Background Preeclampsia is one of the most frequent and severe pregnancy complications, which reaches 15–25% women in our country. It was found that the formation of hypertensive states in pregnancy due to endothelial dysfunction and the associated imbalance of angiogenic factors. The danger lies in the development of complications such as preeclampsia or eclampsia, fetoplacental insufficiency, fetal growth retardation, fetal hypoxia and fetal death. The aim of the work was to study role of VEGF as prognostic marker of preeclampsia. Methods We studied 84 pregnant women in different weeks of gestation, with various type of preeclampsia and 40 healthy pregnant women, which was the control group. All pregnant women were treated in Tashkent Maternal Complex ‘-6. All women underwent standard lab tests according to modern protocols. We investigated vascular endothelial growth factor (VEGF) determined by enzyme immunoassay. Results In control group the level of VEGF has averaged 5,4 ± 0,3 pg/ml. In women with preeclampsia in II trimester 11,6 ± 0,6 pg/ml, III trimester 22,2 ± 1,4 pg/ml. Emphasis is placed on the following most significant changes in the content of VEGF in serum. Two times increasing in VEGF in the serum of women with preeclampsia. During pregnancy level of VEGF in II and III trimester increasing remains stable. The level of VEGF in physiological pregnancy is increasing only in the first 10 weeks. In the subsequent curve, reflecting the content of VEGF accepts plateau-like character and does not change until the end of pregnancy. Conclusions Increased production of growth factor is nonspecific and is likely to reflect the disturbance of angio-and vasculogenesis. Increased VEGF is already in I trimester of pregnancy can be understood as an early sign of predicting the formation of obstetric pathology at a later stage of pregnancy. Increased level of VEGF in the II and III trimester could be a predicted factor of preeclampsia.