Lateral Peak Research Articles

Abstract 4123631: Significance of collagen triple helix repeat-containing protein 1 as a right ventricular biomarker in pulmonary hypertension

Background: Right ventricular failure is a major prognostic determinant of pulmonary hypertension and progresses with myocardial fibrosis. Extracellular matrix proteins play a major role in myocardial fibrosis. Right ventricular biomarkers for right ventricular function and fibrosis are poorly examined in pulmonary hypertension. This study investigated the significance of collagen triple helix repeat-containing protein 1 (CTHRC1), one of the extracellular matrix proteins, as a right ventricular biomarker. Methods and Results: A monocrotaline-induced pulmonary hypertension rat model was used in this study. CTHRC1 expression in the right ventricle was higher in rats with monocrotaline-induced pulmonary hypertension than in controls. CTHRC1 was associated with fibrosis in the rat's right ventricle. Next, human circulating CTHRC1 levels were evaluated in controls (n = 20), pulmonary arterial hypertension (PAH, n = 46), and chronic thromboembolic pulmonary hypertension (CTEPH) patients (n = 64). Human circulating CTHRC1 levels were higher in PAH (P = 0.006) and CTEPH patients (P = 0.011) than in controls (Figure). Human circulating CTHRC levels were correlated with tricuspid lateral annular peak systolic velocity (R = -0.213, P = 0.029), right ventricular fractional area change (R = -0.225, P = 0.017), and right ventricular global longitudinal strain evaluated by magnetic resonance imaging (R = 0.429, P = 0.009). In addition, human circulating CTHRC1 levels were decreased after balloon pulmonary angioplasty (P < 0.001) in CTEPH patients. Conclusions: CTHRC1 could be a novel biomarker associated with right ventricular failure and fibrosis in pulmonary hypertension patients.

Effect of Lateral Load to the Behavior of Single Piles Subjected to Earthquake Load in Sand

In fact, pile usually carry static and dynamic load in same time, the case of simulations lateral and dynamic load is possible occurred. This case is not cover enough by previous researches especially by laboratory model. Therefore, the purpose of this study is to determine the extent to which altering the horizontal lateral loads impacts the behavior of individual piles during seismic events. An experimental test was devised using a physical model with an advanced shaking table that using El Centro earthquake. Sandy soil with 65% relative density used raining technique. Lateral loads were applied at levels of 0%, 50% and 100% from allowable lateral load capacity. It was observed that when lateral load increased from 0% to 50% and 100%, the lateral displacement response decreased by 32.10% and 49.59% respectively. While the vertical displacement increased by 49.96% and 76.95%. Finally, the acceleration decreased by 34.39% and 41.03%. This is possibly due to the load acts at an angle opposite to the earthquake as a restraining factor for the pile. led to a decrease in lateral displacement, vertical displacement, and peak ground acceleration.

Comparison of knee biomechanical characteristics during gait between patients with knee osteoarthritis and healthy individuals

ObjectiveThis study aim to quantify the differences in knee biomechanics during gait between knee osteoarthritis (KOA) patients and healthy individuals. MethodsTwenty KOA patients (4 males and 16 females, 66.2 ± 7.7 years) and twenty controls (16 males and 4 females, 64.8 ± 5.4 years) were recruited for gait test using the motion capture system and force-platform system. The spatiotemporal parameters, knee kinematics and kinetics, and tibiofemoral contact force (TFCF) were calculated using an improved musculoskeletal model. ResultsKOA patients walked with reduced speed (48.6 %), stride length (32.9 %), stride height (33.0 %), time proportions of single-support phases (19.2 %), increased gait cycle time (31.0 %), time proportions of stance (8.5 %) and double-support phases (57.7–75.9 %). KOA patients had significant smaller peak flexion angle (29.1 %), flexion ROM (50.6 %) and peak flexion moment (90.2 %), greater peak adduction moment (KAM) (40.7 %), peak rotation moments (KRM) (50.0 %), KAM impulse (106.2 %) and KRM impulse (126.0 %). In proximodistal direction, greater medial TFCF impulse (238 %), total and medial first-peak TFCF (9.6 % and 15.2 %), and smaller lateral peak TFCF (33.3 %) and TFCF impulse (38.4 %) were found in KOA patients. Besides, significant differences were found in the total, medial and lateral peak TFCFs and TFCF impulses in mediolateral direction, and the medial and lateral TFCFs and TFCF impulses in anteroposterior direction. ConclusionsSignificant differences were found in the spatiotemporal parameters, knee kinematics and kinetics, and TFCF between the two groups. The results of this study have important implication for clinicians and rehabilitation physicians. These quantified biomechanical differences can provide data support for the personalized and quantified rehabilitation strategies, give suggestions for the exercises of KOA patients, help monitor disease, evaluate surgical treatment, and develop more effective preoperative planning and postoperative rehabilitation strategies.

