Tissue heating by laser irradiation has attained importance in many clinical applications. Accurate temperature measurements of laser-irradiated tissues are difficult to achieve, and experiments have produced conflicting results. Fiber optic radiometry allows temperature measurement of laser-irradiated tissues by remote sensing of the emitted infra red (IR) radiation. We have developed an IR fiber optic radiometer capable of accurate tissue temperature measurements (+/- 0.2 degrees C) and utilized it to monitor and control the heating of tissues by CO2 laser irradiation. Tissue temperature control of +/- 2.5 degrees C was achieved. This system was used to control tissue temperature during CO2 laser-assisted welding of urinary bladders in rats. The strength of the welds was recorded for different welding temperatures. A temperature of 55 degrees C was found to be optimal.