Later Stages Of Process Research Articles

Independent Early and Late Sensory Processes for Proprioceptive Integration When Planning a Step.

Somatosensory inputs to the cortex undergo an early and a later stage of processing which are characterized by an early and a late somatosensory evoked potentials (SEP). The early response is highly representative of the stimulus characteristics whereas the late response reflects a more integrative, task specific, stage of sensory processing. We hypothesized that the later processing stage is independent of the early processing stage. We tested the prediction that a reduction of the first volley of input to the cortex should not prevent the increase of the late SEP. Using the sensory interference phenomenon, we halved the amplitude of the early response to somatosensory input of the ankle joints (evoked by vibration) when participants either planned a step forward or remained still. Despite the initial cortical response to the vibration being massively decreased in both tasks, the late response was still enhanced during step planning. Source localization indicated the posterior parietal cortex (PPC) as the likely origin of the late response modulation. Overall these results support the dissociation between the processes underlying the early and late SEP. The later processing stage could involve both direct and indirect thalamic connections to PPC which bypass the postcentral somatosensory cortex.

Modulation of forgiveness on processing hurt situations: A study of event-related potentials

To explore the neuro-mechanism of the time course of processing a hurt situation, we analyzed event-related potentials (ERPs) generated in the brain in response to stimuli in individuals with different degrees of forgiveness. Participants were 216 university students. Of the early ERP components, the negative-deflecting N1 was modulated neither by degree of forgiveness nor by the hurt situation, and the positive-deflecting P2 was larger for low-forgiveness than for high-forgiveness participants, and for low-hurt than for high-hurt situations. The N2, which identifies and encodes stimulus, was enhanced in the high-forgiveness group and for high-hurt situations. Importantly, the late positive component (LPC) stage of stimulus evaluation was larger in the high-forgiveness group for high-hurt situations, but in the low-forgiveness group was evident for low-hurt situations. These data indicate that the modulation of forgiveness on processing hurt situations occurs at the late stage of information processing.

How Semantic Radicals in Chinese characters Facilitate Hierarchical Category-Based Induction

Prior studies indicate that the semantic radical in Chinese characters contains category information that can support the independent retrieval of category information through the lexical network to the conceptual network. Inductive reasoning relies on category information; thus, semantic radicals may influence inductive reasoning. As most natural concepts are hierarchically structured in the human brain, this study examined how semantic radicals impact inductive reasoning for hierarchical concepts. The study used animal and plant nouns, organized in basic, superordinate, and subordinate levels; half had a semantic radical and half did not. Eighteen participants completed an inductive reasoning task. Behavioural and event-related potential (ERP) data were collected. The behavioural results showed that participants reacted faster and more accurately in the with-semantic-radical condition than in the without-semantic-radical condition. For the ERPs, differences between the conditions were found, and these differences lasted from the very early cognitive processing stage (i.e., the N1 time window) to the relatively late processing stages (i.e., the N400 and LPC time windows). Semantic radicals can help to distinguish the hierarchies earlier (in the N400 period) than characters without a semantic radical (in the LPC period). These results provide electrophysiological evidence that semantic radicals may improve sensitivity to distinguish between hierarchical concepts.

Information properties of morphologically complex words modulate brain activity during word reading.

Neuroimaging studies of the reading process point to functionally distinct stages in word recognition. Yet, current understanding of the operations linked to those various stages is mainly descriptive in nature. Approaches developed in the field of computational linguistics may offer a more quantitative approach for understanding brain dynamics. Our aim was to evaluate whether a statistical model of morphology, with well‐defined computational principles, can capture the neural dynamics of reading, using the concept of surprisal from information theory as the common measure. The Morfessor model, created for unsupervised discovery of morphemes, is based on the minimum description length principle and attempts to find optimal units of representation for complex words. In a word recognition task, we correlated brain responses to word surprisal values derived from Morfessor and from other psycholinguistic variables that have been linked with various levels of linguistic abstraction. The magnetoencephalography data analysis focused on spatially, temporally and functionally distinct components of cortical activation observed in reading tasks. The early occipital and occipito‐temporal responses were correlated with parameters relating to visual complexity and orthographic properties, whereas the later bilateral superior temporal activation was correlated with whole‐word based and morphological models. The results show that the word processing costs estimated by the statistical Morfessor model are relevant for brain dynamics of reading during late processing stages.

