Abstract. Heat extremes and associated impacts are considered the most pressing issue for German regional governments with respect to climate adaptation. We explore the potential of a unique high-resolution, convection-permitting (2.8 m), multi-GCM (global climate model) ensemble with COSMO-CLM (Consortium for Small-scale Modeling Climate Limited-area Modelling) regional simulations (1971–2100) over Germany regarding heat extremes and related impacts. We find a systematically reduced cold bias especially in summer in the convection-permitting simulations compared to the driving simulations with a grid size of 7 km and parametrized convection. The projected increase in temperature and its variance favors the development of longer and hotter heat waves, especially in late summer and early autumn. In a 2 ∘C (3 ∘C) warmer world, a 26 % (100 %) increase in the heat wave magnitude index is anticipated. Human heat stress (universal thermal climate index (UTCI) > 32 ∘C) and region-specific parameters tailored to climate adaptation revealed a dependency on the major landscapes, resulting in significantly higher heat exposure in flat regions such as the Rhine Valley, accompanied by the strongest absolute increase. A nonlinear, exponential increase is anticipated for parameters characterizing strong heat stress (UTCI > 32 ∘C, tropical nights, very hot days). Providing region-specific and tailored climate information, we demonstrate the potential of convection-permitting simulations to facilitate improved impact studies and narrow the gap between climate modeling and stakeholder requirements for climate adaptation.