCs-depleted. 5-FU treatment caused a significant reduction of pulmonary MDSCs and fungal loads. The specific depletion of MDSCs by 5-FU reduced all pulmonary CD4+ T-cell populations (Th1, Th2, Th17, and Treg) resulting in improved tissue pathology and increased survival rates. Importantly, this reduction was concomitant with increased frequencies of Th1/Th17 cells and the increased levels of Th1/Th2/Th17 cytokines in the lungs and liver of treated mice suggesting an early and efficient protective effect of these cells. Furthermore, the immuneprotection conferred by the specific depletion of MDSCs by 5FU treatment could be reversed by the adoptive transfer of MDSCs. 5-FU treatment depletes lung-MDSCs of P. brasiliensis-infected mice resulting in enhanced immunity. The protective effect of 5-FU treatment in pulmonary PCM suggests that the specific depletion of MDSCs can be viewed as a potential immunotherapeutic tool for PCM.

The Impact of the Spanish Turn in Recognising the Moroccanness of the Sahara in Latin America

The Impact of the Spanish Turn in Recognising the Moroccanness of the Sahara in Latin America

The Empty Chair. The Loss of Congressional Seats in Colombia Due to Corruption and Criminal Ties

Objective/context: This article has three objectives: to differentiate the theoretical arguments on the empty chair policy in Latin America, to analyze the process of institutional change that culminated with its implementation in Colombia, and to describe how it has been carried out between 2010 and 2024. Methodology: The methodological approach has three components: a theoretical part, a documentary component, and an empirically based analysis. The first describes the contrast between two approaches to the autonomy, control, and accountability of political parties and parliamentarians. The second reviews how these approaches are reflected in the rules on seat ownership (of parties or congresspersons/deputies), accountability, and sanctions for parties and congresspersons when they violate the law. The third consists of identifying cases of loss of seats, their analysis, and the determination of their effects. The principal sources of the study are constitutional reforms, Supreme Court rulings, and decisions of the Attorney General’s Office on convictions of congressmen. The information is complemented with journalistic reports and electoral data. Conclusions: The empty chair policy is established in two Latin American countries (Colombia and Peru). It is an effective legal norm to sanction political parties and legislators convicted for their links with criminal groups, corruption, electoral fraud, and other crimes. It has been applied in eighteen cases due to links to paramilitarism, drug trafficking, and corruption. The affected parties have decreased their electoral performance and their seats in Congress. Originality: This is the first empirical study on the subject in Colombia.

Prevalence and treatment of oral cancer in older of Latin America

Prevalence and treatment of oral cancer in older of Latin America

Impacts of geopolitics and policy on Latin American biodiversity and water resources

AbstractLatin America is a major agricultural producer with important natural resources. Efforts have been made to protect sensitive areas but are hindered by agricultural trade disruptions outside the control of individual countries due to globally integrated crop markets. This analysis assesses the effects of two trade shocks, that is, the war in Ukraine and vehicle decarbonization in the United States (US), on biodiversity and water resources in Latin America. Results show that an increase in maize and wheat exports from the region triggered by the war in Ukraine negatively affects biodiversity in Brazil and leads to cropland expansion into drought‐prone areas in Argentina and Chile. For the case of reduced crop exports from Latin America due to US vehicle decarbonization and the corresponding shift away from US maize ethanol, the pressure on arable land in areas of high biodiversity and water stress is eased. As opposed to agricultural carbon emissions, which have global impacts, biodiversity and water issues have a strong local and regional significance. Regulatory frameworks aiming to protect these regions should be forward looking to detect and shield vulnerable areas from future threats. Other changes affecting global agriculture and trade, for example, sustainable aviation fuels in the US or the European Farm‐to‐Fork policy, need to be anticipated for effective policies in Latin America [EconLit Citations: Q13, Q25, Q34, Q56].

Refuge in Revolution: Chilean and Uruguayan Exiles in Cuba, 1973-1990

ABSTRACT This article examines the refuge revolutionary Cuba offered to Chilean and Uruguayan exiles. Fleeing dictatorships during Latin America’s Cold War, thousands arrived in, or passed through, Cuba. Cuba was a logical refuge, representing a revolution suffused with promises of solidarity, internationalism and socialist modernity. It was also conceived as a route of resistance and return. Centring the memories of former exiles, this article examines expectations and reality of refuge in Cuba. Revealing a diversity of exile experiences, it asks what different forms of refuge existed in Cuba, how these evolved and with what significance for understanding the Cold War.

