Large-scale Mass Production Research Articles

Mass-Producible Transparent Flexible Passive-Cooling Film.

Passive cooling is regarded as the desired method for interior temperature regulation due to its advantage of energy consumption reduction. An ideal passive-cooling window is expected to exhibit a high emissivity in the mid-infrared (MIR, 8-13 μm) spectral range for cooling and a low transmittance in the near-infrared (NIR, 780-2100 nm) spectral range for reducing heat flow, while presenting a high transmittance in the visible (VIS, 400-780 nm) spectral range for daylighting. However, material structures that meet these requirements often come with high demands for precision in manufacturing and elevated processing costs, which have limited their potential for large-scale mass production. Here, we propose a mass-producible transparent flexible passive-cooling film that is relatively easy to process and low-cost and meets all of the requirements mentioned above. The film is made of poly(methyl methacrylate) mixed with Cs0.33WO3 nanoparticles, and it shows a high absorptance (80%) in NIR for blocking solar radiation penetration and a high emissivity (93%) in MIR for radiative cooling as well as a reasonable transmittance (40%) in VIS for visibility. Under solar intensity of ∼900 W/m2, a maximum temperature reduction of 8.4 and 7.8 °C has been achieved for a window coated by the film compared to the uncoated window in the condition of the absorbing chamber and car, respectively. Such a mass-producible transparent flexible passive-cooling film holds promising applications in large windows, such as those used in automobiles and buildings, where there is a high demand for both daylighting and cooling.

Isolation, purification, and structural elucidation of a water-soluble polysaccharide derived from Phellinus baumii Pilát mycelia

This study involved the successful production of mycelial polysaccharides by optimizing submerged culture conditions of Phellinus baumii Pilát. Then, the investigation focused on the composition and chemical structure of the water-soluble polysaccharide from P. baumii Pilát mycelia (PBMP) by extraction and purification. Specifically, this study indicated that a water-soluble PBMP fraction 1 (PBMP1) was isolated from PBMP. Moreover, this study discovered a PBMP1 isolated from PBMP, which was found to have the monosaccharide compositions comprised of fucose (Fuc), glucose (Glc), and galactose (Gal) despite the absence of proteins. Subsequently, the composition and structure of PBMP1 were characterized using Fourier transform infrared (FT-IR) spectroscopy, periodate oxidation, Smith degradation, methylation reaction, gas chromatography-mass spectrometer (GC-MS), and Nuclear magnetic resonance (NMR). The composition and structure of PBMP1 were characterized in this study, revealing an α-glycosidic bond conformational linkage with 1,4-Glc residues and 1,6-Gal residues forming the backbone. Additionally, a highly branched hetero-polysaccharide was identified with a non-reducing terminus of Fuc containing 1,3,4- and 1,4,6-Glc branching. The findings of this study offer valuable insights and information that can be utilized by researchers, manufacturers, and other stakeholders to advance the field of P. baumii Pilát product development. Moreover, these results have significant implications for future large-scale mass production and functional applications of PBMP1 products.

Enhanced corrosion protection of steel strip through advanced Zn–Mg alloy coatings manufactured by Continuous Physical Vapor Deposition: A review

The growing global consensus on the “carbon peak and neutrality” has focused on high-strength steel, highlighting its critical role in enhancing energy efficiency, reducing emissions in the steel industry, and reducing the weight of automobiles. Traditional Electro-Galvanizing (EG) and Hot-Dip Galvanizing (HDG) technologies face challenges in meeting the surface protection demands of these applications. This limitation is evident with the development of Zn–Mg coated strip steel, which offers high corrosion resistance. Continuous Physical Vapor Deposition (CPVD) effectively addresses these issues in a sealed vacuum environment, drawing significant attention in the strip coating industry owing to its superior surface quality, diverse material options, and environmental advantages. This article reviews the latest advancements and current status of Zn–Mg alloy coatings prepared using the CPVD technology. It discusses the typical thermal evaporation process used in CPVD, traces the development history of CPVD coatings on strip steel, and examines the microstructure, corrosion resistance, and adhesion performance evolution mechanisms of Zn–Mg alloy coatings. By designing multilayer structures, adjusting the Mg composition, and implementing controllable heat treatments, the overall performance of the coatings is enhanced. This study also comprehensively analyzes the feasibility of applying multilayer, highly corrosion-resistant Zn–Mg coatings. Additionally, it identifies the main challenges in applying CPVD technology to Zn–Mg coatings on strip steel, such as the large-scale, stable, and low-cost mass production of typical processes and controlling the void content at multilayer interfaces. Finally, future research directions are anticipated, underscoring the potentially significant impact of further alloying and computer simulations in advancing steel surface treatments.

