Latin America Countries Research Articles

Global Fragmentation Phenomenon: New Imperatives of the Transcontinental Cooperation for Eurasia and Latin America

The article analyzes current state of the global economy and the emerging phenomenon of global fragmentation amid the formation of new regional centers of economic growth. Particular attention is paid to the intercontinental cooperation of the countries of Latin America and the Caribbean (LAC) with Eurasia, primarily with the member states of the Eurasian Economic Union (EAEU). The influence of the Western countries’ sanctions on the development of integration processes in the EAEU and Latin America is studied, whereas potential areas for increasing cooperation axis EAEU-Latin America are highlighted.

Toward food sovereignty and self-sufficiency in Latin America and the Caribbean: opportunities for agricultural complementarity

Abstract Food self-sufficiency is a relevant political issue in many countries, developed and developing, particularly to satisfy the internal nutritional needs of the population and face situations in which the prices of basic products are unstable or when a country faces an external shock. Improving resilience involves strengthening local rural communities to meet demand with domestic production. The member countries of Latin America and the Caribbean (LCN) produce enough food to sustain their population and to be one of the world's largest food exporters. From the theoretical discussion and using data from FAO, the research shows that there is a potential to improve food sovereignty and to define food and agricultural policies through agricultural complementarity among the LCN countries. Diverting part of the current trade with third parties to intraregional trade, for products in which the region has a comparative advantage, would mean that LCN countries could save up to 2.7 billion dollars per year, that is, 6.8% of total imports of food in 2018, avoiding the outflow of foreign currency and promoting greater economic integration between countries.

Анализ внешнеэкономического потенциала стран Латинской Америки

The article analyzes the foreign economic potential of Latin American countries in the context of its development in the last decade, characterized by significant global crises and geopolitical upheavals. Considering that Latin American countries are active participants in international relations, including with the Russian Federation, and also play a significant role in the international division of labor, we have set the goal of the study – to quantify the changes and the state of the main economic indicators that reflect both foreign economic and domestic processes in the leading countries of the region under consideration, which determine their foreign economic potential. To achieve this goal, traditional methods of scientific knowledge, analysis and synthesis, as well as methods of analytical tools for working with statistical data were used: tabular, graphical, coefficient method, analytical indicators of time series. Based on the results of the study, a number of patterns of recent years have been identified. In particular, the region under consideration experienced the colossal destructive impact of the COVID-19 pandemic crisis, however, under these conditions, it generally retained its position in the share of world GDP, which is demonstrated by the analyzed international statistics. According to the results of the analysis, it was noted that the realization of the potential of Latin American countries and the development of their economies is ensured through significant structural changes with priorities for such sectors as the agro-industrial complex and high technology, which largely provides prospects for further development of foreign economic activity and strengthening its position in world markets. The data of international statistics demonstrate the effectiveness of the efforts of the leadership of these states to reduce dependence on the export of the oil and gas industry and develop other types of economic activity. A special place in the economies of countries and their potential as a global supplier is occupied by the modernizing agro-industrial complex, and the tourism services sector plays a significant role. The development of enterprises in the field of information and communication services and digital technologies is assessed by experts as the potential for new positive qualitative changes both for the domestic economy and for international cooperation. However, despite the potential, the economies of Latin America are also subject to systemic problems, which are also clearly reflected in the statistics. The main ones are: corruption, which prevents the formation of a favorable market environment; the complexity of organizing business activities; negative investment flows reflecting capital flight; low standard of living of the population as a whole. As a conclusion, conclusions are drawn about the main systemic problems that prevent the countries of Latin America from realizing their socio-economic potential, as well as about the possibilities of foreign economic cooperation between the Russian Federation and them.