Inhibition of MRTF-A Ameliorates Pathological Remodeling of the Pressure-loaded Right Ventricle.

Right ventricular (RV) fibrosis is associated with RV dysfunction in a variety of RV pressure-loading conditions where RV mechanical stress is increased, but the underlying mechanisms driving RV fibrosis are incompletely understood. In pulmonary and cardiovascular diseases characterized by elevated mechanical stress and transforming growth factor - beta-1 (TGF-β1) signaling, myocardin-related transcription factor A (MRTF-A) is a mechanosensitive protein critical to driving myofibroblast transition and fibrosis. Here we investigated whether MRTF-A inhibition improves RV pro-fibrotic remodeling and function in response to a pulmonary artery banding (PAB) model of RV pressure-loading. Rats were assigned into either 1) sham or 2) PAB groups. MRTF-A inhibitor CCG-1423 was administered daily at 0.75mg/kg in a subset of PAB animals. Echocardiography and pressure-volume hemodynamics were obtained at a terminal experiment 6-weeks later. RV myocardial samples were analyzed for fibrosis, cardiomyocyte hypertrophy, and pro-fibrotic signaling. MRTF-A inhibition slightly reduced systolic dysfunction in PAB rats reflected by increased lateral tricuspid annulus peak systolic velocity, while diastolic function parameters were not significantly improved. RV remodeling was attenuated in PAB rats with MRTF-A inhibition, displaying reduced fibrosis. This was accompanied with a reduction in PAB-induced upregulation of yes-associated protein (YAP) and its paralog transcriptional co-activator with PDZ-binding motif (TAZ). We also confirmed using a second-generation MRTF-A inhibitor CCG-203971 that MRTF-A is critical in driving RV fibroblast expression of TAZ and markers of myofibroblast transition in response to TGF-β1 stress and RhoA activation. These studies identify RhoA, MRTF-A, and YAP/TAZ as interconnected regulators of pro-fibrotic signaling in RV pressure-loading, and as potential targets to improve RV pro-fibrotic remodeling.

Poster 254: Improvements in Kujala at Minimum Two-Years Following Medial Patellofemoral Ligament Reconstruction are Correlated with Intraoperative Instability Measurements: A Multivariate Analysis of Risk Factors

Objectives: Isolated medial patellofemoral ligament reconstruction (MPFLR) is an effective treatment for those suffering from patellofemoral instability. Currently, many concomitant procedures are associated with MPFLR that address underlying pathologic anatomy. The indication and need for such procedures are currently not well understood and often involve the use of more invasive techniques. We aim to identify patients who may be more vulnerable to worse outcomes. The purpose of this study is to correlate demographic, anatomical, and clinical risk factors to minimum two-year outcomes following isolated MPFLR. Methods: A retrospective review of patients undergoing isolated MPFLR for recurrent patellar instability at a single institution between December 2015-June 2021 was performed. Patients with concomitant osseous procedures beyond chondroplasty and any ligamentous procedure were excluded. Included patients completed patient reported outcome (PRO) surveys preoperatively then at a minimum of 2 years postoperatively. Demographic, radiographic, surgical, and clinical data was collected. Univariate correlations to minimum 2-year delta-PRO scores were calculated, then those reaching significance were included in a multivariable linear regression analysis. Results: One hundred and thirteen MPFLR patients were included (77 female, 36 male; age: 21.6 ± 9.1 years). Final Kujala score was 88.44 ± 14.12 at 2.97 ± 1.11 years postoperatively. On univariate testing, final Kujala score was significantly correlated with age at time of surgery ( P=0.035; r=0.218), body mass index (P=0.035; r=-0.204), and the degree of knee flexion at which the patella can no longer be manually dislocated laterally during an examination under anesthesia (Instability Resolution Angle — IRA; P=0.010; r=-0.318). The delta final Kujala score (mean score 30.72 ± 19.68) was significantly correlated with age at time of surgery (P=0.032; r=-0.207), age at time of first patellar instability event (P=0.001; r=0.364), Caton-Deschamps Index (CDI; P=0.026; r=-0.235), trochlear width (P=0.016; r=0.251), the percentage of trochlear-patellar overlap on sagittal MRI (P=0.031; r=0.227), and the depth of the central trochlear trough from the lateral trochlear peak (P=0.035; r=0.221)(Table 1). On multivariable linear regression analysis, a larger IRA remained significantly correlated with worse final Kujala scores ( P= 0.018) and delta final Kujala ( P= 0.04). Conclusions: A larger IRA on examination under anesthesia is independently correlated with worse final and delta final Kujala scores at a minimum of two-years after isolated MPFLR. This finding can help guide surgeons in their decision to do an isolated MPFLR or add in larger, more invasive procedures that address underlying anatomic pathologies.

