Primary Non-Hodgkin's Lymphoma of the Bone: A case report

Abstract

Primary non-Hodgkin's lymphoma of the bone (PLB) is a rare entity. Patients generally present with localized bone pain, soft-tissue swelling or palpable mass. Pathological fracture of the proximal femur and humerus secondary to soft-tissue tumors is well documented in the literature. Lymphomas presenting primarily at these sites with pathological fractures are unusual. A review of the literature shows that the incidence of the skeletal manifestations from non-Hodgkin's lymphoma is less than 5%, and in all these cases, bony involvement was reported many years after the presentation of the primary cancer. Histopathologically, PLB usually represents diffuse large B-cell lymphoma. We report a 56-year-old female patient with primary non-Hodgkin's lymphoma of proximal femur with pathological fracture and management. In January 2014, a 56-year-old woman was diagnosed with stage IV B primary large-cell diffuse primary non-Hodgkin’s lymphoma. After one year of initial diagnostic procedures and chemotherapy with rituximab together with cyclophosphamide, vincristine, procarbazine, and prednisolone she achieved a complete response.