ФАКТОРНИЙ АНАЛІЗ ПОЛІТИКИ ЕКОНОМІЧНОГО РИВКА В ЛАТИНОАМЕРИКАНСЬКИХ КРАЇНАХ

In order to identify the key factors of the economic growth of Latin American countries (Argentina, Brazil, Mexico), a factor analysis of the dependence of the state of economic development on a number of macroeconomic indicators in the period of 1960–2020 is carried out. During the analysis gross domestic product in current prices, are selected as the result indicator. In the same time, are selected the following factors: the share of industry in the GDP, the share of agriculture in GDP, export and import of goods and services in the GDP, attracting foreign direct investment, population and gross capital accumulation. It is revealed that the following factors (in descending order) have the greatest influence on the economic growth opportunities of newly industrialized countries: Argentina – population size; import of goods and services; share of industry and agriculture in GDP; Brazil – population; share of agriculture in the GDP; import of goods and services; Mexico – import of goods and services, population; export of goods and services; attraction of foreign direct investment. Thus, the analysis established that the policy of the economic level in Latin American countries has the character of deindustrialization, and in terms of factors of economic growth, it differs significantly from the countries of Europe and the Asian region, where important factors were the development of industry; the export of innovative products; involvement capital for extended reproduction. According to the research data, the main problems related to the implementation of import substitution policy in the newly industrialized countries of Latin America are detected, and key lessons for Ukraine that should be learned from the experience of these countries are developed. These recommendations are the need to build up one's own industrial potential; diversification of industry under the conditions of expansion of exports not of raw materials, but of technologically more complex products with higher competitiveness on the foreign market; stimulating scientific and technical progress and improving the qualifications of labor resources at the national level; increase in gross accumulation etc.

ДЕРЖАВНА ПОЛІТИКА СТИМУЛЮВАННЯ ЕКОНОМІЧНОГО РОСТУ НОВИХ ІНДУСТРІАЛЬНИХ КРАЇН ЛАТИНСЬКОЇ АМЕРИКИ

The experience of implementing the state policy of stimulating economic growth in the newly industrialized countries of Latin America is analyzed in the article. The basis of the economic policy of Argentina, Brazil, Mexico and Chile, starting from the 40s of the last century to the present, is considered. It is revealed that during this period the political course was aimed at promoting an industrial policy focused on import substitution. It is founded that such a policy contributed to the economic growth of the countries, but in fact, import-substituting industrialization began before the internal prerequisites for its implementation were fully matured. It began primarily under the pressure of external circumstances, and not because of internal development impulses. It was established that the policy of import substitution industrialization, although it was aimed at ensuring economic growth and weakening the external dependence of Latin American economies on industrialized countries, it only changed the form of this dependence and led to cycles of exacerbation of macroeconomic instability. It is established that the ineffective policy of stimulating the economic growth of Latin American countries caused a number of problems, the main ones of which are: low level of domestic investment, lack of development resources; significant social differentiation; structural heterogeneity, coexistence of advanced achievements and large areas of backwardness in each country; maintaining and in some ways deepening the lag behind developed countries; low quality of the workforce, insufficient development of education; the absence or, in this case, the weakness of its own scientific and technological potential, lagging in the development of new technologies, etc. It is summarized that the political foundations of the economic growth of Latin American countries are underdeveloped, which causes a number of negative socio-economic effects in society and delays in its progressive development. It is established that inefficient public institutions made it difficult to form an effective state economic policy aimed at preserving financial stability and ensuring long-term economic growth. Recommendations on the formation of the industrial policy of Ukraine, taking into account the experience of the import substitution industrialization policy of Latin American countries, are developed.

Demographic and fertility transition in Nigeria; the progress made so far: a literature review

Background: Nigeria, since its inception as a sovereign nation, has been plagued by population explosion. This may be due to factors that need to be addressed by the government and individuals alike such as fertility desires. Main body: In the course of this review, we drew our resource information from the Nigerian Demographic and Health survey of 2018, PubMed, and African Journals Online (AJOL, Scholarly publications on sub-Saharan Africa and Nigeria in particular that dwell on the area under review. The total fertility rate (TFR) meaning the number of children a woman would bear in her lifetime is high, at a rate of 5.3 Children per woman. Population explosion is also a consequence of the low contraceptive use in Nigeria which stands at a rate of 17 % amongst married couples. Other factors that could be responsible for this population explosion include a lack of good population policies and few or non-existent national family planning programs. These negative effects on the Nigerian population made it grow at an annual rate of 2 %. Fifty percent (50%) of the Nigerian age distribution is under 19 years. This means that the Nigerian demography may not transit (change) readily. Conclusion: A community or country is said to undergo demographic transition when the death rate and fertility rate balance each other, and the age distribution is made of working-class people against the young and the aged who are dependent on others for a living. The economy of such a country is industrialized, with good health systems and a long life span for its citizens. Fertility transition on the other hand means a situation where a community or national fertility rate shows a substantial decline compared to industrialized countries of Europe, The USA, and Latin America in the contemporary world.

