Late Changes Research Articles

Quasinormal modes of Reissner–Nordström–AdS: the approach to extremality

We consider the quasinormal spectrum of scalar and axial perturbations of the Reissner–Nordström–AdS black hole as the horizon approaches extremality. By considering a foliation of the black hole by spacelike surfaces which intersect the future horizon we implement numerical methods which are well behaved up to and including the extremal limit and which admit initial data which is nontrivial at the horizon. As extremality is approached we observe a transition whereby the least damped mode ceases to be oscillatory in time, and the late time signal changes qualitatively as a consequence.

Трансформація вимог до сертифікації інженерів-геодезистів та інженерів-землевпорядників

In this article, the authors highlight the latest changes in the requirements for the certification of surveying engineers and land surveying engineers, as well as in the upgrading of the qualifications of already certified surveying engineers and land surveying engineers, which took place in 2023, compared to the previous requirements for the certification and upgrading of the qualifications of engineers – surveyors and land surveying engineers who have been operating until now

Hybrid designs and kick-off batch production experience for the CMS Phase-2 Upgrade

The CMS Tracker Phase-2 Upgrade requires the production of new sensor modules to cope with the requirements of the HL-LHC. The two main building blocks of the Outer Tracker are the Strip-Strip and Pixel-Strip modules. All-together 47'520 hybrid circuits will be produced to construct 8'000 Strip-Strip and 5'880 Pixel-Strip modules. The circuit designs for the mass production were fine-tuned and kick-off batches were manufactured to verify the latest changes in the designs before the series production. This contribution focuses on lessons learned from the prototyping stage, design optimization details for the mass production as well as test results and production yield from the kick-off batches.

Accounting of foreign economic activities: impact on current aspects of currency operations supervision and financial monitoring during the period of martial state in Ukraine

Introduction. Accounting for foreign economic activity was and remains a relevant area of accounting support for business entities, which is associated with an increased risk of errors in connection with changes in regulatory documents on such activities, different conditions for carrying out activities due to the variability of the terms of foreign economic contracts, the need to take into account different exchange rates and the correct submission and presentation of information in financial statements. It is important for business entities to comply with the requirements of legislation, to organize proper internal control/internal audit to prevent errors in reflected transactions in the conditions of foreign economic activity. The purpose of the paper is to highlight the features of accounting for foreign economic activity, taking into account the latest changes and the impact on currency supervision and financial monitoring. Results. Subjects of foreign economic activity must also comply with the rules of currency exchange, import and export licensing, as well as customs procedures. Starting from 2019, currency supervision replaced currency control, a risk-oriented approach was introduced. Correct accounting is affected by the control of settlement deadlines, i.e. the time between the customs declaration and the payment. The experience of regulating foreign economic activity in Ukraine was the mandatory sale of proceeds by exporters under foreign economic contracts, which was canceled in 2019 by the NBU Resolution of February 6, 2019, №. 3. During the martial law, it was not restored. Funds, before entering the current account, may first be credited to a distribution account in the bank, which is in transit, and the operations of crediting to the distribution account and transferring to the current account may take place both during the same day and on different days. Based on the set of criteria for risky operations of foreign economic activity and taking into account internal documents, the bank can make a decision to break up the operation and violate the deadlines even if formal criteria are observed in export-import operations. Conclusion. Under the conditions of extraordinary events, there is a need to establish new currency regulation and control measures. Currency supervision is based on a risk-oriented approach and certain indicators of violations of currency legislation should be taken into account when implementing internal control measures.

