Background: Breast cancer is a significant health challenge in Southeast Nigeria, contributing to high morbidity and mortality among women. Factors such as limited access to healthcare, lack of awareness, and cultural stigmas exacerbate the burden, leading to late-stage diagnosis and poor survival rates. Objectives: This study aims to assess the prevalence, awareness, and attitudes towards breast cancer among women in Southeast Nigeria, and to identify the risk factors and preventive measures practiced in this region. Materials and Methods: A cross-sectional descriptive survey was conducted in Southeast Nigeria. A stratified sampling method was used to select participants from urban and rural areas. Data were collected from 360 women using a structured. Descriptive statistics and cross-tabulations were utilized for data analysis. Results: Awareness of breast cancer was high (96.67%), primarily obtained through the internet/social media (43.51%) and healthcare professionals (19.18%). However, knowledge about risk factors and symptoms was moderate to low, with only 14.17% considering themselves very knowledgeable. Regular breast self-examinations were practised by 30.28%, while 69.72% had never undergone clinical breast examinations. The prevalence of breast cancer diagnosis was 16.39%. Attitudes towards screening were positive, with 71.11% strongly agreeing that regular screening aids early detection. Despite this, confidence in identifying symptoms was low, with only 3.33% feeling very confident. Conclusions: The study highlights significant gaps in knowledge and practices related to breast cancer despite high awareness levels. There is an urgent need for targeted educational programs to enhance knowledge about risk factors, symptoms, and the importance of regular screening. Improving healthcare access and addressing cultural barriers are crucial for early detection and better outcomes.