Impacts and Measures of COVID-19 on Forest Development

The COVID-19 epidemic has disrupted human life in many ways. The governments have put in place measures to restrict human activities in order to control the development of the epidemic, which has had a number of effects. This paper briefly discusses the impacts of COVID-19 on forest development in terms of forest fires, forest management, forestry, and forest tourism. This paper illustrates the impacts by giving examples from countries in North America, Latin America, Western Europe, Eastern Europe, Asia and Africa. Among these regions, most governments delayed fire prevention due to the need to control the epidemic. For forest management, due to the restriction on human activities, some forest management work have been postponed or canceled. For the forestry, demand for forest products and in import and export markets have changed. For forest tourism, because of restrictions on people's activities, significant reduction has happened in ecotourism. In addition, this paper presents the mitigation measures developed by different governments in the face of the impacts of the epidemic on forestry. most governments have undertaken targeted investment and financing measures to mitigate the impacts of the epidemic, promote forest-related businesses and trade, and provide support and assistance to local residents. Some countries are trying to use this opportunity to shift their focus to a green economy. This essay expects that governments will pay attention to the impacts of the COVID-19 epidemic on forest development and respond to mitigate the damage caused by the epidemic.

A macro analysis of gender segregation and job quality in Latin America

Latin America has seen vast improvements in gender educational and health equality. Favorable supply-side conditions, however, have not translated into greater gender economic equality, a process that also depends on structural economic change and global macroeconomic conditions. In this paper, we assess the role of a variety of macro-level policies and structures in influencing trends in women’s access to high-quality jobs for a sample of 15 countries in Latin America over the period 1990–2018. Using micro-level data, we first evaluate women’s relative share of good jobs, defined in terms of women’s weekly earnings in an industry or occupation relative to the national median wage. Further, we econometrically estimate the association between a variety of macro-level variables and the relative quality of women’s jobs. Results indicate that the most significant and robust positive correlate of women’s relative access to good jobs is public social spending as a share of GDP. Other important macro-covariates include measures of labor market regulation, monetary and fiscal policy, and macroeconomic structure and global orientation, including financial openness. The results suggest that macro-level structures and policies related to globalization that hamper the achievement of greater gender equality can be offset by appropriately targeted government policies.

Social policy expansion and segmentation in the first two decades of the 21st century in Latin America

AbstractLatin American countries saw an important expansion in social policy in the first two decades of the 21st century. Along with this increased inclusion, however, social policy remains segmented. Using recent data from ECLAC, World Bank, and other sources, this paper offers a comprehensive analysis of trends in social policy for the period 2000–2020 for 17 countries in Latin America. Four areas of social policy are assessed in longitudinal and comparative perspectives: transfers, health care, education, and family policies. Conditional cash transfers (CCT) and noncontributory pensions (NCP) are the two main policy innovations that allowed countries in the region to expand social rights to previously excluded populations (outsiders). At the same time, due to their design, these policies have introduced new layers of fragmentation to the welfare mix, without resolving—or even increasing—segmentation in social policy. Segmentation is still the rule for the areas of health care and education, and increasing privatisation went unabated even in the periods of social policy expansion and in the countries governed by left coalitions.

