Integration of renewable and waste energy sources, decentralisation, electrification and energy storage, are key pillars of energy transition in the district heating sector. Such a strategy can be implemented at the building level using the multi-carrier energy hub concept, which has recently gained popularity. This paper presents a technical and financial feasibility study of a building-integrated multi-carrier energy hub concept. The case study is performed for an existing large medical centre, where demand occurs simultaneously for electricity, cold, and heat at different temperature levels, including hot process water and steam. The central idea is to replace the high-exergy steam with heat from the municipal district heating network. The concept also includes the integration of heating and cooling loads, heat storage and implementation of an on-site photovoltaic (PV) power plant. The key components of the proposed hub technological structure are high-temperature heat pumps. Five alternative structures of the system configuration are examined using an hour-by-hour annual simulation. The results reveal that the proposed multi-carrier energy hub is fully operational. The project is also profitable, which results mainly from significant energy savings compared to the existing heat supply system using high-pressure steam. However, the profitability strongly depends on the system configuration, and the choice of the best option is ambiguous. The system with heat storage reaches the highest net present value (NPV) while the one without the storage results in the highest internal rate of return (IRR) due to significantly lower capital expenditures (CAPEX). In all cases, the project leads to a considerable cumulative CO2 emissions reduction, which is at the level of 1351 up to 2961 tons annually depending on system configuration.