Lateral Translation Research Articles

Palinspastic restoration of Variscan oroclines – implications for dextral transpression and terrane affinities

Abstract The Paleozoic Variscan orogen in Europe has a markedly circuitous trace for which several different origins have been postulated, including deformation around promontories on the colliding continental margins, extrusion within the collision zone, folding of a ribbon continent and collision with a substantial dextral component. Adopting the latter assumption, unfolding of the large, steeply plunging folds (‘oroclines’) of Iberia and the Moroccan Meseta requires more than 4000 km of dextral lateral translation of Laurussia with respect to Gondwana. Constraints on the age of the folding require that this lateral translation occurred in mid-late Carboniferous time. Significant dextral translation of Laurussia with respect to Gondwana late in the Variscan collision is supported by palaeomagnetic data for the two supercontinents, although the exact timing of this relative motion is not well constrained due to large uncertainties in the palaeomagnetic pole positions. Our palinspastic reconstruction of the major Variscan folds of Iberia places the rocks of the South Portuguese Zone of western Iberia adjacent to the Rhenish Massif; for instance, as part of Avalonia. By the same token, the Sehoul Block in the Moroccan Meseta probably originated at the western end of Cadomia, although nothing in our analysis precludes it also being derived from Avalonia.

A proper sequence of dynamic alignment in transtibial prosthesis: insight through socket reaction moments

Dynamic alignment in prosthetic fitting is important because it affects the user’s stability, kinematics, and kinetics such as socket reaction moments. It is performed by tuning the spatial relationship between the transtibial prosthetic socket and the foot following sequential observational gait analysis in the three anatomical planes. However, the order of planes in which the adjustment should be performed is still unclear. To investigate the appropriate sequence of dynamic alignment adjustment, ten participants with transtibial amputation were asked to walk in different alignment conditions (flexion, extension, adduction, abduction; lateral, medial, anterior, and posterior translation of the socket, and plantarflexion, dorsiflexion, inversion, and eversion of the foot) to measure socket reaction moments in the out-of-planes (e.g., the effect of sagittal alignment on the coronal moment). A significant difference was found only among socket posterior translation, socket flexion, and baseline alignment in the coronal moment (P = 0.02). The results of the current and previous studies suggest that moments in the coronal plane are affected by alignment changes in all three planes, whereas moments in the sagittal plane are affected only by sagittal alignment changes. It is suggested that the procedure of alignment adjustments should be finalized in the coronal plane.

Relationship between the bilateral ratios of the thoracic shape and electromyographic activity of the thoracic and lumbar iliocostalis muscles during thoracic lateral translation.

[Purpose] This study aimed to determine the relationship between thoracic lateral deviation, the bilateral ratio of the thoracic shape, and the bilateral ratio of the thoracic and lumbar iliocostalis muscles during resting sitting and thoracic lateral translation. [Participants and Methods] We included 23 healthy adult males in the study. The measurement tasks were resting sitting and thoracic lateral translation relative to the pelvis. The thoracic lateral deviation and bilateral ratio of the upper and lower thoracic shapes were measured using three-dimensional motion capture. The bilateral ratio of the thoracic and lumbar iliocostalis muscles were measured using the surface electromyographic recording. [Results] The bilateral ratio of the lower thoracic shape was significantly positively correlated with the thoracic translation distance and the bilateral ratio of the thoracic and iliocostalis muscles. In addition, the bilateral ratio of the thoracic iliocostalis muscles was significantly negatively correlated with the bilateral ratios of the lower thoracic shape and lumbar iliocostalis muscles. [Conclusion] Our findings showed that the asymmetry of the lower thoracic shape is associated with left lateral deviation of the thorax at rest and thoracic translation distance. In addition, the thoracic and lumbar iliocostalis muscle activity differed between the left and right translations.

