Different climate characteristics put forward different requirements for the performance of air conditioning system. Climatic division has been proposed to facilitate the selection or design of HVAC systems to match indoor cooling/heating loads of buildings better. However, humidity parameter and distinction of sensible and latent loads are usually ignored, bringing problems to the operation and control of HVAC systems. Therefore, this study proposed a novel climatic division method for China during the cooling period taking the coupling effect of cooling and dehumidification of HVAC systems into account. The humidity-based cooling degree-day was firstly taken as an index to evaluate the influence of outdoor humidity parameter. Then, 96 cities, whose cooling loads are particularly affected by the humidity, were selected for further analysis. Indoor cooling loads were calculated using EnergyPlus and the climatic division based on sensible heat ratio and total cooling load was presented. Finally, on the basis of the novel climatic division, hourly sensible cooling load and latent cooling load of representative cities in each zone were analyzed to get the characteristics of load boundary and frequency distribution. A new design method was therefore proposed and discussed, paving a new way for the customized design of HVAC systems for each climate zone.