Neural mechanisms of selective listening to pitch and timbre in musical sounds

Previous research showed that different dimensions of sound such as pitch and timbre elicit distinct patterns of neural activities. Here, we report event related potential (ERP) along with functional magnetic resonance imaging (fMRI) data during a selective listening task of musical sounds. The participants were 12 normal adults. The stimuli were 4 musical tones with timbre (piano vs. violin) and pitch (high vs. low) contrasts. The stimuli were normalized for duration and intensity. In the timbre condition, the listener needed to indicate the instrument category. In the pitch condition, the listener needed to indicate the pitch level. While both conditions reached the ceiling-level accuracy, the pitch condition required significantly longer reaction time. Significant fMRI activations were found in the superior temporal gyri with right dominance for both conditions. The right superior temporal gyrus and left inferior frontal regions were important for coding pitch whereas the anterior cingulate cortex was exclusively active in selectively attending to timbre. These data demonstrate how different cortical networks contribute to selective listening. The ERP data further showed larger N1 and N2 peaks for the timbre condition than the pitch condition, suggesting that attentional modulation operates at both early and later stages of processing for selective listening.

The effect of feature-based attention on flanker interference processing: An fMRI-constrained source analysis

The present study examined whether feature-based cueing affects early or late stages of flanker conflict processing using EEG and fMRI. Feature cues either directed participants’ attention to the upcoming colour of the target or were neutral. Validity-specific modulations during interference processing were investigated using the N200 event-related potential (ERP) component and BOLD signal differences. Additionally, both data sets were integrated using an fMRI-constrained source analysis. Finally, the results were compared with a previous study in which spatial instead of feature-based cueing was applied to an otherwise identical flanker task. Feature-based and spatial attention recruited a common fronto-parietal network during conflict processing. Irrespective of attention type (feature-based; spatial), this network responded to focussed attention (valid cueing) as well as context updating (invalid cueing), hinting at domain-general mechanisms. However, spatially and non-spatially directed attention also demonstrated domain-specific activation patterns for conflict processing that were observable in distinct EEG and fMRI data patterns as well as in the respective source analyses. Conflict-specific activity in visual brain regions was comparable between both attention types. We assume that the distinction between spatially and non-spatially directed attention types primarily applies to temporal differences (domain-specific dynamics) between signals originating in the same brain regions (domain-general localization).

Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence.

The attention of drug-dependent persons tends to be captured by stimuli associated with drug consumption. This involuntary cognitive process is considered as attentional bias (AB). AB has been hypothesized to have causal effects on drug abuse and drug relapse, but its underlying neural mechanisms are still unclear. This study investigated the neural basis of AB in abstinent heroin addicts (AHAs), combining event-related potential (ERP) analysis and source localization techniques. Electroencephalography data were collected in 21 abstinent heroin addicts and 24 age- and gender-matched healthy controls (HCs) during a dot-probe task. In the task, a pair of drug-related image and neutral image was presented randomly in left and right side of the cross fixation, followed by a dot probe replacing one of the images. Behaviorally, AHAs had shorter reaction times (RTs) for the congruent condition compared to the incongruent condition, whereas this was not the case in the HCs. This finding demonstrated the presence of AB towards drug cues in AHAs. Furthermore, the image-evoked ERPs in AHAs had significant shorter P1 latency compared to HCs, as well as larger N1, N2, and P2 amplitude, suggesting that drug-related stimuli might capture attention early and overall require more attentional resources in AHAs. The target-related P3 had significantly shorter latency and lower amplitude in the congruent than incongruent condition in AHAs compared to HCs. Moreover, source localization of ERP components revealed increased activity for AHAs as compared to HCs in the dorsal posterior cingulate cortex (dPCC), superior parietal lobule and inferior frontal gyrus (IFG) for image-elicited responses, and decreased activity in the occipital and the medial parietal lobes for target-elicited responses. Overall, the results of our study confirmed that AHAs may exhibit AB in drug-related contexts, and suggested that the bias might be related to an abnormal neural activity, both in early and late attention processing stages.

Electrophysiological correlates of incidentally learned expectations in human vision.