TBM excavation of São Paulo Metro Line 6 South in heterogeneous ground in urban area

AbstractThe São Paulo Metro is expanding its network in the São Paulo Metropolitan Area inhabited by 21 million people. Metro Line 6 connects the north of the city to the existing metro network further South. The construction of Line 6 currently represents the largest infrastructure project in Latin America, combining the excavation of tunnel boring machine (TBM) and conventional tunnels, cut‐and‐cover stations and a number of deep emergency exit shafts. This paper presents the main features of the TBM tunnel excavated in the South stretch through the Tertiary soils of the São Paulo Basin and through the challenging Embu Complex, which consists of a mixture of fractured rock, saprolite and residual soils. The alignment runs under the dense urban grid of São Paulo under high‐rise buildings and other infrastructure, such as existing Metro lines.

Project Management and Sensory Acceptance in Ready-To-Use Bakery Products: A Systematic Literature Review

Bakery nutritional products are limited in a global market considering the consumer preferences. Recent years have seen a surge in publications, especially in India and Latin America, reflecting nutritional and development of new products challenge, however, there are project management tools that could help in the development of new products because proactive approaches are necessary to navigate bakery product development complexities. Malnutrition and obesity pose global health challenges, elevating the importance of providing more nutritious bakery options. This systematic literature review explores the intersection of bakery product development with project management methodologies, emphasizing nutritional enhancement and consumer acceptance by the analysis of 69 articles from 2013 through 2024 from prestigious database such as Scopus and Redalyc to generate an overview for new future projects related to enhance the sector in Mexico. The study identifies multiple opportunities in bakery product research. The most researched products in this area are bread, cake, cookies and tortillas compared to pasta, pizza, pudding, waffles, etc. Additionally, only a quarter of articles explore new commercial prototypes, indicating significant potential for further development in this area.

Assessing the impact of small firm dynamics on public mental health amid the pandemic in Latin America

ObjectiveThe aim of our study is to examine the relationship between the economic activity of small firms and the mental well-being of the population in five Latin American countries in the early stages of the pandemic.MethodsWe utilize the search volume of certain keywords on Google Trends (GT), such as “boredom,” “frustration,” “loneliness,” “sleep”, “anxiety”, and “depression”, as an indicator of the well-being of the population. By examining the data from Facebook Business Activity Trends, we investigate how social attention reacts to the activity levels of different economic sectors.ResultsIncreased business activity is generally associated with reduced levels of boredom, loneliness, sleep problems and anxiety. The effect on depression varies by sector, with positive associations concentrated in onsite jobs. In addition, we observe that strict Non-Pharmaceutical Interventions (NPIs) tend to exacerbate feelings of boredom and loneliness, sleep issues, and anxiety.ConclusionsOur findings suggest a strong association between different indicators of psychological well-being and the level of activity in different sectors of the economy. Given the essential role of small and medium-sized enterprises (SMEs) in generating employment, especially during crises like the pandemic, it is imperative that they remain resilient and adaptable to support economic recovery and job preservation. To accomplish this, policymakers need to focus on providing financial stability and support for SMEs, fostering social support networks within companies, and incorporating mental health services into workplace environments. This comprehensive strategy can alleviate mental health challenges and enhance public health resilience.

Multinational evaluation of anthropometric age (AnthropoAge) as a measure of biological age in the USA, England, Mexico, Costa Rica, and China: a population-based longitudinal study.

To validate AnthropoAge, a new metric of biological age (BA), for prediction of all-cause mortality and age-related outcomes and characterize population-specific aging patterns using multinational longitudinal cohorts. We analyzed harmonized multinational data from the Gateway to Global Aging, including studies from the US, England, Mexico, Costa Rica, and China. We used body mass index and waist-to-height ratio to estimate AnthropoAge and AnthropoAgeAccel in participants aged 50-90 years old as proxies of BA and age acceleration, respectively. We compared the predictive capacity for all-cause mortality of AnthropoAge and chronological age (CA) using Cox models, described aging trends in all countries and explored the utility of longitudinal assessments of AnthropoAgeAccel to predict new-onset functional decline and age-related diseases using generalized estimating equations (GEE). Using data from 55,628 participants, we found AnthropoAge (c-statistic 0.772) outperformed CA (0.76) for prediction of mortality independently of comorbidities, sex, race/ethnicity, education, and lifestyle; this result was replicated in most countries individually except for Mexico. Individuals with accelerated aging had a ∼39% higher risk of death, and AnthropoAge also identified trends of faster biological aging per year. In longitudinal analyses, higher AnthropoAgeAccel values were independently predictive of self-reported health deterioration and new-onset deficits in basic/instrumental activities of daily living (ADL/IADL), diabetes, hypertension, cancer, chronic lung disease, myocardial infarction, and stroke. AnthropoAge is a robust and reproducible BA metric associated with age-related outcomes. Its implementation could facilitate modeling trends of biological aging acceleration in different populations, although recalibration may enhance its utility in underrepresented populations such as individuals from Latin America.

