The construction of quantum maximum distance separable (abbreviated to MDS) error-correcting codes has become one of the major concerns in quantum coding theory. In this paper, we further generalize the approach developed in the previous paper, and construct several new classes of Hermitian self-orthogonal generalized Reed-Solomon (GRS) codes. By employing these classical MDS codes, we obtain several classes of quantum MDS codes with large minimum distance. It turns out that our quantum MDS codes exhibited here have less constraints on the selection of code length and some of them have not been constructed before, and in some cases, have larger minimum distance than previous literature. Meanwhile, about half of the distance parameters of our codes are greater than q2+1.