Periapical disease may occur through an inflammatory response in a non-vital tooth. The treatment of choice for most of these periapical lesions may be a conservative non-surgical approach. An accurate diagnosis of the periapical lesion whether it is of endodontic or nonendodontic origin has to be made. Non- surgical endodontic therapy has shown a success rate of 94.4% with complete or partial healing. The present clinical cases show two large periapical lesions in 14 year and 17-year-old male patients respectively which were healed with non- surgical approaches using different formulations of calcium hydroxide. Healing was seen after few months in both the lesion without invasive treatments. As the first case revealed periapical healing within 2 months of calcium hydroxide placement whereas the second case showed a much slower rate of healing over one year.