Large Facilities Research Articles

WAVE ATTENUATION OF SALTMARSH VEGETATION UNDER STORM CONDITIONS

Nature-based solutions (NbS) for coastal protection has recently gained increased attention worldwide as a sustainable, economical and eco-friendly alternative to conventional grey structures, particularly under the threat of climate change (Temmerman et al. 2013). Wave energy dissipation by vegetation can be parameterized by the total horizontal force acting on the plant; expressed using a Morison-type equation considering only the form drag component (Dalrymple et al. 1984). Modelling wave-vegetation interaction is challenging in a laboratory environment (Lara et al. 2016) and it is difficult to accomplish a realistic representation of a plant’s biomechanical behavior and geometry using plant mimics or surrogates. Few studies have modelled real saltmarsh vegetation in large scale laboratory facilities (Moller et al. 2014; Maza et al. 2015) and quantified wave attenuation, particularly for engineered living shorelines (Maryland DoE, 2013). Further research is needed, particularly in the Canadian context, to investigate the capacity of different saltmarsh species to effectively attenuate waves and wave runup under storm conditions, to examine the plant’s drag coefficient and to bridge the gap to develop technical design specifications for the detailed design of living shorelines.

백제지역 무덤 용어에 대한 논의

This study started with the problem consciousness that the concept of each terminology should be clearly established prior to research on Baekje tombs. Therefore, the concept of tomb (墳墓) and mounded tomb (古墳) were examined along with the problem of Bungumyo (墳丘墓), and a new classification and name were presented based on the research of Baekje tombs.
 First, the tomb was used as a collective term for all tombs, regardless of temporality and hierarchy, and the mounded tomb was named only for some tombs what hierarchy is clearly revealed after the middle of 3rd century. In addition, the tomb that appear from the middle of the 3rd century but are relatively low hierarchy was defined as Myo (墓), and tomb with high hierarchy was defined as Bun (墳). On the other hand, it was defined as Chong (塚) only in some tomb with large external facility that was stoned, reflecting their political stature. On the other hand, it was judged that the Bungumyo is difficult to use in Korean archaeology because there is a big difference in concepts used among researchers and regions, and also a difference from the concept used in Japanese archaeology.
 Next, Baekje tombs are classified based on the material, shape, and structure of the burial facility. First, it was classified into wooden, stone, brick, jar according to constructive material. Next, among coffin, outer coffin, and chamber, which are the shape of the burial facility, the outer coffin and chamber were clearly distinguished according to the existence of access facility, In addition, vertical style, corridor style, and open-enterance style were classified according to the structure of the burial facility.
 Lastly, the tombs with high hierarchy that appeared after the middle of the 3rd century, which is defined the mounded tombs (古墳) and high mounded tombs (古塚) were classified into wooden coffin mounded tombs (木棺墳), wooden outer coffin mounded tombs (木槨 墳), the stone lined mounded tombs with vertical style (竪穴式 石槨墳), the stone chamber mounded tomb with corrider style (橫口式 石室墳), the stone chamber mounded tomb with open-entrance style (橫穴式 石室墳), brick chamber mounded tomb (塼築墳). stone mounded tomb (積石塚), The tombs with low hierarchy were classified wooden coffin tomb (木棺墓), stone lined tomb (石槨墓), jar coffin tomb (甕棺墓), stone tomb (積石墓). However, tombs that have already been accepted universly, such as pit tomb (土壙墓), open-entrance tomb(橫穴墓), crematory tomb (火葬墓), pit tomb with the ditch (周構土壙墓) were named as they are used. In addition, as considering regional characteristics in the the Yeongsan river basin, the wooden coffins mounded tombs (木棺古墳) and the jar coffins mounded tombs (甕棺古墳) were named, and the tombs similar to the keyhole-shaped tombs of Japan should be named as the keyhole-shaped style mouned tombs (前方後圓形古墳).