Clinical relevance of Bennett\'s contribution – An overview

Bennett movement has been extensively discussed in the literature, yet the clinical relevance of Bennett’s contribution in the field of Prosthodontics and restorative dentistry remains unclear. An electronic search of articles in PubMed database for relevant literature published between 1958 until present day was meticulously scrutinized with the following search terms: lateral movements or immediate mandibular lateral translation or mandibular side shift or Bennett side shift or Bennett movement. After conducting an extensive and in-depth review of the literature, the authors were unable to conclusively find the clinical relevance of Bennett movement. Moreover, the logical sequence could not be negated fully. For the beginners in the profession, it is desirable to incorporate this for intellectual and logical satisfaction until new research proves otherwise. The Bennett movement have little or no clinical impact in a restorative occlusal scheme.

A combined anterior cruciate ligament/Meniscal injury alters the patellofemoral joint kinematics of anterior cruciate ligament-deficient knees during a single-leg lunge exercise: A cross-sectional study.

Anterior cruciate ligament deficiency (ACLD) is often accompanied by concomitant meniscal tears. The study aimed to assess the kinematic alterations of patellofemoral joint (PFJ) in anterior cruciate ligament deficiency knees with or without meniscal tears during a single-leg lunge. Sixty unilateral anterior cruciate ligament deficiency patients were recruited for the study, including 15 isolated anterior cruciate ligament deficiency patients (group 1), 15 anterior cruciate ligament deficiency patients with medial meniscal tears (group 2), 15 patients with lateral meniscal tears (group 3) and 15 patients with combined medial/lateral meniscal tears (group 4). The patellofemoral joint kinematics were determined by a single fluoroscopic image system. Patellofemoral joint kinematics of contralateral anterior cruciate ligament-intact (ACLI) and anterior cruciate ligament deficiency knees were compared. With or without meniscal tears, anterior cruciate ligament deficiency knees had significantly smaller patellar flexion than the anterior cruciate ligament-intact knees (∼5°-10°; p < 0.05). anterior cruciate ligament deficiency knees had more patellar lateral tilting by approximately 1°-2° than the anterior cruciate ligament-intact knees (p < 0.05) in groups 2, 3, and 4. anterior cruciate ligament deficiency groups with medial meniscal deficiencies showed consistent increased lateral patellar translations (2-4mm) compared to the anterior cruciate ligament-intact group during a single-leg lunge. The results indicate that meniscal tears alter anterior cruciate ligament deficiency patients' patellofemoral joint kinematics and the types of the meniscal injuries also affect the patellofemoral joint kinematics. Considering the varying effects of meniscal tears on the patellofemoral joint kinematics, specific treatments for anterior cruciate ligament deficiency patients with meniscal tears should be proposed in some closed kinetic chain (CKC) exercise programs, such as single-leg lunge.

Biomechanical Comparison of 3 Medial Patellofemoral Complex Reconstruction Techniques Shows Medial Overconstraint but No Significant Difference in Patella Lateralization and Contact Pressure

The purpose of this study was to investigate biomechanical differences of medial patellofemoral ligament (MPFL) reconstruction, medial quadriceps tendon femoral ligament (MQTFL) reconstruction, and a combination of these techniques to restore lateral patellar constraint and contact pressures. Eight fresh frozen cadaver knees were mounted to a custom jig with physiological quadriceps tendon loading. Flexion angles and contact pressure (CP) were dynamically measured using Tekscan® pressure sensors and Polhemus® Liberty 6 degree of freedom (6DOF) positioning sensors in the following conditions: 1) intact 2) MPFL and MQTFL deficient, 3) MPFL reconstructed, 4) Combined MPFL+ MQTFL reconstructed, and 5) MQTFL reconstructed. Lateral patellar translation was tested using horizontally directed 30 N force applied at 30° of knee flexion. The knees were flexed in dynamic fashion, and CP values were recorded for 10°, 20°, 30°, 50°, 70°, and 90° degrees of flexion. Group differences were assessed with ANOVA's followed by pairwise comparisons with Bonferroni correction. MPFL (P= .002) and combined MPFL/MQTFL (P= .034) reconstruction significantly reduced patellar lateralization from+19.28% (9.78%, 28.78%) in the deficient condition to-17.57% (-27.84%,-7.29%) and-15.56% (-33.61%, 2.30%), respectively. MPFL reconstruction was most restrictive and MQTFL reconstruction the least-7.29% (-22.01%, 7.45%). No significant differences were found between the three reconstruction techniques. Differences in CP between the three reconstruction techniques were not significant (<.02 MPa) at all flexion angles. The present study found no significant difference for patellar lateralization and patellofemoral CP between MPFL, combined MPFL/MQTFL, and MQTFL reconstruction. All 3 techniques resulted in stronger lateral patellar constraint compared to the native state, while the MQTFL reconstruction emulated the intact state the closest. Various surgical techniques for medial patellofemoral complex reconstruction can restore patellar stability with similar patellofemoral articular pressures.

