Large Volume Research Articles

The Impact of Volume of Dissolution Medium for Biopredictive Dissolution/Permeation Studies of Enabling Formulations: A Comparison of Two Brands of Telmisartan / Amlodipine Tablets.

For compendial dissolution testing of solid dosage forms, media volumes of 500 to 900 mL are used in apparatus I and II to ensure sink conditions. However, these volumes are considerably larger than those in the gastrointestinal tract. Thus, the experiments are not biomimetic and possibly not suitable for biopredictive dissolution testing. The present study investigates the influence of volumes of dissolution media in non-compendial dissolution/permeation settings. Dissolution/permeation studies of two commercial bilayer tablets (Twynsta® and Arrow) containing the active pharmaceutical ingredients telmisartan (40 mg) and amlodipine (10 mg) were evaluated using the MacroFlux tool with various biomimetic media mimicking fasted and fed states as well as biological variability ("biorelevant"). Particularly, the two-stage dissolution process of telmisartan from the tablets is interesting because the compound has a pH-dependent solubility, and 2-stage dissolution leads to supersaturation and precipitation upon pH shift. For telmisartan, lower dissolution volumes significantly induced precipitation, leading to lower permeation, while no precipitation was observed in the larger volume. The permeation of telmisartan was overly sensitive to both pH and micelle concentrations in the biomimetic media. Amlodipine showed complete dissolution under any conditions, which correlates with its known complete absorption in vivo. In conclusion, volumes of dissolution media (and their compositions) are key parameters and play a significant role for designing relevant biomimetic experiments used to predict the bioavailability of supersaturating systems.

Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.

Background Structural and functional MRI studies have revealed brain alterations associated with opioid use disorder (OUD). However, previous research has been limited by small sample sizes, few female participants, and single-modality analyses. Purpose To identify structural and functional brain alterations in individuals with OUD using whole-brain data-driven methods to analyze T1-weighted MRI and resting-state functional MRI (rsfMRI). Materials and Methods This secondary analysis of the Collaboration Linking Opioid Use Disorder and Sleep study compared participants with OUD (data collection February 2021 to February 2023) receiving methadone treatment with healthy control participants (data collection February 2018 to May 2023). T1-weighted MRI and rsfMRI were analyzed using tensor-based morphometry and intrinsic connectivity distribution, respectively. Primary outcome measures included regional brain volumes and functional connectivity. Voxel-wise linear regression was used to assess group differences, with family-wise error correction. Pearson partial correlations were used to examine structure-function relationships. Results Compared with healthy control participants (n = 105; median age, 27 years [IQR, 23-37 years]; 58 female), participants with OUD (n = 103; median age, 37 years [IQR, 31.5-46 years]; 62 male) showed smaller volumes (corrected P < .05) in the thalamus (β = -17.42 [95% CI: -26.56, -8.27]) and right medial temporal lobe (β = -8.02 [95% CI: -12.25, -3.78]). Larger volumes (corrected P < .05) were seen in the brainstem (pons and medulla, β = 15.21 [95% CI: 7.03, 23.40]; midbrain, β = 13.04 [95% CI: 6.61, 19.47]) and cerebellum (right, β = 14.96 [95% CI: 7.25, 22.67]; left, β = 14.88 [95% CI: 7.32, 22.43]). An interaction between sex and group was found for medial prefrontal cortex volume (β = -19.38, corrected P < .05), with female participants having smaller volumes than male participants in the OUD group. Increased functional connectivity (corrected P < .05) was noted in the thalamus (β = 0.50 [95% CI: 0.25, 0.75]), right medial temporal lobe (β = 0.43 [95% CI: 0.21, 0.66]), right cerebellum (β = 0.46 [95% CI: 0.21, 0.71]), and brainstem (β = 0.48 [95% CI: 0.22, 0.74]) in the OUD group. Structure and function were positively correlated in the cerebellum (Pearson r = 0.32 [95% CI: 0.17, 0.44], P < .001) and brainstem (Pearson r = 0.23 [95% CI: 0.09, 0.37], P = .002). Conclusion Individuals with OUD showed overlapping structural and functional brain alterations in opioid receptor-dense regions compared with healthy control participants. © RSNA, 2024 Supplemental material is available for this article. See also the editorial by Filippi and Messina in this issue.

