Laryngeal Lymphoma Research Articles

Laryngeal Lymphoma: A Case Report

Primary laryngeal lymphoma is a rare entity, accounting for less than 1% of all primary laryngeal neoplasms. It is mainly primary non-Hodgkin's malignant lymphoma (NHLM). We report a new case in a 56-year-old woman who presented with progressive onset dysphonia [1]. Laryngoscopy revealed a budding lesion of the glotto-supglottic level (vocal cords, arytenoids, ventricular bands, epiglottis). Histology showed a peripheral T-cell lymphoma, CD3 and Ki67 positive, this pathology is difficult to diagnose, requires particular vigilance and should be managed according to current treatment trends for nodal LMNH.

B-cell non-Hodgkin lymphoma of the larynx: Case report and review of literature

Objectives The aim of the study is to expose and highlight the clinical, imaging and therapeutic features of B-cell laryngeal lymphoma, with a brief review of literature. Material and Methods We report a rare case of B-cell laryngeal lymphoma Results A 42-year-old female was referred to the Otorhinolaryngology department for progressive dyspnea and dysphonia. Endoscopic examination and imaging reveals a supraglottis mass. The final diagnosis is a B-cell non-Hodgkin lymphoma of the supraglottis. Conclusion Primary laryngeal lymphoma is a rare condition that should be considered in the differential diagnosis of a laryngeal mass, especially if it affects the supraglottic region. The diagnosis is difficult. Direct laryngoscopy with multiples and deep biopsies makes the diagnosis. The treatment and prognosis depend on the stage and grade of the lymphoma.

Primary T-cell non-Hodgkin's lymphoma of the larynx: A case report

Lymphoma is a malignant disease of lymphatic cells. Despite numerous sub-types, the disease is generally divided into two main groups: Hodgkin and non-Hodgkin lymphoma. Primary laryngeal non-Hodgkin lymphoma accounts for less than 1% of all laryngeal tumors. We herein present a 43-year-old male patient with difficulty swallowing due to a laryngeal mass. Morphological and immunohistochemical examination revealed T cell lymphoma according to the World Health Organization classification. The patient was referred for chemo-radiotherapy. Primary lymphoma of the larynx is a rare, and primary T-cell laryngeal lymphoma is an even rarer tumor.

Primary Laryngeal Lymphoma and Voice Hoarseness: A Rare Etiology for A Common Clinical Feature

Despite the fact that NHLs are the second most frequently presenting hematologic tumors, they make up for just 1% of all primary laryngeal tumors

A Case of Laryngeal MALT Lymphoma that Disappeared Spontaneously

A Case of Laryngeal MALT Lymphoma that Disappeared Spontaneously

Primary laryngeal lymphoma in China: a retrospective study of the last 25 years

To retrospectively study the primary laryngeal lymphoma cases in China reported in Chinese-language literature. Chinese-language literature was searched for papers on primary laryngeal lymphoma published in the last 25 years. The selected papers comprised a total of 115 cases. The male-to-female ratio was 3.4:1. Non-Hodgkin's lymphoma was the exclusive pathological type. The estimated 3-year, 5-year and 10-year survival rates were 70.9 ± 6.4 per cent, 63.4 ± 7.6 per cent and 56.4 ± 9.5 per cent respectively, as determined by Kaplan-Meier analysis. B-cell non-Hodgkin's lymphoma patients had a better prognosis than T-cell non-Hodgkin's lymphoma patients (p = 0.032). Patients with lymph node involvement at diagnosis had a poorer prognosis (p < 0.01). Primary laryngeal lymphoma is a rare disease with no specific clinical features. More than one biopsy might be needed to obtain the correct diagnosis. Proper treatment could lead to promising outcomes. The T-cell subtype and lymph node involvement at diagnosis might indicate worse prognosis.

Subglottic pathologies

Subglottic pathologies are rare and show a clinical unspecific appearance i. e. through tissue increase around the cricoid or the cranial trachea. Typical symptoms are hoarseness, an overstimulated coughing, a globus laryngeus feeling as well as dyspnea or a stridor. Differential diagnosis include benign diseases like involving a posttraumatic status (e. g. stenosis), infection (i. e. pseudocroup), rheumatic disease (i. e. granulomatosis with polyangiitis) or benign tumor (i. e. papilloma, hemangioma or granular cell tumor). On the other hand, malignant diseases like the squamous cell carcinoma, a chondrosarcoma or the very rare laryngeal lymphoma manifestation must be considered as well. Idiopathic causes should also be taken into account. To secure the final diagnosis of such tumor formation a tissue sample should be histologically analyzed. The therapy is multimodal e. g. in close collaboration with internal medicine and ENT specialists.