The human visual system is remarkably sensitive to environmental regularities, which can facilitate behavioral performance when sensory events conform to past experience. The point at which prior knowledge is integrated during visual perception is unclear, particularly for incidentally learned associations. One possibility is that expectation shapes neural activity prospectively, in an anticipatory fashion, allowing prior knowledge to affect the earliest stages of sensory processing. Alternatively, cognitive processes underlying object recognition and conflict detection may be necessary precursors, constraining effects to later stages of processing. Here we used electroencephalography (EEG) to uncover neural activity that distinguishes between visual stimuli that match prior exposure and those that deviate from it. Participants identified visual targets that were associated with possible target locations; each location was associated with a high-probability target and a low-probability target. Alongside a behavioral cost for stimuli that had occurred infrequently at a cued location compared with those that had occurred frequently, we observed a focal modulation of the evoked EEG response at 250 ms after target onset. Relative to likely targets, unlikely targets evoked an enhanced negativity at midline frontal electrodes, and individual differences in the magnitude of this effect were correlated with the response time difference between likely and unlikely targets. In contrast, the evoked response at the latency of the P1, a correlate of early sensory processing, was indistinguishable for likely and unlikely targets. Together, these results point to postperceptual processes as a key stage at which experience modulates visual processing. NEW & NOTEWORTHY We combined electroencephalography with an incidental learning paradigm to investigate whether prior knowledge of environmental regularities modulates visual processing at early or late stages of sensory analysis. Our results reveal that modulations of neural activity arising at midlevel processing stages predict behavioral costs for unexpected stimuli rather than effects at early stages of sensory encoding.

The Nature of Affect in the Structural Mere Exposure Effect

This paper investigates the characteristics of the affective component in the structural mere exposure effect (SMEE). Two approaches are considered – fluency attribution approach (FA) and affect as predictive efficiency approach (APE) – within a predictive coding framework. Using the artificial grammar learning and affective priming paradigms, we demonstrate that a violation of implicitly learned regularities elicits an automatic negative affective response. This result suggests that SMEE can be observed without any overtly evaluative judgment. Participants’ decisions on the grammaticality of stimuli did not change this pattern. We conclude that SMEE is based on the affective response to prediction errors made by the cognitive system and may include the fluency attribution process in the later stages of processing.

NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells

ABSTRACTIn the advanced stages of cancer, autophagy is thought to promote tumor progression through its ability to mitigate various cellular stresses. However, the details of how autophagy is homeostatically regulated in such tumors are unknown. Here, we report that NUPR1 (nuclear protein 1, transcriptional regulator), a transcriptional coregulator, is aberrantly expressed in a subset of cancer cells and predicts low overall survival rates for lung cancer patients. NUPR1 regulates the late stages of autolysosome processing through the induction of the SNARE protein SNAP25, which forms a complex with the lysosomal SNARE-associated protein VAMP8. NUPR1 depletion deregulates autophagic flux and impairs autolysosomal clearance, inducing massive cytoplasmic vacuolization and premature senescence in vitro and tumor suppression in vivo. Collectively, our data show that NUPR1 is a potent regulator of autolysosomal dynamics and is required for the progression of some epithelial cancers.

Visual processing deficits in 22q11.2 Deletion Syndrome.

Carriers of the rare 22q11.2 microdeletion present with a high percentage of positive and negative symptoms and a high genetic risk for schizophrenia. Visual processing impairments have been characterized in schizophrenia, but less so in 22q11.2 Deletion Syndrome (DS). Here, we focus on visual processing using high-density EEG and source imaging in 22q11.2DS participants (N = 25) and healthy controls (N = 26) with an illusory contour discrimination task.Significant differences between groups emerged at early and late stages of visual processing. In 22q11.2DS, we first observed reduced amplitudes over occipital channels and reduced source activations within dorsal and ventral visual stream areas during the P1 (100–125 ms) and within ventral visual cortex during the N1 (150–170 ms) visual evoked components. During a later window implicated in visual completion (240–285 ms), we observed an increase in global amplitudes in 22q11.2DS. The increased surface amplitudes for illusory contours at this window were inversely correlated with positive subscales of prodromal symptoms in 22q11.2DS.The reduced activity of ventral and dorsal visual areas during early stages points to an impairment in visual processing seen both in schizophrenia and 22q11.2DS. During intervals related to perceptual closure, the inverse correlation of high amplitudes with positive symptoms suggests that participants with 22q11.2DS who show an increased brain response to illusory contours during the relevant window for contour processing have less psychotic symptoms and might thus be at a reduced prodromal risk for schizophrenia.