Thermodiffusively-unstable lean premixed hydrogen flames: Length scale effects and turbulent burning regimes

This paper presents direct numerical simulations (DNS) of thermodiffusively-unstable lean premixed hydrogen flames in the canonical turbulent flame-in-a-box configuration. A range of reactant (pressure, temperature, and equivalence ratio) and turbulent (Karlovitz and Damköhler number) conditions are used to explore the effects of the small and large turbulent scales on local and global flame response. Turbulence-flame interactions are confirmed to be independent from integral length scale (or equivalently, from Damköhler number) for a fixed Karlovitz number. Furthermore, a recent model that predicts mean local flame speed as a function of an instability parameter and Karlovitz number is also demonstrated to be independent from integral length scale. This model thereby reduces turbulent flame speed modelling for thermodiffusively-unstable cases to predicting surface area enhancement. Flame surface area wrinkling is found to have good agreement with Damköhler’s small-scale limit. There is some scatter in the data, although this is comparable with similar experimental data, and the freely-propagating flame properties have a greater impact on the turbulent flame speed than the flame surface area. It is demonstrated that domain size can have an effect on flame surface area even if the integral length scale remains unchanged; the larger volume into which flame surface area can develop results in a higher turbulent flame speed. This is not accounted for in conventional algebraic models for turbulent flame speed. To investigate the influence of the fuel Lewis number Lef, an additional study is presented where Lef (alone) is artificially modified to span a range from 0.35 to 2. The results demonstrate that more flame surface area is generated for smaller Lef, but the difference for Lef≲1 is much smaller than that observed for Lef>1. A volume-filling-surface concept is used to argue that there is a limit to how much flame surface can develop in a given volume, and so there is only so much more flame surface can be induced by the thermodiffusive response; whereas the thermodiffusive response at high Lef is to reduce flame surface area. The agreement of the present data (and previous work) with Damköhler’s small-scale limit (even for low-to-moderate Karlovitz numbers) suggests that a distinction should be made between the small-scale limit and the distributed burning regime. Furthermore, it is argued that the distinction between large- and small-scale limits should be made based on Damköhler number. Consequently, the flamelet, thin reaction and distributed regimes should be distinguished by Karlovitz number (as usual), but the two latter regimes both have separate large- and small-scale regimes. Finally, implications for the turbulent premixed regime diagram are discussed, and a modified regime diagram is proposed.Novelty and significanceThis paper: confirms that turbulence-flame interactions at the flame scale are independent of integral length scale (at fixed Karlovitz number), as is the local flame speed model for thermodiffusively-unstable flames (Howarth et al., 2023); demonstrates potential domain size effect not accounted for in turbulent-flame models; flame surface wrinkling agrees with Damköhler’s small-scale limit for thermodiffusively-unstable flames in the thin reaction zone at low Damköhler number; and flame surface wrinkling increases slightly for low fuel Lewis numbers, but decreases significantly at high fuel Lewis numbers. There are significant consequences for the turbulent premixed regime diagram: distinction between Damköhler’s small-scale limit and distributed burning regime; separation of small- and large-scale limit by Damköhler number; application of the λ-flames concept to thin reaction zone; and exclusive use of Karlovitz and Damköhler number for regime classification and diagram axes.

Screening and surveillance practices for Multiple Endocrine Neoplasia type 1-related Neuroendocrine Tumours in European Neuroendocrine Tumor Society Centers of Excellence (ENETS CoE)-An ENETS MEN1 task force questionnaire study.

Multiple Endocrine Neoplasia type 1 (MEN1) Clinical Practice Guidelines (2012) are predominantly based on expert opinion due to limited available evidence at the time, leaving room for interpretation and variation in practices. Evidence on the natural course of MEN1-related neuroendocrine tumours (NET) and the value of screening programs has increased and new imaging techniques have emerged. The aim of this study is to provide insight in the current practices of screening and surveillance for MEN1-related NETs in ENETS Centers of Excellence (CoEs). A clinical practice questionnaire was distributed among all 65 ENETS CoEs. Response rate was 91% (59/65). In 14% of CoEs <10 patients, in 50% 10-49, in 31% 50-100 and in 3 centres (5%) >100 patients with MEN1 are seen. Practices with regard to screening and surveillance of NETs were markedly heterogeneous. Differences between countries were noted in the use of gut hormones for biochemical screening and the choice for imaging modality for screening/surveillance of pancreatic NETs (PanNETs). Magnetic resonance imaging (MRI) is the preferred modality for screening and surveillance of PanNETs, whereas this is computed tomography (CT) for thoracic NETs. Practices regarding screening for thoracic NETs were more homogeneous among larger volume CoEs, with longer screening intervals. The majority of CoEs tailored the surveillance of small pancreatic and lung NETs to observed growth rate. 68% of CoEs advise patients with clinical MEN1 with negative genetic testing to undergo periodic screening like mutation-positive patients. In conclusion, there is still marked heterogeneity in practice, although there are also common trends. Differences were sometimes associated with volume or country, but often no association was found. This underscores the need for clear and evidence-based practice recommendations.