The Role of Galectin-3 Levels for Predicting Paroxysmal Atrial Fibrillation in Patients with Embolic Stroke of Undetermined Source.

Background/Objectives: Paroxysmal atrial fibrillation (PAF) is an important cause that is thought main potential factor in Embolic stroke of undetermined source (ESUS). Extended Holter ECG is an expensive and time-consuming examination. It needs another tools for predicting PAF in ESUS patients. In this study, serum galectin-3 levels, ECG parameters (PR interval, P wave time and P wave peak time) LA volume index, LA global peak strain and atrial electromechanical conduction time values were investigated for predicting PAF. Methods: 150 patients with ESUS and 30 volunteers for the control group were recruited to study. 48-72 h Holter ECG monitoring was used for detecting PAF. Patients were divided into two groups (ESUS + PAF and ESUS-PAF) according to the development of PAF in Holter ECG monitoring. Results: 30 patients with ESUS whose Holter ECG monitoring showed PAF, were recruited to the ESUS + PAF group. Other 120 patients with ESUS were recruited to the ESUS-PAF group. PA lateral, PA septum, and PA tricuspid were higher in the ESUS + PAF group (p < 0.001 for all). Serum galectin-3 levels were significantly higher in ESUS + PAF than in ESUS-PAF and control groups (479.0 pg/mL ± 435.8 pg/mL, 297.8 pg/mL ± 280.3 pg/mL, and 125.4 ± 87.0 pg/mL, p < 0.001, respectively). Serum galectin-3 levels were significantly correlated with LAVI, PA lateral, and global peak LA strain (r = 0.246, p = 0.001, p = 0.158, p = 0.035, r = -0.176, p = 0.018, respectively). Conclusion: Serum galectin-3 levels is found higher in ESUS patients which developed PAF and Serum galectin-3 levels are associated LA adverse remodeling in patients with ESUS.

Stability control of goaf‐driven roadway surrounding rock under interchange remaining coal pillar in close distance coal seams

AbstractThe roadway surrounding rock stability under the influence of interchange remaining coal pillar in close distance coal seams is one of the key factors affecting the coal mines safe and efficient mining. To reduce the roadway deformation, theoretical analysis, numerical simulation, and on‐site verification were used to study the influence of geological, mining, and support factors on the stability of the floor roadway surrounding rock. A design method for strengthening the roadway surrounding rock support was proposed. The results showed that the coal seam depth, the distribution characteristics of the remaining coal pillar load, the starting point position of stress recovery in the upper coal seam goaf and the lower coal seam goaf lateral load had a significant influence on the lower coal seam stress. The peak stress in the lower coal seam increased linearly with the increase of the coal seam depth, the remaining coal pillar, and the lower coal seam goaf lateral peak stress. The remaining coal pillar influence area width increased linearly and exponentially with the increase of the remaining coal pillar width and the distance between the starting point of stress recovery in goaf and the coal pillar edge, respectively. The peak stress and shear strength of the narrow coal pillar decreased exponentially with the increase of the spacing between bolts or cables. The roadway surrounding rock deformation decreased exponentially with the increase of the distance between the strengthening support area and the remaining coal pillar edge. For the Baigou coalmine, a design scheme for bolt strengthening support parameters has been proposed. The roadway surrounding rock deformation tended to stabilize after 21 days, with deformation values of 264 and 488 mm for the roof and floor, and two sides, respectively.

Quantification of left ventricular myocardial strain: Comparison between MRI tagging, MRI feature tracking, and ultrasound speckle tracking.