Ukusebenza/Ukuphangela: Raiding the Work of the Future

This paper is not about work or labour itself, and how it changes historically in South Africa (from pastoral, to agricultural and industrial; native labour, wage labour, migrant labour etc.), but about how the meaning of 'work' and 'labour' itself changes. What we want to suggest, is that an 'original' meaning of the tasks/duties associated with 'work' was 'woman': ukusebenza. What men did, does not constitute 'work' but something else entirely: raiding, moving, occasional, going etc.: ukuphangela. It is in the latter term, ukuphangela, that the term 'raid' emerges, and the argument draws on this notion and meaning of raid to underscore the re-thinking of gender, the subject and her relation to work, and history. The paper operates in two registers, focusing on the historic meanings of work and labour in the Eastern Cape and tracing lateral translations of these meanings into East London in the 1950s. It argues that in re-thinking meanings of labour and work through multiple temporalities, and through the contested meanings of the isiXhosa terms ukusebenza and ukuphangela, these word fragments are read as 'entryways to a wordliness' that puts lateral universals and temporalities of work back into circulation. As such, we pose the question rather, following Anne Kelk Mager and Helen Bradford, of whether it is gender (and what it means to be a man or a woman) that is at the forefront not only of class and race struggles, but of what comes to constitute the meaning of 'work', a concept whose provenance and meaning changes, as we have noted, with the making of modernity, industrialisation/capitalism, and the 'Europeanisation' of the world.

The Effect of Minimally Invasive Hallux Valgus Correction on Sesamoid Position and Rotation

Category: Bunion; Midfoot/Forefoot Introduction/Purpose: Minimally invasive hallux valgus correction is increasing in popularity. Third generation minimally invasive chevron / Akin (MICA) techniques have low complication rates and high patient satisfaction. The MICA technique utilizes burrs to make percutaneous osteotomies of the distal first metatarsal and base of the first proximal phalanx. Deformity correction is achieved through lateral translation of the metatarsal head and closure of the Akin osteotomy. In open hallux valgus procedures, derotation of the first metatarsal and reduction of the sesamoids has shown to be essential to optimizing outcome. To our knowledge, the impact of the MICA technique on sesamoid and first metatarsal rotation has not been evaluated. In this study, we attempt to quantify the correction of metatarsal rotation and sesamoid rotation following MICA bunion correction. Methods: A cohort of patients undergoing minimally invasive hallux valgus correction at a single center were prospectively followed. All bunion deformities were corrected utilizing the MICA technique. Demographic information including age, sex, BMI, and laterality were collected. Concomitant procedures and any complications were recorded. All patients underwent a weight bearing CT scan and had weight bearing radiographs performed both before surgery and at a minimum of 6 months after surgery, after the osteotomy sites had healed. Weight bearing CTs were utilized to compare sesamoid station, sesamoid rotation, and metatarsal rotation (alpha angle). Radiographs were used to compare HVA, IMA, and sesamoid station pre and postoperatively. PROMIS scores were also collected from patients before surgery and at their most recent follow-up visit to assess the impact of minimally invasive bunion correction on patient outcomes. Results: Twelve patients, all female, with an average age of 49.8 +- 13.5 years were included. There were no major complications and all osteotomies healed. Hallux valgus angle (HVA) and intermetatarsal angle (IMA) improved significantly from 29.4 +- 5.00 and 13.6 +- 1.38 to 13.6 +- 7.13 and 5.92 +- 3.99 respectively (p&lt;.05). Alpha angle did not significantly change pre and postoperatively (p=.715). Rotation of the fibular sesamoid (p=.011) was significantly different postoperatively, while tibial sesamoid rotation trended towards significance (p=.136). Average sesamoid station significantly improved on CT scan from 1.45 preoperatively to 0.5 postoperatively (p=.001). PROMIS scores did not differ significantly from pre to postoperatively. Conclusion: MICA correction of hallux valgus deformity offers powerful correction of the IMA and HVA. The MICA technique, using a translational chevron osteotomy, does not significantly change first metatarsal rotation but does lead to reduction of the sesamoids, as measured by sesamoid station and improved sesamoid rotation. While differences in PROMIS scores were not seen in this study, larger studies are required to delineate the relationship between patient outcome measures and degree of sesamoid reduction in MICA hallux valgus correction.