Harnessing polysialic acid (PSA)-embedded exudate-absorbing hydrogel for on-demand trigeminal neuralgia treatment

A key characteristic of trigeminal neuralgia (TN) is cytokine-enriched exudate and a “reactive oxygen species (ROS) storm” generated from the inflammatory cascade, resulting in demyelination of the sensory root of the trigeminal nerve, tissue swelling, and intense electric shock-like pain. The clinically approved drug carbamazepine (CBZ) is capable of inhibiting pain, reducing inflammatory factors, and alleviating oxidative stress, but its clinical application is restricted by its systemic toxicity. Herein, we developed an exudate-absorbing hydrogel incorporating polysialic acid (PSA) and CBZ (F127@PSA@CBZ) for on-demand TN treatment. Owing to the strong water absorption properties of PSA and F127, the F127@PSA@CBZ hydrogel can quickly absorb the lesion exudate and swell into a larger volume with a looser structure, thus releasing payloads sustainably, such as CBZ and PSA, for approximately 7 days in vivo. The released CBZ can scavenges the ROS storm and inhibits the levels of proinflammatory factors. More importantly, the residual PSA was found to promoted the proliferation of Schwann cells by upregulating the expression of STAT3 and Ki67, contributing to enhanced myelin sheath regeneration in a rat TN model. These findings highlight that the PSA-embedded exudate-absorbing hydrogel has great potential for facilitating the repair of the trigeminal nerve myelin sheath.

Changes Over Time in Masseter Muscle Activity, Symptoms of Discomfort, Stress Level and Salivary Flow Rate Following Intra-Oesophageal Acid Infusion.

Intra-oesophageal acid stimulation increases masseter muscle activity. However, the infusion speeds used in previous studies are significantly slow, with minimal acid volume (30 mL over 30 min). Additionally, it is unclear how masseter muscle activity, symptoms of discomfort, stress levels and saliva quantity change over time. The time course of masseter muscle activity, heartburn and discomfort symptoms, salivary cortisol concentration to assess stress, autonomic nervous system (ANS) activity and saliva quantity under the influence of intra-oesophageal acid infusion were evaluated at a faster injection rate and larger volume than in previous studies. Ten healthy adults underwent polygraphic monitoring, consisting of electromyography of the masseter muscle and electrocardiography during intra-oesophageal acid infusion (10 mL/min, 10 min). Symptoms of heartburn and discomfort were assessed using the visual analogue scale (VAS), and saliva quantity was measured. Friedman's test was used for multiple comparisons. Masseter muscle activity, VAS scores for heartburn and discomfort, as well as saliva quantity during the 10-min acid infusion, increased significantly compared with that before acid infusion (p < 0.001, 0.001, 0.019 and 0.047, respectively) and decreased 10 and 20 min after acid infusion (p = 0.004, 0.004 and 0.007, respectively). No significant changes were observed in the salivary cortisol concentration or ANS activity. Intra-oesophageal acid infusion stimulated symptoms of heartburn and discomfort and increased masseter muscle activity and saliva production, which may not be related to psychological stress.

Prevention of Air Embolism in Extracorporeal Membrane Oxygenation Systems: An In Vitro Study on Protection of Central Venous Catheter Lumen.