A jumble of partial democratizing initiatives in mid-century Latin America

The “second wave” metaphor is a convenient but somewhat misleading approximation to how the republics of Latin America adjusted to the post-1945 balance of world forces. In a short period the region experienced a reverberating jumble of democratizing experiments. Although these were loosely linked they were also fragmentary, unstable, and potentially clashing. These diverse, kaleidoscopic, and partially reversible processes developed unevenly over time, often recycling prewar concerns. They reflected competing understandings of what democracy might involve. Some features were highly localised, some expressed region-wide linkages, while global influences also played a part.

High Incidence of Gastric Cancer in El Salvador: A National Multisectorial Study 2000-2014.

Gastric adenocarcinoma (GC) is the fourth leading cause of global cancer mortality, and leading infection-associated cancer. GC has significant geographic variability, with a high incidence in East Asia and mountainous regions of Latin America. In the U.S., GC represents a marked disparity with incidence rates that are 2-3 times higher in Hispanics compared to non-Hispanic whites. We conducted a national retrospective study of incident GC in El Salvador from to 2000-2014 to estimate the age-standardized incidence rate (ASIR) by using a combination of pathology and endoscopy databases. A unique multisectorial coalition was formed between the Ministry of Health (MINSAL) and ES Gastroenterology Society (AGEDES), representing public hospitals (n=5), governmental employee hospitals (ISSS, n=5), and private facilities (n=6), accounting for >95% of national endoscopy capacity. HER2 and EBV tumor status was ascertained in a representative sample during 2014-2016. 10,039 unique cases of GC were identified, 45.5% female, and mean age of 65. 21% and 9.4% were <55 and <45 years old, respectively. ASIRs (M, F) were 18.9 (95%CI;14.4-20.7) and 12.2 per 100,000 persons (95%CI;10.9-13.5), respectively, in the period 2010-2014 with all centers operational. Intestinal GC was 2.8 times more common than diffuse GC. 23.2% had partial or complete pyloric obstruction. The HER2 2+/3+ status was 16.7% and EBER positivity was 10.2%. A high incidence of gastric cancer was confirmed in El Salvador, and nearly half of patients were female. The findings have implications for cancer control in the Central America LMICs and for U.S. Latino populations.

High Incidence of Gastric Cancer in El Salvador: A National Multisectorial Study 2000-2014.

Gastric adenocarcinoma (GC) is the fourth leading cause of global cancer mortality, and leading infection-associated cancer. GC has significant geographic variability, with a high incidence in East Asia and mountainous regions of Latin America. In the U.S., GC represents a marked disparity with incidence rates that are 2-3 times higher in Hispanics compared to non-Hispanic whites. We conducted a national retrospective study of incident GC in El Salvador from to 2000-2014 to estimate the age-standardized incidence rate (ASIR) by using a combination of pathology and endoscopy databases. A unique multisectorial coalition was formed between the Ministry of Health (MINSAL) and ES Gastroenterology Society (AGEDES), representing public hospitals (n=5), governmental employee hospitals (ISSS, n=5), and private facilities (n=6), accounting for >95% of national endoscopy capacity. HER2 and EBV tumor status was ascertained in a representative sample during 2014-2016. 10,039 unique cases of GC were identified, 45.5% female, and mean age of 65. 21% and 9.4% were <55 and <45 years old, respectively. ASIRs (M, F) were 18.9 (95%CI;14.4-20.7) and 12.2 per 100,000 persons (95%CI;10.9-13.5), respectively, in the period 2010-2014 with all centers operational. Intestinal GC was 2.8 times more common than diffuse GC. 23.2% had partial or complete pyloric obstruction. The HER2 2+/3+ status was 16.7% and EBER positivity was 10.2%. A high incidence of gastric cancer was confirmed in El Salvador, and nearly half of patients were female. The findings have implications for cancer control in the Central America LMICs and for U.S. Latino populations.