Premolar Extraction Affects Mandibular Kinematics.

The practice of premolar extraction in orthodontics is controversial for its potential detrimental effects on the stomatognathic system. However, the ways in which premolar extraction affects mandibular function are still poorly understood. The purpose of this study was to assess the influence of premolar extraction on mandibular kinematics by evaluating axiographic tracings. Forty-five orthodontically treated patients with premolar teeth extraction were compared with 45 paired untreated controls, selected for the absence of malocclusions. Systematic three-dimensional axiographic recordings of the mandibular movements were performed for protrusive-retrusive movements and speech. The transversal deviations and length of the movements were recorded for both sides along with the rotation angle during speech. Differences between the axiographic variables were analyzed via the permutation test and Wilcoxon rank-sum test. Linear regression was performed to test whether axiographic parameters were predictive of group affiliation. Dot plots were used to explore the distribution of each of the axiographic outcomes, and isometric principal component analysis to assess the differences between the cumulative effects of premolar extraction on jaw motion. The mandibular lateral translation in protrusion-retrusion and speech, the amount of rotation as well as the length of mandibular movements during speech were significantly higher in the treated subjects than in the controls, while retral stability did not differ. The linear regression yielded significant results for the mandibular lateral translation in protrusion-retrusion. The isometric principal component analysis showed higher values of the axiographic variables for 11 out of 45 individuals in the study sample compared with the control group. Premolar extraction altered mandibular kinematics in at least 25% of the cases within our sample, and the transversal discrepancy between protrusive and retrusive tracings was even predictive of group affiliation. These results support the notion that the routine practice of premolar extraction as part of the orthodontic treatment should be discouraged. It is compelling to perform further studies to assess whether a disrupted kinematics of the mandible is associated to temporomandibular disorders.

6DOF knee kinematic alterations due to increased load levels.

Whether load carriage leads to six-degrees-of-freedom (6DOF) knee kinematic alterations remains unclear. Exploring this mechanism may reveal meaningful knee kinematic information that can be used to improve load carriage conditions, the design of protective devices, and the knowledge of the effects of load carriage on knees. We recruited 44 subjects to explore kinematic alterations from an unloaded state to 60% bodyweight (BW) load carriage. A three-dimensional gait analysis system was used to collect the knee kinematic data. One-way repeated analysis of variance (ANOVA) was used to explore the effects of load levels on knee kinematics. The effects of increasing load levels on knee kinematics were smooth with decreased or increased trends. We found that knees significantly exhibited increased lateral tibial translation (up to 1.2 mm), knee flexion angle (up to 1.4°), internal tibial rotation (up to 1.3°), and tibial proximal translation (up to 1.0 mm) when they went from an unloaded state to 60%BW load carriage during the stance phase (p < 0.05). Significant small knee adduction/abduction angle and posterior tibial translation alterations (<1°/mm) were also identified (p < 0.05). Load carriage can cause significant 6DOF knee kinematic alterations. The results showed that knee kinematic environments are challenging during increased load. Our results contain kinematic information that could be helpful for knee-protection-related activities, such as target muscle training to reduce abnormal knee kinematics and knee brace design.

