Laser Therapy In Patients Research Articles

Laser and cellular technologies in treatment of patients with focal alopecia

Alopecia areata (OA) is the most common cause of hair loss, occurring in approximately 4.5 million people. The incidence of OA in the structure of dermatological diseases is approximately 2.1 %. Promising in terms of the treatment of alopecia is low-intensity laser therapy and cell technology.Material and methods. The clinical study involved 98 patients with a verified diagnosis of focal alopecia (OA). Among them, 53 (53.9 %) women and 45 (46.1 %) men aged 18 to 52 years. Patients received combination therapy, including laser plasma therapy for lesions and percutaneous laser irradiation of blood.Results. The use of combined laser therapy in patients with focal alopecia promotes the relief of inflammation in the foci, the growth of core hair and the restoration of trace elements, according to dermatoscopy, phototrichogram and biochemical studies of hair composition.

Laser safety in isotretinoin use: online survey of public perception

Background The safety of laser therapy in patients taking isotretinoin is controversial. Recent evidence suggests that laser during isotretinoin treatment is safe. Our study aims to assess public perception and willingness to undergo laser intervention while receiving isotretinoin. Methods An online-based cross-sectional survey was conducted between November 2019 and March 2020. Information on participants knowledge about isotretinoin precautions with laser therapy and their willingness to undergo laser intervention while on isotretinoin therapy was collected. Results Out of 509 respondents, almost one-third used laser therapy while on isotretinoin treatment. Those who did not use laser therapy most commonly attributed to isotretinoin treatment (43%). Forty-two percent of participants thought that laser therapy while on isotretinoin is harmful. Almost half of the participants were aware that current guidelines recommend waiting for six months after isotretinoin. Nearly, half of the participants decided to postpone laser therapy for acne scars even after knowing that recent studies reported the safety of laser therapy for acne scars while on isotretinoin. Conclusion Even with the knowledge of recent safety data of laser during isotretinoin therapy, a significant proportion of patients are still concerned about potential complications. Increasing awareness regarding the safety of laser skin therapy during isotretinoin treatment might be needed.

Unsedated Office-Based Thulium Laser Therapy in Patients With Reinke's Edema

To report the outcome of unsedated office based Thulium laser therapy for Reinke's edema. A retrospective chart review of patients operated between March 2017 and November 2018 was conducted. Twelve patients were included, two of whom had two procedures performed. Demographic data included age, gender, smoking status, and grade of Reinke's edema. Outcome measures included Voice Handicap Index-10 (VHI), perceptual evaluation, extent of disease regression, acoustic analysis, and maximal phonation time. Twelve patients were enrolled in this study, one of whom was lost for follow-up. There were eight females and three males. The mean age was 51.27 ± 9.12 years. Endoscopic evaluation 6-12 weeks after surgery revealed complete and partial regression of disease in three and eight patients, respectively. There was a significant improvement in the mean score of VHI-10 (15.00 ± 9.45 vs 3.07 ± 3.81) and the mean score of GRABS parameters following surgery (P < 0.05). The mean habitual pitch increased from 125.11 ± 28.48 Hz to 155.86 ± 55.14 Hz (P=0.070). There was improvement in the mean jitter and shimmer but none reached a statistical significance. There was no significant change in the mean Maximum phonation time (MPT) scores before and after surgery. Unsedated office-based Thulium laser therapy can be considered as an alternative therapy to patients with Reinke's edema who are not willing to undergo conventional microlaryngeal surgery.

The effectiveness of combined laser therapy in patients with trophic leg ulcer and chronic venous insufficiency

Development and scientific justification for the low-intensity laser radiation of different wavelengths combined use in patients with trophic leg ulcers and chronic venous insufficiency (CVI). 102 patients with trophic leg ulcers and CVI were examined. They were divided into 3 equal groups using simple randomization. Patients in the control group received only traditional conservative therapy; comparison group - traditional conservative therapy and an intravenous laser blood irradiation (ILBI) (λ - 635 nm); the main group - traditional conservative therapy and different wavelengths laser therapy (LT) course. A more significant improvement in the clinical condition occurred under the influence of the course application of combined different wavelengths laser therapy in patients with trophic venous leg ulcers. Compared to patients who received traditional conservative therapy and in combination with ILBI 635 nm, the speed of reparative regeneration of trophic ulcers increased, the time for cleansing trophic ulcers from devitalized tissues was reduced. Computer capillaroscopy data showed that the positive effect of laser exposure on all parts of the microcirculation underlies its therapeutic efficacy.