Diffuse large B-cell lymphoma of thyroid gland with pyriform fossa extension presenting as emergency airway obstruction: a case report

&lt;p class="abstract"&gt;Primary thyroid lymphoma and laryngeal lymphoma are rare malignancies of the head and neck region. Airway obstruction caused by primary thyroid lymphoma is mainly by means of direct compression of trachea by huge thyroid mass. We present the first case report of diffuse large B cell lymphoma of thyroid gland with extension to pyriform fossa, in the absence of preexisting chronic thyroiditis. In this case, emergency airway obstruction was caused by direct extension of disease into pyriform fossa, occluding laryngeal inlet. We reviewed English literature between 1981 and 2018 for cases of primary thyroid lymphoma. There are no reported cases of primary thyroid lymphoma with direct extension into pyriform fossa. This presentation posed a great challenge in securing a patent airway by means of oral intubation and tracheostomy.&lt;/p&gt;&lt;p class="abstract"&gt; &lt;/p&gt;

Epidemiology and prognostic indicators in laryngeal lymphoma: A population-based analysis.

To characterize the epidemiology of primary laryngeal lymphoma and to determine the prognostic factors affecting survival in patients with this disease. A retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database, including cases from 1973 to 2014. A population-based analysis was conducted with patients from more than 15 different geographic regions across the United States. Patients were chosen based on a diagnosis of lymphoma and a primary lymphoma site within the larynx. Two hundred cases were eligible based on the inclusion criteria, and characteristic as well as clinical variables were then extracted from the database and analyzed. Characteristic and clinical variables included age, race, sex, primary site of lymphoma involvement, general histology, specific histologic subtype, tumor grade, and Ann Arbor staging. Exposure variables that were analyzed included radiation therapy and chemotherapy. Overall survival (OS) and disease-specific survival (DSS) were the main outcomes calculated using multivariate analysis. A total of 200 cases of laryngeal lymphoma were identified. The mean age at diagnosis was 64.2 years. The cohort was composed of 53% males. B-cell non-Hodgkin's lymphoma (NHL) accounted for 74% of cases, whereas natural killer/T-cell NHL accounted for 10% of cases. A total of 53.1% of patients received radiation therapy, whereas 47.5% received chemotherapy. The median OS was 9.15 years and median DSS was 24.5 years. OS at 2, 5, and 10 years was 74%, 63%, and 44%, respectively. On multivariate analysis, older age, male sex, and advanced Ann Arbor staging were associated with worse OS, whereas only male sex and advanced Ann Arbor staging were associated with worse DSS (all P values < .05). Radiation and chemotherapy were not associated with improved survival. Female sex and lower Ann Arbor staging are independent positive prognostic indicators for survival, whereas other clinical variables such as grade and histology do not have an effect on survival. Radiation and chemotherapy do not appear to confer a mortality benefit in patients with primary laryngeal lymphoma, which may have implications on clinical decision making as well as patient education about disease prognosis. 4. Laryngoscope, 128:2044-2049, 2018.

A case of primary mucosa-associated lymphoid tissue lymphoma of the larynx

Mucosa- associated Lymphoid Tissue (MALT) Lymphoma is a Non-Hodgkin Lymphoma. This marginal zone lymphoma is typically a low-grade neoplasm. Primary Laryngeal MALT Lymphoma is an extremely rare entity. No case has been reported from India till now. We present a case of Laryngeal MALT Lymphoma in a 49 year old lady with complain of progressive hoarseness of voice since 6 months and history of orbital pseudo-tumour. MALT Lymphoma was diagnosed after biopsy and managed with 6 cycles of R-Benda Chemotherapy. The patient has had uneventful follow-up for past 3 years. Primary MALT lymphoma is a rare but curable disease and clinicians should keep it in mind while forming differential diagnosis for a suspicious mass during laryngeal evaluation.

Individual participant data meta-analysis of primary laryngeal lymphoma: Focusing on the clinical characteristics and prognosis.