Ultrasound speckle tracking is frequently used to quantify myocardial strain, and magnetic resonance imaging (MRI) feature tracking is rapidly gaining interest. Our aim is to validate cardiac MRI feature tracking by comparing it with the gold standard method (i.e., MRI tagging) in healthy subjects and patients. Furthermore, we aim to perform an indirect validation by comparing ultrasound speckle tracking with MRI feature tracking. Forty-two subjects (17 formerly preeclamptic women, three healthy women, and 22 left bundle branch block patients of both sexes) received 3-T cardiac MRI and echocardiography. Cine and tagged MRI, and B-mode ultrasound images, were acquired. Intrapatient global and segmental left ventricular circumferential (MRI tagging vs. MRI feature tracking) and longitudinal (MRI feature tracking vs. ultrasound speckle tracking) peak strain and time to peak strain were compared between the three techniques. Intraclass correlation coefficient (ICC) (< 0.50 = poor, 0.50-0.75 = moderate, > 0.75-0.90 = good, > 0.90 = excellent) and Bland-Altman analysis were used to assess correlation and bias; pless than 0.05 indicates a significant ICC or bias. Global peak strain parameters showed moderate-to-good correlations between methods (ICC = 0.71-0.83, p< 0.01) with no significant biases. Global time to peak strain parameters showed moderate-to-good correlations (ICC = 0.56-0.82, p< 0.01) with no significant biases. Segmental peak strains showed significant biases in all parameters and moderate-to-good correlation (ICC = 0.62-0.77, p< 0.01), except for lateral longitudinal peak strain (ICC = 0.23, p= 0.22). Segmental time to peak strain parameters showed moderate-to-good correlation (ICC = 0.58-0.74, p< 0.01) with no significant biases. MRI feature tracking is a valid method to examine myocardial strain, but there is bias in absolute segmental strain values between imaging techniques. MRI feature tracking shows adequate comparability with ultrasound speckle tracking.

Axial compressive and cyclic lateral behavior of a structural masonry prism constructed from crushed COVID‐19 face masks concrete bricks

AbstractDiscarded medical face masks endanger the environment worldwide. In this study, experiments were conducted to investigate the effect of a shredded face mask (SFM) at 0% (control mix), 0.5%, 1.0%, and 2.0% by volume of concrete in the form of pieces that were 1 cm wide and 2 cm long on the properties of fresh and hardened concrete. After performing experimental testing on the materials, finite element masonry prisms with dimensions of 400 × 200 × 560 mm3 were modeled on the ANSYS platform. Four prisms with different fabric contents were numerically examined to study the compressive behavior, and 12 prisms with three different mortar joints were analyzed under an incremental horizontal load in the presence of four vertical displacements of 0.5, 1.0, 3.0, and 4.5 mm. The results revealed that increasing the SFM content in concrete led to a decrease in fresh and hardened concrete properties, including density, slump, split‐tensile strength, and compressive strength, by 9.5%, 20%, 24%, and 34%, respectively, compared with the control concrete at 0.5%. Moreover, the addition of 0.5% SFMs to the prism bricks reduced the maximum compressive load, deflection, and strain energy by 24%, 10%, and 39%, respectively. Altering the mortar type and vertical load affected the lateral cyclic behavior of the prisms. Compared with the M3 prism subjected to the same axial displacement, the M2 prism had 21.36%, 11%, 27.2%, and 10.48% higher lateral peak load, lateral peak displacement, equivalent stress, and strain energy, respectively. Furthermore, the lateral stiffness of the prism increases as the axial pressure increases. The lateral peak load of the M3 prism measured at 1.0, 3.0, and 4.5 mm axial displacement was raised by 60%, 142%, and 182%, respectively, as compared with the same prism at 0.5 mm axial displacement. The outcome provides a feasible concept for reusing masks in concrete construction with controllable strength deterioration on the masonry prism at 0.5% recycled SFM, resulting in attractive responses of these composites at the nonstructural scale

Shallow trochlear groove and narrow medial trochlear width at the proximal trochlea in patients with trochlear dysplasia: Athree-dimensional computed tomography analysis.

Although the Dejour classification is the primary classification system for evaluating trochlear dysplasia, concerns have been raised about its reliability owing to its qualitative criteria and challenges associated with obtaining accurate radiographs. This study aimed to quantify trochlear dysplasia using three-dimensional (3D) computed tomography (CT) reconstruction with novel parameters related to the transepicondylar axis (TEA). Sixty patients were enrolled, including 20 with trochlear dysplasia and 40 healthy controls. The 3D CT model was generated using the Materialise Interactive Medical Image Control System software. The following six parameters were measured in eight consecutive planes at 15° intervals (planes 0-105): the distance from the TEA to the most cortical point of the lateral condyle ('LP-TEA', where LP stands for lateral peak), medial condyle ('MP-TEA', MP for medial peak)and deepest point of the trochlea ('TG-TEA', TG for trochlear groove). The distances from the medial epicondyle (MEC) to the corresponding TEA points were measured ('LP-MEC', 'MP-MEC'and 'TG-MEC'). In the dysplasia group, TG-TEA (planes 0, 15and 30) and MP-MEC (planes 0, 15and 30) were significantly greater than those in the control group (all p < 0.05 for planes of TG-TEA and MP-MEC). For type A dysplasia, LP-MEC (plane 0) was greater than that in the control group. For type B dysplasia, the MP-MEC (planes 0 and 15) and TG-TEA (planes 0 and 15) were greater than those of the control group. For type D dysplasia, MP-MEC (planes 0, 15and 30) and TG-TEA (planes 0 and 15) were elevated. The 3D CT reconstruction analysis established a reproducible method for quantifying osseous trochlear morphology. Patients with trochlear dysplasia had a shallow TG and narrow medial trochlear width at tracking angles of 0°-30°. This finding corroborates the clinical manifestations of recurrent patellar instability that occur during early flexion. Level III.