Simultaneous DHA and organic selenium production by Schizochytrium sp.: a theoretical basis

Docosahexaenoic acid (DHA) and selenium (Se) are nutrients that confer several health benefits to both humans and animals. Widespread use of DHA in milk powder and health products requires large-scale mass production via Schizochytrium sp., while Se intended for human consumption is produced as organic Se via yeast. However, producing these nutrients on an industrial scale is constrained by various factors. We found that supplementing Schizochytrium sp. with Na2SeO3 (0.5 mg/L) improves its biomass and DHA production and also provides organic Se. De novo assembled transcriptome and biochemical indicators showed that Na2SeO3 promotes forming acetyl coenzyme A and L-cysteine via the glycerol kinase and cysteine synthase pathways, promoting DHA synthesis through the polyketide synthase pathway. However, high doses of Na2SeO3 (5 mg/L) limited the biomass of Schizochytrium sp. and DHA content. This study provided a theoretical basis for the simultaneous production of organic Se and DHA via Schizochytrium sp.

Highly tunable and ultrasensitive hybrid plasmonic platform for multi-spectral sensing: Non-invasive diabetes surveillance and global warming directives

The development of tunable and extremely sensitive devices, as well as the emergence of metamaterials, has tremendously aided the evolution of plasmonic sensing technologies. However, the natural property of metamaterials severely restricts the scalability and application potential of mono-functional sensor systems. To address this shortcoming, we have investigated an ultranarrow five-band plasmonic sensor with structural tunability and high sensing behaviors in compatibility with multi-purpose application scenarios, using the finite-difference time-domain approach rigorously. Meanwhile, we theoretically formulated a hybridization model for the mutual induction of Fabry–Pérot resonances and localized surface plasmon polariton resonance, providing a theoretical basis for the utilization and conception of the highly-sensitive tunable plasmonic sensor. Most notably, we discovered and interpreted far-field phase extinction inducing separation of polarization resonance peaks in physical mechanisms. The tunability of its mutual inductance effect at the intersection distances from two-intersecting silver nanogroove was adequately exploited to further validate and effectively attain five ultra-narrow absorptivities of 96.70%, 93.93%, 99.73%, 100.00%, and 89.72% by top-level optimization. In addition, the redundant proximity between nearby peaks is compensated, extending the operating band and enhancing the practicability in multi-purpose scenarios. As a reliable source for future optical sensing, it performs well in the visible to near-infrared region, enabling detection response to non-invasive diabetes mellitus, global climate warming, and unrestricted temperature and pressure measurement. Meanwhile, minimum FWHM = 4.806 nm and maximum FOM = 115.13 RIU−1 are obtained at 293.15 K, with an associated highest sensitivity of 557.93 nm/RIU. Moreover, the fabrication technologies development of electron beam lithography and focused ion beam etching technologies enables large-scale mass production at low cost and long-term stability.

A global perspective of entomopathogens as microbial biocontrol agents of insect pests

The growing global population has created a significant demand for both quality and quantity of agricultural products, resulting in a significant increase in the use of agrochemicals such as chemical pesticides to counter insect pests. Consumers, on the other hand, have grown increasingly concerned in recent years about the adverse effects of chemical insecticides on human health and the environment. As a result, researchers worldwide have been compelled to conduct research into alternative crop protection solutions. Biological control through entomopathogens has gained prominence among these alternatives, and several microbial biocontrol agents, including baculoviruses, Bacillus , Beauveria , Steinernema , and Heterorhabditis species, have been tested. Microbial biopesticide products are currently being used to combat specific insects that harm crops. The modes of action of entomopathogens, their advantages and constraints are discussed. An overview of processes for their development are highlighted with examples, as well as the issues that impede their development. Finally, special attention was paid to the gaps identified in this sector and the factors limiting their application particularly with respect to market potential. The future potential of entomopathogens may be affected by changing agricultural systems. • Entomopathogens have great potential in controlling insect pest populations in agroecosystems. • Commercial application of a microbial biopesticide necessitates large-scale mass production, formulation with appropriate additives to increase the product's shelf-life, and storage. • Stringent regulatory framework due to biosafety or environmental concerns raises overall costs and delays microbial biopesticide commercialization. • Additional regulatory challenges will be required for the new microbial biopesticide products in order to define low-risk contenders for easy commercialization and free market entry.