Late Quaternary glacial history of the Ulugh Muztagh, central Kunlun Mountains

Only a few studies of Quaternary glaciation have been conducted in the central Kunlun Mountains, hindering a full understanding of Late Pleistocene and Holocene climatic changes on the Tibetan Plateau. This study presents 30 new 10Be surface exposure ages from five moraine crests, two moraine platforms and two glaciofluvial terraces on the northwestern slopes of the Ulugh Muztagh in the central Kunlun Mountains. The moraine ages indicate that an old glacial advance occurred no later than ∼87.10 ka, an extensive glacial advance at ∼35.61 ka and Holocene advances at ∼7.61 ka, ∼1.65 ka, ∼0.69 ka, and ∼ 0.36 ka. Two glaciofluvial terraces were tentatively determined to have been deposited at ∼24.87 ka and ∼ 17.35 ka, possibly implying the occurrence of limited global Last Glacial Maximum (LGM) and Heinrich Stadial 1 glacial advances. After combining these findings with geomorphic evidence, it was inferred that glacial coverage was more extensive during MIS 3 than the global LGM, indicating that the timing of the LGM in the Ulugh Muztagh was asynchronous with that of the monsoon-dominated Tibetan Plateau. Reference to other palaeoclimatic archives suggested that glacial advances since MIS 3 were most likely driven by a combination of cool to cold temperatures and a relatively humid climate. The limited global LGM advance was attributed to increased aridity.

Assessment of Tracheostomy Tube Placement and Late Change Practices in an Academic Tertiary Care Center.

Introduction The optimal time for tracheostomy changes is unknown. Most surgeons opt to wait until five to seven days postoperatively, while more recent studies suggest that changes occurring as early as two to three days postoperatively are also safe. Objective To evaluate the safety of changing the tracheostomy tube later than 14 days postoperatively. Methods The charts of patients who underwent tracheostomy placement and change at a tertiary care center from 2015 to 2019 were retrospectively reviewed, and the subjects were divided into 2 cohorts (late and very late), depending on the time of the first tracheostomy change. Results The study included 198 patients, 53 of whom aged between 0 and 18 years, and 145, aged > 18 years. The time until the first tracheostomy change was on average of 131.1 days. The most common indication for tracheostomy tube placement was prolonged intubation. Adverse events were observed in 30.8% of the cases (the most common being the formation of granulation tissue), a rate that does not differ much from the incidence reported in the literature (of 34% to 77%) when tracheostomy tubes are changed as early as 3 to 7 days postoperatively. There was no significant difference in the incidence of complications between patients undergoing late and very late changes ( p = 0.688), or between pediatric and adult subjects ( p = 0.36). There were no significant correlations regarding the time of the first or second change and the incidence of complications (r = -0.014; p = 0.84 for the first change; and r = -0.57; p = 0.64 for the second change). Conclusion The late first tracheostomy tube change was safe and could save resources and decrease the financial burden of frequent changes. It is always crucial to provide adequate information about home tracheostomy care for patients.

Alternation between terrestrial and aquatic plants dominated organic matter sources in the Tiaoshu wetland (south China) and its response to late Pleistocene environmental changes

Widely distributed wetlands in China play an important role in the global carbon cycle. However, the long-term response of wetland evolution and carbon storage in tropical southern China to climate change remains unclear. Here, we present a sediment core record from the Tiaoshu Wetland in the northern Leizhou Peninsula and multiple proxy indicators are investigated, with the aim of better understanding past vegetation and environmental changes. The following conclusions were drawn: (i) The organic matter deposited in the Tiaoshu Wetland was mainly derived from terrestrial C3 plants and aquatic plants growing in and/or around the catchment. The temporal variability in the relative proportions of organic matter contributed by various sources revealed paleoenvironmental changes in the study area, generally consistent with regional and global climate records. (ii) The peat formation pattern in the Tiaoshu Wetland is in contrast to some individual sites reported in subtropical China, suggesting that there may be different peat formation patterns in the tropical and subtropical regions of China, which may be closely related to specific hydrothermal conditions in different regions. In addition, by comparison with atmospheric CH4 concentrations, our results suggest potential relationships between the evolution of wetlands in tropical China and global atmospheric CH4 cycles.