Collagen Triple Helix Repeat-Containing Protein 1 Is a Novel Biomarker of Right Ventricular Involvement in Pulmonary Hypertension

BackgroundPulmonary hypertension leads to right ventricular failure, which is a major determinant of prognosis. Circulating biomarkers for right ventricular function are poorly explored in pulmonary hypertension. This study aimed to clarify the significance of collagen triple helix repeat-containing protein 1 (CTHRC1) as a biomarker of right ventricular failure in pulmonary hypertension. MethodsA monocrotaline-induced pulmonary hypertension rat model was used to evaluate right ventricular CTHRC1 expression and its relationship with fibrosis. Next, human plasma CTHRC1 levels were measured in controls (n = 20), pulmonary arterial hypertension (n = 46), and patients with chronic thromboembolic pulmonary hypertension (CTEPH) (n = 64) before the first and after the final balloon pulmonary angioplasty. ResultsCTHRC1 expression was higher in the right ventricles of rats with monocrotaline-induced pulmonary hypertension than in those of controls. CTHRC1 was colocalized with vimentin and associated with fibrosis in the right ventricles. Plasma CTHRC1 levels were higher in human patients with pulmonary arterial hypertension (P = 0.006) and CTEPH (P = 0.011) than in controls. Plasma CTHRC levels were correlated with B-type natriuretic peptide (R = 0.355, P < 0.001), tricuspid lateral annular peak systolic velocity (R = –0.213, P = 0.029), and right ventricular fractional area change (R = –0.225, P = 0.017). Finally, plasma CTHRC1 levels were decreased after the final balloon pulmonary angioplasty (P < 0.001) in CTEPH. ConclusionsCTHRC1 can be a circulating biomarker associated with right ventricular function and fibrosis in pulmonary hypertension and might reflect the therapeutic efficacy of balloon pulmonary angioplasty in CTEPH.

Abstract P159: Echocardiographic Cardiac Phenotype in Val122Ile Variant Transthyretin Amyloidosis Among Hispanics/Latinos: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Background: Transthyretin amyloidosis, most often caused by Val122Ile mutation, is linked to a higher risk of heart failure (HF) and mortality. Subclinical abnormalities in cardiac structure and function linked to Val122Ile mutations are less well defined in Hispanics/Latinos. We studied the cardiac phenotype of Hispanic/Latino Val122Ile carriers versus non-carriers. Methods: Val122Ile carrier status was determined with genome-wide data. We analyzed echocardiographic data from adults 45 years or older (unweighted n= 6376) from HCHS/SOL and the Echocardiographic Study of Latinos, Echo-SOL. Measures of cardiac structure and function (Table) were compared among Val122Ile carriers and non-carriers using age-and-sex-adjusted least square means (continuous variables) and proportions (categorical variables). Prevalence of pre-HF, identified by the presence of at least one abnormal echocardiographic parameter, was also compared among those with vs. without Val122Ile mutation. Complex survey statistics and sample weights are utilized for all analyses. Results: Val122Ile carriers (0.8%; unweighted n= 40) were younger (mean ±SE, 55.5 years ±1.7), had higher systolic blood pressure (mean ±SE, 130 mmHg ±3.6), but lower body mass index (mean ±SE, 28.5 kg/m 2 ±1.4) than non-carriers, p &lt;0.0001. Lower mean values of left ventricle (LV) ejection fraction, LV end diastolic volume, right ventricle (RV) fractional area change, lateral peak e’ velocity and lower pre-HF prevalence was seen among carriers vs non-carriers. Val122Ile carriers also had higher LV mass, worse concentric remodeling, and worse measures of diastolic function than non-carriers. Most measures of RV function were higher among carriers vs non-carriers (Table) . However, none of the differences found in cardiac phenotype of carriers vs non-carriers were statistically significant (p &gt;0.05). Conclusion: There is a lack of difference in the echocardiographic cardiac phenotype among Hispanic/Latinos who carry the Val122Ile mutation versus non-carriers.

