Late Period Research Articles

Costumes of the Kings on the Temples of the Late Period

Costumes of the Kings on the Temples of the Late Period

Study on the Formation of Japanese Kaniarare Textiles

Kaniarare pattern (窠に霰文), a typical and representative design among the Japanese Yusoku patterns (有職文樣), becomes stylized at least during the 11th to 12th centuries in the late Heian period. The design of kaniarare pattern became stylized at least during the 11th to 12th centuries in the late Heian period, while the earliest known stylized kaniarare-mon silk fabric could be dated from late 13th century during the Kamakura period. Although the study of the trade and cultural exchanges between Song and Liao Dynasties and late Heian to early Kamakura Japan became more distinctive in the past decades, the transmission of silk art and relative impact on Japanese silk design have not been fully studied. By comparing with a few groups of extant and unearthed silk relics and connecting their relevancy, this article attempts to analyze the possible influence of silk design from the Liao to Song dynasties on Japanese silk design then and later.

Caches, Memory, and Ritual at the Maya City of Cival

Abstract This article examines Middle and Late Preclassic period ritual activity and caches discovered in the Central E Group complex at the ancient Maya site of Cival, which is located in northeastern Peten, Guatemala. It focuses on a series of excavations conducted in 2013 and 2014 at Structure 9, the E Group's western radial pyramid and uses theories of social memory and sacred place to provide insight into the recently discovered caches, termination rituals, and the deliberate destruction of architectural features found there. It also draws on previous ritual activity conducted in the Central E Group plaza and the site's broader history to obtain a more comprehensive understanding of the role of this complex as a sacred place and hub of memory at Cival for more than 1,000 years.

Examining the long-term effects of COVID-19 in surgical nurses: Case of Aegean Region.

To examine the long-term effects of COVID-19 on surgical nurses. Individuals contaminated with COVID-19 may face several metabolic or psychological issues, primarily in the respiratory, cardiovascular, nervous, musculoskeletal and renal systems during the late period. However, the long-term epidemiology is still not clear. Descriptive cross-sectional study. The study included nurses (n = 509) who had been diagnosed with COVID-19 at least 12 weeks before and worked in surgical departments. We collected the study data via an online survey using the snowball sampling method between December 2021 and May 2022. This study followed the Reporting of Observational Studies in Epidemiology Guideline. The mean age of the nurses was 31.66 ± 8.74 years. Nurses stated that they were diagnosed with COVID-19 approximately 36 weeks before participating in this study. We found that the nurses mostly experienced palpitation (83.5%), headache (73.5%), dyspnea (64.1%), anosmia (57.6%), arthralgia (55.7%) and burnout (58.4%) during the late period after COVID-19. The long-term effects of COVID-19 were related to multiple organ dysfunctions. Since the study was conducted with healthy individuals who had previously experienced COVID-19, there is no patient contribution. This study focuses on the long-term effects of COVID-19 on nurses. The results support the long-term effects of COVID-19 and are thought to contribute to the literature.

Assessing Temperament Risk Factors in Late Childhood and Early Adolescence: Development and Validation of the Integrative Late Childhood Temperament Inventory.

Childhood temperament has a well-documented influence on later life outcomes, notably behavior problems, quality of interpersonal relationships, and academic achievement. However, there is at present a lack of brief measures that assess temperament characteristics which are represented across models of temperament in the late childhood and early adolescence period. To redress this gap, the aim of the current study was to develop and validate a short questionnaire that extends an earlier integrative measure of temperament, the Integrative Child Temperament Inventory (ICTI) to the late childhood period. The new measure (named Integrative Late Childhood Temperament Inventory, ILCTI) includes all five components of the ICTI (frustration, behavioral inhibition, attention/persistence, activity level, sensory sensitivity), plus affiliation. German- or English-speaking parents rated a total of 525 children, aged 8 to 14years. Confirmatory factor analyses supported the predicted structure of the new measure. Examination of fit indices and psychometric analyses showed that 24 items are sufficient to capture all six dimensions reliably. Next to convergent validity with established measures of temperament and personality, we also present analyses of associations with measures of externalizing problems, internalizing problems, and school failure all of which support the instrument's clinical utility. Thus, despite its brevity, the ILCTI is a reliable and valid measure of late childhood temperament that can be helpful in assessing risk of developing behavior problems or school failure.