Criminal legal and criminological analysis of offenses against sexual freedom and immunity in Ukraine: current state and prospects

The highest social values of any legal country are the protection of natural rights, which include life, health, dignity, freedom and inviolability of the person. Ukraine declared these rights as the basic ones in the Art. 3 and 29 of the Constitution. The number of criminal offenses is large enough and gradually increasing, but only a small number of them are really important for the life of the individual and the consequences of their actions remain until the end of the life of the victim. Such criminal offenses include articles that protect sexual freedom and immunity. Ukraine has been under martial law for 10 months, and during this period cases of sexual violent criminal offenses have taken place. The aim of the study is to analyze the statutes, declarations and conventions that should protect persons from the said criminal offenses. The study analyzed 1) the attitude of the ECHR to criminal offenses related to sexual freedom and immunity, and changes in legislation in connection with the ratification of international law; 2) conflicts and inconsistencies that exist in the law on criminal liability now and those that do not comply with international treaties that were ratified, for example, the new version of Art. 155 and 303 of the Criminal Code of Ukraine; 3) the latest changes in the legislation of Ukraine concerning Art. 156 “Child abuse for sexual purposes”of the Criminal Code of Ukraine; 4) data from the Office of the Prosecutor General of Ukraine on criminal offenses related to sexual freedom and immunity. As a result, it has been established that 40% of the analyzed difficulties do not end with the indictment in the court. There is a doubt about the determination of the same degree of social danger of rape (Art. 152 the Criminal Code of Ukraine) and sexual violence (Art. 154 the Criminal Code of Ukraine). The Art. 154 the Criminal Code of Ukraine concerning the difficulty of proving the criminal offense was analyzed, and a new version of this article was proposed. Diagrams with the data from the register of court decisions the correlation of indictments and court decisions on the recognition of persons guilty of the mentioned criminal offenses were created. The explanations of the Supreme Court concerning this category of cases were analyzed and presented. Finally, proposals were formulated to improve the current version of the criminal legislation of Ukraine.

Review article: Recent advances in ascites and acute kidney injury management in cirrhosis.

Better understanding of disease pathophysiology has led to advances in managing ascites and its associated complications including hepatorenal syndrome-acute kidney Injury (HRS-AKI), especially medicinal and interventional advances. To review the latest changes in the management of ascites and HRS-AKI. A literature search was conducted in Pubmed, using the keywords cirrhosis, ascites, renal dysfunction, acute kidney injury, hepatorenal syndrome, beta-blockers, albumin, TIPS and vasoconstrictors, including only publications in English. The medicinal advances include earlier treatment of clinically significant portal hypertension to delay the onset of ascites and the use of human albumin solution to attenuate systemic inflammation thus improving the haemodynamic changes associated with cirrhosis. Furthermore, new classes of drugs such as sodium glucose co-transporter 2 are being investigated for use in patients with cirrhosis and ascites. For HRS-AKI management, newer pharmacological agents such as vasopressin partial agonists and relaxin are being studied. Interventional advances include the refinement of TIPS technique and patient selection to improve outcomes in patients with refractory ascites. The development of the alfa pump system and the study of outcomes associated with the use of long-term palliative abdominal drain will also serve to improve the quality of life in patients with refractory ascites. New treatment strategies emerged from better understanding of the pathophysiology of ascites and HRS-AKI have shown improved prognosis in these patients. The future will see many of these approaches confirmed in large multi-centre clinical trials with the aim to benefit the patients with ascites and HRS-AKI.