Higher Library Education in the Countries of Latin America

The purpose of the article is look into historical features and to determine the formation stages and the current state of the library specialists’ education system and its level in Latin American countries.
 The methodology. There were used historical-genetic and systemic-structural approaches. It made it possible to establish the main stages periodization of the higher education levels in Library Studies’ origin and development in the leading countries of Latin America. The study proved the influence of North American and European traditions on the development of the training of highly qualified library personnel system in the founding countries of graduate library education on the continent. A comparative and content analysis of the bachelor’s, master’s and Doctoral Degrees’ educational programs in the specialty “Library and Information Sciences” provided by leading universities in Argentina, Brazil, and Mexico, made it possible to determine the general and specific aspects of the specialists training for the information industry, to establish the peculiarities of cognitive and institutional components of bachelor’s and master’s educational programs, justify the objective necessity of strengthening their interdisciplinarity and flexibility.
 The results. It has been established that Argentina was the first among Latin American countries to establish a training school for librarians in the structure of the Philosophy and Literature Faculty of the University of Buenos Aires back in 1922. In the 1940s and 1950s, universities opened Library Studies (Schools) in Panama (1941), Brazil (1942), Peru (1943), Uruguay (1943), Mexico (1945, 1956), Chile (1949), Costa Rica (1950) and Colombia (1956). The system of post-graduate library education began to take shape in the 1970s, when in 1972 the first post-graduate program in the field of “Library and Information Science” was opened in Brazil at the School of Communication and Arts of the University of São Paulo, and in 1980 — the doctoral program as well. Currently, in the countries of Latin America, only the leading metropolitan universities have educational programs of master’s and Doctoral levels. It is due to the low scientific qualification of graduate departments and the insufficient number of professors who can carry out qualified supervision of master’s and Doctoral thesis research.
 The current state of the library and information education system development on the Latin American continent is demonstrated by the following statistics: Brazil has 47 universities with their structure including schools or departments for the library specialists training, Argentina has 16 of such universities, Mexico — 13, Colombia — 6, Chile — 4, Cuba — 3, Costa Rica, El Salvador, Peru, Venezuela — 2 universities each, Bolivia, Ecuador, Panama, Paraguay, Uruguay, Jamaica — 1 university each.
 The scientific topicality. The formation of the higher library education levels system on the Latin American continent took place in several stages: the genesis stage (1920–1930s), the stage of active development (1940–1960s), the stage of starting post-graduate training of library specialists at the postgraduate level, and later — master’s and Doctoral studies (1970–1990s); the stage of strengthening the interdisciplinary integration of educational program profiles (2000 — present). The results of the educational programs (EPs) content analysis of various levels of training in the specialty “Library and Information Sciences” made it possible to establish a certain conservatism of their profiling, to determine that the promising directions for their modernization are interdisciplinary and strengthening of the digital and information and communication components with, for example, such relevant EPs as “Communication, organization, management of information and knowledge”, “Sociocultural, political and economic configurations of information”.
 The practical significance. The research results can be used by Ukrainian institutions of higher education in the process of improving master’s and Doctoral educational programs in the specialty 029 “Information, Library and Archival Affairs”. The introduction of the best foreign training practices of library specialists will improve their quality and competitiveness at the global information market.

NOMAC-E2 shows a better contraceptive effectiveness than LNG combined oral contraceptives in women under 25: real-world PRO-E2 study

Objective: To investigate unintended pregnancy and changes in mood, acne, and weight in NOMAC-E2 vs levonorgestrel-containing COC (COCLNG) users under 25 years. Methods: In this large, observational study, new users (first-ever users of an eligible COC or restarting with the same or a new eligible COC after a break of at least 2 months) of NOMAC-E2 and COCLNG were recruited in 12 countries in Europe, Australia, and Latin America and followed up via questionnaires for up to 2 years. Unintended pregnancy was expressed by the Pearl Index (PI; contraceptive failures/100 women-years). Crude (HRcrude) and adjusted hazard ratios (HRadj) were calculated. Mood and acne changes were defined as change of score from baseline. Weight change was defined as percent change of body weight. Results: Overall, 12,829 NOMAC-E2 users and 17,095 COCLNG users under 25 were followed-up. The risk of unintended pregnancy was statistically significantly lower in the NOMAC-E2 cohort; confirmed events: 30 NOMAC-E2 (PI 0.24; 95% CI, 0.16–0.35) vs 94 COCLNG (PI 0.51; 95% CI, 0.41–0.62). The HRcrude for unintended pregnancy comparing NOMAC-E2 to COCLNG was 0.47 (95% CI, 0.31–0.71) and the HRadj was 0.52 (95% CI, 0.34–0.78). No differential effect on acne, mood, and weight was observed between cohorts. Conclusions: NOMAC-E2 shows a significantly better contraceptive effectiveness in young women and has no differential effect on acne, mood, and weight compared to COCLNG.