Background and Objectives: This study aimed to investigate the risk and mechanisms of air entry into the extracorporeal membrane oxygenation (ECMO) circuit through the central venous catheter (CVC) in a veno-venous configuration. The primary goal was to assess the impact of different air volumes on ECMO circuit performance at varying pump speeds. Material and Methods: The study utilized a circuit model to simulate ECMO conditions and evaluate the potential entry points of air, specifically through the unprotected lumen of the CVC. Various interventions, such as the use of a closed three-way stopcock or clave, were implemented to assess their efficacy in preventing air entry. Results: The unprotected lumen of the central venous catheter posed a significant risk for air entry into the ECMO circuit. The introduction of a closed three-way stopcock or clave proved effective in preventing air ingress through the central venous catheter. Auditory cues, such as a distinct hissing sound, served as an early warning sign of air presence in the circuit. The study demonstrated that even small volumes of air, as minimal as 1 mL, could pass through the oxygenator at specific pump speeds, and larger volumes could lead to pump dysfunction. Conclusions: The study identified the unprotected lumen of the central venous catheter as a potential entry point for air into the ECMO circuit. The use of a closed three-way stopcock or one-way valve was found to be a reliable protective measure against air infiltration. Early detection through the observation of a hissing sound in the circuit provided a valuable warning sign. These findings contribute to enhancing the safety and performance of ECMO systems by minimizing the risk of air embolism.

Validation of Double Constant and Falling Head Permeameter for Determination of Hydraulic Conductivity of Soils in the Laboratory

The objective of this research was to validate alternative equipment for determining the hydraulic conductivity of saturated soil (Ksat) in laboratory settings. The aim was to develop a single piece of equipment that could be used to carry out tests using both the constant-head permeameter (CHP) and the falling-head permeameter (FHP) methods with minimal disturbance to the samples. To this end, undisturbed soil samples were collected (in volumetric cylinders with 100 and 250 cm3) from three soil profiles with different textures to evaluate the sensitivity of the double permeameter (DP) in determining Ksat, considering the method, the sample size, and the textural class of the soils. To assess the efficacy of the DP in estimating Ksat, the coefficient of variation (CV) was determined for the two methods (CHP and FHP), the sample size (100 and 250 cm3), and the applied hydraulic head (cwc) (constant: 1.5 and 2.5 cwc; falling: Δhi, upper limit, h1 = 67.6 and h2 = 57.6 cwc; Δhii, medium limit, h1 = 49.3 and h2 = 39.3 cwc; and Δhiii, lower limit, h1 = 31.3 and h2 = 21.3 cwc). The results indicate that the DP may be employed as an alternative permeameter for Ksat tests employing the CHP and FHP methods. The most favorable statistical coefficients were observed in tests conducted with samples of a sandy texture (Profile 3, Ap horizon), particularly those with a larger volume (250 cm3), for both the CHP and FHP methods, irrespective of the applied hydraulic head. The equipment can be utilized within the full range of methodological limits employed in this study, and the appropriate limit must be selected according to the physical properties of the soil to be employed in the tests.

Simplifying acquisition of essential diagnostics: A comprehensive costing tool for anatomic pathology.

Histopathology is the core diagnostic tool for cancer in pathology laboratories around the world, but there are disparities in access to diagnostics globally. As recognition of the need for cancer care and treatment grows, especially in the wake of World Health Organization programs for cervical, breast, and pediatric cancers, policymakers and health care funders are seeking tools and processes that allow for the largest number of patients to receive a diagnosis at the lowest cost. As histopathology represents the most cost-effective diagnostic method by sheer number of tumor types and volume, understanding the detailed logistics and costs for histology as well as the impactful benefits of economies of scale (ie, larger volumes are less expensive per patient) and scope (ie, the multiple stains available after basic histology sectioning) is paramount to planning an effective publicly funded or government laboratory. Understanding the economic structure of a country's population along with the financial model of a histology laboratory also leads to a market understanding of private laboratories, which can provide services at a profit as well as pro bono services more cost-effectively than purely public laboratories. We have developed a comprehensive, scalable costing tool of a functioning histology laboratory that accounts for all feasible costs and variations in models of service. The tool allows for a standardized approach to selecting goods needed to provide histology services and serves as a guide for implementation of pathology services. Using the tool, laboratories can achieve self-sustainment and long-term financial health while incorporating a proportion of impoverished patients who cannot afford out-of-pocket expenses.

Testing the unintended cost effects of health policies for generic substitutions: the case of China's National Volume-Based Procurement (NVBP) policy.