Field Notes: Why We Need Eastern Europe?

These Field Notes map the impact that the Russian invasion of Ukraine has had on research in architectural history. We asked scholars already involved with Eastern Europe and Russia how the conflict has affected their approach to the region and to their work. In five responses to this question, these authors identify the need to dismantle conceptual and geopolitical frameworks that have been inherited from the late Soviet period, critically re-read the historiography of Russian avant- garde and constructivist architecture, and confront the question of postcolonial critique in Eastern Europe from a viewpoint in the Global South. Taken together, these notes from the field offer both immediate reactions from scholars to the terrible war in Ukraine and reflections on possible paths for architectural history writing in the aftermath of this shock.

Estimates of the global burden of cancer-related deaths attributable to residential exposure to petrochemical industrial complexes from 2020 to 2040

The petrochemical industry is a major industrial emitter of greenhouse gas (CO2) and environmental pollution, posing health risks to nearby communities. Although previous studies have indicated that residents living near petrochemical industrial complexes are at a higher risk of cancer, they have focused on local or regional burdens. This study aimed to estimate the global cancer burden attributable to residential exposure to petrochemical industrial complexes. The geographical coordinates of petrochemical plants and oil refineries were retrieved and verified from published sources. The ArcGIS software and global population data were used to estimate the number of people living within specific distances (exposed population). The exposure time window was framed as ranging from 1992 to 2035, extending to the latest period of the exposure time window for all cancer types to estimate the attributable deaths between 2020 and 2040. The relative risk of cancer was estimated from 15 published studies. Population attributable fraction (PAF) method was used to estimate the risk of cancer attributable to residential exposure and calculate the number of cancer-related deaths. Our findings indicate that >300 million people worldwide will be estimated to live near petrochemical industrial complexes by 2040. The overall global burden of cancer-related deaths was 19,083 in 2020, and it is estimated to increase to 27,366 deaths by 2040. The region with the highest attributable cancer deaths due to exposure is the high-income region, which had 10,584 deaths in 2020 and is expected to reach 13,414 deaths by 2040. Residential exposure to petrochemical industrial complexes could contribute to global cancer deaths, even if the proportion is relatively small, and proactive measures are required to mitigate the cancer burdens among these residents. Enforcing emissions regulations, improving monitoring, educating communities, and fostering collaboration are vital to protecting residents’ health.

The earliest stamped hard pottery and high-firing technology dating back to 5000 BP: Evidence from two sites in southeastern China

This study focuses on the technological origin of stamped hard pottery, one of the precursors to Chinese porcelain, developed in the Late Neolithic period of China. 160 ceramic sherds of stamped hard wares from the Nanshan site (5300–4300 cal. BP) and Yanzaidong site (5000–4300 cal. BP) were investigated through water absorption, Vickers hardness, petrography, ED-XRF, thermodilatometry, XRD, and SEM-EDS. The results indicate that two categories of samples exhibit commendable physical properties, comparable to stoneware, attributed to specific high-alumina clay with low fluxing elements (porcelain stone), fired at high temperatures ranging from 1100 to 1250 °C. The other categories of samples appear to be defective products during firing process, or have another raw material source, contributing to a diversity of pottery at the two sites. Nanshan and Yanzaidong unequivocally emerge as the earliest known production of stamped hard pottery, dating back to 5000 cal. BP, marking a revolutionary advancement in high-firing technology during the Late Neolithic China.

The General Movement Optimality Score-Revised (GMOS-R) with Socioeconomically Stratified Percentile Ranks.

Background: The general movement optimality score (GMOS) quantifies the details of general movements (GMs). We recently conducted psychometric analyses of the GMOS and developed a revised scoresheet. Consequently, the GMOS-Revised (GMOS-R) instrument necessitated validation using new percentile ranks. This study aimed to provide these percentile ranks for the GMOS-R and to investigate whether sex, preterm birth, or the infant's country of birth and residence affected the GMOS-R distribution. Methods: We applied the GMOS-R to an international sample of 1983 infants (32% female, 44% male, and 24% not disclosed), assessed in the extremely and very preterm period (10%), moderate (12%) and late (22%) preterm periods, at term (25%), and post-term age (31%). Data were grouped according to the World Bank's classification into lower- and upper-middle-income countries (LMICs and UMICs; 26%) or high-income countries (HICs; 74%), respectively. Results: We found that sex and preterm or term birth did not affect either GM classification or the GMOS-R, but the country of residence did. A lower median GMOS-R for infants with normal or poor-repertoire GMs from LMICs and UMICs compared with HICs suggests the use of specific percentile ranks for LMICs and UMICs vs. HICs. Conclusion: For clinical and scientific use, we provide a freely available GMOS-R scoring sheet, with percentile ranks reflecting socioeconomic stratification.