Combination laser therapy for epiretinal membrane: a physico-mathematical model

An epiretinal membrane (ERM) is a product of abnormal cell proliferation on the inner surface of the retina and at the vitreomacular interface. Laser therapy is an interesting modality for treating pathologies of the vitreomacular interface. The wise choice of laser settings (wavelength, exposure time, power) minimizes damage to the retina and ensures a good therapeutic effect. This could be a serious impetus to the development and refinement of laser technologies for treating ERM. This work investigates the biophysical response of structural retinal components, including the dynamics of temperatures and acoustic oscillations, protein denaturation, and stimulation of tissue regeneration, to a quasi-cw laser beam and a subsequent series of laser micropulses. The manuscript also analyzes the mechanisms underlying the therapeutic effect of the proposed laser therapy in patients with ERM.

T-CELL REACTIVITY TO ANTIGENS OF STREPTOCOCCUS IN ERYZIPELAS PATIENTS ON LASER THERAPY

Erysipelas is a widespread infectious disease, with severe hemorrhagic forms, frequent recurrence and complications. Activation of T-cell immunity by individual streptococcus antigens determines the nature of the course and outcomes of erysipelas. Laser therapy is widely used in the treatment of erysipelas, however, indications for its purpose are often empirical, laboratory criteria for indications for purpose are absent. The goal is to study the effectiveness of infrared laser therapy in terms of the dynamics of leukocyte migration in vitro in response to S. pyogenes antigens. Materials and methods. 95 patients with erysipelas (55 women and 40 men) aged 20-65 years were examined, of which 34 were with primary erysipelas of extremity, 23 were with face erysipelas, 39 were with relapsed l erysipelas of extremity. All patients received basic antibiotic therapy. Laser therapy of the local focus area was performed in 30 of them. The leukocyte migration is determined in vitro by screening test of cell migration (STCM) during stimulation with polysaccharide, surface proteins, and the antigen of L-forms of S. pyogenes in various concentrations. Results. Laser therapy of patients with erysipelas had a noticeable immunomodulatory effect in the reaction of blood cells to the polysaccharide and surface proteins. At the same time, in patients with erythematous-hemorrhagic form of erysipelas, the clinical effect was manifested in a shorter duration of erythema, edema, hemorrhages, and regional lymphadenitis. Conclusion. The STCM method, which makes it possible to evaluate the migration of leukocytes to the surface specific antigens of streptococcus, can be used as a screening method for patients with erysipelas, in whom laser therapy may have a more pronounced effect.

Low-level laser therapy in patients with Burning Mouth Syndrome: A double-blind, randomized, controlled clinical trial.

BackgroundEvaluate the effect of LLLT in the treatment of burning mouth syndrome (BMS).Material and MethodsTwenty-one BMS patients were randomly assigned to two groups: 12 in the laser group (LG) and 9 in the control group (CG). Patients in the LG underwent 2-week sessions of LLLT for 4 weeks. The spot tip area of this tool is 0.088cm2, semi-conductor GaAlAs, with a wavelength of 808nm ±5nm (infrared), 200 mW output power, 1.97W/cm2 of power density, 3 J energy per point and application time 15 seconds per point. LLLT was applied punctually, in continuous emissions, on each of the sites where there was a symptom. Symptoms were evaluated with a visual analogue scale (VAS) and patient psychological profiles were assessed using the Hospital Anxiety-Depression Scale. No side effects were recorded. Statistical analysis was carried out via ANOVA and logistic regression analysis.ResultsThe initial VAS score mean was 8.9 for the LG and 8.3 for the CG (p >0.05). After the eighth session the VAS score was 5.5 and 5.8 respectively, and at two months it was 4.7 and 5.1 respectively. Improvement variables were established by dichotomizing the pain scales. We obtained levels of significance for the improvement variable for the LG at the two-month follow-up (p=0.0038) and for the univariate analysis of the treatment. The improvement was marginally significant in the multivariant analysis of: dry mouth, dysgeusia, pain and the treatment (p=0.0538).ConclusionsLLLT may be an alternative treatment for the relief of oral burning in patients with BMS. Key words:Burning mouth syndrome, oral pain, laser dentistry, laser therapy, low intensity laser therapy.

