Wind loads play an important role in the design and construction of long-span bridges, especially for that built in mountain valley, and wind characteristics in mountain terrain are still unclear. To further understand the wind characteristics at a bridge site in a mountain valley, large eddy simulations were employed to comprehensively study the wind characteristics at the bridge site in an L-shaped canyon. Different wind directions consisting of 0°, 45°, 90°, 135°, 180°, 225°, 270°, and 315° were considered, and the wind characteristics on the main girder and towers, as well as the flow field, were comprehensively investigated. The results indicate that the mean and fluctuating wind characteristics are significantly different from those specified in the relevant specifications, and it is inappropriate to apply the specifications directly to mountainous terrain. When wind flows along a channel, it leads to a large wind speed amplification factor, strong non-Gaussianity, and large kurtosis and skewness. The steeper the slope of the mountain, the stronger the non-Gaussianity of the fluctuating wind. The coherence function remains nearly unchanged when the distance between the two points is constant, regardless of the location. The wind characteristics at the main girder and towers are so different that they should be considered separately and taken into account in engineering practice. This study provides a reference for the wind-resistant design of bridges and structures built on mountainous terrains.