All-arthroscopic Knee Patellofemoral Ligament Repair

Patellar dislocations are common injuries in the pediatric and adolescent population, with an estimated mean incidence of 42/100,000 person-years. The medial patellofemoral ligament is the most important structure preventing lateral patellar translation, whereas its patellar attachment is frequently damaged after patellar dislocations. This technical note presents an all-arthroscopic medial patellofemoral ligament repair technique suggested after a first episode of patellar dislocation.

Knee Kinematic Patterns and Early Cartilage Lesion Characteristics in Patients with Anterior Cruciate Ligament Reconstruction.

Specific knee kinematic alterations have been theorized to correlate with the progression of cartilage degeneration, and therefore, post-traumatic osteoarthritis in patients with anterior cruciate ligament reconstruction (ACLR). However, how specific knee kinematic alterations contribute to knee joint cartilage degenerations remains to be unclear. To solve this problem, we hypothesized that there are specific cartilage-degenerating kinematic gait patterns that could be supported by the specific areas of cartilage lesions in ACLR knees. Thirty patients with unilateral ACLR knees and 30 healthy controls were recruited for the study. The kinematic differences between the ACLR knees and the healthy control knees during the stance phase were calculated to identify the kinematic patterns. Cartilage lesion distribution characteristics were acquired for patients with ACLR knees to validate the kinematic patterns using magnetic resonance images. Two kinematic patterns were modeled, i.e., sagittal (increased flexion angle and posterior tibial translation) and coronal (increased lateral tibial translation and abduction angle) kinematic patterns. For the sagittal pattern, the cartilage lesion distributions showed that there were more cartilage lesions (CLs) in the superoposterior regions than the posterior regions in the femoral condyles (p = 0.001), and more CLs in the posterior regions than the middle regions in the tibial plateau (p < 0.001). For the coronal pattern, the cartilage lesion distributions showed that there were more CLs in the lateral compartments near the tibial spine than the medial compartments near the tibial spine (tibial sides, p = 0.005 and femoral sides, p = 0.290). To conclude, the cartilage degeneration distribution evidence largely supports that the two kinematic patterns may contribute to cartilage degeneration in ACLR knees. These findings may provide a potential strategy of delaying early cartilage degeneration in ACLR knees by using motion (kinematic) pattern modification or training. However, investigations should be conducted on the actual effects of this potential strategy.

Regional pleural strain measurements during mechanical ventilation using ultrasound elastography: A randomized, crossover, proof of concept physiologic study.

BackgroundMechanical ventilation is a common therapy in operating rooms and intensive care units. When ill-adapted, it can lead to ventilator-induced lung injury (VILI), which is associated with poor outcomes. Excessive regional pulmonary strain is thought to be a major mechanism responsible for VILI. Scarce bedside methods exist to measure regional pulmonary strain. We propose a novel way to measure regional pleural strain using ultrasound elastography. The objective of this study was to assess the feasibility and reliability of pleural strain measurement by ultrasound elastography and to determine if elastography parameters would correlate with varying tidal volumes.MethodsA single-blind randomized crossover proof of concept study was conducted July to October 2017 at a tertiary care referral center. Ten patients requiring general anesthesia for elective surgery were recruited. After induction, patients received tidal volumes of 6, 8, 10, and 12 mL.kg–1 in random order, while pleural ultrasound cineloops were acquired at 4 standardized locations. Ultrasound radiofrequency speckle tracking allowed computing various pleural translation, strain and shear components. We screened 6 elastography parameters (lateral translation, lateral absolute translation, lateral strain, lateral absolute strain, lateral absolute shear and Von Mises Strain) to identify those with the best dose-response with tidal volumes using linear mixed effect models. Goodness-of-fit was assessed by the coefficient of determination. Intraobserver, interobserver and test-retest reliability were calculated using intraclass correlation coefficients.ResultsAnalysis was possible in 90.7% of ultrasound cineloops. Lateral absolute shear, lateral absolute strain and Von Mises strain varied significantly with tidal volume and offered the best dose-responses and data modeling fits. Point estimates for intraobserver reliability measures were excellent for all 3 parameters (0.94, 0.94, and 0.93, respectively). Point estimates for interobserver (0.84, 0.83, and 0.77, respectively) and test-retest (0.85, 0.82, and 0.76, respectively) reliability measures were good.ConclusionStrain imaging is feasible and reproducible. Future studies will have to investigate the clinical relevance of this novel imaging modality.Clinical trial registrationwww.Clinicaltrials.gov, identifier NCT03092557.

