Study of the species composition of catfish helminths in water bodies of the middle reaches of the Syrdarya river. The material was collected in 2019–2021 in natural and artificial reservoirs of the middle reaches of the Syrdarya river. We examined 216 specimens of the catfish by methods of complete parasitological dissection proposed by V.A. Dogel (1933), A.P. Markevich (1950) and I.E. Bykhovskaya-Pavlovskaya (1952). The helminths found were undergone laboratory inspection according to generally accepted methods of I.E. Bykhovskaya-Pavlovskaya (1952), A.A. Shigin (1986) and O.N. Bauer (1987). As the research results show, the prevalence in catfish was 31.5% with the intensity of invasion 1–70 specimens. 29 species of helminths were recorded in the catfish: 7 species of cestodes, 10 species of trematodes, 9 species of nematodes, and 3 species of proboscis worms, which belong to 27 genera, 19 families, 11 orders and 4 classes. Events of mono- and associative invasions have been reported. From 29 species of helminths found, 17 species were found in the larval form, and 12 species in the sexually mature form. In natural and artificial reservoirs of the Syrdarya region of Uzbekistan, the catfish is infected with 29 species of helminths. The total infection rate in fish is 31.5%. This parameter varies depending on the season of the year