Large Increase Research Articles

Combination Therapy of Cuban Policosanol (Raydel®, 20 mg) and Intensive Exercise for 12 Weeks Resulted in Improvements in Obesity, Hypertension, and Dyslipidemia without a Decrease in Serum Coenzyme Q10: Enhancement of Lipoproteins Quality and Antioxidant Functionality in Obese Participants.

Obesity and overweight, frequently caused by a lack of exercise, are associated with many metabolic diseases, such as hypertension, diabetes, and dyslipidemia. Aerobic exercise effectively increases the high-density lipoproteins-cholesterol (HDL-C) levels and alleviates the triglyceride (TG) levels. The consumption of Cuban policosanol (Raydel®) is also effective in enhancing the HDL-C quantity and HDL functionality to treat dyslipidemia and hypertension. On the other hand, no study has examined the effects of a combination of high-intensity exercise and policosanol consumption in obese subjects to improve metabolic disorders. In the current study, 17 obese subjects (average BMI 30.1 ± 1.1 kg/m2, eight male and nine female) were recruited to participate in a program combining exercise and policosanol (20 mg) consumption for 12 weeks. After completion, their BMI, waist circumference, total fat mass, systolic blood pressure (SBP), and diastolic blood pressure (DBP) reduced significantly up to around -15%, -13%, -33%, -11%, and -13%, respectively. In the serum lipid profile, at Week 12, a significant reduction was observed in the total cholesterol (TC) and triglyceride (TG) levels, up to -17% and -54% from the baseline, respectively. The serum HDL-C was elevated by approximately +12% from the baseline, as well as the percentage of HDL-C in TC, and HDL-C/TC (%), was enhanced by up to +32% at Week 12. The serum coenzyme Q10 (CoQ10) level was increased 1.2-fold from the baseline in all participants at Week 12. In particular, the male participants exhibited a 1.4-fold increase from the baseline. The larger rise in serum CoQ10 was correlated with the larger increase in the serum HDL-C (r = 0.621, p = 0.018). The hepatic function parameters were improved; the serum γ-glutamyl transferase decreased at Week 12 by up to -55% (p < 0.007), while the aspartate aminotransferase and alanine transaminase levels diminished within the normal range. In the lipoprotein level, the extent of oxidation and glycation were reduced significantly with the reduction in TG content. The antioxidant abilities of HDL, such as paraoxonase (PON) and ferric ion reduction ability (FRA), were enhanced significantly by up to 1.8-fold and 1.6-fold at Week 12. The particle size and number of HDL were elevated up to +10% during the 12 weeks, with a remarkable decline in the TG content, glycation extent, and oxidation. The improvements in HDL quality and functionality were linked to the higher survivability of adult zebrafish and their embryos, under the co-presence of carboxymethyllysine (CML), a pro-inflammatory molecule known to cause acute death. In conclusion, 12 weeks of Cuban policosanol (Raydel®, 20 mg) consumption with high-intensity exercise displayed a significant improvement in blood pressure, body fat mass, blood lipid profile without liver damage, CoQ10 metabolism, and renal impairment.

Free vibration analysis of functionally graded carbon nanotubes reinforced double plates

The specific objective of this study is to analyze the dynamics of functionally graded carbon nanotubes (FGCNT) reinforced double plates. Connected via an elastic layer, the plates have simply supported boundary conditions. In the current study, three carbon nanotubes functionally graded patterns, varying in the thickness direction are considered, including uniformly distributed, functionally graded O-pattern, and functionally graded X-pattern. Following the development of the coupled equations of motion using the Hamilton principle while considering the influences of the elastic layer, the equations are subsequently solved utilizing a two-spatial-variable modal decomposition method. For verification purposes, the equations developed are compared to simplified configurations provided in the existing studies. The solution methodology is verified through comparing against numerical results of simplified configurations of plates obtained from the development of the finite element method and existing studies. Both verifications have shown very good agreement. Influences of plates’ dimensions, carbon nanotubes reinforcement, and the stiffness of elastic layer are analyzed and provided in this study. The transverse-motion natural frequencies of the double plates are also identified, and they follow a decreasing trend as the aspect ratio increases for all the cases. The fundamental lateral-motion and axial-motion natural frequency also follows a similar trend as the aspect ratio increases. The reinforcement effect of carbon nanotubes on the transverse-motion natural frequencies is less obvious for thinner plates. An increase in the elastic layer stiffness increases the second series transverse-motion natural frequencies of the double-plate system. Among the considered functionally graded patterns, the functionally graded X-pattern reinforcement provides the largest increase in the transverse-motion natural frequencies.