In vivo kinematic comparison of medial pivot total knee arthroplasty in weight-bearing and non-weight-bearing deep knee bending

BackgroundThis study aimed to determine the kinematics of medial pivot total knee arthroplasty by comparing weight-bearing and non-weight-bearing deep knee bending and to evaluate the effect of the weight-bearing state on the kinematics. MethodsThe kinematics of 19 knees were investigated under fluoroscopy during squatting (weight-bearing) and active-assisted knee bending (non-weight-bearing) using two- to three-dimensional registration technique. Accordingly, range of motion, anteroposterior translation for the medial and lateral low contact points, axial rotation of the femoral component relative to the tibial component and kinematic pathway were evaluated. FindingsThere was no difference in range of motion between the two states. The medial anteroposterior translation showed no significant movement with no anterior translation in both the weight-bearing and non-weight-bearing from 0° to 90° of flexion. Regarding the lateral anteroposterior translation, a posterior translation was observed during weight-bearing, whereas a slight anterior translation from 0° to 30° of flexion and subsequent posterior translation were found in the non-weight-bearing. Femoral external rotation was observed in the weight-bearing, whereas femoral internal rotation was seen from 0° to 30° of flexion and subsequent femoral external rotation was observed in the non-weight-bearing. The kinematic pathway showed medial pivot motion and subsequent bicondylar rollback in the weight-bearing, whereas only medial pivot motion was observed in the non-weight-bearing. InterpretationThe medial anteroposterior translation of the femur during deep knee bending showed no anterior motion in the two states. The lateral anteroposterior translation and femoral rotation were different in the mid-flexion range between the two states.

Main clinical approaches to orthognathic surgery for class II open bite and genioplasty patients: a brief systematic review

Introduction: Orthognathic surgery (OS) is used to improve the patient's facial appearance and to correct maxillary and mandibular deformities resulting from malocclusions, disease, or trauma. In this context, genioplasty is a procedure to correct an aesthetic and functional deformity of the chin region, improving the contour. Moreover, anterior open bite (AOB) is the lack of vertical contact or negative overbite between the anterior teeth of the superior and inferior arches when the posterior teeth are in occlusion. Objective: The present study aimed to perform a brief systematic review with risk of bias analysis by funnel plot to highlight the main clinical approaches of orthognathic surgery in class II patients with open bites and also concerning genioplasty. Methods: The research was carried out from February 2022 to May 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 115 articles were found. In total, 57 articles were fully evaluated and 34 were included and evaluated in this study. And of the total of 34 articles, only 11 articles were developed as the main clinical results. A total of 32 articles were excluded because they did not meet the GRADE classification, and 16 were excluded because they were at risk of bias. The symmetric funnel plot does not suggest a risk of bias between the small sample size studies. A retrospective observational study compared 57 patient charts on treatment outcomes for anterior occlusion and vertical skeletal stability after maxillary or mandibular surgery to correct Class II malocclusion with a mild to moderate open bite. After surgery, 87% of Le Fort I patients and 63% of patients with bilateral sagittal split osteotomy had a positive overbite, and at the 6-month follow-up, the percentages were 90% and 74%, respectively. Another study showed Class II patients had significantly greater amounts of lateral and lower translation than class III patients. Also, genioplasty represents one of the most common auxiliary procedures and may be associated with corrective surgery for dentofacial dysmorphisms. However, care must be taken with mental nerve injuries, asymmetries, and intraoperative bleeding are the main immediate complications.

