The technique of laser resonance ionization is employed for an element-selective ionization of multi-nucleon transfer reaction products which are stopped and neutralized in a gas cell filled with argon gas at 50kPa. We have been searching for efficient laser ionization schemes for refractory elements of Z=73–78 using a time-of-flight mass-spectrometer (TOF-MS) chamber. To evaluate the isotope shift and ionization efficiency for each candidate of the ionization scheme, isotope separation using the TOF-MS was devised. The TOF-MS was designed to separate the isotopes using two-stage linear acceleration with a mass resolving power M/ΔM of >350. A mass resolving power of 250 was experimentally confirmed by measuring the TOF of laser-ionized tantalum (Z=73) ions with mass number 181. We searched for a laser resonance ionization scheme of tantalum using the TOF-MS.