대형연구시설 기반 혁신클러스터 성공요인에 대한 연구 - 방사광가속기 클러스터 사례 분석을 중심으로 -

대형연구시설 기반 혁신클러스터 성공요인에 대한 연구 - 방사광가속기 클러스터 사례 분석을 중심으로 -

FishSeg: 3D Fish Tracking Using Mask R-CNN in Large Ethohydraulic Flumes

To study the fish behavioral response to up- and downstream fish passage structures, live-fish tests are conducted in large flumes in various laboratories around the world. The use of multiple fisheye cameras to cover the full width and length of a flume, low color contrast between fish and flume bottom and non-uniform illumination leading to fish shadows, air bubbles wrongly identified as fish as well as fish being partially hidden behind each other are the main challenges for video-based fish tracking. This study improves an existing open-source fish tracking code to better address these issues by using a modified Mask Regional-Convolutional Neural Network (Mask R-CNN) as a tracking method. The developed workflow, FishSeg, consists of four parts: (1) stereo camera calibration, (2) background subtraction, (3) multi-fish tracking using Mask R-CNN, and (4) 3D conversion to flume coordinates. The Mask R-CNN model was trained and validated with datasets manually annotated from background subtracted videos from the live-fish tests. Brown trout and European eel were selected as target fish species to evaluate the performance of FishSeg with different types of body shapes and sizes. Comparison with the previous method illustrates that the tracks generated by FishSeg are about three times more continuous with higher accuracy. Furthermore, the code runs more stable since fish shadows and air bubbles are not misidentified as fish. The trout and eel models produced from FishSeg have mean Average Precisions (mAPs) of 0.837 and 0.876, respectively. Comparisons of mAPs with other R-CNN-based models show the reliability of FishSeg with a small training dataset. FishSeg is a ready-to-use open-source code for tracking any fish species with similar body shapes as trout and eel, and further fish shapes can be added with moderate effort. The generated fish tracks allow researchers to analyze the fish behavior in detail, even in large experimental facilities.

“This is not built for me”: A qualitative study of adult-sized changing tables and public restroom accessibility

BackgroundAdult-sized changing tables allow individuals with disabilities or medical conditions related to toileting to change with or without assistance. These tables are rarely found in public restrooms, and as a result, those who need them are often changed on floors, in vehicles, or are unable to stay in public spaces for more than a few hours. ObjectiveThis study aimed to understand how individuals who utilize adult-sized changing tables, or self-advocates, and caregivers for disabled people, access public restrooms and to report recommendations to improve inclusivity of public restrooms. MethodsWe virtually interviewed five self-advocates and sixteen caregivers in February and March 2023. We performed a qualitative analysis of the interview transcripts using MAXQDA 2022. ResultsFour major themes arose during interviews: social consequences, health effects, caregiver effects, and inaccessibility of restrooms in the healthcare setting. All caregivers have changed disabled individuals in vehicles, and 11 on public restroom floors, experiencing guilt and stress, and often receiving injuries. Several respondents reported limiting intake of fluids or using suppositories to prevent the need to toilet during unavoidable outings. Respondents most need height adjustable changing tables in healthcare settings, airports, and large recreational facilities. ConclusionsWithout adult-sized changing tables, individuals with disabilities are forced to risk their health and dignity to utilize public spaces.

Multiscale Modeling of Radio Frequency Reactor Coupled Catalyst Heating for Ethylene Production

Ethylene is the petrochemical compound with the highest production worldwide. Whether reactors are heated by direct fired heating or indirect heating via steam, manufacturers rely on economies of scale to overcome inherent thermodynamic inefficiencies while burning fossil fuels. New approaches to supply energy to chemical reactor systems can reduce energy waste created by traditional techniques while enabling large scale facilities to use other sources of raw materials and energy. Electromagnetic (EM) induction heating is one potential solution for providing energy efficiently to reactor systems. By taking advantage of the nature of radio frequency (RF) waves, heterogeneous-catalyst can be precisely targeted for heating inside the reactors. Site-selective heating can significantly reduce the energy requirements of the process by providing heat at reaction sites and reducing unnecessary heat transfer elsewhere. Other advantages to an EM enhanced system include rapid volumetric heating, broader turn-down capacity, and reduced process footprint.The purpose of this work is to establish a multiscale computational fluid dynamics (CFD) model that can be used to emulate the proposed process mechanics at the macroscale and microscale. At the macroscale, coil geometry (coil diameter, gap between coils, distance between coil and susceptors) is investigated to elucidate coil design and effects on heating rates. In the microscale, the oxidative (CO2) dehydrogenation (ODH) of ethane is explored using different catalysts and possible catalyst/susceptor configurations with heat supplied by an EM susceptor. This multiscale method can also be applied to electrochemical systems.

