Large-ring Lactones Research Articles

Intramolecular palladium-catalyzed cyclizations of esters containing vinyl triflate and vinylstannane groups at the termini. Synthesis of large ring lactones

Synthese de methylene-8 octahydro-3,4,5,6,7,8,11,12 oxacyclododecinnone-2 par cyclisation de trifluoromesyloxy-7 octene-7oate de tributylstannyl-4 butene-3yle; application a l'obtention de cycles a 13, 14 et 15 chainons a partir des derives d'acides nonene-8-, decene-9- et undecene-10oiques

ChemInform Abstract: Preparation of Medium‐ and Large‐Ring Lactones. SmI2‐Induced Cyclization of ω‐(α‐Bromoacyloxy) Aldehydes.

ChemInform Abstract: Preparation of Medium‐ and Large‐Ring Lactones. SmI₂‐Induced Cyclization of ω‐(α‐Bromoacyloxy) Aldehydes.

Preparation of medium- and large-ring lactones. SmI 2-induced cyclization of ω-(α-bromoacyloxy) aldehydes

ω-Bromoacetoxy- andω-(α:-bromopropionyloxy) aldehydes were cyclized by SmI 2 giving 8- to 14-membered ringβ-hydroxy lactones in excellent yields.

The facile synthesis of a large ring lactone by acid-catalysed cyclisation of an (z)-ene-diyne hydroxy acid precursor.

A Large ring lactone is obtained in good yield by acid catalysed cyclisation of the w-hydroxy acid precursor.

Large-ring lactones by internal ketophosphonate cyclizations

Large-ring lactones by internal ketophosphonate cyclizations

A Rapid Esterification by Means of Mixed Anhydride and Its Application to Large-ring Lactonization

Abstract A rapid and mild esterification method using carboxylic 2,4,6-trichlorobenzoic anhydrides in the presence of 4-dimethylaminopyridine was developed. The method was also successfully applied to the synthesis of large-ring lactones, including Dl-2,4,6-tridemethyl-3-deoxymethynolide.