Tracking the Effects of Mangrove Changes and Spartina alterniflora Invasion on Soil Carbon Storage: A Case Study of the Beibu Gulf of Guangxi, China

In order to clarify the long-term changes in mangroves in the Beibu Gulf of Guangxi and the carbon storage changes after the invasion of Spartina alterniflora (S. alterniflora) in the Dandou Sea area, the Continuous Change Detection and Classification (CCDC) algorithm combined with feature indices was first used to track the changes. Subsequently, the random forest algorithm was applied to classify each change segment, and then sampling was conducted based on the distribution of S. alterniflora in different invasion years. The results showed that the Kappa coefficient of the classification result of the latest change segment was 0.78. The rapid expansion of S. alterniflora, aquaculture pond construction, and land reclamation activities have led to changes in mangroves, causing a decrease in the area of the mangrove region. A total of 814.57 hectares of mangroves has been converted into other land-cover types, with most pixels undergoing one to two changes, and many of these changes were expected to continue until 2022. An analysis of the distribution characteristics and influencing factors of soil organic carbon (SOC) and soil organic carbon storage (SOCS) at different invasion stages revealed that SOC and SOCS were mainly influenced by soil bulk density, soil moisture content, and electrical conductivity. It was found that S. alterniflora had higher SOC content compared to the mudflats. With the increase in invasion years, S. alterniflora continuously increased the SOC and SOCS content in coastal wetlands.

Skin perfusion and oxygen saturation after mastectomy and radiation therapy in breast cancer patients

The pathophysiological mechanism behind complications associated with postmastectomy radiotherapy (PMRT) and subsequent implant-based breast reconstruction are not completely understood. The aim of this study was to examine if there is a relationship between PMRT and microvascular perfusion and saturation in the skin after mastectomy and assess if there is impaired responsiveness to a topically applied vasodilator (Methyl nicotinate – MN).Skin microvascular perfusion and oxygenation >2 years after PMRT were measured using white light diffuse reflectance spectroscopy (DRS) and laser Doppler flowmetry (LDF) in the irradiated chest wall of 31 women with the contralateral breast as a control. In the non-irradiated breast, the perfusion after application of MN (median 0.84, 25th–75th centile 0.59–1.02 % RBC × mm/s) was higher compared to the irradiated chest wall (median 0.51, 25th–75th centile 0.21–0.68 % RBC × mm/s, p < 0.001). The same phenomenon was noted for saturation (median 91 %, 25th–75th centile 89–94 % compared to 89 % 25th–75th centile 77–93 %, p = 0.001). Eight of the women (26%) had a ≥10 % difference in skin oxygenation between the non-irradiated breast and the irradiated chest wall.These results indicate that late microvascular changes caused by radiotherapy of the chest wall significantly affect skin perfusion and oxygenation.

Identification of Differentially Expressed MicroRNAs in the Rat Hippocampus during Adolescence through an Epigenome-Wide Analysis

Introduction: Epigenetic mechanisms involving microRNAs (miRNAs) play a fundamental role in many biological processes, particularly during prenatal and early postnatal development. Their role in adolescent brain development, however, has been poorly described. The present study aimed to explore miRNA expression in the hippocampus during adolescence compared to adulthood in rats. Method: The brains of female and male Wistar rats were extracted, and the hippocampus was freshly dissected at postnatal day 41 (adolescence) and postnatal day 98 (adulthood). An epigenome-wide analysis was conducted to identify the miRNAs significantly expressed in adolescence compared to adulthood. Additionally, target genes of such miRNAs were considered to perform an exploratory Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Results: We identified 16 differentially expressed miRNAs in adolescent male rats compared with adult male rats and 4 differentially expressed miRNAs in adolescent females compared with adult females. Enrichment analysis reinforced that the target genes found are related to neurodevelopmental processes such as cell proliferation, cell migration, and nervous system development. Conclusion: Our findings suggest a complex pattern of miRNA expression during adolescence, which differs from that in adulthood. The differential expression of miRNA in the hippocampus during adolescence may be associated with the late developmental changes occurring in this brain region. Furthermore, the observed sex differences in miRNA expression patterns indicate potential sexual differentiation in hippocampal development. Further comprehensive investigations are needed to elucidate the roles of miRNA in normal brain development.