Роль внутренней трудовой миграции в истории Дацинского нефтяного месторождения (1949–1978 годы)

This paper determines the role of the Chinese state policy in using internal labour migration to ensure accelerated socialist construction of such large industrial facilities as the Daqing Oil Field. The history of the People’s Republic of China from 1949 to 1978 is rich in examples of labour mobilization of military and technical workers as well as young people for the construction and organization of industrial enterprises in adverse climatic conditions. After the discovery of the Daqing Oil Field in the north-eastern province of Heilongjiang in 1959, more than 40,000 military men, engineers and oil workers were relocated to this facility. Chinese workers from the eastern and western provinces took an active part in organizing the process of exploration, drilling, oil extraction and transportation, as well as launching water supply and building storage facilities. Labour migrants were quick to establish new modern settlements in the oil field area under extremely harsh northern conditions. Daqing Oil Field workers steadfastly endured all the hardships, their main slogan being as follows: “Work hard, overcome difficulties, do your best to fight”. The selfless work of internal migrants was highly appreciated by the Chinese government and the Chinese society as a whole. Over 5,000 factories and enterprises throughout China manufactured mechanical and electrical products as well as equipment for the Daqing Oil Field; 200 research and development departments provided technical support to its workers. In the 1960s, an economic campaign “Learn Everything from Daqing” was launched, aimed to share the experience of building this oil field with other regions of China. Party and government officials Zhou Enlai, Zhu De, Dong Biwu, He Long and Chen Yi had repeatedly visited Daqing to inspect the work and evaluate the role of labour migrants from other provinces in the development of the oil industry in Northeast China.

Photochemical model assessment of single source NO2 and O3 plumes using field study data

Single source contribution to ambient O3 and PM2.5 has been estimated with photochemical grid models to support policy demonstrations for National Ambient Air Quality Standards, regional haze, and permit related programs. Limited field data exists to evaluate model representation of the spatial extent and chemical composition of plumes emitted by specific facilities. New tropospheric column measurements of NO2 and in-plume chemical measurements downwind of specific facilities allows for photochemical model evaluation of downwind plume extent, grid resolution impacts on plume concentration gradients, and source attribution methods. Here, photochemical models were applied with source sensitivity and source apportionment approaches to differentiate single source impacts on NO2 and O3 and compare with field study measurements. Source sensitivity approaches (e.g., brute-force difference method and decoupled direct method (DDM)) captured the spatial extent of NO2 plumes downwind of three facilities and the transition of near-source O3 titration to downwind production. Source apportionment approaches showed variability in terms of attributing the spatial extent of NO2 plumes and downwind O3 production. Each of the Community Multiscale Air Quality (CMAQ) source apportionment options predicted large O3 contribution from a large industrial facility in the flight transects nearest the facility when measurements and source sensitivity approaches suggest titration was outpacing production. In general, CMAQ DDM tends to attribute more O3 to boundary inflow and less to within-domain NOX and VOC sources compared to CMAQ source apportionment. The photochemical modeling system was able to capture single source plumes using 1 to 12 km grid resolution with best representation of plume extent and magnitude at the finer resolutions. When modeled at 1 to 12 km grid resolution, primary and secondary PM2.5 impacts were highest at the source location and decrease as distance increases downwind. The use of coarser grid resolution for single source attribution resulted in predicted impacts highest near the source but lower peak source specific concentrations compared to finer grid resolution simulations because impacts were spread out over a larger area.

Evaluation of "Caserotek" a low cost and effective artificial blood-feeding device for mosquitoes.