Generic substitutions are globally considered to contain health expenditures. Yet it is uncertain whether the costs would spill over to other medicines or health services. Contextualizing China's National Volume-Based Procurement (NVBP) policy, which promoted generic substitution, this study tests the changes in patients' utilisation of generic medicines and whether the costs shift to other pharmaceutics or health services post-policy. This population-based, matched, cohort study uses claims data from Tianjin, China in 2018-2020. We focus on Amlodipine, the most commonly used calcium channel blocker with the largest volume. We build comparable post-policy cohorts: Non-switchers who kept using originator Amlodipine, Pure-switchers who loyally switched to generic Amlodipine, and Back-switchers who switched back-and-forth; and compare between each matched pair, respectively, of their annual healthcare costs and that broken down by components, and patients' use of and adherence to Amlodipine post-policy. 1185 Pure-switchers, 1398 Back-switchers, and 2330 Non-switchers are identified (mean age: 63.0 years; 58.5% men). For the matched pairs, Pure-switchers (N=772) incurred an annual total medical costs of CNY 9213.5, 12.2% lower than Non-switchers (N=1544, absolute difference CNY -1309.3, 95%CI: [-2645.8, -19.6]). The cost reduction only results from Amlodipine prescriptions in outpatient encounters, and are equally born on health plans and the enrolees. Pure-switchers and Non-switchers are not different in costs from other medicines, nor from other items including tests, surgeries, beds, and medical consumables for hypertension-related encounters/admissions. Pure-switchers had higher daily dosage and better adherence to Amlodipine than Non-switchers as well. The differences between Back-switchers and Non-switchers show similar trends but are less profound. China's NVBP policy is effective to control pharmaceutical costs. No unintended cost effects have yet been identified in the short run. Other countries may learn from China on the comprehensive sets of auxiliary policies, including listing, bidding, purchasing, and reimbursing, to better promote generic substitutions.

Exploring the correlation between tree structure characteristics and carbon storage in historic gardens using TLS technology: a case study of Jian Xin Pavilions at Jingyi Park, Fragrant Hills Park

Historic gardens contain a greater number and variety of ancient trees, which are older, have unique forms, and larger volumes. These trees hold significant value in both natural ecosystems and cultural heritage. However, current research on the carbon sequestration value of ancient and non-ancient trees in historical gardens is relatively lacking. Based on the unique morphology and carbon storage estimation needs of ancient trees in historic gardens, this paper proposes a morphology-based point cloud single-tree segmentation method. This method can precisely extract the morphological structures of various tree species and accurately estimate their carbon storage. From the perspective of carbon sequestration, it evaluates the correlation between the structural characteristics and carbon storage of trees in historic gardens, as well as the potential changes in their carbon storage capacity.Using the Jing Yi Park’s Jian Xin Pavilions in Fragrant Hills Park as a case study, this method was applied to extract structural indicators of 116 ancient and non-ancient trees. The total carbon storage was found to be 19,171.13 kg, with an average carbon storage of 165.27 kg per tree. Among these, ancient trees accounted for 13,178.32 kg, or 68.74% of the total carbon storage. The study revealed that the correlation between tree age and carbon storage varied by species, and there were significant positive correlations between carbon storage and tree height, DBH, and canopy volume. Notably, there was a significant linear growth trend between DBH, canopy volume, and carbon storage. By 2030, the total carbon storage is projected to increase to 21,924.96 kg, with an annual average increase of 393.40 kg, representing a growth rate of 14.4%.The results indicate that studying the correlation between structural characteristics and carbon storage of aged trees in historical gardens can shed light on the important role of trees in sustainable carbon sequestration. The precise extraction of tree information through 3D digital technology and the prediction of carbon storage potential not only offer new perspectives for the conservation of cultural heritage in historical gardens, urban microclimate planning and design, and spatial management of carbon sinks and emissions but also have significant value for promoting the scientific management and protection of urban green spaces.