The main clinical symptoms in patients with posterior vaginal wall prolapse and modern non-drug technologies for its relief

Background. Rectocele is one of the leading causes of abnormal position and dysfunction of the pelvic floor and rectum.&#x0D; Objective: to develop and scientifically substantiate the use of a rehabilitation complex, including general magnetotherapy, electromyostimulation with biofeedback in combination with fractional microablative CO2 laser therapy in patients of different age groups with rectocele after surgery.&#x0D; Methods. The article presents the results of treatment of 100 women with rectocele, who were divided into main and control groups, within each group, depending on their age, they were divided into 2 subgroups: women of childbearing age were included in subgroup A, and women of peri- and menopausal age were included in subgroup B. Patients of the main group in the early postoperative period after plastic surgery for rectocele (from 1 day) were given a course of General magnetotherapy and in the late postoperative period (one month after the operation) a set of measures was performed, consisting of a course of electromyostimulation with biological connection of the pelvic floor muscles 2 intravaginal procedures of fractional microablative CO2 laser therapy at intervals of 45 weeks. Patients of the control group after surgical treatment of rectocele in the late postoperative period received symptomatic therapy, including painkillers and spasmolytics and a set of Kegel exercises.&#x0D; Results. Significant improvements in postoperative treatment were observed in patients of the main group: pelvic pain and periodic pain in the lower abdomen and lower back disappeared in 100% of cases; the main complaints related to violation of rectal emptying and urination were preserved in no more than 57% of cases, sexual complaints in 5%; in 95% of cases, general, vegetative and pre-climacteric complaints disappeared.&#x0D; Conclusion. As a result of the conducted research, it is shown that under the influence of the developed rehabilitation complex, regardless of age, there was a highly reliable dynamics of all complaints due to the influence of physical factors included in it on various pathogenetic links in the development of the disease.

Effectiveness of low level laser therapy for treating male infertility.

In half of the cases, the infertility of the couple is due to the disorder of the male fertility. The leading factors that cause male infertility are urogenital infections, disorders of the immune system, testicular and prostate pathology, as well as endocrine disorders.Low level laser therapy (LLLT) is a very effective physical therapy method, used in many areas of medicine, including obstetrics and gynaecology, andrology and urology; and it is recommended as an integral part of the complex treatment of infertility.The literature review showed that LLLT is beneficial in treating male infertility. Laser can significantly improve the survival, motility and speed of movement of spermatozoa. Laser therapy of patients with prostatitis and vesiculitis can eliminate infiltrative-exudative changes, improve reproductive and copulatory functions. Local illumination of red (635 nm) and infrared (904 nm) spectra should be combined with intravenous laser blood illumination (ILBI) of red (635 nm) and ultraviolet (UV) (365 nm) spectra.

Class IV laser therapy for trapeziometacarpal joint osteoarthritis: Study protocol for a randomized placebo-controlled trial.

Osteoarthritis (OA) is a chronic and prevalent joint disorder with great impact on quality of life and high economic burden. Although a number of conservative therapies have proven to be effective for the management of hand OA, only modest treatment effects were reported for most individual interventions. The aim of the proposed study is to assess the effect of Class IV laser therapy (LT) on pain and pinch strength in patients with thumb carpometacarpal (TCMC) OA. A randomized, controlled, single-centre, double-blind, clinical trial, with 1:1 allocation ratio, will be carried out involving patients presenting TCMC-OA Grades 1-2 (aged >18years). Both assessor and statistician will remain blinded. Patients with TCMC-OA will be randomly assigned to the experimental group (will receive LT) and control group (will receive a placebo treatment). Outcome measures will be pain scores at the base of the thumb measured with visual analogue scale (0-10: 0, no pain and 10, worst pain) and changes in pinch strength, both collected at baseline, 4, and 12weeks. Statistical analyses will be based on an intention-to-treat analysis using the last value forward method. A two-tailed independent Student's t test for the continuous variable of age and baseline scores will be used for comparison of baseline characteristics and outcome variables. Paired Student's t tests will be used to determine the level of significance of the differences between the pretreatment and posttreatment measurements of the individual groups. Repeated measures analysis of variance will be used to determine the differences in time as the within-subjects factor and group as the between-subjects factor. To our knowledge, the results of this study will provide the first double-blinded evidence for Class IV LT in patients with TCMC-OA.