Understanding health center–client relationships in the context of a developing Latin America country

This study investigates community health center–client relationships in a developing country. Community health centers deliver health care services to clients who are often financially, or socially disadvantaged. This research empirically explores the extent to which clients’ perceptions of the center’s physical environment, the quality of their social relationships with staff, and the center’s subsidized prices encourage them to engage in favorable behaviors, including place dependence, spreading word of mouth, attending educational events, and complying with health providers’ instructions. The results reveal that the center’s subsidized prices for services are better determinants for favorable outcomes than the setting or relationships. Hoteliers that target budget travelers should realize that although physical and social servicescape elements are important, they are often of lesser importance to these travelers compared to room rates. Namely, budget travelers do not expect elaborate environments or interpersonal communication with employees; therefore, hoteliers should refrain from unnecessary investments.

Implementation of PrEP in Latin America

Although many countries in Latin America have made progress in expanding access to HIV services, efforts to reduce the number of new HIV infections remain insufficient, with a 5% increase from 2010 to 2021.1 In Latin America, 54% of new HIV infections in 2021 were in men who have sex with men (MSM) and transgender women.1 Pre-exposure prophylaxis (PrEP) reduces the risk of HIV infection and is cost-effective in populations at risk. Yet, at the end of 2021, only 11 of 17 countries in Latin America provided some access to PrEP.

MORTALITY RISK BY STATE-LEVEL POVERTY IN COLOMBIA AT DIFFERENT AGE GROUPS

Abstract Residence in high poverty states has been associated with increased mortality risk in the United States, but less attention has been paid to the relationship between state-level poverty and mortality in younger to older adults in Latin America. Poorer states in Colombia, one of the most populous and rapidly aging countries in Latin America, tend to report less access to healthcare, education, and economic opportunities. We examine the relationship between mortality and state-level poverty in Colombia by age and gender. We use data from the 2018 Colombian Census and Vital Statistics to calculate mortality levels and male-female ratios in mortality separately for three broad age categories: young (ages 20-39), middle-aged (40-69), and older adults (70 or older). We find an association between high poverty and high mortality risk among younger men, no association for middle-aged men, and a negative association between mortality risk and poverty among older men. We did not find any evidence for an association between state-level poverty and mortality at any ages. Our results highlight that, for men at older ages, poverty had a counterintuitive association with mortality. These results may be due to selective survival older ages in Colombia or to older adults who are aging into a social safety net that includes healthcare and income benefits. Future research should investigate the impact that unequal access to economic resources and distribution of health care resources has on women and men across age groups in Colombia.

