Consuming leafy vegetables with excessive thiophanate-methyl (TM) residue poses serious risks to human health. To realize rapidly and sensitively detecting TM in leafy vegetables, we developed a fluorescent probe based on zeolitic imidazolate framework-8-modified carbon dots using Hami melon as the green precursor (HM-CDs@ZIF-8). Meanwhile, the mechanism of HM-CDs@ZIF-8 for detecting TM was investigated and explained. The results of the performance tests showed that the prepared HM-CDs@ZIF-8 exhibited high sensitivity, excellent selectivity, robust anti-interference capability, reliable reproducibility and repeatability, and long-term stability. After optimization experiments, the fluorescence intensity of HM-CDs@ZIF-8 showed a strong linear correlation with the concentration of TM (0.00171–3.4239 mol/L) with a detection limit of 2.025 μmol/L. The HM-CDs@ZIF-8 was successfully applied to determine TM in spiked leafy vegetables with satisfactory recoveries of 96–105%. The relative standard deviations were in the range of 0.26–2.55%. The sensor has a promising application for detecting TM in leafy vegetables.