The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) Trial: study protocol for a multi-country, multi-centre, double-blind, three-arm, placebo-controlled, individually randomized trial of antenatal corticosteroids for women at high probability of late preterm birth in hospitals in low- resource countries

BackgroundPreterm birth complications are the leading cause of newborn and under-5 mortality. Over 85% of all preterm births occur in the late preterm period, i.e. between 34 and < 37 weeks of gestation. Antenatal corticosteroids (ACS) prevent mortality and respiratory morbidity when administered to women at high risk of an early preterm birth, i.e. < 34 weeks’ gestation. However, the benefits and risks of ACS in the late preterm period are less clear; both guidelines and practices vary between settings. Emerging evidence suggests that the benefits of ACS may be achievable at lower doses than presently used. This trial aims to determine the efficacy and safety of two ACS regimens compared to placebo, when given to women with a high probability of late preterm birth, in hospitals in low-resource countries.MethodsWHO ACTION III trial is a parallel-group, three-arm, individually randomized, double-blind, placebo-controlled trial of two ACS regimens: dexamethasone phosphate 4 × 6 mg q12h or betamethasone phosphate 4 × 2 mg q 12 h. The trial is being conducted across seven sites in five countries—Bangladesh, India, Kenya, Nigeria, and Pakistan. Eligible women are those with a gestational age between 34 weeks 0 days and 36 weeks 5 days, who have a high probability of preterm birth between 12 h and 7 days (up to 36 weeks 6 days gestation). The primary outcome is a composite of stillbirth or neonatal death within 72 h of birth or use of newborn respiratory support within 72 h of birth or prior to discharge from hospital, whichever is earlier. Secondary outcomes include safety and health utilization measures for both women and newborns. The sample size is 13,500 women.DiscussionThis trial will evaluate the benefits and possible harms of ACS when used in women likely to have a late preterm birth. It will also evaluate a lower-dose ACS regimen based on literature from pharmacokinetic studies. The results of this trial will provide robust critical evidence on the safe and appropriate use of ACS in the late preterm period internationally.Trial registrationISRCTN11434567. Registered on 7 June 2021.

Кримські татари в історичній та культурній спадщині України XV–XVII ст.

The article aims to study the history of the Crimean Tatars of the XV–XVII centuries within historical cultural heritage materials. The territorial is limited to the Volyn region, namely the cities of Ostroh and Dubno. The study methodology is based on the principles of historicism and objectivity. Besides these principles, we use the principle of systematicity to study the documents. The factor analysis was effective in examining the social and political processes that took place in the late medieval and early modern periods. We also use the typological method considering material culture objects. Analytical and synthesizing methods were used to generalize the information obtained. The scientific novelty of the article lies in the fact that it studies the historical, cultural, and material heritage of one of the indigenous peoples of Ukraine - the Crimean Tatars in the late Middle Ages and early modern times. During the Ukrainian independence historians and archaeologists prepared some publications on the subject, but the generalized monographic study is absent. In addition, a significant part of material artifacts are kept in the collections of various museums and are not available in exhibition halls. Conclusions. The study of the Crimean Tatars’ material heritage on the territory of mainland Ukraine is important. Despite the rather complicated relations during the XV–XVII centuries, there are many examples of cooperation against common enemies, such as the Moscow state or the Polish-Lithuanian Commonwealth. Communities of immigrants from Crimea lived in many Ukrainian cities, towns, and villages, and together with the locals, they contributed to the common welfare and prosperity. All this has left a significant mark on the history, culture, and historical memory of different peoples. The presented artifacts of the Crimean Tatars from the collections of the museums of Ostroh and Dubno will contribute to the study and popularization of the cultural heritage of one of the indigenous peoples of Ukraine. We are firmly convinced that other Ukrainian museums (especially in their collections) hold many items related to the Crimean Tatars. Therefore, our research will continue.

