Comet 46P/Wirtanen, prime target of ESA's ROSETTA mission, was successfully observed at the Very Large Telescope Observatory in Chile: on 17 May 1999 with the Test Camera at the Cassegrain focus of the 8.2-m VLT Kueyen telescope and on 8 December 2001 with FORS1 at Unit Telescope 4 Yepun. May 1999: no coma was detected at heliocentric distance r = 4.98 AU. From the measured brightness in the Bessell R-filter, a mean nucleus radius of 555 ′ 40 m is derived (for a geometric albedo of 0.04 and a phase darkening of 0.04 mag/deg). The nucleus signal varies during the 2.7 h observing interval and a peak-to-peak amplitude of ∼0.38 mag is determined. The measured lightcurve is in agreement with a rotation period of 6-7.5 hours and a ratio of the main nucleus axes of at least 1.4. The non-detection of a coma allows one to put an approximate upper limit for Afp of <0.45 cm (suggesting a dust production rate of 0.05 kg/s). December 2001: a weak and condensed coma seems to be present in the seeing disk of the comet at 2.9 AU inbound, causing a higher brightness than expected from the previous size estimates of the nucleus. The colour of the comet appears very red (V - R spectral gradient ∼47%/100 nm). The Afp value of the comet was 6.5 ′ 2 cm (equivalent to a dust production rate of about 1 kg/s).