Cold-formed steel (CFS) framed buildings are becoming increasingly common, notably in the high seismic regions of the United States (US). However, research to understand the seismic performance of CFS-framed buildings specifically using large-scale (building-level) specimens has begun only recently. Therefore, efforts to validate and improve numerical modeling of whole building systems have been limited due to this lack of experimental data. A recently completed experimental program, conducted at the Large High-Performance Outdoor Shake Table at the University of California, San Diego, involved earthquake testing of a full-scale 6-story CFS-framed building. The test building adopted an assembly of continuous tie-rod and built-up compression stud pack at the ends of individual shear walls to resist seismic overturning moment and uplift forces within the building. The objective of this paper is to present a practice-oriented phenomenological finite element modeling approach intended for design engineers and compare the predictions from this model against the measured seismic response of the 6-story building. The model aims to provide a robust, yet computationally efficient approach, with minimal degrees-of-freedom, while also capturing the salient features of seismic response of mid-rise CFS-framed buildings suitable for nonlinear time history analyses-based design. The building model, developed within the OpenSeesPy finite element platform, includes the shear walls and gravity walls as well as the lateral strength and stiffness contribution from exterior and interior gypsum sheathing. The continuous tie-rod system is also modeled to capture the cumulative floor displacements caused by the axial elongation in the steel rods. The effect of built-up compression stud packs on the lateral behavior of a shear wall was estimated using available experimental data and a detailed numerical model of an isolated shear wall, then subsequently incorporated in the nonlinear hysteretic material model. The numerical model captured the natural frequencies of the translation modes of the building in its undamaged state with <3% error. It also predicted the peak roof drift ratio within an error of 0.03% drift ratio under the design earthquake event. These results provide confidence in the proposed numerical modeling approach as a tool for seismic response prediction of mid-rise CFS-framed buildings with similar structural detailing features.