Entomological research studies on mosquito vector biology, vector competence, insecticide resistance, dispersal, and survival (using mark-release-recapture techniques) often rely on laboratory-reared mosquito colonies to produce large numbers of consistently reared, aged, and sized mosquitoes. We developed a low-cost blood feeding apparatus that supports temperatures consistent with warm blooded animals, using commonly available materials found in low resource environments. We compare our system ("Caserotek") to Hemotek and glass/membrane feeding methods. Two experiments were conducted with Aedes aegypti (Linnaeus 1762) and one with Anopheles darlingi (Root 1926) (Diptera: Culicidae); 3 replicates were conducted for each experiment. Aedes aegypti female mosquitoes were provided chicken blood once per week for 30 min (Experiment #1) for 14 days or 1 hour (Experiment #2) for 21 days. Anopheles darlingi were fed once for 1 hour (Experiment #3). Blood-feeding rates, survival rates, and egg production were calculated across replicates. Caserotek had a significantly higher 30-min engorgement rate (91.1%) than Hemotek (47.7%), and the glass feeder (29.3%) whereas for 1-hour feeding, Hemotek had a significantly lower engorgement rate than either of the other two devices (78% versus 91%). Thirty-day survival was similar among the feeding devices, ranging from 86% to 99%. Mean egg production was highest for the Caserotek feeder (32 eggs per female) compared to the glass feeder and Hemotek device (21-22 eggs per female). Our new artificial feeding system had significantly higher blood feeding rates than for more expensive artificial systems and was equivalent to other fitness parameters. Caserotek only requires the ability to boil water to maintain blood temperatures using a Styrofoam liner. It can be easily scaled up to large production facilities and used under austere conditions.

Identification and Mechanism of Residents’ Regional Non-Commuting Flow Patterns Based on the Gradient Boosting Decision Tree Model: A Case Study of the Shanghai Metropolitan Area

With the improvement in residents’ living standards, non-commuting has gradually become an important daily transportation behaviour for residents. The intensity of non-commuting flow can reflect the level of urban functional services and external attractiveness and can intuitively characterise the interconnection pattern and relationship among various cities within the metropolitan area. Related research is also a key topic in the fields of urban planning and transportation geography from a humanistic perspective. Taking the Shanghai Metropolitan Area as an example, this study explored the characteristics of the non-commuting flow of residents in the region and between cities and its nonlinear influencing factors with the help of the mobile phone signalling data and the gradient lifting decision tree model. Three conclusions were identified: first, non-commuting flow within each city in the metropolitan area was concentrated in the central urban area, while non-commuting flow between cities was concentrated in the central urban area of the urban border and strong core cities. Second, the built environment had a nonlinear impact on residents’ non-commuting flow. Different types of large-scale service facilities had different impact mechanisms on non-commuting flow, and public service facilities and transportation infrastructure jointly affected residents’ non-commuting flow. Third, transportation facilities had a more significant impact on the non-commuting flow between cities. Large tourism, cultural, and medical service facilities had a more significant impact on non-commuting flow within cities, with upper or lower thresholds according to the type of facility. The planning strategy needs to conduct targeted planning, regulation, and facility configuration based on the area’s actual needs. In addition, this study identified the characteristics of non-commuter flow differentiation in street towns and the nonlinear impact of the built environment.

Online training and education from the VR-1 reactor—Lessons learned

Hands-on education and training is a key part of fixing and developing technology knowledge and is an inherent part of many engineering and scientific curricula. However, access to large complex training facilities, such as nuclear reactor, could be limited by various factors, such as unavailability of those facilities in the region, high traveling costs or harmonization of the schedules of hands-on E&T with theoretical lectures and with the operational schedule of the facility. To handle the issue, several success stories have been reached with the introduction of the Internet Reactor Labs (IRL). The Internet Reactor Labs can strongly contribute to accessibility of training at research reactors and can contribute to improvements in their utilization. The paper describes the development of the Internet Reactor Lab at the VR-1 reactor of the Czech Technical University in Prague. Contrary to single-purpose IRLs, it presents various modalities of online teaching and training in experimental reactor physics and reactor operation in general as well as outreach activities that have been developed in recent years.

Linking quality supervisory support to turnover intentions among rural healthcare professionals: The mediating role of performance appraisal satisfaction and moderating role of perceived organizational support

This study examines the relationships among quality supervision, performance appraisal satisfaction, and employee turnover. It explores the moderating role of perceived organizational support in these relationships within the context of rural healthcare. Data for this study were obtained from an online survey of employees from a large rural health facility in the Southeastern United States. Hypothesized relationships were examined using regression-based moderated mediation analysis. The empirical results suggest a negative relationship between the quality of supervisory support and turnover intentions, mediated partially by employees’ performance appraisal satisfaction. The indirect effect of quality supervisory support on turnover intention and the direct effect of performance appraisal satisfaction on turnover were also found to be moderated by perceived organizational support. Understanding factors that drive employee retention can help inform effective managerial practices and interventions for reducing turnover. Our study contributes to practice and the existing literature by examining the boundary conditions of perceived organizational support on the direct and indirect association between quality supervisory support and turnover intentions via performance appraisal satisfaction.