Primary lymphoma of the larynx is rare. The symptoms are ambiguous and nonspecific, and confirmation of the diagnosis is often difficult. To better understand the clinical characteristics of this distressing disease, we performed an individual participant data meta-analysis focusing on the diagnoses and treatment outcomes. Systematic review article. A literature search of the MEDLINE, Embase, and Cochrane library databases was conducted using the following Medical Subject Headings and keywords: "primary," "lymphoma," "cancer," and "larynx." The individual data of 57 patients from 41 articles were selected based on the inclusion criteria for the analysis. The mean age of the 57 patients at the time of diagnosis was 53.9 ± 18 years, and there was a preponderance of male patients (male:female = 35:22). The mean follow-up was 33.2 ± 40.5 months. The most common symptom was hoarseness (70.2%). Extension of the lymphoma was found in the supraglottic larynx (63.2%). B-symptoms were noted in only 14.0% of patients. The treatment method and disease extent were not significant factors. The significant prognostic factors were the biopsy frequency (P = .000), B-symptoms (P = .032), and cell type (P < .001). From an analysis of larynx lymphoma patients, accurate biopsy, the presence of B-symptoms, and the cell type of the lymphoma are important to the prognosis. However, the treatment method was not effective in predicting the prognosis. NA.

Primary Lymphoma of the Larynx: A Case Report and Literature Review

Background: Primary non-hodgkin lymphoma of the larynx is a rare entity accounting for 1% of laryngeal tumors. Fewer than 100 cases have been reported in the literature. Case presentation: A 52-year-old man, presented with a two-month history of dysphonia. Nasofibroscopy showed left submucosal bulging of the laryngeal supraglottic floor. Cervical computed tomography showed extensive left supraglottic mass, with partial lysis of the thyroid cartilage. Direct laryngoscopy showed left submucosal bulging of the supraglottic floor. Transmucosal biopsies were performed. Histological study concluded to the presence of a diffuse large-cell B lymphoma. The patient was treated with chemotherapy followed by external radiotherapy. Evolution was favourable. Conclusion: Although primary laryngeal non-hodgkin lymphoma is rare, it should be considered in the differential diagnosis of a mass in the neck region, especially in the supraglottic area. Direct laryngoscopy with biopsy makes the diagnosis. Treatment and prognosis depend on the stage and the grade of the lymphoma.

Subglotic Malt-Lymphoma of the Larynx: An Unusual Presentation of Chronic Cough

Extranodal non-Hodgkin lymphomas limited to the larynx are rare, accounting for less than 1% of all laryngeal neoplasms. The most common site of development of primary laryngeal lymphomas is the supraglottic region. In most cases, the presenting symptoms are hoarseness, dysphagia, dyspnea, and cervical lymphadenopathy. They consist mainly of non-Hodgkin lymphoma, especially of diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue. We report a case of a primary extranodal marginal zone of mucosa-associated lymphoid tissue (Malt Lymphoma) of the larynx in a 73-year-old non-smoker woman, presented as chronic cough, unresponsive to oral corticosteroid. We present a detailed report of her clinical and paraclinical data as well as treatment options. In patients with chronic cough, uncommon causes should be considered when the cough persists after evaluation for common causes. If a cough persists after consideration of the most common causes, CT scan and a bronchoscopic evaluation are fundamental for the diagnosis of tumors of the upper and lower respiratory tract.

Laryngeal lymphoma: the high and low grades of rare lymphoma involvement sites.

The larynx is an extremely rare site of involvement by lymphomatous disease. We present two cases of isolated laryngeal high-grade and another low-grade lymphoma, together with a literature review of laryngeal lymphoma management.

Clinicopathological features and treatment outcomes of primary laryngeal lymphomas in saudi population

Abstract Background: Primary laryngeal lymphomas (PLLs) are rare and account for 1% -3% of all laryngeal neoplasms. Our aim was to describe the symptomology, diagnosis, histological variants and treatment outcomes of

Laryngeal Manifestation of B-Cell Non-Hodgkin Lymphoma

Laryngeal lymphomas are rare, involving less than 1% of all laryngeal tumours. Extranodal non-Hodgkin lymphomas generally appear in places where lymphoid tissue exists, such as the small bowel or parotid; they are very unusual in organs with little or no presence of lymphoid tissue, such as the larynx. When advanced stages are established, initial lymphoma manifestation at the laryngeal level has rarely been documented. We present a case of a small cell lymphocytic lymphoma at stage IV/E with initial laryngeal symptoms and indicate its management and follow up.

