Abstract We report high-pulse-energy ultrafast 3 µm laser generation through optical parametric generation/difference frequency generation (OPG/DFG) in periodically poled magnesium-oxide-doped lithium niobate (PPMgLN). A commercial 1030 nm femtosecond laser is applied as the pump light and a homemade broadband nanosecond pulse laser around 1580 nm is used as the signal light in DFG. The broadband 1580 nm laser has a master oscillator power amplifier (MOPA) structure with a directly modulated superluminescent light-emitting diode (SLED) as the pulse seed and three stages of Er/Yb fiber amplifiers to lift its average power. A portion of the 1030 nm output pulse is converted to an electronic pulse via a pin detector, which is used as the trigger signal of the SLED driving circuit to ensure synchronization between the signal and the 1030 nm pump pulse. When injecting 2.12 W pump light into the PPMgLN, a broadband mid-infrared (MIR) output of 280 mW can be achieved directly through OPG with a center wavelength around 2.94 μm, a pulse width of 1.38 ps and a pulse repetition frequency of 500 kHz. The corresponding MIR pulse energy is 0.56 µJ. When injecting 2.62 W signal light simultaneously, a MIR output of 300 mW is achieved through the DFG process at the same pulse repetition frequency, corresponding to a pulse energy of 0.6 µJ. The conversion efficiency of the ultrafast pump laser to MIR reaches 14.1%. This high-pulse-energy 3 μm ultrafast laser has great prospects for applications in biological tissue ablation.