Clinical results from low-level laser therapy in patients with autosomal dominant cone-rod dystrophy

The objective of this study is to examine long-term effects of low-level laser therapy (LLLT) in patients with autosomal dominant cone-rod dystrophy (CRDs). A He-Ne Laser with continuous emission at 633 nm (01 mW/cm2) was used on five patients with autosomal dominant pedigree of Romani origin with non-syndromic CRDs. The laser radiation was applied transpupillary to the macula six times for three minutes every other day. The experiment was conducted for a period of three years. The clinical evaluation included best corrected visual acuity determination, funduscopy, Humphrey perimetry, Farnsworth Hue-28 color testing, fluorescein angiography, and full-field electroretinogram (ERG).All affected individuals presented reduced visual acuity (0.01 – 0.4) and photophobia. The funduscopic examination and fluorescein angiography revealed advanced changes including bone spicule-like pigment deposits in the midperiphery and the macular area, along with retinal atrophy, narrowing of the vessels, and waxy optic discs. The visual fields demonstrated central scotoma. The electrophysiologic examination of the patients detected an abnormal cone-rod ERG (20 – 30 μV) with photopic amplitudes more markedly reduced than the scotopic. Flicker responses were missing and Farnsworth Hue-28 test found protanopia. There was a statistically significant increase in the visual acuity (p<0.001, end of study versus baseline) for CRDs patients for the period of three years after the treatment with LLLT. Following the LLLT, the central absolute scotoma in CRDs was reduced, as was the prevalence of metamorphopsia in CRDs.This study shows that LLLT may prove be a novel long-lasting therapeutic option for both forms of CRDs. It is a highly effective treatment resulting in a long-term improvement of the visual acuity.

Capillary Malformations Treated With Sequential Pulsed Dye and Nd:YAG Laser Therapy: A Retrospective Study

Introduction and objectiveCapillary malformations are the most common vascular malformations in childhood. The current treatment of choice is pulsed dye laser (PDL) therapy, but this frequently does not result in complete resolution. The search for alternative treatment strategies thus continues. In this study we describe our experience with the use of sequential dual-wavelength PDL and Nd:YAG laser therapy in patients with capillary malformations. Material and methodsWe conducted a retrospective, descriptive study of patients with capillary malformations treated with dual-wavelength PDL and Nd:YAG laser therapy between 2006 and 2011. Four dermatologists rated the effectiveness of treatment on a scale of 10 to 0. We also investigated the potential value of the following factors as predictors of better treatment response: sex, malformation size and color, and presence of associated hypertrophy. Adverse effects were also analyzed. ResultsWe studied 71 patients and most of them experienced a statistically significant improvement after treatment. More favorable responses were observed for violaceous malformations, lesions with associated hypertrophy, and smaller lesions. Adverse effects were reported for 26.76% of patients, and the most common effect was the appearance of isolated areas of skin atrophy. ConclusionsWe consider that sequential dual-wavelength PDL and ND:YAG laser therapy is an effective alternative for treating capillary malformations in selected patients.

Efficiency of high intensity laser therapy in patients with knee osteoarthritis

It is aimed to compare the effects of high-intensity laser treatment (HILT) and the transcutaneous electrical nerve stimulation (TENS) and ultrasound (US) combined treatment on pain, functionality, and quality of life in the patients with knee osteoarthritis. The patients were randomized into 2 groups. Combination of hot pack, TENS and US treatment were applied to the first group and HILT was applied to the second group for 2 weeks. At every visit; resting, movement and night pain scores, function, and stiffness scores were assessed.The patients were invited for the control after the treatment and in the 6th week. A total of 48 patients (33 women and 15 men, aged between 25 and 65 years, average age of 54.25 years) participated in this study. In both groups, a statistical significant change was observed in all the parameters in post-treatment measurements. In the between-groups comparison, it was observed that HILT provided a significant recovery in pain scores both after the treatment and in the 6th week than TENS and US combined treatment. HILT in knee osteoarthritis is a statistically significant efficient method on pain and functional scales compared to TENS+US combined treatment.

Comparative study of shock wave therapy and low level laser therapy effects in patients with myofascíal pain syndrome of the trapezius

