The high degree of uncertainty of market conditions, sanctions pressure and the high need for accelerated import substitution of high-tech products requires government authorities to develop solutions aimed at sustainable development of regions in the long term, taking into account national economic interests. It is impossible to ensure sustainable development without creating and regulating a system of state priorities. The consistency of the goals and actions of state governing bodies will allow us to enter a qualitatively new stage of development, preserving national identity. The key tasks facing the domestic economy during the transition to a new technological order are to increase the competitiveness of products, increase the share of high-tech goods and services in gross output, import substitution in all sectors of the economy. The national policy aimed at the implementation of the above-mentioned tasks requires large-scale investments in all areas of production, in increasing innovation activity and professionalism of personnel. For regions acting as independent economic entities, it is particularly relevant to build up innovation potential, attract investment in the process of capitalization of assets, growth of fixed capital, which become indicators of the attractiveness of the region for potential investors. The sustainable development of individual regions, taking into account their industry specifics, territorial features, the state of material, financial, production and human resources, requires detailed approaches to assessing the factors influencing the formation and use of innovative potential. Innovative potential becomes the foundation of sustainable development in conditions of high environmental volatility and a shortage of investment and financial resources caused by geopolitical crises and transformational processes in the global economy. The need to assess the innovative potential of the region as an economic system is due to the requirements of substantiating managerial decisions aimed at its socio-economic development. The result of investment activity is an increase in the economic and social indicators of the region, which is why it is important to comprehensively and comprehensively study the constituent elements of innovation potential, which will create prerequisites for sustainable development of not only regional, but also national policy. In the conditions of technological transition, innovative projects focused on environmental friendliness and reducing the negative impact on nature deserve special attention – green projects, the success of which requires control.