Automating QA analysis for a six-degree-of-freedom (6DOF) couch using image displacement and an accelerometer sensor

The purpose of this study is to develop an approach for automating quality assurance (QA) analysis for a six-degree-of-freedom (6DOF) couch using image displacement and an accelerometer sensor. A cubic phantom was fabricated using 3D printing and the accelerometer sensor was embedded in the phantom to measure the couch in the pitch and roll directions. The accuracy and reliability of image displacement and the accelerometer sensor were investigated prior to their practical use for 6DOF couch QA. Image displacement performance had an accuracy and reliability of 0.026 ± 0.026 mm for the translation direction and 0.021 ± 0.016° for the rotation direction. Accelerometer sensor performance had an accuracy and reliability of 0.023 ± 0.018° for pitch rotation and 0.051 ± 0.024° for roll rotation. Automating QA analysis was used to perform 6DOF couch QA, and the couch position errors measured using image displacement were less than 0.99 mm, 0.91 mm, 0.82 mm for the vertical, longitudinal, lateral translation in range between ±20 mm, and 0.07°, 0.23°, and 0.2° for pitch, roll, and yaw rotation in range between ±3° whereas the couch position errors measured using the accelerometer sensor were less than 0.1° and 0.19° for the pitch and roll rotation in range between ±3°.

Enabling non-isocentric dynamic trajectory radiotherapy by integration of dynamic table translations

Objective. The purpose of this study is to develop a treatment planning process (TPP) for non-isocentric dynamic trajectory radiotherapy (DTRT) using dynamic gantry rotation, collimator rotation, table rotation, longitudinal, vertical and lateral table translations and intensity modulation and to validate the dosimetric accuracy. Approach. The TPP consists of two steps. First, a path describing the dynamic gantry rotation, collimator rotation and dynamic table rotation and translations is determined. Second, an optimization of the intensity modulation along the path is performed. We demonstrate the TPP for three use cases. First, a non-isocentric DTRT plan for a brain case is compared to an isocentric DTRT plan in terms of dosimetric plan quality and delivery time. Second, a non-isocentric DTRT plan for a craniospinal irradiation (CSI) case is compared to a multi-isocentric intensity modulated radiotherapy (IMRT) plan. Third, a non-isocentric DTRT plan for a bilateral breast case is compared to a multi-isocentric volumetric modulated arc therapy (VMAT) plan. The non-isocentric DTRT plans are delivered on a TrueBeam in developer mode and their dosimetric accuracy is validated using radiochromic films. Main results. The non-isocentric DTRT plan for the brain case is similar in dosimetric plan quality and delivery time to the isocentric DTRT plan but is expected to reduce the risk of collisions. The DTRT plan for the CSI case shows similar dosimetric plan quality while reducing the delivery time by 45% in comparison with the IMRT plan. The DTRT plan for the breast case showed better treatment plan quality in comparison with the VMAT plan. The gamma passing rates between the measured and calculated dose distributions are higher than 95% for all three plans. Significance. The versatile benefits of non-isocentric DTRT are demonstrated with three use cases, namely reduction of collision risk, reduced setup and delivery time and improved dosimetric plan quality.

A Critical Analysis of Lateral Versus Central Endpoint in Distal Tibia Nailing: Does It Affect Alignment?

To evaluate the effect of a traditional "center-center" end point for distal tibia nailing in comparison with a lateral-of-center end point on fracture malalignment in a cadaver model. Nine matched pairs of human cadaveric lower-extremity specimens were used to model the effect of nail end point on fracture alignment in extra-articular distal tibia fractures. After simulation of the fracture through a standardized osteotomy, 1 member of each pair was fixed with an intramedullary nail using a "center-center" end point, whereas a lateral-of-center end point was used for the other member of the pair. Specimens were stripped of soft tissue, and digital calipers were used to measure fracture translation and gap medially, laterally, anteriorly, and posteriorly. Coronal plane angulation at each fracture was measured on the final mortise image. The average coronal angulation was 7.0 degrees of valgus (with a SD of 4.1) in central-end point specimens versus 0.2 degrees of valgus (SD = 1.5) in lateral-end point specimens ( P < 0.001). Lateral-end point specimens also demonstrated significantly less fracture gap medially (mean 0.2 vs. 3.1 mm for central-end point specimens, P < 0.001), anteriorly (mean 0.1 vs. 1.3 mm, P = 0.003), and posteriorly (mean 0.3 vs. 2.2 mm, P = 0.003). Lateral-end point specimens also showed less lateral translation (mean 0.6 vs. 1.6 mm, P = 0.006). Lateral-of-center nail end points may help surgeons restore native alignment in extra-articular distal tibia fractures and avoid valgus malalignment.