Cycle Tests and Structure Repair of Bridge Pier Models

This research was conducted in anticipation of the risk of fatal damage to the structure due to the earthquake. In this study, experiments were carried out on the test object in the form of a bridge pillar model, which consisted of 2 test steps. The cyclic test is in the form of a pier bridge model and is continued in step 2 in the form of repairs with grouting and carbon wrapping materials as well as conducting another cyclic test to evaluate the performance of the repair materials used. This study uses the pier model, which consists of two test objects, namely a column with dimensions of 0.25x0.25x1.68 meters and a column cap of 1.20x0.55x0.36 meters. This test provides a constant axial load of 0.2 fc’.Ag and a cyclic lateral load. Phase 1 testing was carried out until the drift ratio was 3.5%. The achieved lateral peak strength is 8,606 tonf with a drift ratio of 2.20%. Lateral strength experienced a decrease in peak lateral strength of 86.93%. The damage is dominated by shear cracks which are characterized by the number of cracks with a diagonal pattern. Structural performance analysis was carried out according to ACI 374.1-05. The results of the theoretical analysis of the peak strength of the pier model were 15.2144 tonnes in the tensile direction, while the experimental ones were 8.606 in the pushing direction and -7.812 in the pulling direction.

The Influence of a Booster Seat on the Motion of the Reclined Small Female Anthropomorphic Test Device in Low-Acceleration Far-Side Lateral Oblique Impacts.

Belt-positioning booster (BPB) seats may prevent submarining in reclined child occupants in frontal impacts. BPB-seated child volunteers showed reduced lateral displacement in reclined seating in low-acceleration lateral-oblique impacts. As submarining was particularly evident in reclined small adult female occupants, we examined if a booster seat could provide similar effects on the kinematics of the small female occupant to the ones found on the reclined child volunteers in low-acceleration far-side lateral oblique impacts. The THOR-AV-5F was seated on a vehicle seat on a sled simulating a far-side lateral-oblique impact (80 deg from frontal, maximum acceleration ∼2 g, duration ∼170 ms). Lateral and forward head and trunk displacements, trunk rotation, knee-head distance, seatbelt loads, and head acceleration were recorded. Three seatback angles (25 deg, 45 deg, 60 deg) and two booster conditions were examined. Lateral peak head and trunk displacements decreased in more severe reclined seatback angles (25-36 mm decrease compared to nominal). Forward peak head, trunk displacements, and knee-head distance were greater with the seatback reclined and no BPB. Knee-head distance increased in the severe reclined angle also with the booster seat (>40 mm compared to nominal). Seat belt peak loads increased with increased recline angle with the booster, but not without the booster seat. Booster-like solutions may be beneficial for reclined small female adult occupants to reduce head and trunk displacements in far-side lateral-oblique impacts, and knee-head distance and motion variability in severe reclined seatback angles.

An ovine knee simulator: description and proof of concept.

The ovine stifle is an established model for evaluation of knee treatments, such as meniscus replacement. This study introduces a novel ovine gait simulator for pre-testing of surgical treatments prior to in vivo animal trials. Furthermore, we describe a pilot study that assessed gait kinematics and contact pressures of native ovine stifle joints and those implanted with a novel fiber-matrix reinforced polyvinyl alcohol-polyethylene glycol (PVA-PEG) hydrogel meniscus to illustrate the efficacy of the simulator. The gait simulator controlled femoral flexion-extension and applied a 980N axial contact force to the distal tibia, whose movement was guided by the natural ligaments. Five right ovine stifle joints were implanted with a PVA-PEG total medial meniscus replacement, fixed to the tibia via transosseous tunnels and interference screws. Six intact and five implanted right ovine stifle joints were tested for 500k gait cycles at 1.55Hz. Implanted stifle joint contact pressures and kinematics in the simulator were compared to the intact group. Contact pressures were measured at 55° flexion using pressure sensitive film inserted sub-meniscally. 3D kinematics were measured optically across two 30-s captures. Peak contact pressures in intact stifles were 3.6 ± 1.0MPa and 6.0 ± 2.1MPa in the medial and lateral condyles (p < 0.05) and did not differ significantly from previous studies (p > 0.4). Medial peak implanted pressures were 4.3 ± 2.2MPa (p > 0.4 versus intact), while lateral peak pressures (9.4 ± 0.8MPa) were raised post medial compartment implantation (p < 0.01). The range of motion for intact joints was flexion/extension 37° ± 1°, varus/valgus 1° ± 1°, external/internal rotation 5° ± 3°, lateral/medial translation 2 ± 1mm, anterior/posterior translation 3 ± 1mm and distraction/compression 1 ± 1mm. Ovine joint kinematics in the simulator did not differ significantly from published in vivo data for the intact group, and the intact and implanted groups were comparable (p > 0.01), except for in distraction-compression (p < 0.01). These findings show correspondence of the ovine simulator kinematics with in vivo gait parameters. The efficacy of the simulator to evaluate novel treatments was demonstrated by implanting a PVA-PEG hydrogel medial meniscal replacement, which restored the medial peak contact pressures but not lateral. This novel simulator may enable future work on the development of surgical procedures, derisking subsequent work in live animals.

