Head and neck cancer is the fth most common cancer in the world .1 The early diagnosis is crucial for improving the treatment results of laryngopharyngeal cancer. Diagnostic assessment aims at histological diagnosis, mapping, and staging of the tumor However, a biopsy is essential for the histological diagnosis of laryngopharyngealcancer.2 Traditionally, the biopsy of laryngopharyngeal lesions is performed under general anesthesia. Technological advancements in the types of t r a n s n a s a l e n d o s c o p e s , i n s t r u m e n t mi n i at u r i z at i o n , a n d to p i c a l a n e s t h e t i c techniques have led to a shift in laryngeal management from the operation room to an office-based setting [3-5) If the doctor notices anything suspicious during a laryngoscopy or upper endoscopy, a special tool may be attached to the endoscope and used to remove a tissue sample for a biopsy. This is often performed in the operating room under general anesthesia.6 KEY WORDS: OFFICE BASED BIOPSY, OFFICE BASED BENDOSCOPY