Coupling of source rock gas expulsion intensity and reservoir quality in time and space-a key to determine gas accumulation in Upper Paleozoic tight sandstones of the Mugua gas field, Ordos Basin, China

Research on gas accumulation mechanisms and variations in gas saturation is limited in the newly established Mugua gas field in the Ordos Basin. Understanding these aspects is vital for reduce drilling uncertainty and exploration risk. This study employed a variety of methods, including: (1) the use of organic geochemical examinations to determine the gas expulsion intensity of hydrocarbon source rocks; (2) fluid inclusion analyses to determine the time of gas accumulation; (3) a combination of optical microscopy, scanning electron microscopy observations, pore-simulation and permeability tests, mercury-intrusion capillary pressure experiments, and nuclear magnetic resonance studies to assess the properties of the reservoir quality and identify the tight sandstone rock type; (4) wireline logging and interpretive data analyses to research the gas saturations features; and (5) establish reservoir quality evolution model to systematically study this problem. Integrating fluid inclusion homogenization temperatures with burial and thermal histories indicates that gas accumulation in the Mugua gas fields occurred throughout the Early Jurassic to Late Cretaceous period. Five diagenetic facies have been identified: dissolution, quartz-cemented, clay mineral filling, tightly compacted, and carbonate-cemented facies. The reservoir quality evolution model reveals that the five diagenetic facies experienced densification before the period of gas accumulation. Therefore, for gas accumulation in tight sandstones, it is essential that mature and gas-generating source rocks, provide sufficient expulsion forces to drive gas into the rocks. The mechanism of gas accumulation in the Mugua gas field's tight gas sandstone reservoirs involves the process occurring in sandstones that are either near or interbedded with source rocks, under high pore-fluid pressure generated by gas production. Compared to other Upper Paleozoic gas fields in the Ordos Basin, the gas expulsion intensity in the Mugua gas field is lower, ranging from 6.12–8.39 × 108 m3/km2. Due to the low gas expulsion intensity, the Shihezi 8 Member's tight sandstone reservoirs, situated away from the source rock, typically show low gas saturation. Conversely, the dissolution and quartz-cemented facies within the Benxi, Taiyuan, and Shanxi Formations, intimately interbedded with hydrocarbon source rocks, exhibit good reservoir quality. They offer ideal conditions for gas accumulation, making them prime candidates for exploration and development.

MORPHOLOGICAL CHANGES IN THE HIPPOCAMPUS OF THE RAT BRAIN IN ISCHEMIA AND IN CONDITIONS OF COMBINED PRECONDITIONING

BACKGROUND: Preconditioning is an effective method of increasing the body's resistance to hypoxia/ischemia.&#x0D; AIM: The aim is to evaluate morphological changes in the most hypoxia-sensitive fields of the hippocampus CA1 and CA3 in cerebral ischemia in rats and under conditions of combined preconditioning.&#x0D; MATERIALS AND METHODS. Cerebral ischemia was simulated in rats under anesthesia (8% chloral hydrate solution 400 mg/kg) by bilateral ligation of the common carotid arteries. The combined preconditioning method (CPreC) included the alternate use of two preconditional factors – pharmacological (amtisol at a dose of 25 mg /kg) and hypoxic (hypobaric hypoxia, 410 mmHg, exposure time 60 min). Morphometric assessment of brain damage was performed a day after modeling ischemia in the CA1 and CA3 fields of the hippocampus.&#x0D; RESULTS. KPreK has a positive effect on the morphometric parameters of the brain during its ischemia, increasing the survival of neurons in the early and late periods of ischemia modeling, preventing the formation of necrotically and apoptotically altered neurons, hyperactivation of microglial cells and contributing to the preservation of endotheliocytes. &#x0D; CONCLUSION. KPreK (amtisol + hypobaric hypoxia) has a neuroprotective effect in cerebral ischemia.