N400 and P600 Effect of Chinese Words Recognition

Word recognition is an important part of the processing in reading comprehension. N400 component is generally considered as semantic index of word processing, and P600 component is used to interpret syntactic processing. But the discovery of “Semantic P600” effect prompts people to interpret the meaning of P600 again. This study takes normal developing teenagers (ages 12-14) as research subject by using the event-related potentials (ERP) to examine the N400 and P600 effect of Chinese words processing of the true words and pseudo words recognition. The results show that the reaction time of the pseudo words are longer than that of the true words and N400 can also be evoked by the independent Chinese words; the pseudo words evoked larger amplitude of N400 than that of the true words. Compared with the true words, the latency of P600 of pseudo words are significantly delayed. The amplitudes of P600 evoked by true words are larger than by the Pseudo words. The present results suggest that N400 and P600 have different functions and significance in words recognition, N400 reflects the semantic priming effect, P600 reflects the semantic integration in the late stages of semantic processing.

Facial Expressions in Context: Electrophysiological Correlates of the Emotional Congruency of Facial Expressions and Background Scenes.

Facial expressions can display personal emotions and indicate an individual’s intentions within a social situation. They are extremely important to the social interaction of individuals. Background scenes in which faces are perceived provide important contextual information for facial expression processing. The purpose of this study was to explore the time course of emotional congruency effects in processing faces and scenes simultaneously by recording event-related potentials (ERPs). The behavioral results found that the categorization of facial expression was faster and more accurate when the face was emotionally congruent than incongruent with the emotion displayed by the scene. In ERPs the late positive potential (LPP) amplitudes were modulated by the emotional congruency between faces and scenes. Specifically, happy faces elicited larger LPP amplitudes within positive than within negative scenes and fearful faces within negative scenes elicited larger LPP amplitudes than within positive scenes. The results did not find the scene effects on the P1 and N170 components. These findings indicate that emotional congruency effects could occur in late stages of facial expression processing, reflecting motivated attention allocation.

Photoreceptor signalling is sufficient to explain the detectability threshold of insect aerial pursuers.

An essential biological task for many flying insects is the detection of small, moving targets, such as when pursuing prey or conspecifics. Neural pathways underlying such 'target-detecting' behaviours have been investigated for their sensitivity and tuning properties (size, velocity). However, which stage of neuronal processing limits target detection is not yet known. Here, we investigated several skilled, aerial pursuers (males of four insect species), measuring the target-detection limit (signal-to-noise ratio) of light-adapted photoreceptors. We recorded intracellular responses to moving targets of varying size, extended well below the nominal resolution of single ommatidia. We found that the signal detection limit (2× photoreceptor noise) matches physiological or behavioural target-detection thresholds observed in each species. Thus, across a diverse range of flying insects, individual photoreceptor responses to changes in light intensity establish the sensitivity of the feature detection pathway, indicating later stages of processing are dedicated to feature tuning, tracking and selection.

The late-stage "ferruginization" of the Ediacara Member (Rawnsley Quartzite, South Australia): Insights from uranium isotopes.

The paleoenvironmental setting in which the Ediacara Biota lived, died, and was preserved in the eponymous Ediacara Member of the Rawnsley Quartzite of South Australia is an issue of long-standing interest and recent debate. Over the past few decades, interpretations have ranged from deep marine to shallow marine to terrestrial. One of the key features invoked by adherents of the terrestrial paleoenvironment hypothesis is the presence of iron oxide coatings, inferred to represent the upper horizons of paleosols, along fossiliferous sandstone beds of the Ediacara Member. We find that these surficial oxides are characterized by (234 U/238 U) values which are not in secular equilibrium, indicating extensive fluid-rich alteration of these surfaces within the past approximately 2million years. Specifically, the oxide coatings are characterized by (234 U/238 U) values >1, indicating interaction with high-(234 U/238 U) fluids derived from alpha-recoil discharge. These oxides are also characterized by light "stable" δ238/235 U values, consistent with a groundwater U source. These U isotope data thus corroborate sedimentological observations that ferric oxides along fossiliferous surfaces of the Ediacara Member consist of surficial, non-bedform-parallel staining, and sharply irregular patches, strongly reflecting post-depositional, late-stage processes. Therefore, both sedimentological and geochemical evidence indicate that Ediacara iron oxides do not reflect synsedimentary ferruginization and that the presence of iron oxides cannot be used to either invoke a terrestrial paleoenvironmental setting for or reconstruct the taphonomic pathways responsible for preservation of the Ediacara Biota. These findings demonstrate that careful assessment of paleoenvironmental parameters is essential to the reconstruction of the habitat of the Ediacara Biota and the factors that led to the fossilization of these early complex ecosystems.

