Purpose: Radiation therapy with ion beams provides highly conformal dose distributions. These are sensitive to possible variations of the beam settings and changes of the tissue in the beam path, which can deteriorate the dose distribution in the patient. To monitor the ion beam, it was suggested in [Amaldi et al. NIM A 617, 2010] to exploit the information carried by prompt secondary ions produced within the patient during irradiation. Our initial experimental investigations of monitoring the beam position, width and energy in a homogeneous phantom have been published in [Gwosch et al. PMB 58, 2013]. In this contribution we address the performance of the method in phantoms with inhomogeneities. Materials and Methods: The experiments were performed at the Heidelberg Ion-Beam Therapy Center using beam energies and widths typical for therapy. Secondary charged particles emerging from phantoms during irradiation were registered by the pixelated semiconductor detector Timepix [Llopart et al. NIM A 581, 2007], which was developed by the Medipix Collaboration at CERN. Its multi-layered version (3D voxel detector) [Soukup et al. JINST 6, 2011] was used to determine the direction of single particles. Using an anthropomorphic head phantom containing real bones, it was tested whether the distributions of secondary ions around the phantom are sensitive to variations of the beam parameters. In a plastic slab phantom it was studied how changes of its structure affect the secondary ion distribution. Experiments and Results: The measured particle directions were projected to the vertical beam plane. An example of such a projection is shown in figure 1 (inset). Changes of this projection with the beam parameters and phantom structure were analysed. This new imaging modality [Jakubek IEEE, 2011] was found to be capable of detecting lateral beam shifts, changes of the beam energy (affecting the range) and beam width (see figure 1) of a few millimeters in the head phantom. In a homogeneous plastic phantom, missing slabs of 1cm thickness were found to influence the distribution of secondary ions significantly. Conclusion: The presented experimental investigations demonstrate that measurements of charged particle tracks around phantoms irradiated with carbon ion beams enable to detect missing slices of 1cm thickness in an otherwise homogeneous phantom. In the head-phantom it was shown that the method provides an attractive source of information on the actual beam delivery, despite the inherent tissue inhomogeneities.
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