Objective. Neck pain is a very frequent locomotor symptom with an estimated global prevalence interval of 5.9%-to 38.7%. Most frequently, pain is due to myofascial syndrome. The aim of our work was the comparison of the pain relieving effect and the influence on patient quality of life of trigger points shock wave therapy and laser therapy in patients suffering from neck myofascial pain syndrome. Methods. In this randomised single-blinded study patients in the laser group (31 patients out of 61) were treated by soft laser once daily in a 3-week period for a total of 15 occasions while patients in the shock wave group (30 patients out of 61) were treated once in a week in an also 3-week period, for a total of 3 shock wave treatments. Results. Pain at rest was significantly decreased in both groups at the 3rd week and 3rd month; post treatment the shockwave group benefitted more (1,030, 95%CI: -8,116-10,176), while at the 3rd month patients of the laser group demonstrated significantly higher benefits compared to the other group (-1,345, 95%CI: - 14,600-11,910). Pressure pain (pain treshold) was also significantly decreased in both groups during the visits. Patients treated with shockwave therapy demonstrated a significantly higher decrease in the 3rd week (4,078, 95%CI: -7,135-15,292) and the 3rd month, too (9,561, 95%CI: 3,056-22,179). The impairment of neck functions decreased significantly in both groups while the magnitude of change was significantly higher in patients receiving shockwave therapy (Week 3: 0,660, 95%CI: -1,933-3,253; Week 15: 1,072, 95%CI: -2,110-4,254). Quality of life increased significantly in both groups, at each visit measures of patients in the shockwave group were significantly better than those in the laser group. Conclusion. The results of our study point to a conclusion that both laser and shockwave therapy are effective in myofascial pain syndrome, though we found shockwave therapy to be more beneficial clinically.

Serum and urine biochemical markers dynamics after using of laser therapy in patients with chronic posttraumatic osteomyelitis from endemic iodine deficiency regions

The problem of diagnostic evaluation and treatment of patients with chronic post-traumatic osteomyelitis of long limb bones remains complex, multifaceted and not completely resolved in purulent orthopedics.Objective: to determine the biochemical markers of bone tissue in the blood and urine of patients with post-traumatic osteomyelitis for the primary assessment of their condition and control of the effectiveness of treatment.Methods: 47 patients were treated with post-traumatic osteomyelitis: 1st group (10 persons) received from non-endemic areas, 2nd (10) and 3rd (27) — f rom endemic (with iodine deficiency). In the 1st a nd 2 nd g roups t he s tandard t reatment s cheme w as used, in the 3rd it was supplemented with laser therapy. The controls used indicators of clinically healthy persons (20). Glycoproteins, alkaline and acidic phosphatase activity, sialic acids, chondroitin sulfates, total and ionized calcium were determined in the serum of blood; in the urine — the content of oxyproline and uronic acids.Results: Patients in group 1 have been gradually lowering biochemical markers of bone destruction and inflammation, starting from 7 days of treatment. Reduction in the level of excretion of oxyproline and uronic acids indicates a slowdown in catabolism of collagen and proteoglycans. In patients in group 2, the decrease in the content of glycoproteins, cholesterol and haptoglobin in serum was noted only 14 days after the start of treatment. Patients in the 3rd group recovered biochemical blood and urine output more intensively.Conclusions: post-traumatic osteomyelitis is characterized by an in­crease in serum of markers of inflammation and destruction of bone tissue, as well as catabolism of collagen and proteoglycans. The use of the treatment regimen using laser therapy had a higher clinical efficacy, which was confirmed by a decrease in the biochemical markers of inflammation and bone destruction during treatment.

Malformaciones capilares tratadas con aplicación secuencial de láser de colorante pulsado y Nd:YAG: estudio retrospectivo

Introduction and objectiveCapillary malformations are the most common vascular malformations in childhood. The current treatment of choice is pulsed dye laser (PDL) therapy, but this frequently does not result in complete resolution. The search for alternative treatment strategies thus continues. In this study we describe our experience with the use of sequential dual-wavelength PDL and Nd:YAG laser therapy in patients with capillary malformations. Material and methodsWe conducted a retrospective, descriptive study of patients with capillary malformations treated with dual-wavelength PDL and Nd:YAG laser therapy between 2006 and 2011. Four dermatologists rated the effectiveness of treatment on a scale of 10 to 0. We also investigated the potential value of the following factors as predictors of better treatment response: sex, malformation size and color, and presence of associated hypertrophy. Adverse effects were also analyzed. ResultsWe studied 71 patients and most of them experienced a statistically significant improvement after treatment. More favorable responses were observed for violaceous malformations, lesions with associated hypertrophy, and smaller lesions. Adverse effects were reported for 26.76% of patients, and the most common effect was the appearance of isolated areas of skin atrophy. ConclusionsWe consider that sequential dual-wavelength PDL and ND:YAG laser therapy is an effective alternative for treating capillary malformations in selected patients.

SIX YEARS FOLLOW-UP OF LOW-LEVEL LASER THERAPY (LLLT) IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATION (AMD).