Cognitive processing of orientation discrimination in anisometropic amblyopia.

Cognition is very important in our daily life. However, amblyopia has abnormal visual cognition. Physiological changes of the brain during processes of cognition could be reflected with ERPs. So the purpose of this study was to investigate the speed and the capacity of resource allocation in visual cognitive processing in orientation discrimination task during monocular and binocular viewing conditions of amblyopia and normal control as well as the corresponding eyes of the two groups with ERPs. We also sought to investigate whether the speed and the capacity of resource allocation in visual cognitive processing vary with target stimuli at different spatial frequencies (3, 6 and 9 cpd) in amblyopia and normal control as well as between the corresponding eyes of the two groups. Fifteen mild to moderate anisometropic amblyopes and ten normal controls were recruited. Three-stimulus oddball paradigms of three different spatial frequency orientation discrimination tasks were used in monocular and binocular conditions in amblyopes and normal controls to elicit event-related potentials (ERPs). Accuracy (ACC), reaction time (RT), the latency of novelty P300 and P3b, and the amplitude of novelty P300 and P3b were measured. Results showed that RT was longer in the amblyopic eye than in both eyes of amblyopia and non-dominant eye in control. Novelty P300 amplitude was largest in the amblyopic eye, followed by the fellow eye, and smallest in both eyes of amblyopia. Novelty P300 amplitude was larger in the amblyopic eye than non-dominant eye and was larger in fellow eye than dominant eye. P3b latency was longer in the amblyopic eye than in the fellow eye, both eyes of amblyopia and non-dominant eye of control. P3b latency was not associated with RT in amblyopia. Neural responses of the amblyopic eye are abnormal at the middle and late stages of cognitive processing, indicating that the amblyopic eye needs to spend more time or integrate more resources to process the same visual task. Fellow eye and both eyes in amblyopia are slightly different from the dominant eye and both eyes in normal control at the middle and late stages of cognitive processing. Meanwhile, abnormal extents of amblyopic eye do not vary with three different spatial frequencies used in our study.

Distinct Associations Between Low Positive Affect, Panic, and Neural Responses to Reward and Threat During Late Stages of Affective Picture Processing

BackgroundAbnormal patterns of attention to threat and reward have been proposed as potential mechanisms of dysfunction in anxiety and mood disorders. However, research on this topic has been inconsistent, perhaps because of both clinical heterogeneity in the samples assessed and measurement of attentional biases that is temporally imprecise. MethodsThe present study measured transdiagnostic symptoms of anxiety and depression in 205 young adults and recorded affect-modulated event-related potentials in response to task-irrelevant pictures in a speeded response task. ResultsLow positive affect was uniquely associated with reduced modulation of later event-related potentials (i.e., the P300 and the late positive potential) by rewarding images, suggesting deficits in sustained attention to reward. Low positive affect was also associated with a blunted threat-elicited late positive potential. Symptoms of panic were associated with an increased N1 to rewarding images, as well as an increased late positive potential to all picture types. ConclusionsThese data suggest that dysfunction in neural markers of sustained attention to threat and reward relate in specific ways to transdiagnostic symptom dimensions of anxiety and depression. Moreover, event-related potentials are likely to be useful in investigations of the time course of attentional abnormalities associated with these symptom dimensions.

Visual Responses in FEF, Unlike V1, Primarily Reflect When the Visual Context Renders a Receptive Field Salient.