The EPICS control system for IsoDAR

Many large accelerator facilities have adopted the open-source EPICS software as the quasi-industry standard for control systems. They typically have access to their own electronics laboratory and dedicated personnel for control system development. On the other hand, small laboratories, many based at universities, use commercial software like LabView, or entirely homebrewed systems. These often become cumbersome when the number of controlled devices increases over time. Here we present a control system setup, based on a combination of EPICS, React Automation Studio, and our own drivers for electronics available to smaller laboratories – such as Arduinos – that is flexible, modular, and robust. It allows small laboratories, working with off-the-shelf modular electronics, power supplies, and other devices to quickly set up a control system without a large facility overhead, while retaining maximum compatibility and upgradeability. We demonstrate our setup for the MIST-1 ion source experiment at MIT. This control system will later be used to serve the entire IsoDAR accelerator complex and, as such, must be easily expandable.

Experiments on large-scale structures in fully developed turbulent pipe flow

The experimental results reported in present paper represent contributions from the Cottbus large pipe facility to DFG-priority program SPP 1881: Turbulent Superstructures. Fundamental questions regarding turbulence statistics and structures in fully developed turbulent pipe flow were addressed, utilizing thermal and optical measuring techniques integrated into the pipe facility. The facility enables unique in-situ calibration for the hot-wire probe and it has full optical access that allows performing Particle Image Velocimetry and 3D Lagrangian Particle Tracking measurements, resulting in consistent and accurate pipe flow data. A streamwise-spanwise field of view up to ≈20×2 pipe radii has been set for both optical techniques with 4–8 high resolution cameras for a friction Reynolds number range of 8⋅102≤R+≤18⋅103. The setup enabled field of measurements with an unprecedented dynamic range in turbulent pipe flow at high Reynolds numbers with spatial resolution better than 1 vector/mm. Proper Orthogonal Decomposition and Shake-The-Box algorithm were used, highlighting energy contents of the large-scale motions in fully developed turbulent pipe flow regime.

Assessment of medium and long term scenarios for the electrical autonomy in island territories: The Reunion Island case study

Island territories, due to their specific energy context, are at the forefront of energy transition studies with the aim of achieving energy autonomy. This is the case of Reunion Island, where the electricity mix is currently 70% carbon-based and where imports provide 80% of the energy consumption. In this context, this article assesses the facilities to install in the medium and long term to progressively reduce energy imports. Several scenarios of installed power generation capacities are studied for 2030 and 2050, associated with two scenarios for electricity consumption. Simulations are performed according these scenarios in order to define the electricity mix and the investments in new batteries and in the electricity transmission network reinforcement. For 2030, results show that a reduction in consumption compared with the trend could enable reduce costs and environmental impacts. For 2050, investments in new electricity generation technologies are essential to meet the needs of a 100% electrified vehicle fleet. If the overall consumption does not follow an energy demand management plan, all the energy sources on the island will have to be exploited to their maximum. The energy transition will also require large storage facilities and little reinforcement in the current electricity high voltage network.

Значение железной дороги Оренбург – Ташкент для социально-экономического развития Туркестанского края

Introduction. The article is devoted to the analysis of the significance of the Orenburg – Tashkent railway in the socio-economic life of the Turkestan region. This railway line is considered as a mechanism that opened the way for the entry of the region into capitalist relations. The purpose of the work is to define the impact of socio-economic changes resulting from the construction of the railway on the development of the region. Methods and materials. The research is based on the principles of objectivism and historicism, which reject dogmas and concepts and do not align with any political ideology. As a result of working with republican and regional archival funds, the authors introduced new statistical data concerning the construction and operation of the railway into scientific circulation. Analysis. Among other regions of the empire, Turkestan is distinguished by its geographical and socio-economic character. There is a reason to believe that before the construction of the railway, there were no cities in this region where large production facilities were concentrated. The vast majority of residents led a semi-nomadic lifestyle. It was difficult for the peasants to get their goods transported to other consumer environments. It can be argued that this development trend has changed dramatically with the construction of this railway. Due to the activity of the railway, the export-import potential of the region has increased. Turkestan has received ample opportunities to export salt, cotton, santonin, wool, and various types of dried fruits. Results. As a result of the research work, a peculiar approach to the factors that contributed to the construction of the Orenburg – Tashkent railway was revealed. As one of them, it is concluded that the factor of the construction of the highway was carried out not because of competition between the British and Russian Empires (as noted in many studies), but with the aim of involving an isolated part of the empire in integration processes. In general, the railway line had a significant impact on the transition of the region from old feudal relations to a partial agrarian-industrial form. Authors’ contribution. Y.K. Omarbayev is the author and organizer of the idea of implementing this scientific work. He outlined the purpose and objectives of the article. G.T. Zhoraeva, was engaged in the collection, classification, and analysis of archival documents that make up the main source base of the article. In addition, under her leadership, a comparative analysis of scientific papers devoted to the construction and commissioning of the Orenburg – Tashkent railway was carried out. The author classified the available scientific publications by historical periods and sought to determine their historical and ideological directions. A.A. Nurmukhambetov worked with historical facts and photo documents within the framework of the topic and conducted a comparative analysis of differences between the statistical data reflected in other publications on the history of the construction of the Orenburg – Tashkent railway.

