Primary Lymphoma of the Larynx: A Case Report and Literature Review

Khaled Khamassi,Khaoula Ouertani,Madiha Mahfoudhi,Habib Jaafoura,Wafa Kaabachi,Rim Lahiani,Mamia Ben Salah,Lobna Bougacha

doi:10.4236/ojcd.2015.52015

Abstract

Background: Primary non-hodgkin lymphoma of the larynx is a rare entity accounting for 1% of laryngeal tumors. Fewer than 100 cases have been reported in the literature. Case presentation: A 52-year-old man, presented with a two-month history of dysphonia. Nasofibroscopy showed left submucosal bulging of the laryngeal supraglottic floor. Cervical computed tomography showed extensive left supraglottic mass, with partial lysis of the thyroid cartilage. Direct laryngoscopy showed left submucosal bulging of the supraglottic floor. Transmucosal biopsies were performed. Histological study concluded to the presence of a diffuse large-cell B lymphoma. The patient was treated with chemotherapy followed by external radiotherapy. Evolution was favourable. Conclusion: Although primary laryngeal non-hodgkin lymphoma is rare, it should be considered in the differential diagnosis of a mass in the neck region, especially in the supraglottic area. Direct laryngoscopy with biopsy makes the diagnosis. Treatment and prognosis depend on the stage and the grade of the lymphoma.

Highlights

Primary non-Hodgkin lymphoma (NHL) most frequently arises in the gastrointestinal tract, and the head and neck is the second most frequent region [1]
Most head and neck lymphomas arise within the Waldeyer ring, but extranodal extralymphatic sites still accounted for 25% of these tumors
The aim of this study is to report a rare case of primary laryngeal lymphoma, and, with a review of the literature, to precise clinical and paraclinical features and therapeutic modalities of this aggressive lesion

Summary

Introduction

Primary non-Hodgkin lymphoma (NHL) most frequently arises in the gastrointestinal tract, and the head and neck is the second most frequent region [1]. Most head and neck lymphomas arise within the Waldeyer ring, but extranodal extralymphatic sites still accounted for 25% of these tumors. Laryngeal localization is rare, accounting for 1% of laryngeal tumors. Fewer than 100 cases have been reported in the literature. (2015) Primary Lymphoma of the Larynx: A Case Report and Literature Review. Detection of lymphoma allows improved patient care and may result in decreased dissemination of the disease process. The aim of this study is to report a rare case of primary laryngeal lymphoma, and, with a review of the literature, to precise clinical and paraclinical features and therapeutic modalities of this aggressive lesion

Case Report

Discussion

Findings

Conclusion