Mantle cell lymphoma of the larynx: Primary case report.

IntroductionPrimary laryngeal lymphomas are exceedingly rare. Only about a hundred cases have been reported. They consist mainly of non-Hodgkin lymphoma, especially of diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue. We report the first case of a primary laryngeal mantle cell lymphoma.Case presentationWe report a case of a primary mantle cell lymphoma of the larynx in a 70-year-old North African non-smoker male. We present a detailed report of his clinical and paraclinical data as well as treatment options.ConclusionsMantle cell lymphoma is a very aggressive lymphoma subset associated with poor prognosis. Laryngeal mantle cell lymphoma is exceedingly rare. To the best of our knowledge, this is the first case to ever be reported.

Laryngeal mucosa-associated lymphoid tissue (MALT) lymphoma associated with bronchial MALT lymphoma: a case series and review of the literature

The objective of this study is to describe the management of two adults with laryngeal mucosa-associated lymphoid tissue (MALT) lymphoma and concurrent bronchial MALT lymphoma and to review the literature pertaining to laryngeal lymphoma and discuss appropriate evaluation and treatment options. This is a retrospective case series where a retrospective chart review was performed. Demographic data collected includes presenting symptoms, age at presentation, gender, comorbidities, course of illness, and follow-up. Operative reports, serial endoscopic examinations, and serial CT images were used to monitor for recurrence. Between 2004 and 2006, two adult subjects were diagnosed and treated for false vocal cord MALT lymphoma with concurrent low-grade bronchial MALT lymphoma. Both patients were treated with surgical debulking, adjunctive rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (RCHOP) chemotherapy, and external beam radiation. At most recent follow-up, there was no endoscopic, clinical, or radiologic evidence of recurrence. Surgical debulking, RCHOP chemotherapy, and external beam radiation show promising results in treating false vocal cord laryngeal MALT lymphomas with concurrent low-grade bronchial MALT lymphomas. Bronchoscopy and laryngoscopy should be included in the evaluation of a patient with a laryngeal or bronchial MALT lymphoma for staging and optimal treatment since MALT lymphoma can be multifocal in both larynx and bronchus as shown in this case series.

Anaplastic Lymphoma Kinase-positive Primary Diffuse Large B-cell Lymphoma of the Larynx: A Rare Clinical Entity

ABSTRACT Background Primary lymphomas amount to less than 1% of the primary laryngeal tumors. It is the second most common primary hematologic tumor of the larynx after plasmacytoma. Although squamous cell carcinoma amounts to 90% of the laryngeal tumors, diagnosis of laryngeal lymphoma is very important as nonsurgical management is indicated in all stages of this disease. Case report A case of 10-year-old boy with hoarseness of voice with direct laryngoscopic biopsy reported as diffuse B-cell lymphoma. The sections were positive for epithelial membrane antigen (EMA), LCA, CD138, CD4 and Mum1 and ALK. He was managed under MCP 842 protocol. He had complete response after the treatment and was symptom free after 13 months of therapy. Conclusion Primary laryngeal lymphoma is a rare entity and should be managed with current chemotherapeutic protocol. Differentiating it between squamous cell carcinoma is important as management protocol in lymphoma is nonsurgical. Aid of immunohistochemistry helps in early diagnosis and management of these cases. How to cite this article Naik SM, Nanjundappa A, Halkud R, Premlatha CS, Ramarao C, Appaji L, Gupta S. Anaplastic Lymphoma Kinase-positive Primary Diffuse Large B-cell Lymphoma of the Larynx: A Rare Clinical Entity. Int J Phonosurg Laryngol 2012;2(2):57-61.

Primary Marginal Zone B-Cell Lymphoma of the Larynx

Extranodal non-Hodgkin lymphomas limited to the larynx are rare, accounting for less than 1% of all laryngeal neoplasms. The most common site of development of primary laryngeal lymphomas is the supraglottic region. In most cases, the presenting symptoms are hoarseness, dysphagia, dyspnea, and cervical lymphadenopathy. In these cases, larynx lymphoma was the mucosa-associated lymphoid tissue type and located in the supraglottic area.