Factors affecting D90 High-risk Clinical Target Volumes (HR-CTV dose) of intracavitary and interstitial brachytherapy in locally advanced cervical cancer

IntroductionIntracavitary brachytherapy (IC) alone covers a limited target volume; however, intracavitary and interstitial brachytherapy (IC/IS) can increase the dose coverage. We aim to assess the factors that impact D90 HR-CTV dose. We also assess clinical outcomes and toxicities for 3D image-based brachytherapy. Material and methodsWe included a total of 424 cervical cancer patients with FIGO stage IB1 to IVA who received chemoradiation and high-dose-rate brachytherapy between 2014 and 2023. Target delineation was per GEC-ESTRO guidelines with the aim to achieve total dose of ≥ 85Gy (D90 HR-CTV) in EQD2. Implantation, tumor size, lateral extension, and HR-CTV volume were analyzed. ResultsThe median follow-up time was 24 months (range 1 -107). The overall 2-year local control, progression free survival, and overall survival rate were 90.3%, 75% and 95.5%, respectively. Of 424 patients, 86.8% received a total dose of at least 85 Gy of D90 HR-CTV in EQD2. In multi-variate analysis, IC/IS brachytherapy and HR-CTV volume were significant factors associated with HR-CTV D90 ≥ 85Gy in EQD2 (p=0.012 and p=0.000, respectively). Subgroup analysis of patients with HR-CTV volume > 35 ml found that IC/IS was a significant factor in achieving HR-CTV D90 ≥ 85Gy in EQD2 (p=0.017). At the median follow-up, patients with D90 HR-CTV ≥ 85 Gy achieved local control rates of 72.08% in small volume (<20 cm3) group, 68.42% in intermediate volume (21-30 cm3) group, 71.68% in high intermediate volume (31-60 cm3) and 17.67% in larger volume (>60 cm3) group (p=0.005). Grade 3 toxicities including proctitis, cystitis and vaginal stenosis were 7.1%, 1.9% and 0.2%, respectively. ConclusionIC/IS brachytherapy may be used in patients with HR-CTV volumes greater than 35 ml to achieve total doses of D90 HR-CTV ≥ 85Gy in EQD2. IC/IS brachytherapy also provide good local control with favorable toxicity profile.

Analysis of the reservoir properties of rocks of the Lower Kura depression (Azerbaijan)

The article analyzes the features characterizing the Lower Kura depression (LKD). A number of hydrocarbon deposits have been discovered in this oil and gas region. The Kalmas underground gas storage facility, which has the largest volume in Azerbaijan, is also located in this area. In the LKD, all PS formations can be traced throughout the entire well section. The reservoir properties of the rocks were considered to study the features of the area. In order to study the reservoir properties in the well section, the field applies data obtained by using a complex of well logging (WL) methods (laterolog, spontaneous potential logging, induction logging, gamma logging, neutron logging, acoustic logging) and analyses of rock samples. The graphs were constructed to evaluate the relationship between petrophysical parameters (porosity, permeability, etc.) determined in the rocks involved in the well sections of the object of research. In the article, maps of porosity distribution, permeability and permeability of sandy siltstone rocks and fractions greater than 0.1 of the Productive Series of the South-Eastern Gobustan and Baku Archipelago, which are part of the Low Kura Depression, are plotted and analysed. Plots showing the porosity distribution of the Low Kura Depression by depth were also constructed and some results were obtained. Based on reservoir properties, the region is divided into 6 groups, and in each group intermediate values of the porosity and permeability coefficient are determined. In general, the porosity coefficient ranges within 5-25%, permeability – 1-250 mD. The reservoir properties of rocks vary over area from worse to better. The capacitance-filtration properties of rocks were studied. The rock samples analysed identified rocks with good and low reservoir characteristics. To study the variation in the determining factors, maps of the distribution of reservoir properties indicators (fractions greater than 0.1 mm; porosity and permeability in sand-siltstone-containing rocks) were compiled by area and their causes were determined by comparison with other oil and gas fields. It was found that with distance from the mouth of the Kura River (towards the right and left banks), the reservoir properties of the rocks deteriorate. This is due to an increase in the amount of clay in rocks. It is also clarified that the change in porosity coefficient does not depend on depth. The content of sand-siltstone composition in the rocks along the section is 20-50%.

Effect of severe periodontitis of maxillary molars on the maxillary sinus and the treatment principles of periodontitis related maxillary sinusitis

Maxillary sinus is located in the maxilla bone with the largest volume in all sinuses and is closest to the roots of maxillary posterior teeth, especially the mesiobuccal root of the maxillary second molar. The thickness of the normal maxillary sinus mucosa is about 1 mm. When stimulated or infected, it shows thickening of the mucosa. Periodontitis is one of the most common oral diseases in human beings, and the complex root anatomy of the maxillary molars aggravates the difficulty of inflammation control. Severe periodontitis of maxillary molars without effective treatment can affect the maxillary sinus, increasing the possibility of the mucosa thickening, and is also one of the reasons for the occurrence of odontogenic maxillary sinusitis (OMS). There are many different schemes for the treatment of OMS caused by severe periodontitis of maxillary molars. Extraction of teeth with severe periodontal disease without retention value or successful periodontal treatment can significantly reduce the thickness of maxillary sinus mucosa. For the patients with uncontrollable sinusitis by using drug treatment and eliminating odontogenic causes, or ones with severe symptoms, periodontal treatment and endoscopic sinus surgery can be combined to effectively control the periodontitis related maxillary sinusitis.