Impact of Chronic Kidney Disease on the Coronary Revascularization Guided by Intracoronary Physiology: Results of the First Registry with Long-Term Follow-Up in a Latin American Population

The use of invasive physiology methods in patients with renal dysfunction is not well elucidated. Our objective was to evaluate the in-hospital and long-term results of using intracoronary physiology to guide revascularization in patients with chronic kidney disease. In this retrospective study, we evaluated 151 patients from January 2018 to January 2022, divided into 2 groups: CKD (81 patients [114 lesions]) and non-CKD (70 patients [117 lesions]). The mean age was higher (p &lt; 0.001), body mass index was lower (p = 0.007), contrast volume used was lower (p = 0.02) and the number of ischemic lesions/patients was higher (p = 0.005) in the CKD group. The primary outcomes (rate of major adverse cardiac events during follow-up, defined as death, infarction, and need for new revascularization) in the CKD and non-CKD groups were 22.07% and 14.92%, respectively (p = 0.363). There was a significant difference in the target lesion revascularization (TLR) rate (11.68%, CKD group vs. 1.49%, non-CKD group, p = 0.02), this initial statistical difference was not significant after adjusting for variables in the logistic regression model. There was no difference between the rates of death from all causes (6.49%, CKD group vs. 1.49%, non-CKD group, p = 0.15), reinfarction (3.89%, CKD group vs. 1.49%, non-CKD group, p = 0.394), and need for new revascularization (11.68%, CKD group vs. 5.97%, non-CKD group, p = 0.297). As there was no difference in the endpoints between groups with long-term follow-up, this study demonstrated the safety of using intracoronary physiology to guide revascularization in patients with CKD.

Impacts of geopolitics and policy on Latin American biodiversity and water resources

Impacts of geopolitics and policy on Latin American biodiversity and water resources

Oral Oncology: Two elective courses for advanced undergraduates - An Argentine teaching experience

The COVID-19 pandemic prompted significant adaptations in educational practices at Universidad Nacional de Córdoba, including the integration of e-learning and virtual education modalities. In response to an observed increase in advanced-stage oral cancer cases post-2020, we developed new educational strategies aimed at OC prevention and awareness. This study presents our experience with an innovative undergraduate program focusing on Oral Oncology and Oral Potentially Malignant Disorders. Two elective courses were integrated into the curriculum, featuring contributions from Oral Medicine and Pathology experts across several Latin American countries via virtual platforms. Each course provided comprehensive training, including clinical practice and telemedicine protocols for early lesion identification. A total of 107 students successfully completed the courses, highlighting the program's effectiveness in enhancing student engagement and competence in OC prevention. Recommendations from this initiative include reinforcing undergraduate curricula with OC-focused education and promoting international collaboration in higher education for comprehensive training. Future research should assess the long-term impact of such programs on early OC diagnosis and patient referral practices.

Impact of Chronic Kidney Disease on the Coronary Revascularization Guided by Intracoronary Physiology: Results of the First Registry with Long-Term Follow-Up in a Latin American Population

Impact of Chronic Kidney Disease on the Coronary Revascularization Guided by Intracoronary Physiology: Results of the First Registry with Long-Term Follow-Up in a Latin American Population

Antifascist Atlantic: Anticolonial imaginations and the Spanish Civil War

ABSTRACT The Spanish Civil War (1936–1939) is a conflict widely characterized as international in its scale and Spanish or European in its causes, without much attention given to the conflict’s colonial implications. However, there are reasons to argue that the conflict, at the level of both causes and consequences, was connected to issues of Spanish imperialism in Latin America and North Africa as it was to the strictly European factors at play. In this essay, I privilege a perspective from the Global South rather than a Euro-Spanish understanding of this conflict. To that end, I write about the writings of Langston Hughes and Nicolás Guillén during the Spanish Civil War, both through their contact with well-known Republican leaders and with each other. Through these dialogues, Hughes and Guillén theorize the possibility of a Global North antifascism that, taken to its logical conclusion, becomes coherent and allied with Global South anticolonialism.

Stewards, defenders, progenitors, and collaborators: Courts in the age of democratic decline

AbstractIn this introductory essay to the special issue of Law &amp; Policy, “Global Perspectives on Judicial Politics and Democratic Backsliding,” we critically examine the paradoxical role of courts during episodes of democratic backsliding. Despite operating without direct democratic accountability—relying instead on legal precedents and doctrinal interpretations—courts are pivotal in defending democratic integrity during episodes of backsliding. This issue, featuring 10 articles by 15 scholars, offers a comprehensive and nuanced analysis of judicial politics of autocratization. Half of the articles deal directly with the U.S. judiciary, highlighting its unique standing that allows it to both enable and resist democratic backsliding. The other half of the issue explores case studies from Europe, Southeast Asia, and Latin America, highlighting a great deal of variability of tactics, approaches and outcomes. Published during a critical electoral year in 2024, this collection emphasizes the need for ongoing research into the judiciaries' dual capacity to both safeguard and undermine democratic norms.