MODIFIKASI DAN INOVASI OLAHAN KELAPA MUDA MENJADI PUDING DOGAN SEBAGAI PROGRAM MBKM MAHASISWA INDO GLOBAL MANDIRI

Natural resources are resources obtained from nature and can be utilized to meet the needs of human life. Abundant natural resources if not managed properly will be in vain, because this requires a community that is entrepreneurial, creative and innovative in taking advantage of these opportunities. Therefore, I am a UIGM student who wants to make the latest changes and innovations around Km 14 Palembang, namely "Dogan Pudding" which is the basic ingredient of Young Coconut. Activities were carried out around km 14 Palembang. The method I use is a direct method to sell dogan pudding products made from young coconuts. In this product I make new changes and improvements starting from the appearance, taste and others that distinguish it from other dogan pudding products. Compared to other soft drinks, coconut water contains good nutrients classified as very nutritious, hygienic and natural drinks and has been tested many times to cure various diseases. The delicious taste of young coconut and soft texture make young coconut loved by children to adults. Young coconut water has a very good nutritional content for health.

Evaluation of the histopathological effects of injectable hyaluronic acid as a filler material in rat’s lip

ObjectivesThe present work aimed to examine the early and late histopathological changes occurring in the lower lips of rats, as a result of hyaluronic acid injection, and to determine whether it could really bring us closer to the ideal soft tissue filler material. This research highlights the importance of experimental studies on this subject, since adverse reactions have been observed routinely in dental practice. Material and methodsThe present study was carried out on 36 adult male albino rats and was divided into two equal groups, each consisting of 18 rats; group I (control group) and group II (experimental group). Rats in the experimental group were injected with hyaluronic acid (0.07 ml), whereas rats in the control group were injected with 0.9% sodium chloride. ResultsThe results showed inflammation triggered by the injection of hyaluronic acid. On examining the specimens histologically using Hematoxylin and Eosin stains, Toluidine Blue stain and immunohistochemistry with anti-CD68 antibody, there was a significantly greater inflammatory response in the groups at early interval with hyaluronic acid compared with the control (P < 0.0001). Higher collagen formation was also observed with Masson’s Trichrome staining. ConclusionThe undesirable effects of hyaluronic acid filler injection can be detected at early intervals following its injection. Fortunately, all the undesirable effects are transient and decrease by time, reaching levels comparable to normal. Overall, HA was well-tolerated by tissues, reflecting how this filler material possesses a biocompatible property.

Deep mitochondrial phylogeographical pattern: cryptic population structure within an ecological niche in the near-threatened Himalayan vulture (Gyps himalayensis)

Abstract The Himalayan vulture (Gyps himalayensis) has higher environmental specificity than other species in the same genus, and its population has declined due to diclofenac exposure and shortage of carcasses as a food source. Previous analysis of mitochondrial (mt) DNA cytochrome b (Cyt b) sequences reported no distinct geographical population structure in the Himalayan vulture. Contradictory results were obtained in the present study, which investigated the population structure of 14 Himalayan vultures that migrated to Thailand during winter. Using samples obtained between 2010 and 2021, as well as limited GenBank samples, the study found that the Cyt b locus was incapable of distinguishing population structure. This dataset contrasted with the mtDNA control region (CR) and Cyt b + CR dataset, which divided them into two groups, as explained by the Middle–Late Pleistocene climate change scenario. The species split into populations from the central, western, and northern regions of its distribution range within the highland vulture ecological niche. This study reviews the different methods used as compared with previous proposals for defining guidelines for the conservation of this near-threatened scavenging species.