High average power ultrafast laser technologies for driving future advanced accelerators

Large scale laser facilities are needed to advance the energy frontier in high energy physics and accelerator physics. Laser plasma accelerators are core to advanced accelerator concepts aimed at reaching TeV electron electron colliders. In these facilities, intense laser pulses drive plasmas and are used to accelerate electrons to high energies in remarkably short distances. A laser plasma accelerator could in principle reach high energies with an accelerating length that is 1000 times shorter than in conventional RF based accelerators. Notionally, laser driven particle beam energies could scale beyond state of the art conventional accelerators. LPAs have produced multi GeV electron beams in about 20 cm with relative energy spread of about 2 percent, supported by highly developed laser technology. This validates key elements of the US DOE strategy for such accelerators to enable future colliders but extending best results to date to a TeV collider will require lasers with higher average power. While the per pulse energies envisioned for laser driven colliders are achievable with current lasers, low laser repetition rates limit potential collider luminosity. Applications will require rates of kHz to tens of kHz at Joules of energy and high efficiency, and a collider would require about 100 such stages, a leap from current Hz class LPAs. This represents a challenging 1000 fold increase in laser repetition rates beyond current state of the art. This whitepaper describes current research and outlook for candidate laser systems as well as the accompanying broadband and high damage threshold optics needed for driving future advanced accelerators.

Density-extrapolation Global Variance Reduction (DeGVR) method for large-scale radiation field calculation

The lack of a universal and effective Global Variance Reduction (GVR) method for the deep-penetration Monte Carlo calculation makes it difficult or impossible to calculate the radiation field of large nuclear facilities. We propose a Density-extrapolation Global Variance Reduction (DeGVR) method for the large-scale radiation field calculation. After reducing the density of all materials to avoid the deep penetration problem, two global flux distributions of the two different material densities are obtained with two fixed-source calculations, and then the global flux distribution of the original material density is obtained by extrapolating the two global flux distributions. The global flux distribution of the original material density is then used for global variance reduction. In a large-scale model with a flux attenuation of 1080, the DeGVR method only takes 40.3 minutes to build the radiation field, improves the Average Figure-of-Merit (AV.FOM) up to 85652 times and the counting rate per time (CRPT) up to 88107 times compared with the standard Monte Carlo method. In addition to the high efficiency, the DeGVR method has high universality and robustness because it constructs the global information in a clever way that does not rely on the complex mathematical derivation and geometric modeling. The DeGVR method shows excellent application potential in large-scale radiation analysis.

Formation of biosafety and greening of the production environment of food production with application of anolyte