27Sep 2017 SIX YEARS FOLLOW-UP OF LOW-LEVEL LASER THERAPY (LLLT) IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATION (AMD). Krassimir Koev , Latchezar Avramov and Ekaterina Borissova. Chair of Emergency Medicine, Department of ophthalmology, Medical University ? Sofia, Bulgaria. Institute of Electronics, Bulgarian Academy of Sciences.

Endoscopic diode laser therapy for chronic radiation proctitis.

The purpose of this study is to determine the effectiveness of endoscopic diode laser therapy in patients presenting rectal bleeding due to chronic radiation proctitis (CRP). A retrospective analysis of CRP patients who underwent diode laser therapy in a single institution between 2010 and 2016 was carried out. The patients were treated by non-contact fibers without sedation in an outpatient setting. Fourteen patients (median age 77, range 73-87years) diagnosed with CRP who had undergone high-dose radiotherapy for prostatic cancer and who presented with rectal bleeding were included. Six required blood transfusions. Antiplatelet (three patients) and anticoagulant (two patients) therapy was not suspended during the treatments. The patients underwent a median of two sessions; overall, a mean of 1684J of laser energy per session was used. Bleeding was resolved in 10/14 (71%) patients, and other two patients showed improvement (93%). Only one patient, who did not complete the treatment, required blood transfusions after laser therapy; no complications were noted during or after the procedures. Study findings demonstrated that endoscopic non-contact diode laser treatment is safe and effective in CRP patients, even in those receiving antiplatelet and/or anticoagulant therapy.

Safety and Effectiveness of Low-Level Laser Therapy in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Introduction: Low-level laser therapy (LLLT) was introduced as an alternative non-invasive treatment for osteoarthritis, but its effectiveness is still controversial. The main objective of this article was to determine the safety and efficacy of LLLT in patients with knee osteoarthritis (KOA). Methods: In order to gather evidence, main medical databases as well as relevant websites were browsed without time limit. We searched with appropriate keywords and strategies. After quality assessment of studies, study data were extracted by two reviewers. Standard mean difference proposed through inverse variance was used in the meta-analysis using the random-effects model. Twelve values were used for the evaluation of heterogeneity. Results: A total of 823 studies, 14 randomized controlled trials (RCTs) were selected after final review. There was a significant difference between LLLT and placebo in pain at rest (P=0.02), pain at activity (P=0.01), total pain (P=0.03), WOMAC function (P=0.01), WOMAC stiffness (P=0.02) and WOMAC total (P<0.0001) in favor of the LLLT. There was no significant difference between LLLT and Placebo in WOMAC pain (P=0.09) and range of motion (P=0.1). Conclusion: In spite of some positive findings, this meta-analysis lacked data on how LLLT effectiveness is affected with important factors: wavelength, energy density, treatment duration, numbers of sessions the treatment, severity of KOA and site of application.

THE EFFECTIVENESS OF A NEODYMIUM (1064 NM) LASER AND FRACTIONAL PHOTOTHERMOLYSIS FOR THE CORRECTION OF THE ATROPHIC SCARS

One of the challenging problems for modern cosmetology is the cosmetic correction of the cutaneous scars of the skin that arises in the first place from the high prevalence of this condition and the lack of reliable and safe methods for its treatment The application of laser technologies including selective laser therapy as the method of fractional photothermolysis and the use of a neodymium (1064 nm) laser is considered to be a promising approach to address this problem. The present study included 18 patients presenting with hormone-dependent atrophic scars. All the patients were assigned for the treatment by selective photothermolysis (at the rate of 2 sessions per each treatment course performed with a 4 week interval) and irradiation by the neodymium laser (at the rate of 6-8 sessions conducted after fractional photothermolysis). The use of combined laser therapy in patients with hormone-dependent atrophic scars produced a pronounced effect as evidenced by the improvement of the clinical picture and was accompanied by the 78.1% reduction of the symptom index according to the DISC symptom scale and the 76.5% improvement of the dermatology life quality index (DLQI). The use of the combined method for the correction of atrophic cutaneous scars helps to restore the epidermal-dermal and epidermal structures of the skin in the association with the 1.4-fold, 1.7-fold, and 1.6-fold increase in the thickness of the epidermis, dermis, and hypodermis respectively; simultaneously, the acoustic density of the tissues increased by 1.8 times which corresponded to the improvement of the ultrasound picture by almost 75% when estimated in accordance with the Vancouver scar scale.