Late Quaternary ostracode stratigraphy of Mono Lake (California, USA): evidence for benthic ecosystem sensitivity to climate change

ABSTRACTThe response of aquatic ecosystems in the Sierra Nevada (California, USA) to late Quaternary hydroclimate changes remains mostly unknown. Mono Lake, a large endorheic lake just east of the Sierra Nevada, contains an expanded archive of laminated sediments that can be used to examine the response of benthos to environmental changes. Fossil ostracodes from a radiocarbon‐dated core were used to examine paleoecologic changes from ~16.6 to 4.3k cal a bp. Seven species were identified, with the co‐occurrence of Limnocythere ceriotuberosa and Limnocythere staplini indicating a large SO42−‐rich lake in the Pleistocene. The Younger Dryas was complex, with Fabaeformiscandona caudata reflecting a cold and deep lake ~13.0–12.2k cal a bp, followed by an interval of extensive littoral habitat from ~12.2–11.6k cal a bp. Ostracode diversity, valves g–1 and the ratio of adult:juvenile valves declined after ~10.7k cal a bp due to regression, altered hydrochemistry and seasonal anoxia. Strong seasonality during the Early Holocene is suggested by the presence of reworked ostracodes and macrocharcoal, delivered to Mono Lake by erosion of ancient lake beds in the basin. A depauperate ostracode fauna in the Middle Holocene suggests a strong sensitivity to drought in this ecosystem, which has implications for biodiversity in the future.

Prefabricated shouldered abutments enable successful restoration of molar crowns on implants.

This retrospective study evaluated the effect of selected clinical and patient factors on survival, success, and peri-implant bone level changes of locking taper implants supporting molar crowns on Bicon's prefabricated shouldered abutments. A total of 234 patients, who received 274 single molar crowns supported by locking taper implants were included in this retrospective study. Kaplan-Meier survival analysis was used to assess overall implant survival, prostheses survival, and success. Crowns were either monolithic (resin based) or bilayered (milled fiber-reinforced composite coping veneered with indirect composite). Early and late changes in marginal bone levels were plotted and analyzed with equivalence testing to compare the effects of different factors on crestal bone levels. At 9.5 years after implant surgery, the implant survival probability was 94.2%, the probability of prosthesis survival was 91.4%, and the probability of prosthetic success was 90.4%. Neither the use of different crown materials, nor the choice of monolithic versus bilayered crown construction, significantly affected the probability of prosthetic success. Marginal bone levels, on average, trended downwards towards the top of the implant within the first 2 years after functional loading, and remained stable on average, since then. Factors affecting bone levels included the use of nonsteroidal anti-inflammatory drugs, which precluded early implant bone loss; and subcrestal implant placement, which was linked to significantly higher long-term bone levels. The implant and abutment system studied resulted in high implant and prosthetic survival rates, regardless of prosthetic material used, with stable bone levels over time.

What’s next: Evergreen Marine Corp. after the Suez Canal incident

Research methodology This case study was built from secondary data such as news articles and videos. Several drafts of the case study with teaching note were tested in classroom settings and shared at a case writing conference. The case was revised based on feedback from students and roundtable discussions from the conference. Case overview/synopsis “What’s next: Ever Given after the Suez Canal incident (Evergreen Marine Corporation in, 2022)” explores the situation of the firm Evergreen Marine Corporation, a world-leading cargo shipping company headquartered in Taiwan, and its efforts to deal with challenges stemming from a pandemic and the global supply chain transition. The case provides background on the latest changes in global business environments, the Suez Canal Incident stemming from the grounding of Ever Given and firm-specific information, which would help students to understand the context affecting Evergreen Marine Corporation’s (EMC) strategic decisions. The case enables students to evaluate EMC’s overall position and to analyze the actions that they can take to deal with these challenges in a dynamic global environment. Complexity academic level This case would be appropriate for a course in strategy or international business, especially with the topic of international supply chain management.