Introduction: Electrochemically activated aqueous solutions are widely used in medical institutions, animal husbandry, as well as in large food processing facilities. This work presents a literature review on the use of electrochemically activated solutions in the food industry. These solutions can be used as a safe means for processing food raw materials, equipment, food containers, and surfaces of foodservice facilities. The question of using activated aqueous solutions in relation to foodservice establishments is not fully explored in the scientific literature.Purpose: The aim of the research is to study the possibility of using electrochemically activated aqueous solutions as safe and environmentally friendly means for treating objects in the production environment to eliminate the risk of contamination by microorganisms.Materials and Methods: Surfaces of the production environment were selected as the objects of study, including a table, scales, a knife, a slicer, and a gastronorm container. Sweet pepper fruits of the "Avangard" variety were chosen as non-heat-treated food products. An electrochemically activated aqueous solution of chlorine dioxide and hydrogen peroxide compounds with a concentration of active substances of 0.5 ± 0.05 g/L (Anolyte ANK-SUPER) was chosen as the treatment agent. Microbiological studies were conducted using XLD Agar medium and petrifilms. To assess the effectiveness of treatment, microbiological studies were conducted with the determination of Coliform Bacteria (BGKP) and Mesophilic Aerobic and Facultative Anaerobic Microorganisms (KMAFAnM). To achieve acceptable microorganism counts for counting purposes, the tenfold dilution method was used. The residual active chlorine concentration was determined using the iodometric method to determine the actual concentrations of working solutions.Results: The use of undiluted disinfectant with a concentration of 0.5 ± 0.05 g/L confirmed the effectiveness of electrochemically activated solutions against Coliform Bacteria (BGKP), with a significant reduction in the content of Mesophilic Aerobic and Facultative Anaerobic Microorganisms (KMAFAnM) compared to control samples. However, the results of the experiments suggest that parameter selection is required, specifically the concentration of the disinfectant and the duration of treatment depending on the object. The data obtained from preliminary experiments characterize the potential use of reduced concentrations of the working solution (no less than 0.05 ± 0.005 g/L of active chlorine), but do not confirm the possibility of full-scale application of the used concentrations due to the lack of quantitative data on the degree of contamination of the initial surfaces. The possibility of using the solutions as a single agent for treating both working surfaces and fruit and vegetable products has been demonstrated.Conclusion: As a result of the conducted research, the effectiveness of disinfectants based on electrochemically activated solutions against Escherichia coli bacteria (BGKP) and the reduction of Mesophilic Aerobic and Facultative Anaerobic Microorganisms (KMAFAnM) has been confirmed. In addition, among the possible prospects for research, determining the minimum concentrations and contact times for achieving stable disinfecting effects can be mentioned. The results obtained showed that the use of electrochemically activated solutions ensured the biological safety of treated production objects and surfaces of thermally untreated food products. An alternative method of using electrochemically activated solutions as a universal environmentally friendly agent has been proposed. Thus, in foodservice establishments, an effective "green" technology based on electrochemically activated solutions can be implemented.

Assessing Clinical Utility ofPharmacogenetic Testing inthe Military Health System.

Response to medications can differ widely among individual patients. Adverse drug reactions can lead to serious morbidity and mortality. Pharmacogenetic (PGx) testing can predict responses to medications and increased risks of adverse events where the genetic basis is understood. Several published manuscripts suggest positive impacts of systematic preemptive PGx testing. However, few studies have been conducted on PGx implementation in the Military Health System (MHS). A cross-sectional study of adult beneficiaries in a primary care clinic at a large military treatment facility was conducted in 2022. Participants underwent PGx genotyping of CYP2C19 and CYP2D6 genes at the Defense Health Agency Genetics Reference Laboratory. Participant medication lists were compared to the current Clinical Pharmacogenetic Implementation Consortium (CPIC) PGx gene-drug guidelines to assess potential actionability of these results. Genotyping of CYP2C19 and CYP2D6 in 165 MHS beneficiaries (mean age: 65 years) revealed that 81.2% of participants had at least one abnormal PGx finding. Among those with an abnormal PGx result, 65% were taking a medication listed on the CPIC website with an association with the particular gene in which the finding was identified. In addition, 78% of all of the participants in the study were taking at least one medication that is metabolized by CYP2C19 or CYP2D6 with associated CPIC guidelines. Pharmacogenetic testing for CYP2C19 and CYP2D6 identified a substantial proportion of MHS patients at a single center who could benefit from evaluation of current medication regimens based on the CPIC guidelines. Individualized medical management may be warranted to a greater degree than previously recognized based on the findings given possible differences in medication metabolism. Many MHS beneficiaries already take medications metabolized by CYP2C19 and CYP2D6, and a substantial proportion may be at risk for preventable adverse events for medications metabolized by these enzymes. While preliminary, a large number of actionable polymorphisms among a relatively small set of individuals taking at-risk medications suggest that implementing PGx testing in clinical practice may be beneficial in the MHS with appropriate clinical infrastructure.