1765. Antibiotic Consumption in a Healthcare System in Bolivia During the First Wave of COVID-19 Pandemic

Abstract Background Several countries in Latin America reported an increase in antibiotic use during the first wave of the COVID-19 Pandemic. Methods We retrospectively evaluated antibiotic use among 10,752 members of a private healthcare system in Santa Cruz de la Sierra, Bolivia, between Jan-Dec 2019 (pre-pandemic) and Jan-Aug 2020 (pandemic). Antibiotic use was calculated as daily defined doses (DDD) per 1,000 member-days, per 100 ambulatory visits, and per 100 inpatient-days, and categorized using the World Health Organization classification (Access, Watch, and Reserve), based on the impact of different antibiotics on antimicrobial resistance. In April 2020, the antibiotic stewardship team developed COVID-19 treatment guidelines for ambulatory and hospitalized patients and provided recommendations on all patients hospitalized due to COVID-19. Due to the nature of the network, guideline use is usually high. During the pandemic period and due to local restrictions, patient interactions were mostly limited to COVID-19 presentations. Differences with 95% confidence intervals (CI) between groups were estimated. Results Pandemic and pre-pandemic antibiotic use in DDD/1,000 member-days was 8.48 and 18.37, respectively (diff. –8.89, 95%CI –10.11 to –9.67). Outpatient DDD/100 ambulatory visits was 67.68 vs. 86.20 (diff. –18.52, 95%CI –19.94 to –17.1), and hospital DDD/per 100 inpatient-days was 39.79 vs. 61.71 (diff. –21.92, 95%CI –26.2 to –17.68) for pandemic and pre-pandemic periods, respectively. During the pandemic period, an overall reduction in macrolides use was also observed (–3.13 DDD/100 ambulatory visits, 95%CI –3.84 to –2.44, and –2.05 DDD/per 100 inpatient-days, 95%CI –2.88 to –1.26). Additionally, an increase in Access antimicrobials (83.3% vs. 79.5%; diff. 3.8%, 95%CI 0.3% to 7.4%) and a reduction in the Watch group (16.7% vs. 20.5%; diff. –3.7%, 95%CI –7.4% to –0.1%) were observed for pandemic and pre-pandemic periods, respectively. Conclusion In this closed network, we observed a reduction in antibiotic use both in ambulatory and inpatient settings. Although, multifactorial, we believe the enhanced antibiotic stewardship approach on COVID-19 patients played a role in limiting antimicrobial use in this private healthcare system. Disclosures All Authors: No reported disclosures.

Dynamics and Prospects for China - Latin America Relations from the Perspective of Latin American Scholars

The research reveals Latin American academic thought on the relationship between Latin America countries and China. The relevance of the topic is linked to the growing importance and presence of China in the foreign policy of Latin American countries, whose bilateral relations are developing against a backdrop of growing US - China tensions. Today, China is one of the key economic partners of several Latin American countries, as well as implementing a number of infrastructure projects on the continent. This forces Latin America to choose between traditional ties of dependence vis-à-vis Washington and increasing economic and investment cooperation with Beijing. Methodologically the article is based on the study and interpretation of the ideas of Latin American scholars and experts gathered from secondary sources, monographs and academic articles. The author puts forward two hypotheses based on the existence of two conjectures. The first hypothesis is that there is no consensus among Latin American scholars and representatives of research centers about the impact of China’s bilateral relations with the countries of the region in the logic of the core-periphery model on the economic development of Latin America. The second hypothesis is that the views of the local academic community have little or even no influence on the decisions Latin American governments make regarding China. The author concludes that at a time when Latin America is going through a crisis cycle of integration processes the region is unable to take a unified position on the issue of assessing China’s performance.

1717. In Vitro Activity of Aztreonam-Avibactam Against Enterobacterales Isolated from Pediatric and Adult Patients Collected During the ATLAS Global Surveillance Program, 2017-2020