When light falls within a neuronal visual receptive field (RF) the resulting activity is referred to as the visual response. Recent work suggests this activity is in response to both the visual stimulation and the abrupt appearance, or salience, of the presentation. Here we present a novel method for distinguishing the two, based on the timing of random and nonrandom presentations. We examined these contributions in frontal eye field (FEF; N = 51) and as a comparison, an early stage in the primary visual cortex (V1; N = 15) of male monkeys (Macaca mulatta). An array of identical stimuli was presented within and outside the neuronal RF while we manipulated salience by varying the time between stimulus presentations. We hypothesized that the rapid presentation would reduce salience (the sudden appearance within the visual field) of a stimulus at any one location, and thus decrease responses driven by salience in the RF. We found that when the interstimulus interval decreased from 500 to 16 ms there was an approximate 79% reduction in the FEF response compared with an estimated 17% decrease in V1. This reduction in FEF response for rapid presentation was evident even when the random sequence preceding a stimulus did not stimulate the RF for 500 ms. The time course of these response changes in FEF suggest that salience is represented much earlier (<100 ms following stimulus onset) than previously estimated. Our results suggest that the contribution of salience dominates at higher levels of the visual system.SIGNIFICANCE STATEMENT The neuronal responses in early visual processing [e.g., primary visual cortex (V1)] reflect primarily the retinal stimulus. Processing in higher visual areas is modulated by a combination of the visual stimulation and contextual factors, such as salience, but identifying these components separately has been difficult. Here we quantified these contributions at a late stage of visual processing [frontal eye field (FEF)] and as a comparison, an early stage in V1. Our results suggest that as visual information continues through higher levels of processing the neural responses are no longer driven primarily by the visual stimulus in the receptive field, but by the broader context that stimulus defines-very different from current views about visual signals in FEF.

P 141 Cerebellar impacts on neural networks of emotional attention as evidenced by event related potentials

Background The cerebellum is highly indicative to contributions to high-order functions of emotion, supporting responsible domains of cerebral neural networks in processing of distinct emotional cues. So the impact of the attentional modes of the cerebellum deems of particular interest for separating a selective pathway of emotionally driven cues, corresponding neurophysiological patterns in cerebellar disorders might provide further informations about the cerebellar role in emotional attention. Methods Eight patients with a ischemic lesion of the cerebellum (five unilateral, three bilateral) and seven patients without stroke history were studied. Four neurophysiological paradigms were engaged along a confined set of the International Affective Picture System (IAPS) with neutral as well as emotional cues of different valence and arousal, each presented in a protocolled stream. Event-related Potentials (ERP) of early and late processing stages of selective and divided attention to stimulus processing were recorded by a 129 sensor array (Geodesic Inc.). Results In opposite to control subjects, patients with a cerebellar lesion predominately of the posterior lobe showed a deviant early posterior negativity (EPN) at temporo-occipital locations in paradigms probing the divided attention to emotional arousing cues, whereby these effects were only significant for the acccording cognitive ERP (P200, P300). Patients with a cerebellar lesion in opposite to control subjects showed also a reduction of the Late Positive Potentials (LPP) at centro-parietal locations, whereby this observation was without a striking statistical significance rather due to the small sample size. Conclusions Patients of cerebellar damage in our study disclosed neurophysiological patterns of impaired divided attention at the early stage and presumably also at forwarding stages of emotional processing. According to the findings of preserved selective attention to emotional cues as well as the indicative neurophysiologic patterns of enhanced cognitive activities mainly served by domains of the attentional and executive functions, compensatory guidance of the ventromedial and dorsolateral prefrontal cortex are highly warranted as crucial to ERP generation in our study sample. In respect to some restrictions of statistical output, application of the used paradigms to a greater study sample as well as a more in-depth analysis of the dipole sources should provide an increased precision of concerned regions of neural ERP generation.

Musical training modulates the early but not the late stage of rhythmic syntactic processing.

Syntactic processing is essential for musical understanding. Although the processing of harmonic syntax has been well studied, very little is known about the neural mechanisms underlying rhythmic syntactic processing. The present study investigated the neural processing of rhythmic syntax and whether and to what extent long-term musical training impacts such processing. Fourteen musicians and 14 nonmusicians listened to syntactic-regular or syntactic-irregular rhythmic sequences and judged the completeness of these sequences. Nonmusicians, as well as musicians, showed a P600 effect to syntactic-irregular endings, indicating that musical exposure and perceptual learning of music are sufficient to enable nonmusicians to process rhythmic syntax at the late stage. However, musicians, but not nonmusicians, also exhibited an early right anterior negativity (ERAN) response to syntactic-irregular endings, which suggests that musical training only modulates the early but not the late stage of rhythmic syntactic processing. These findings revealed for the first time the neural mechanisms underlying the processing of rhythmic syntax in music, which has important implications for theories of hierarchically organized music cognition and comparative studies of syntactic processing in music and language.