The Effects of Running Kinematics on Peak Upper Trunk GPS-Measured Accelerations during Foot Contact at Different Running Speeds

The overall aim of this study was to determine the effects of running kinematics on the peak upper trunk segmental accelerations captured with an accelerometer embedded in a commonly used GPS device. Thirteen male participants (age: 27 ± 3.7 years, height: 1.81 ± 0.06 m, mass: 82.7 ± 6.2 kg) with extensive running experience completed a single trial of treadmill running (1 degree inclination) for 40 s at nine different speeds ranging from 10 to 18 km/h at 1 km/h increments. Three-dimensional peak upper trunk acceleration values were captured via a GPS device containing a tri-axial accelerometer. Participants’ running kinematics were calculated from the coordinate data captured by an 18-camera motion capture system. A series of generalized linear mixed models were employed to determine the effects of the kinematic variables on the accelerometer acceleration peaks across the key gait phases of foot contact. Results showed that running kinematics had significant effects on peak accelerometer-measured accelerations in all axes (p &lt; 0.05). Overall, peak segment velocities had a larger effect than joint/segment kinematics on resultant (F values = 720.9/54.2), vertical (F values = 149.8/48.1) and medial–lateral (F values = 55.4/33.4) peak accelerometer accelerations. The largest effect on peak accelerometer accelerations were observed during the impact subphase of foot contact at the adduction/abduction velocity of the shank (F value = 129.2, coefficient = −0.03) and anterior/posterior velocity of the pelvis (F value = 58.9, coefficient = 0.01). Axis-dependent effects of running kinematics were also observed, specifically at the trunk segment in the vertical and anterior–posterior peak accelerometer accelerations. This study showed the intersegmental relationship between joint/segment kinematics, segment velocities and the resulting peak accelerations of the upper trunk during running over several speeds. These findings provide insights into the lower body’s GRF attenuation capacity and its contribution to trunk stability whilst running.

Providing a computationally derived, mechanically optimised target correction during preoperative planning can improve joint contact mechanics of hip dysplasia treated with periacetabular osteotomy.

Preoperative identification of acetabular corrections that optimally improve joint stability and reduce elevated contact stresses could further reduce osteoarthritis progression in patients with hip dysplasia who are treated with periacetabular osteotomy (PAO). The purpose of this study was to investigate how providing patient-specific, mechanically optimal acetabular reorientations to the surgeon during preoperative planning affected the surgically achieved correction. Preoperative CT scans were used to create patient-specific hip models for 6 patients scheduled for PAO. A simulated acetabular fragment was extracted from the preoperative pelvis model and computationally rotated to simulate candidate acetabular reorientations. For each candidate, discrete element analysis was used to compute contact stresses during walking, which were summed over the gait cycle and scaled by patient age to obtain chronic contact stress-time exposure. The ideal patient-specific reorientation was identified using a cost function that balances minimising chronic stress exposures and achieving surgically acceptable acetabular coverage angles. The optimal reorientation angles and associated contact mechanics were provided to the surgeon preoperatively. After PAO was performed, a model of the surgically achieved correction was created from a postoperative CT scan. Radiographic coverage and contact mechanics were compared between preoperative, optimal, and surgically achieved orientations. While surgically achieved reorientations were not significantly different from optimal reorientations in radiographically measured lateral (p = 0.094) or anterior (p = 0.063) coverage, surgically achieved reorientations had significantly (p = 0.031) reduced total contact area compared to optimal reorientations. The difference in lateral coverage and peak chronic exposure between surgically achieved and optimal reorientations decreased with increasing surgeon experience using the models (R² = 0.758, R2 = 0.630, respectively). Providing hip surgeons with a patient-specific, computationally optimal reorientation during preoperative planning may improve contact mechanics after PAO, which may help reduce osteoarthritis progression in patients with hip dysplasia.