Abstract Background The rapid spread of antimicrobial resistance among clinically isolated Enterobacterales (Eba) continues to threaten public health. Aztreonam (ATM) is a monobactam stable to hydrolysis by metallo-β-lactamases (MBLs) and avibactam (AVI) inhibits class A, class C, and some class D serine β-lactamases. ATM-AVI is being developed for use against drug-resistant isolates of Eba, especially those co-producing MBLs and other β-lactamases. This study evaluated the in vitro activity of ATM-AVI and comparators against Eba collected in 2017-2020 from pediatric and adult patients as part of the ATLAS global surveillance program. Methods Non-duplicate clinical Eba isolates were collected from 239 sites in 55 countries in Europe, Latin America, Asia/Pacific (excluding mainland China and India), and Middle East/Africa. Susceptibility testing was performed by CLSI broth microdilution and interpreted using CLSI 2022 breakpoints. PCR and sequencing were used to determine the β-lactamase genes present in all isolates with meropenem MIC >1 µg/mL, and Escherichia coli, Klebsiella spp. and Proteus mirabilis with ATM or ceftazidime MIC >1 µg/mL. Results MIC90 values for ATM-AVI of 0.12 µg/ml were observed for Eba isolates collected from both pediatric and adult patients. Against all Eba isolates, ≤8 µg/ml of ATM-AVI was sufficient to inhibit 99.97% (pediatric) and 99.95% (adult), whereas ATM alone inhibited only 72.0% and 75.9% of these isolates at ≤8 µg/ml, respectively (table). Among isolates that screened positive for an MBL, MIC90 values were 0.25 µg/ml (pediatric) and 0.5 µg/ml (adult). Among MBL-positive isolates, ATM-AVI inhibited 100% (pediatric) and 99.9% (adult) at concentrations ≤8 µg/ml. In contrast, ATM alone only inhibited 19.0% (pediatric) and 25.3% (adult) of isolates carrying MBLs at ≤8 µg/ml. Conclusion Based on MIC90 values, ATM-AVI demonstrated potent in vitro activity against Eba isolated both from pediatric and adult patients. The capability of AVI to potentiate ATM against MBL-positive isolates warrants its continued development. Disclosures All Authors: No reported disclosures.

1720. In Vitro Activity of Aztreonam-Avibactam and Comparator Agents Against Enterobacterales from Patients with Urinary Tract Infections Collected During the ATLAS Global Surveillance Program, 2017-2020

Abstract Background β-lactamase-producing Enterobacterales (Eba) frequently carry resistance mechanisms for multiple drug classes, limiting treatment options. Avibactam (AVI) inhibits class A, class C, and some class D serine β-lactamases, while aztreonam (ATM) is refractory to hydrolysis by class B metallo-β-lactamases (MBLs). ATM-AVI is being developed for use against drug-resistant isolates of Eba, especially those co-producing MBLs and serine β-lactamases. This study evaluated the in vitro activity of ATM-AVI and comparators against Eba collected in 2017-2020 from patients with urinary tract infections (UTI) as part of the ATLAS global surveillance program. Methods Non-duplicate clinical isolates were collected from 239 sites in 55 countries in Europe, Latin America, Asia/Pacific (excluding mainland China and India), and Middle East/Africa. Susceptibility testing was performed by CLSI broth microdilution and interpreted using CLSI 2022 and FDA (tigecycline) breakpoints. PCR and sequencing were used to determine the β-lactamase genes present in all isolates with meropenem MIC >1 µg/mL, and Escherichia coli, Klebsiella spp. and Proteus mirabilis with ATM or ceftazidime MIC >1 µg/mL. Results Based on MIC90 values, ATM-AVI was at least as active as every comparator agent tested against all 15085 Eba isolates collected from UTI (0.12 µg/ml; table), with only five isolates testing with MIC values >8 µg/ml (not shown). Against resistant subsets of isolates, MIC90 values for ATM-AVI were 0.25-0.5 µg/ml, 4- to 8-fold lower than any comparator tested. Against MBL-positive isolates, ATM-AVI MIC values ranged from ≤0.015-2 µg/ml with the exception of one Escherichia coli isolate testing with an MIC value of 16 µg/ml that carried NDM-5, CMY-145, CTX-M-55 and TEM (not shown). Conclusion Based on MIC90 values, ATM-AVI was the most potent agent tested against drug-resistant and MBL-positive subsets of Eba collected from UTI. Based on the potent in vitro activity of ATM-AVI, continued development of this combination for treatment of UTI caused by drug-resistant Eba is warranted. Disclosures All Authors: No reported disclosures.