SiO2 Nanoparticles as New Repairing Treatments toward the Pietraforte Sandstone in Florence Renaissance Buildings

In this work, the consolidation efficiency of SiO2 nanoparticles (synthesized in the Chemistry laboratories at the Tor Vergata University of Roma) was tested on Pietraforte sandstone surfaces belonging to the bell tower of San Lorenzo (Florence, Italy) and was fully investigated. Nanoparticles (synthesized in large-scale mass production) have been characterized by XRD—X-Ray Diffraction; Raman and FTIR—Fourier Transform Infrared spectroscopy; SEM—Scanning Electron Microscopy; while the Pietraforte sandstone morphology was examined by Porosimetry, capillary absorption test, surface hardness test, drilling resistance and tensile strength. The colorimetric measurements were also performed to characterize the optical modification exhibited by Pietraforte sandstones, especially after the SiO2 treatments. Our results show that applying to the Pietraforte, the new consolidating agent based on SiO2 nanoparticles, has several advantages, as they are more resistant to perforation, wear, and abrasion even long range (for long times of exposure and consolidating exercise against Florentine sandstone), compared to the CaCO3 nanoparticles (tested in our previous paper), which instead show excellent performance but only close to their first application. This means that over time, their resistance to drilling decreases, they wear much more easily (compared to SiO2-treated sandstone), and tend to exhibit quite a significant surface abrasion phenomena. The experimental results highlight that the SiO2 consolidation efficiency on this kind of Florentine Pietraforte sandstone (having low porosity and a specific calcitic texture) seems to be higher in terms of water penetration protection, superficial cohesion forces, and an increase in surface resistance. Comparing the performance of SiO2 nanoparticles with commercial consolidants in solvents such as Estel 1000 (tested here), we demonstrate that: (A) the restorative effects are obtained with a consolidation time over one week, significantly shorter when compared to the times of Estel 1000, exceeding 21 days; (B) SiO2 nanoparticles perform better than Estel 1000 in terms of cohesion forces, also ensuring excellent preservation of the optical and color properties of the parent rock (without altering it after application).

Molecular design for all-in-one self-assembled donor–acceptor organic solar cells

The stability of organic solar cells still remains one of the main challenges to make this technology suitable for large scale mass production. The stability of the morphology is one main degradation channel in currently used bulk heterojunction systems. We introduce three different all-in-one donor–acceptor amphiphilic triads and perform molecular dynamics simulations in order investigate the stacking of the donor and acceptor sub-molecules after performing a simulated annealing step. We show that the molecular volume of each sub-molecule of the triad plays an important role for the stability of the π -stacking within the bilayer sheet. Further, we found that TIPS-pentacene and TIPS-tetraazapentacene sub-molecules serving as donor and acceptor, respectively, keep their crystalline nature in the bilayer sheet. Thus, by such a system, charge carrier mobilities in the range of 1 cm 2 /Vs should be possible, which is three orders of magnitude higher compared to measured mobilities in existing highly efficient organic solar cells. Therefore, by this approach not only the stability can be increased, but also the fill factor and therefore the power conversion efficiency can be improved. • Design rules for an ideal donor–acceptor morphology based on bilayer sheets. • Molecular proposal for all-in-one donor–acceptor molecules. • Improve stability and power conversion efficiency by stable donor–acceptor heterojunctions.

Temperature-controlled slot-die coating for efficient and stable perovskite solar cells

Currently, the main challenge in the field of perovskite solar cells (PSCs) is to transform lab-scale into industry-related processes for commercialization; however, most of the scalable fabrication has employed many processing treatments, which are incompatible with large-scale mass production. Hence, for the purpose of simple and useful scaled-perovskite film processing, the hot slot-die coating method is presented. This technique releases a hot solution through a hot slot-die head and deposits it onto a hot substrate. The temperature-controlled head and bed can have a significant impact on the perovskite morphology and device performance, and at optimal processing temperatures (head: 75 °C, bed 150 °C), the hot slot-die device shows a high power conversion efficiency (PCE) of 17.05% without other processing treatments. In addition, the optimum condition was employed to fabricate the scaled device, having a comparable PCE of 14.61%, which comes close to the cell efficiency prepared by the spin-coating method. This hot slot-die coating approach can provide a simple and useful way to fabricate the perovskite film to achieve highly efficient and reliable PSCs and acceptable potential for industrial uses.