Neonatal mortality during the war in Tigray: a cross-sectional community-based study

Neonatal mortality is among the key national and international indicators of health services. The global Sustainable Development Goal target for neonatal mortality is fewer than 12 deaths per 1000 livebirths, by 2030. Neonatal mortality estimates in the 2019 Ethiopian Demographic Health Survey found 25·7 deaths per 1000 livebirths. Subnational surveys specific to Tigray, Ethiopia, reported a neonatal mortality lifetime prevalence of 7·13 deaths. Another government report from the Tigray region estimated a neonatal mortality rate of ten deaths per 1000 livebirths in 2020. Despite the numerous interventions in Ethiopia's Tigray region to achieve the Sustainable Development Goals, the war has disrupted most health services, but the effect on neonatal mortality is unknown. Thus, this study aimed to investigate the magnitude and causes of neonatal mortality during the war in Tigray. A cross-sectional community-based study was conducted in Tigray to evaluate neonatal mortality that occurred from Nov 4, 2020, to May 30, 2022. Among the 31 districts, 121 tabias were selected using computer-generated random sampling, and 189 087 households were visited. We adopted a validated WHO 2022 verbal autopsy tool, and data were collected using an interviewer-administrated Open Data Kit. In the absence of the mother, other respondents to the verbal autopsy interview were household members aged 18 years and older who provided care during the final illness that led to death. 29 761 livebirths were recorded during the screening of 189 087 households. Verbal autopsy was administered for 1158 households with neonatal deaths. 317 neonates were stillborn, and 841 neonatal deaths were recorded with the WHO 2022 verbal autopsy tool from Nov 4, 2020, to May 30, 2022, in 31 districts. The neonatal mortality rate was 28·2 deaths per 1000 livebirths. 476 (57%) of the 841 neonatal deaths occurred at home and 296 (35%) in health facilities. A high rate of neonatal deaths was reported in rural districts (80% [673 of 841]) compared with urban districts (20% [168 of 841]), and 663 (79%) deaths occurred during the early neonatal period, in the first week of life (0-6 days). The leading causes of neonatal death were asphyxia (35% [291 of 834]), prematurity (30% [247 of 834]), and infection (12% [104 of 834]). Asphyxia (37% [246 of 663]) and infection (28% [50 of 178]) were the leading causes of death for early and late neonatal period deaths, respectively. Neonatal mortality in Tigray is high due to preventable causes. An urgent response is needed to prevent the high number of neonatal deaths associated with the depleted health resources and services resulting from the war, and to achieve the Sustainable Development Goal on neonatal mortality. UNICEF and United Nations Fund for Population Activities. For the Tigrigna translation of the abstract see Supplementary Materials section.

Prediction of in-hospital complications in takotsubo syndrome: prospective cohort study

BACKGROUND: Until recently, takotsubo syndrome (TS) was considered a fairly benign disease in both early and late periods. However, in recent years, in-hospital complications in the acute period of TS are common and can be life-threatening.&#x0D; AIM: Based on clinical and laboratory-instrumental data, this study aimed to build models for predicting the risk of developing in-hospital complications in patients with TS during the acute period.&#x0D; MATERIALS AND METHODS: This prospective cohort study included 60 patients with TS, with an average age of 65.5±13.4 years. In the acute period (7–14 days), standard clinical and laboratory examination, peripheral arterial tonometry using the «EndoPAT 2000» apparatus, and psychological testing using validated questionnaires (hospital anxiety and depression scale and Beck depression scale) were performed.&#x0D; RESULTS: The integrated model for predicting the risk of acute heart failure (AHF) development (pulmonary edema and cardiogenic shock) identified admission LVEF as the leading prognostic parameter. With LVEF ≤40.5%, the probability of AHF in patients with TS in the acute period was 62.5%, and in patients with TS and QTc interval 487 ms, the risk reached 100%. The sensitivity and specificity of the developed model were 72.7% and 97.4%, respectively. The integrated model for predicting the development of cardiovascular complications (CVCs) revealed that the number of leukocytes in the peripheral blood was the leading risk factor for adverse events in patients with TS in the acute period. With a leukocyte count 11.1×109/L, the risk of CVCs in patients with TS increased to 89.9%, and if the erythrocyte count was 4.69×1012/L or ≤4.29×1012/L, it could reach 100%. The sensitivity and specificity of the resulting model were 92.6 and 97.0%, respectively.&#x0D; CONCLUSION: The models proposed in this study for predicting the likelihood of developing severe AHF and the overall risk of CVCs in the acute period of TS are personalized and easy to use, allowing for the selection of optimized treatment techniques.