Analysis Welding Types Pipe Fabrication Process in Missile Fast Attack Boat Construction

The equipment in the piping system consists of pipes, valves, flanges, filters, fittings, pumps, and others. The installation schedule for this piping system begins after the connection between blocks. Pipes as part of a ship's system have several steps in their installation procedure, one of which is welding. Welding on pipes is carried out by professional welders who have met more complex competency requirements than welders in general, such as flat position welders, vertical welders, or overhead welders. The purpose of this study was to determine the welding process and types of welding in pipe fabrication for the construction of the Missile Fast Attack Boat. Result comparison between the diameters of the welded pipes, the greater the value of the welding volume formed. The largest volume is 426 mm3, with a pipe length for the fabrication process of 4,3 m. On the other hand, the shortest fabrication is for welding pipes with a diameter of 2,5 m, which has a volume of 127 mm3. While the welding process using GTAW / Gas Tungsten Arc Welding (TIG) is very appropriate for welding in small areas and thin pipes. The TIG welding process has an average volume of below 150 mm3.

Effects of surface morphology and chemical composition on friction properties of Xenopeltis hainanensis scales

The scales of Xenopeltis hainanensis, a snake that can crawl in fields, valleys, and other places, can serve as inspiration for the design of scale-like bionic materials. We present a systematic morphological, microstructural, chemical, and mechanical analysis, including elastic modulus, hardness, and wear morphology of the scales to understand the friction basis for achieving the reptile requirements. At the surface level, a comb-like arrangement of microstructures on the ventral scales provides more surface area and reduces pressure. The separation of microstructures, along with the bending and delamination of collagen fibrils could contribute to energy dissipation, which helps prevent catastrophic failure at deeper structural levels. At the cross-sectional level, a greater thickness provides more distribution of stresses over a larger volume, reducing local deformation and increasing the resistance to damage. At the material level, the ventral scales show higher modulus (E = 384.65 ± 19.03 MPa, H = 58.67 ± 6.15 MPa) than other regions of snake scales, which is attributed to the increased thickness of the scales and the higher concentration of sulfur (S). The experimental results, combined with Energy-dispersive X-ray spectroscopy and SEM characterization, provide a complete picture of the fiction properties influenced by surface morphology and chemical composition during scratch extension of the Xenopeltis hainanensis scales.

Инженерный расчет гибких оболочек лесосплавных опор

Currently, the issue of delivering wood raw materials from remote forest areas, where the largest volumes are located, is relevant. Often, this delivery is economically justified only when using a network of medium and small rivers with the use of environmentally friendly technologies. On such rivers, it is preferable to use mobile anchors, in particular shore fillable ones, for fixing timber-rafting objects. A description has been given of a new modification of such an anchor, which differs from the prototype by a container having a flexible shell. This allows to significantly reduce the material consumption for manufacturing the container, the dimensions of the anchor in the transport position, and to produce anchors of any realistic size. The choice of the most rational option for such a container implies the scientific justification of its parameters. The aim of the study is to develop a scientific basis for this justification. Analytical formulas have been theoretically obtained for determining the basic geometric characteristics of the cross-section of the container under consideration. These formulas are useful in scientific research, but their application is very problematic in practical engineering calculations. This is due to the dependence of the specified characteristics on elliptic integrals and parameters, which are very difficult to measure in engineering practice. Having performed calculations using these formulas for a single cross-sectional area, we have obtained its specific geometric characteristics for various shapes, i.e. for various width-to-height ratios of a container to be filled. The results of the calculations have been approximating dependencies linking the named characteristics with the specified ratio, which is called the shape factor. Multiplying the specific characteristics by the square root of the cross-sectional area gives the absolute values of the corresponding characteristics. As a result, we have obtained formulas convenient for practical use, allowing to determine the width and height of the container to be filled, the width of its base, the perimeter of the cross-section, the heights of the zero pressure line and the extreme lateral point of the cross-section above the base of the container. The accuracy of calculations based on these and analytical formulas is almost the same. A formula for determining the specific tension of a flexible container shell has been obtained. The nature and degree of influence of the shape factor and length of the container on its other geometric characteristics have been established. An algorithm for substantiating the key parameters of a container to be filled with a flexible shell has been developed using the described results.

