AbstractFaults and folds on the southern flank of the Ozark dome in northern Arkansas, USA, record flexural extension in a foreland area followed by shortening in response to the late Paleozoic Ouachita orogeny. Map‐scale structures and an analysis of fault‐slip data collected systematically during geologic mapping demonstrate that most deformation in the area accommodated north‐south extension as the southern margin of Laurentia was flexed beneath the thrust load of the Ouachita belt, probably during Middle Pennsylvanian. Extension was concentrated in northeast‐ and west‐northwest‐trending structural zones having sets of discontinuous, often en echelon normal and strike‐slip faults and associated monoclinal folds. Reactivation of basement weaknesses that underlie these zones is indicated by their close match to oblique‐rift models in which both the proportions of normal and strike‐slip faulting and the internal extension directions vary with orientation of the zones. Subsequent propagation of north‐south Ouachita shortening into the foreland formed small‐offset strike‐slip and sparse reverse faults that overprinted older extensional structures. Strike‐slip faults were concentrated in reactivated northeast‐trending structural zones. In two areas, reverse faults and local anticlines were developed in the footwalls of older normal faults, both near intersections of northeast‐ and west‐northwest‐trending structural zones. These are interpreted as areas of incipient inversion due to compressional stress concentrations at fault‐block corners. Spatial overlap of areas of north‐south shortening and fluid flux marked by silicification or lead‐zinc mineralization indicates that regional fluid flow of brines was coeval with and may have enhanced inversion during Late Pennsylvanian to early Permian.