Charging dynamic, resistance and accumulation process of tight sandstone oil of the paleogene Es3 member in linnan sag, jiyang depression

The study of the coupling relationship between the dynamic and resistance of oil charging is the key to revealing the process of tight oil accumulation. The Paleogene Es3 member of Linnan sag, Jiyang Depression was taken as an example, basin simulation, fluid inclusion analysis, and porosity inversion were comprehensively utilized to recovery the residual fluid pressure and charging resistance during the critical oil accumulation periods. Combined with the physical modeling of tight oil charging, the charging process and characteristics of tight oil under dynamic and resistance coupling were reproduced and the effects of dynamic and resistance on the oiliness of tight reservoirs were analyzed. The comprehensive analysis indicates that there were early and late periods of oil accumulation in early Dongying period and late Guantao-Quaternary period. The reservoirs had not been densified during the early oil accumulation period. The residual pressure of the formation was between 1.0–4.4 MPa and the reservoir charging resistance was generally small, so that the dynamic was generally greater than the resistance. But the oil saturation of the reservoirs was low due to the small amount of hydrocarbon generation. During the late oil accumulation period, the source rocks entered the peak period of hydrocarbon generation and expulsion and the residual pressure of the formation was between 4.2–12.1 MPa. The reservoirs had been close to or completely densified. The dynamic, resistance and dynamic and resistance difference all increased significantly. Under the stronger dynamic, the oil saturation of reservoirs rapidly increased, ultimately achieving tight oil enrichment. The results of this study provide insights into the dynamic process of tight oil accumulation and the distribution of oil in tight reservoirs.

Congenital anomalies during Covid-19: artifact of surveillance or a real TORCH?

Infections in the first trimester of pregnancy can be teratogenic, but the possibility that Covid-19 could lead to birth defects is unclear. We examined whether SARS-CoV-2 infection during pregnancy or exposure to pandemic conditions were associated with the risk of congenital anomalies. We carried out a retrospective study of 420,222 neonates born in Quebec, Canada in two time periods: prepandemic (January 1, 2017 to March 12, 2020) vs. pandemic (March 13, 2020 to March 31, 2022). We classified pandemic births as early (first trimester completed before the pandemic) or late (first trimester during the pandemic), and identified patients with SARS-CoV-2 infections during pregnancy. We applied (1) adjusted log-binomial regression models to assess the association between SARS-CoV-2 infection and congenital anomalies, and (2) autoregressive interrupted time series regression to analyze temporal trends in the monthly number of defects in all patients regardless of infection. In total, 29,263 newborns (7.0%) had a congenital anomaly. First trimester SARS-CoV-2 infections were not associated with a greater risk of birth defects compared with no infection (RR 1.07, 95% CI 0.59-1.95). However, births during the late pandemic period were more likely to be diagnosed with congenital microcephaly compared with prepandemic births (RR 1.44, 95% CI 1.21-1.71). Interrupted time series analysis confirmed that the frequency of microcephaly increased during the late pandemic period, whereas other anomalies did not. We conclude that Covid-19 is likely not teratogenic, but enhanced surveillance of anomalies among late pandemic births may have heightened the detection of infants with microcephaly.

Before Mnemosyne: Wilhelmine Cultural History Exhibitions and the Genesis of Warburg's Picture Atlas.

Aby Warburg's Bilderatlas Mnemosyne, left unfinished in 1929, has attracted significant interest in recent decades. This essay offers a new interpretation of Warburg's "picture atlas," not in relation to modernist collage and photomontage, but as an heir to scientific pedagogical exhibitions of the late Wilhelmine period. It deals in particular with two "public enlightenment" shows curated by the Leipzig medical historian Karl Sudhoff, whose work Warburg admired and employed: the first on with the history of hygiene in Dresden in 1911, the second in Leipzig, three years later, on the development of scientific images. Like Warburg, Sudhoff appreciated artworks and artifacts as sources for the history of science and medicine. His exhibitions consisted of assemblages of photographic reproductions-some of which were provided by Warburg himself-and uncannily anticipate Mnemosyne in both form and content. By examining the exchange of materials and display methods between the two scholars, the article explores how their respective visual projects reflected deeper disagreements over the public role of science, the epistemic power of images, and the persistence of the irrational in the human psyche.