COMUNICAÇÃO DE RISCO DE INUNDAÇÃO

The aim of the present study is to present an overview of, and research trends to investigate, flood risk communication between 2010 and 2020. Thus, bibliometric analysis was used as research technique. The main results comprised 34 identified articles that were mainly published from 2014, onwards. Most authors were from European, North American and Asian countries. It was possible observing lack of authors from developing countries in Africa and Latin America, which are areas acknowledged as vulnerable to, and affected by, disproportionate impacts caused by natural disasters. Studies conducted so far have presented elucidative findings about the effects of effective risk communication presence or absence on society. Keywords: Risk Information. Resilience. Bibliometrics. Collaboration Networks

148. Imipenem-Relebactam activity and genotypic characteristics of Carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa Isolates from Latin American Infections - Study for Monitoring Antimicrobial Resistance Trends (SMART) 2017 – 2020

Abstract Background Imipenem/relebactam (IMI/REL) is a combination of Imipenem with Relebactam, an inhibitor of class A and C β-lactamases and has been approved in the US and EU, but not in Latin America. This report evaluates the in vitro activity of IMI/REL and comparators against Latin America (LATAM) Enterobacterales and P. aeruginosa (PSA) and the frequency of carbapenemase encoding genes (CEG) among gram-negative bacilli (GNB) isolated through the SMART Program (2017-2020). Methods 21606 nonconsecutive GNB isolates were collected in 10 LATAM countries. MICs for amikacin (AK), ceftazidime-avibactam (C-A), ceftolozane/tazobactam (C/T) and IMI/REL were determined by broth microdilution and interpreted by CLSI; a subset of Enterobacterales and P. aeruginosa carbapenem resistant was selected for characterization of carbapenemase encoding genes by PCR followed by DNA sequencing. Results Escherichia coli (N=9872; EC) tested susceptible to > 96% of all antibiotics analyzed; for P. aeruginosa (N=4528), C/T and C-A had the best susceptibility rates (85.7 and 86.6% respectively); for Enterobacter cloacae (N=1091; ECL) and Klebsiella pneumoniae (N=6115; KPN), we note that only IMI/REL and C-A were ≥ 95%. Profile of 2845 carbapenem resistant isolates was analysed and the main isolated agent in most countries was KPN, corresponding to 55% (1470), except in Mexico, Panama and Venezuela where PSA was the main carbapenemase producer. The blakpc-2, 3 were found in KPN 76.7, 79.2, 53.3, 52.1 and 85.3% in Argentina, Brazil, Colombia, Ecuador and Puerto Rico, respectively; Guatemala, Mexico, Venezuela presented blaNDM-1 in 74.3, 44.1 and 51.4%. Among ECL blakpc-2 (35.7%-Brazil, 48.2%-Colombia) and blaNDM-1(45.7%-Mexico) were most frequent, blaVIM-24 (16.6%) and blaIMP-18 (38.8%) were observed in Venezuela and Puerto Rico and in the latter, we observed first time reported blakpc-45 in 27.7 %. PSA expressed blakpc-2 (33.33%- Colombia), Chile and Venezuela blaVIM-2 (44.3%, 58.8%); blaspm-1 occurred only in Brazil (6.9%). Most common carbapenemase-producing bacteria in LATAM (n=2845) Antimicrobial susceptibility of Enterobacterales and P. aeruginosa (full data analysis=21606) Most Frequent CEG detected among carbapenemase producing isolates in Latin American countries (Genotypical sample analyzed n=2845) Conclusion The frequency of CEG is a threat in LATAM, mostly in Enterobacterales, whereas PSA as expected, has a lower frequency, but still a concern. In LATAM, IMI/REL has shown relevant activity against CEG producers, showing it is an option for treatment infections caused by MDR strains. Disclosures Gustavo Mizuno, PharmD, MSD Brazil: Employee Thales Polis, MD, MSD Brazil: Employee Jacqueline Ferrari, MD, MSD Brazil: Employee Jacqueline Pavia, MD, MSD COLOMBIA: EMPLOYEE Elisa Beirão, MD, MSD BRAZIL: Grant/Research Support Ana C. Gales, MD, MSD BRAZIL: Grant/Research Support Felipe Tuon, MD, MSD BRAZIL: Grant/Research Support Alexandre Alcantara, PharmD, MSD BRAZIL: EMPLOYEE Paula M. Batista, PharmD, MSD BRAZIL: EMPLOYEE.