Inadequate management of large in-train forces transferred through coupler systems of a railway train leads to running and structural failures of vehicles. Understanding these phenomena and their mitigation requires accurate estimation of relative motions and in-train forces between vehicle bodies. Previous numerical studies have ignored inertia of coupling elements and the impacts between couplers. Thus, existing models underestimate the additional dynamic variations in in-train forces. Detailed multi-body dynamic models of two AAR (Association of American Railroads) coupler systems used in passenger and freight trains are developed, incorporating coupler inertia and various slacks. Due to the modeling and simulation complexities involved in a full train model, with such details of coupler system, actual longitudinal train dynamics is not studied. A system comprising only two coupling units, inter-connecting two consecutive vehicles, is modeled. Considered system has been fixed at one end and an excitation force is applied at the other end, to mimic a relative force transmission through combined coupler system. Simulation results obtained from this representative system show that, noticeable influence in in-train forces are expected due to the combined effect of inertia of couplers and intermittent impacts between couplers in the slack regime. Maximum amplitude of longitudinal reaction force, transferred from draft gear housing to vehicle body, is expected to be significantly higher than that predicted using existing models of coupler system. It is also observed that the couplers and knuckles are subjected to significant longitudinal and lateral contact forces, due to the intermittent impacts between couplers. Thus, accurate estimation of draft gear reaction force and impact forces between couplers are essential to design vehicle and coupler components, respectively.