Sustained Decline in Hospitalisations for Anogenital Warts in Australia: Analysis of National Hospital Morbidity Data 2003-2020.

In Australia, school-based human papillomavirus (HPV) vaccination was introduced initially for girls in 2007, and then also for boys in 2013. While studies have shown declines in the incidence of anogenital warts, there is a paucity of recent data analysis assessing the impact of vaccination on more severe disease. The National Hospital Morbidity Database of the Australian Institute of Health and Welfare (AIHW) hospitalisation admission data that included ICD-10-AM code A63.0 ('anogenital warts') as the diagnoses, for the years 2003-2020, were analysed to estimate hospitalisation rates per 100,000 mid-year population. The annual average hospitalisation rates per 100,000 population for anogenital warts in both genders combined in the age groups 10-19 years, 20-29 years, and 30-39 years decreased, respectively, from 16.9, 49.6, and 23.6 in 2003-2007 (pre-vaccine period) to 2.6, 15.2, and 14.6 in 2008-2020 (post-vaccine period), equating to declines of 84.7%, 69.4%, and 38.2%, respectively. Following the introduction of the boy's vaccination, hospitalisation rates decreased further in the respective age bands from 4.3, 22.8, and 18.4 in 2008-2013 (early post-vaccine period) to 1.1, 9.3, and 11.7 in 2014-2020 (late post-vaccine period), equating to respective declines of 73.4%, 59.3%, and 36.4%. This analysis confirms that there is a substantial incremental decline in anogenital warts hospitalisations among Australians aged 10-39 years.

Intraosseous resection of bone tumors: our experience

Introduction. The effectiveness of efficient surgical interventions in patients with benign, borderline, and malignant bone tumors remains an important topic because such operations imply lower injury rate and volume of surgical intervention while being more physiological. In terms of radicality and consequently recurrence rates they are comparable to more traumatic surgeries such as segmental resections with various types of reconstructions (arthrodesis, endoprosthesis, auto- and allotransplantation using bone fragments, et al) and amputation.Aim. To analyze the results of intraosseous resection for benign, malignant, giant cell, and metastatic bone tumors.Materials and methods. Between 2015 and 2023, 45 interventions of intraosseous resection were performed in 44 patients: 19 (43 %) had enchondroma, 6 (14 %) – giant cell tumor, 4 (9 %) – fibrous dysplasia, 3 (7 %) – solitary bone cyst, 3 (7 %) – aneurysmal bone cyst, 2 (5 %) – chondromyxoid fibroma, 4 (9 %) – metastatic bone lesions, 1 (2 %) – osteoid osteoma, 1 (2 %) – benign fibrous histiocytoma, 1 (2 %) – chondrosarcoma G1 . Among them, 27 interventions were performed in combination with adjuvants (liquid nitrogen cryoablation, argon plasma coagulation, hydrogen peroxide, ethanol). In 24 patients, reconstruction was performed using lyophilized corpse bones, in 5 using autotransplant (fragments of the iliac crest), in 10 using plastic material (in 6 – polymethacrylate, in 4 – osseointegrative material “Rekost”), in 6 using xenoplastic material “Silorif.” Additionally, 16 surgeries were augmented with osteosynthesis (14 extramedullary and 3 intramedullary osteosyntheses).Results. Complications in the early postoperative period were observed in 3 (7 %) patients, in the late postoperative period in 2 (5 %) patients. At follow ups (between 2 and 97 months), 42 (95 %) patients did not have signs of recurrence. Musculoskeletal Tumor Society Score (MSTS) at these follow ups in recurrence-free patients was excellent (mean score – 93.6 %) and good (mean score – 77 %). Eastern Cooperative Oncology Group (ECOG) performance status also showed high functional potential of intraosseous resection: its mean value was 0.3.Conclusion. Use of intraosseous resection including augmentation with adjuvant measures, allowed to achieve excellent functional results in 42 (95 %) of patients with mean follow-up duration of 39.8 months. Fractures in 2 patients demonstrate the necessity of extramedullary osteosynthesis in surgeries on long bones experiencing high load irrespective of the volume of intervention. The obtained results show applicability and high effectiveness of intraosseous resection. For certain indications, it can be the treatment of choice.