CuFSDAF: An Enhanced Flexible Spatiotemporal Data Fusion Algorithm Parallelized Using Graphics Processing Units

Spatiotemporal data fusion is a cost-effective way to produce remote sensing images with high spatial and temporal resolutions using multisource images. Using spectral unmixing analysis and spatial interpolation, the flexible spatiotemporal data fusion (FSDAF) algorithm is suitable for heterogeneous landscapes and capable of capturing abrupt land-cover changes. However, the extensive computational complexity of FSDAF prevents its use in large-scale applications and mass production. Besides, the domain decomposition strategy of FSDAF causes accuracy loss at the edges of subdomains due to the insufficient consideration of edge effects. In this study, an enhanced FSDAF (cuFSDAF) is proposed to address these problems, and includes three main improvements. First, the TPS interpolator is replaced by an accelerated inverse distance weighted (IDW) interpolator to reduce computational complexity. Second, the algorithm is parallelized based on the compute unified device architecture (CUDA), a widely used parallel computing framework for graphics processing units (GPUs). Third, an adaptive domain decomposition (ADD) method is proposed to improve the fusion accuracy at the edges of subdomains and to enable GPUs with varying computing capacities to deal with datasets of any size. Experiments showed while obtaining similar accuracies to FSDAF and an up-to-date deep-learning-based method, cuFSDAF reduced the computing time significantly and achieved speed-ups of 140.3&#x2013;182.2 over the original FSDAF program. cuFSDAF is capable of efficiently producing fused images with both high spatial and temporal resolutions to support applications for large-scale and long-term land surface dynamics. Source code and test data available at <uri>https://github.com/HPSCIL/cuFSDAF</uri>.

Design of high friction elastic surface double eccentric wheel self-clamping structure and unlocking mechanism

Discussed The eccentric-wheel clamping mechanism which used for clamping workpieces in industry, how to use the design method with double eccentric wheel self-clamping mechanism for civil life, and through this method to designed and realized a small clamping device which can be used for desktop or wall hanging. After extensive measurements for the practical use of mug drainage, the effectiveness of the design method discussed in this article is verified. It has been proved that even if the volume is not more than 85 * 85 * 40mm, it is possible to use a double eccentric wheel clamping mechanism to achieve a long time (&gt;72 hours) can be effectively fixed. And can be achieved at low cost using ordinary 3D printing materials (PLA) and adhesive tape, etc., with the potential for large-scale mass production. In addition, through this example, it is also shown that pure mechanical equipment still has great practical significance in some long-term, low-energy consumption applications, and has the value of further in-depth exploration and development.

A Secure Block Chain Based Contract Manufacturing System for Pharma Industries Using Imperative Ant Loop Optimization Algorithm

Manufacturers that work under contract for another firm may make their goods under their own brand or label. Using their own or their clients' designs, formulas, and needs as a guide, contract manufacturers perform this service. The pharmaceutical industry relies heavily on contract manufacturing. Due to a lack of capital, some companies are unable to obtain the required equipment for large-scale mass production of certain chemicals. In order to create the final product, they can work with a third-party chemical manufacturer to obtain the necessary chemicals and combine them with their own resources. An organization should carefully assess the benefits and drawbacks of contract manufacturing before committing to this strategy. There may be advantages to contract manufacturing, if the company works with the right service provider capable of delivering high-quality products. The contract manufacturing system proposed in this study is a blockchain-based solution for the pharmaceutical business. Initially, the customer uploads the order details that are preprocessed using normalization method. The preprocessed data is authenticated using the crypto smart contracts before being stored in the blockchain ledger. Then the stored data can be encrypted for security purpose by using the triple MD5 algorithm. Finally, the trust of the order data is evaluated using the proposed Imperative Ant loop optimization algorithm. In order to demonstrate the effectiveness of our system, we use the MATLAB simulation programme to compare it to other approaches.

Diet impacts on the biological aspects of pink bollworm, Pectinophora gossypiella (Lepidoptera: Gelechiidae) under controlled laboratory conditions.