Regional Soil Patterns as Indicators of Late Cenozoic Change in the Critical Zone: A Baseline Synthesis for the Landscapes of Peninsular India

Regolith across the South Indian shield has not previously been mapped. Here we provide a diagnosis of directional and lasting climate change from humid to semi-arid since the late Cenozoic based on evidence provided by mosaics of 1) residual, 2) colluvial and 3) alluvial soils across 700,000 km2 of southern peninsular India. Results are inferred from a systematic geomorphological and palaeoenvironmental interpretation of 1:250,000 scale legacy soil maps at order to subgroup level, complemented by field surveys and controls of soil parent material—i.e., regolith. The inventory highlights two generations of residual soils: 1) deep Lixisols, hosting low-activity clays and large iron hydroxide concentrations indicative of humid conditions in the geological past; and 2) shallow Luvisols containing high-activity clays and large stocks of exchangeable bases, indicative of drier conditions compatible with the modern climate. Where still present, the relict Lixisol inliers straddle drainage divides and are in the final stages of being thinned or fully stripped by headward stream erosion. They are being replaced by the Luvisols over shallow weathering fronts. Colluvial and alluvial soils, including widespread Vertisols, are used as tools for detecting and mapping different generations of Quaternary flood deposits: fluvial terraces, coastal fan-deltas, and shallow upland palaeolakes. In a region mostly devoid of carbonate rock outcrops, the widely distributed pool of soils hosting abundant accumulations of pedogenic CaCO3 also reveals the magnitude of silicate bedrock weathering as a process for generating secondary calcium carbonate in the rock cycle, thereby highlighting an under-appreciated contribution to inorganic carbon sequestration in the global carbon cycle. The results and maps produced provide exploration tools for future, more systematic and coordinated investigations of the nature and chronology of Quaternary deposits in peninsular India. This includes assessing their potential for hosting different generations of prehistoric archaeological remains.

Speleothems uncover Late Holocene environmental changes across the Nuragic period in Sardinia (Italy): A possible human influence on land use during bronze to post-Iron Age cultural shifts

During the Bronze and Iron Age, Sardinia was home of one of the most technologically advanced Mediterranean societies (the Nuragic culture). Given its key geographical location, the island was also the fulcrum of deep cultural exchanges. Toward the end of the Iron Age, Phoenicians, and especially Carthaginians and Romans, massively frequented Sardinia for different purposes. This marks an important cultural transition for the region, as the ancient Nuragic-related society terminated. At the same time, this impacted the subsistence and land use practices. Together with middle to late Holocene climate changes, the novel anthropic activities had a pivotal role in shaping the landscape around the island. However, high resolution climate and environmental records for these culturally important phases are still lacking in Sardinia. Thus, this paper explores palaeoenvironmental changes from the Bronze Age to post Iron Ages times by using carbonate speleothems from Suttaterra de Sarpis Cave (Urzulei, central east Sardinia), strategically located nearby the Or Murales Nuragic Village. U–Th ages (n = 20) indicate that five stalagmites comprehensively span the last ∼7000 years. Peculiarly, they all show an evident stratigraphic discontinuity. Age models attest that hiatuses can be at times associated with the discontinuities, spanning periods of ∼1200 to ∼200 years. Importantly, the discontinuities occurred from the Late Iron Age to the Roman period. Based on fabric observations, trace elements and δ13C- δ18O analyses, the discontinuities are primarily attributed to a progressive change of land use above the cave. We suppose that deforestation aimed to clearance for agriculture and livestock practices probably was the most impacting factor for infiltration dynamics and soil state, thus affecting the studied speleothems, although archaeological and historical data are absent for the specific study area. Instead, this is in line with the cultural transition occurring in Sardinia toward the end of the Iron Age, with novel agricultural practices imported by the overseas populations. The anthropic disturbance to the millennial-long karst equilibrium possibly overprinted the response of speleothem proxies to climate oscillations, although future higher resolution analyses are necessary to better investigate the evolution of climate during the Holocene as well as its role in the development of ancient civilizations. Indeed, this is the first speleothem-based Holocene palaeoenvironmental reconstruction accomplished in Sardinia. Considering the paucity of natural lakes in this key location, speleothems here demonstrate their potential in exploring human-driven palaeoenvironmental changes during times of cultural transitions within the Mediterranean context.