Impact of the evaluation method on 4D flow-derived diastolic transmitral and myocardial peak velocities: Comparison with echocardiography

PurposeTo compare agreement of different evaluation methods of magnetic resonance (MR) 4D flow-derived diastolic transmitral and myocardial peak velocities as well as their ratios, using echocardiography as reference. MethodsIn this prospective study, 60 subjects without symptoms of cardiovascular disease underwent echocardiography and non-contrast 3 T MR 4D flow imaging of the heart. Early- (E) and late-diastolic (A) transmitral peak filling velocities were evaluated from 4D flow data using three different strategies: 1) at the mitral valve tips in short-axis orientation (SA-method), 2) between the mitral valve tips in 4-chamber orientation (4-chamber-method), and 3) as maximal velocities in the transmitral inflow volume (max-velocity-method). Septal, lateral and average early-diastolic myocardial peak velocities (e’) were derived from the myocardial tissue in the vicinity of the mitral valve. 4D flow parameters were compared with echocardiography by correlation and Bland-Altman analysis. ResultsAll 4D flow-derived E, A and E/A values correlated with echocardiography (r = 0.65–0.73, 0.75–0.83 and 0.74–0.86, respectively). While the SA- and 4-chamber-methods substantially underestimated E and A compared to echocardiography (p < 0.001), the max-velocity-method provided E (p = 0.13) and E/A (p = 0.07) without significant bias. Septal, lateral and average e’ from 4D flow as well as the max-velocity-method-derived E/e’ correlated with echocardiographic measurements (r = 0.64–0.81) and showed no significant bias (p = 0.26–0.54). ConclusionMR 4D flow imaging allows precise and accurate evaluation of transmitral and myocardial peak velocities for characterization of LV diastolic function without significant bias to echocardiography, when transmitral velocities are assessed from the transmitral inflow volume. This enables the use of validated echocardiography threshold values.

Repair of Pier Bridge Model Post-Earthquake

This study concentrates on the bridge pier model which was damaged by the earthquake and repaired using grouting and carbon wrapping materials. This research consists of a one pier bridge model with two steps of testing, namely step 1 in the form of a cyclic test of the pier bridge model which will be followed by step 2 in the form of structural repairs with grouting and carbon wrapping materials and retesting. to evaluate the performance of the structural repair technology used. This research will show the cyclic test results using the repair material applied to the same sbr latex concrete material test object. The test object used is a pier bridge model with dimensions of 0.25×0.25×1.68 meters. The material specifications used are concrete f'c 30, fy 400 MPa deformed longitudinal reinforcement and stirrups fy 240 MPa. The test was carried out with a constant axial load of 0.2.f'c.Ag and a cyclic lateral load. Structural performance analysis was carried out according to ACI 374.1-05. Step 1 cyclic test was carried out until the drift ratio was 3.5%. The lateral peak strength achieved was 8.606 tonf with indications of shear damage indicated by the number of cracks in the web area. The second step of the cyclic test was carried out to a drift ratio of 6.25% with a lateral peak strength of 8.640 tonf with indications of flexural damage. Cyclic test results show that repair with a grouting material and carbon wrap can restore peak strength, deformation capacity, and stiffness degradation.

Numerical simulations on flow control of the long hanger around a bridge tower based on active suction and blowing method

Long hangers around the bridge tower are subjected to severe vibrations caused by the tower wakes. This study adopted an active suction/blowing control measure at the tower corners to control hanger vibrations and included four combination measures: upstream suction (US), upstream blowing (UB), downstream suction (DS), and downstream blowing (DB). The effects of control cases on the near-wake flow structures of the tower were first studied in two-dimensional RANS simulation, and the vibration behaviors of the hanger and control mechanism were further analyzed. The cases associated with UB and DS cannot effectively suppress hanger vibrations, and both lead to unfavorable upward trends in the aerodynamic coefficients of the tower. Especially for the cases associated with DS, at a specific control speed, the second-order frequency of the drag coefficient of the hanger is very close to its natural frequency, resulting in significant longitudinal vibration. The cases associated with US and DB are effective control schemes with longitudinal peak amplitudes of the hanger reduced by 94.1% and 94.5%, and lateral peak amplitudes reduced by 95.8% and 97.0%, respectively, compared with the case baseline. This is because the dominant frequency of the lift of the hanger is away from its natural frequency, and the fluctuating wind loads on the hanger are effectively suppressed. Finally, the control effect and vibration suppression mechanism for typical cases were further reproduced in three-dimensional large eddy simulations.