Pink bollworm, Pectinophora gossypiella (Lepidoptera: Gelechiidae) is a native pest of Asia and preferably invasion on cotton (Gossypium hirsutum L.) crop as a commendatory host plant. Commercially, G. hirsutum is known as white gold and is an important cash crop all over the globe. Limited studies were published to focus on certain dietary compositions against different cotton pests. Therefore, the present study was undertaken in the laboratory under controlled conditions (temperature: 27 ± 2°C and relative humidity: 60 ± 10%) to determine the impact of three different treatment diets (wheat germ meal, okra, and chickpea) on the biological aspects (lifetime, developmental period) of P. gossypiella. Results revealed that the shortest larval time of P. gossypiella was observed on the okra feed diet while the longest period was recorded on the wheat germ diet. Meanwhile, the pupation delay was noted on the wheat germ diet. The dietary influence was also observed on adult stages of female and male P. gossypiella (43.00 and 37.50 days respectively) and compared with a standard diet (56.50 and 52.50 days respectively). Furthermore, larval weighed more on the okra and chickpea diet followed by the wheat germ diet, whereas highest pupal weight was observed on the standard diet followed by the chickpea diet and okra diet. Developmental parameters were significantly variant across all treatment diets, whereas the higher significant difference was reported on the okra diet. Therefore, the existing data of this study offers fruitful interventions for the future as a modified diet for large-scale and rapid mass production of P. gossypiella larvae.

Atomic Layer Deposition of Ultrathin ZnO Films for Hybrid Window Layers for Cu(Inx,Ga1-x)Se2 Solar Cells.

The efficiency of thin-film chalcogenide solar cells is dependent on their window layer thickness. However, the application of an ultrathin window layer is difficult because of the limited capability of the deposition process. This paper reports the use of atomic layer deposition (ALD) processes for fabrication of thin window layers for Cu(Inx,Ga1−x)Se2 (CIGS) thin-film solar cells, replacing conventional sputtering techniques. We fabricated a viable ultrathin 12 nm window layer on a CdS buffer layer from the uniform conformal coating provided by ALD. CIGS solar cells with an ALD ZnO window layer exhibited superior photovoltaic performances to those of cells with a sputtered intrinsic ZnO (i-ZnO) window layer. The short-circuit current of the former solar cells improved with the reduction in light loss caused by using a thinner ZnO window layer with a wider band gap. Ultrathin uniform A-ZnO window layers also proved more effective than sputtered i-ZnO layers at improving the open-circuit voltage of the CIGS solar cells, because of the additional buffering effect caused by their semiconducting nature. In addition, because of the precise control of the material structure provided by ALD, CIGS solar cells with A-ZnO window layers exhibited a narrow deviation of photovoltaic properties, advantageous for large-scale mass production purposes.

Advances in strain engineering on oxide heteroepitaxy

Advances in strain engineering on oxide heteroepitaxy

Chemical characterization and nutritional value of Spirulina platensis cultivated in natural conditions of Chichaoua region (Morocco)

The aim of the current study was to characterize the phytochemical, phytopigments, and nutritional value of Spirulina platensis produced in Chichoua region of Morocco. A natural medium based on well water-wood ash is used instead of an artificial Zarrouk medium. Several analyses including phytochemical screening and antioxidant activity (DPPH and ABTS) were performed in extracts (methanol, ethanol and acetone) of S. platensis. The phytopigments were analyzed by measuring chlorophylls a and b, carotenoids, and phycobiliproteins. The nutritional composition was evaluated through dry matter, lipids, carbohydrates, crude protein, acidic detergent lignin, neutral detergent fiber, acidic detergent fiber, minerals, and vitamins. The methanolic extract showed the highest phenolic contents (7.00±0.07 mg GAEs/g), flavonoids (1.00±0.011 mg QEs/g), and ABTS•+ free radical scavenging activity (38.35±1.68%). Spirulina platensis produced in the well water-wood ash medium is rich in crude proteins (53.29%), c-phycocyanins (18.25±1.81%), and minerals. It also contains a high vitamin concentrations such as pantothenic acid (B5), niacin (B3), riboflavin (B2), and folic acid (B9). The results confirmed that the cultivation of S. platensis under natural conditions, using well water-wood ash medium increases the amounts of some minerals, c-phycocyanin, and water-soluble vitamins. Furthermore, this medium can be profitable for large-scale mass production of S. platensis with yields similar to that obtained from Zarrouk medium.

The Artisan Economy and the New Spirit of Capitalism

Against the backdrop of deindustrialization and the rise of the service economy, small artisan businesses have been promoted as a liberatory alternative to large-scale enterprise and mass production in the wake of the 2007 global financial crisis. We analyze advice manuals for aspiring artisan entrepreneurs by adapting Boltanski and Chiapello’s (2005) framework and analysis of management textbooks to investigate books for would-be artisan business owners. These texts are “manuals of moral instruction” (58) that offer the reader the promise of a more fulfilling and ethical life through self-employment. We reveal that the artisan economy promoted by these advice manuals represents a further evolution in capitalism’s co-optation of the artistic critique via the oppositional strata of punk and indie youth subcultures—and their style.