The risk of tibial eminence avulsion fracture with bi-unicondylar knee arthroplasty

AimsThe aim of this study was to determine the risk of tibial eminence avulsion intraoperatively for bi-unicondylar knee arthroplasty (Bi-UKA), with consideration of the effect of implant positioning, overstuffing, and sex, compared to the risk for isolated medial unicondylar knee arthroplasty (UKA-M) and bicruciate-retaining total knee arthroplasty (BCR-TKA).MethodsTwo experimentally validated finite element models of tibia were implanted with UKA-M, Bi-UKA, and BCR-TKA. Intraoperative loads were applied through the condyles, anterior cruciate ligament (ACL), medial collateral ligament (MCL), and lateral collateral ligament (LCL), and the risk of fracture (ROF) was evaluated in the spine as the ratio of the 95th percentile maximum principal elastic strains over the tensile yield strain of proximal tibial bone.ResultsPeak tensile strains occurred on the anterior portion of the medial sagittal cut in all simulations. Lateral translation of the medial implant in Bi-UKA had the largest increase in ROF of any of the implant positions (43%). Overstuffing the joint by 2 mm had a much larger effect, resulting in a six-fold increase in ROF. Bi-UKA had ~10% increased ROF compared to UKA-M for both the male and female models, although the smaller, less dense female model had a 1.4 times greater ROF compared to the male model. Removal of anterior bone akin to BCR-TKA doubled ROF compared to Bi-UKA.ConclusionTibial eminence avulsion fracture has a similar risk associated with Bi-UKA to UKA-M. The risk is higher for smaller and less dense tibiae. To minimize risk, it is most important to avoid overstuffing the joint, followed by correctly positioning the medial implant, taking care not to narrow the bone island anteriorly.Cite this article: Bone Joint Res 2022;11(8):575–584.

QUANTIFICATION OF 6D INTER-FRACTION TUMOUR LOCALISATION ERRORS IN TONGUE AND PROSTATE CANCER USING DAILY KV-CBCT FOR 1000 IMRT AND VMAT TREATMENT FRACTIONS.

This study aimed to evaluate the 6D inter-fraction tumour localisation errors in 20 tongue and 20 prostate cancer patients treated with intensity-modulated radiation therapy and volumetric-modulated arc therapy. The patient tumour localisation errors in lateral, longitudinal and vertical translation axes and pitch, roll and yaw rotational axes were analysed by automatic image registration of daily pretreatment kilovoltage cone-beam computed tomography (kV-CBCT) with planning CT in 1000 fractions. The overall mean error (M), systematic error (Σ), random error (σ) and planning target volume (PTV) margins were evaluated. The frequency distributions of setup errors were normally distributed about the mean except for pitch in the tongue and prostate. The overall 3D vector length≥5mm was 14.2 and 49.8% in the ca-tongue and ca-prostate, respectively. The frequency of rotational errors ≥1 degree was a maximum of 37 and 59.5%, respectively, in ca-tongue and ca-prostate. The M, Σ and σ for all translational and rotational axes decreased with increasing frequency of verification correction in ca-tongue and ca-prostate patients. Similarly, the PTV margin was reduced with no correction to alternate day correction from a maximum of 4.7 to 2.5mm in ca-tongue and from a maximum of 8.6 to 4.7mm in ca-prostate. The results emphasised the vital role of the higher frequency of kV-CBCT based setup correction in reducing M, Σ, σ and PTV margins in ca-tongue and ca-prostate patients.