Amplifiers based on two-photon decay channels of inverted metastable species are examined from a rate-equation and practical-feasibility viewpoint. Approximate analytical solutions, within the rate-equation approximation, predict that resonant parametric generation coupled with anti-Stokes-stimulated Raman scattering (ASRS) is a strong competitor to straight two-photon emission. Expressions for initial growth rates indicate that large linear chromatic dispersion, proper linear absorptions, and resonant enhancements can initially favor two-photon emission, but that ASRS will ultimately dominate in most practical situations if inversion depletion does not occur early. For an amplifier based on degenerate two-photon processes, this situation has led to the proposal of running the system as an odd-harmonic generator, first extracting energy via two-photon emission followed by greater-than-100% conversion to the third, fifth, seventh, etc., harmonics. This type of amplifier response has important potential applications for laser-induced thermonuclear fusion as well as for the production of coherent vacuum-uv soft-x-ray systems. An examination of practical constraints provides further analytical relationships between various physical properties of prospective metastable species. Combining these results, several two-photon schemes are pointed out. Based on current technology, atomic iodine, which is inverted to the $^{2}P_{\frac{1}{2}}$ state, appears to be the best medium for experiments, but other materials, such as atomic oxygen, show greater promise if absolute population inversions of high-density material are created at high efficiency.
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