Robustness to Large-Scale Mass Production Manufacturing Tolerances by Means of Sensitivity and Statistical Analysis for IPMSMs

This article deals with highlighting some pragmatic approaches for determining the key-parameters that one has to monitor in order not to jeopardize the fulfillment of the customer specifications, due to the tolerances, that occur in large-scale mass production. For that, two parametrization models (symmetric vs. asymmetric) and two types of parameter distributions (uniform vs. normal) are compared when considering lamination, stack assembly and material properties tolerances. Results in different scenarios for both the motor (in open-circuit and under load), and the whole drive (with and without position sensor detection errors) are provided and compared with end-of-line measurements (where available) for a 12-slots 10-poles IPM-type PMSM with fractional slot concentrated winding. After including the effect of the temperature in the full asymmetric model, rather good agreements between calculations and measurements are reported for back-EMF and torque constant. Furthermore, it is shown that the interaction between the uncertainties of the motor parameters and the rest of the drive's components (e.g. position sensor) cause large inaccuracies into the system, and they are hardly predictable by taking the individual deviations separately. Finally, towards the end, attempts are made to reduce the computational and the modeling effort using various techniques and ultimately fitted artificial neural networks (ANNs) as surrogates.

L-cysteine reduced/functionalized graphene oxide application as a smart/control release nanocarrier of sustainable cerium ions for epoxy coating anti-corrosion properties improvement

One of the main limitations for large scale mass production of reduced graphene oxide is the application of some toxic and hazardous reducing agents such as hydrazine and borohydride. In this study, the effectiveness of the l-Cys (HSCH2CH(NH2)CO2H) molecules, as a green amino acid in the GO reduction, as well as its active corrosion inhibition capacity were explored. The l-Cys/GO nanosheets were then modified by trivalent-cerium ions to obtain a nanocarrier with excellent controlled release activity. The electrochemical impedance spectroscopy (EIS) and polarization tests were used to measure the smart corrosion inhibition activity of the cerium modified l-Cys/GO nanocarrier in the saline solution and epoxy coating. The results showed that the cerium ions adsorption on the l-Cys/GO nanosheets obeyed a Langmuir isotherm model. The l-Cys/GO sample showed cerium ions adsorption capacity about 66% higher than the unmodified GO nanosheets. Furthermore, the EIS tests results revealed that in the presence of cerium modified l-Cys/GO nanocarriers the improvement in the corrosion resistance of bare steel in the solution phase and coated sample was about 7.5 times (after 24 h) and 950 times (after 40 days) higher than the blank saline solution and the pure epoxy sample, respectively.

Miniature fiber-optic tip pressure sensor assembled by hydroxide catalysis bonding technology.

A miniature fiber-optic tip Fabry-Perot (FP) pressure sensor with excellent high-temperature survivability, assembled by hydroxide catalysis bonding (HCB) technology, is proposed and experimentally demonstrated. A standard single-mode fiber is fusion spliced to a fused silica hollow tube with an outer diameter (OD) of 125 µm, and a 1-µm-thick circular silicon diaphragm with a diameter slightly larger than the OD is bonded to the other endface of the hollow tube by HCB technology. The ultrathin silicon diaphragm is prepared on a silicon-on-insulator (SOI) wafer produced by microelectromechanical systems (MEMS), providing the capability of large-scale mass production. The HCB technology enables a polymer-free bonding between diaphragm and hollow tube on fiber tip with the obvious advantages of high alignment precision, normal pressure and temperature (NPT) operation, and reliable effectiveness. The static pressure and temperature response of the proposed sensor are discussed. Results show that the sensor has a measurable pressure range of 0∼100 kPa, which is well consistent with the measurement range of biological blood pressure. The pressure sensitivity is up to 2.13 nm/kPa with a resolution of 0.32% (0.32kPa). Besides, the sensor possesses a unique high-temperature resistant capability up to 600 °C, which can easily survive even in high-temperature sterilization processes, and it has a low temperature dependence of 0.09 kPa/°C due to the induced HCB bonding technology and the silicon-based diaphragm. Thus, the proposed fiber tip pressure sensor is desirable for invasive biomedical pressure diagnostics and pressure monitoring in related harsh environments.