Enchanting optical, electronic, and mechanical properties of the sodium based Na2MgSiZ6 (Z = I, Br, Cl) halides have been explored through DFT

Materials. with perovskite structures have been extensively studied due to their remarkable properties, which are important in various aspects of daily life. In the present approach, Na2MgSiZ6 (Z = I, Br, Cl) halides were extensively studied, and it was realized from the band structure results that all these halides display semiconducting natures with indirect band gaps. The semiconducting natures of Na2MgSiZ6 (Z = I, Br, Cl) halides were further confirmed by their TDOS results. The optimized values of the lattice constants were found to be 11.70 Å, 10.4 Å, and 10.22 Å for Na2MgSiI6, Na2MgSiBr6, and Na2MgSiCl6, respectively. Moreover, the largest volume was observed for the Na2MgSiI6 compound, while the smallest volume was recorded for the Na2MgSiCl6 compound. Na2MgSiCl6 compound exhibited brittle nature, whereas Na2MgSiBr6 and Na2MgSiI6 were found to be ductile. All three materials demonstrated attractive values of optical conductivities, making them befitting candidates for solar cells, LEDs, detectors, and various other optoelectronic devices. From the achieved negative values of formation energy for all the Na2MgSiZ6 (Z = I, Br, Cl) halides, it was comprehended that these compounds could be synthesized practically.

Scoring System Assessing Risks of Growth in Sporadic Vestibular Schwannoma.

Surveillance studies offer sparse knowledge of predictors of future growth in sporadic vestibular schwannomas (VS).Our aim was identification of these risk factors. We propose a scoring system to estimate the risk of growth in sporadic vestibular schwannoma. This retrospective study is based on the demographic and radiological data of 615 adult patients under the surveillance for single VS in our center. Univariate analysis, multivariate regression, and Kaplan-Meier analysis were used when appropriate. The regression coefficient-based "VS score" was calculated based on Cox proportional-hazards regression. During surveillance, 285 tumors (46%) remained stable, 314 tumors (51%) grew, and 16 tumors (3%) shrank. The significant risks factors for future growth identified both in univariate and multivariate analyses were younger age at onset, cystic morphology, larger tumor volume, and cisternal location (as per Hannover grade). The proportion of growing tumors was 40%, 75%, and 96% among the homogeneous VS, primary cystic, and VS transformed to cystic, respectively. Moreover, tumor growth during the 1st year was significant predictor of continuous growth. Our "VS score" includes variables such as age, sex, morphology, and Hannover grade. The score extends between -3 and 6 points. Kaplan-Meier, confusion matrix, and receiver operating characteristic analysis proved high accuracy of our scoring model. Our retrospective study revealed that younger age, cystic morphology, cisternal extent, larger volume, and growth during 1st year were strong predictors of future growth. Moreover, we propose a scoring system that accurately estimates the risks of future tumor growth.

PANORAMA OF THE SCIENTIFIC PRODUCTION OF AZUKI BEANS IN 10 YEARS

Azuki bean (Vigna angularis), belonging to the Fabaceae family, is one of the most traditional crops in East Asia. It is widely consumed in Japan in dishes such as porridge, soups, cakes, pastries, and mixed with rice. Rich in fiber, magnesium, potassium, calcium, and folic acid, azuki beans contain approximately 55% starch. In Brazil, this legume is still relatively unknown, with little information available on its agricultural production. This study aims to analyze and quantify the availability of scientific articles on azuki beans, both at the national and international levels, based on publications from 2012 to 2022. The analysis period it covered the months of August to October 2022. The descriptor “Adzuki Beans” yielded the highest number of publications, with 2021 being the year with the largest volume, totaling 73 articles. In contrast, the descriptor “Feijão Azuki” showed a significantly lower number of articles, with only three publications in 2015. The Web of Science database had the highest number of published articles, totaling 488 publications during the analyzed period.