A STUDY ON SATISFACTION OF INTERNATIONAL STUDENTS IN CHINA

Currently, China has become one of the countries with the largest increase in the number of international students in the world, but the current evaluation of the quality of higher education in China does not focus on the satisfaction of international students in China. Therefore, this study examines the quality of education in China from the perspective of international students. The current situation provides ideas for university development to improve the quality of education for studying abroad in China. Based on the research on student satisfaction and the actual experience of managing international students, the theoretical aspects of international student satisfaction in China were constructed according to five indicators: hardware, teacher qualifications, application achievements, management services, and learning outcomes, and the International Students Program in China was developed accordingly. The satisfaction scale is used to conduct surveys and collect data, and to find out the status quo of international students’ satisfaction in China and its influencing factors. Through descriptive statistics and analysis of variance, the study suggests that the current international students in China are highly satisfied with Chinese education and scholarship, and that the level of knowledge of the Chinese language could significantly affect the satisfaction of international students in China.

Study finds new ADHD prescriptions climbed during pandemic

While new prescription rates for most medications to treat behavioral health conditions were steady during the COVID‐19 pandemic, prescriptions for attention deficit hyperactivity disorder (ADHD) medications rose sharply, a study published last week in JAMA Psychiatry found. The largest increases in ADHD medication prescriptions were among women and people aged 20 to 39, according to an APA Psychiatric News Alert.

Continuous Hydrothermal Carbonization of Olive Pomace and Orange Peels for the Production of Pellets as an Intermediate Energy Carrier

The ever-increasing volumes of food waste generated and the associated environmental issues require the development of new processing methods for these difficult waste streams. One of the technologies that can treat these waste streams directly is hydrothermal carbonization. In this work, olive pomace and orange peels were treated via a mild hydrothermal carbonization process (TORWASH®) in a continuous-flow pilot plant. For olive pomace, a solid yield of 46 wt% and a dry matter content of 58% for the solid press cakes were obtained during continuous operation for 18 days. For orange peels, the values were lower with 31 wt% solid yield and a 42% dry matter content during 28 days of continuous operation. These values corresponded fully with initial laboratory-scale batch experiments, showing the successful transformation from batch to continuous processing. The obtained hydrochar from both feedstocks showed an increase in higher heating value (HHV) and a significant reduction in ash content. Pellets produced from the solids met the requirements for industrial use, demonstrating a large increase in the deformation temperature and a significant reduction in the potassium and chlorine content compared to the original feedstock. These results indicate the excellent potential of these pellets for combustion applications.

Clinic Readiness for Trauma-Informed Health Care Is Associated With Uptake of Screening for Adverse Childhood Experiences.

Adverse childhood experiences (ACEs) are strongly correlated with many of the most common causes of preventable illness, preventable death, and health disparities. In January 2020, California launched the first statewide initiative to integrate ACE screening throughout its Medicaid system. A key element of the initiative was the California ACEs Learning and Quality Improvement Collaborative, a 48-clinic, 16-month learning collaborative. This evaluation aimed to determine whether developing a trauma-informed environment of care was associated with uptake of ACE screening. Participants included 40 of 48 clinics that participated in the statewide learning collaborative. Clinics completed an assessment of progress in 5 essential components of trauma-informed health care at baseline and 1-year follow-up. Clinics tracked data on ACE screens completed on an ongoing basis and submitted data quarterly. A hierarchical linear model was used to examine the association between change in readiness for trauma-informed health care and change in quarterly screens. Readiness for trauma-informed health care increased for all participating clinics over the course of the learning collaborative. The average number of quarterly screens also increased, with considerable variability among clinics. Clinics with larger increases in readiness for trauma-informed health care had larger increases in quarterly screens. The findings align with long-standing recommendations for trauma screening to occur in the context of trauma-informed environments of care. A trauma-informed clinic is the foundation for successful adoption of ACE screening. ACE screening initiatives should include education and sufficient support for clinics to embrace a trauma-informed systems change process.

Transient investigations of teeth on rotor and teeth on stator modified labyrinth seals

Teeth-on-rotor (TOR) and teeth-on-stator (TOS) layouts are compared in this paper to explore better arrangement for different labyrinth seals. The diaphragm labyrinth seal (DLS) and hole diaphragm labyrinth seal (HDLS) are both redesigned into TOR and TOS layouts. To accurately predict the rotordynamics and leakage performance of different seals, a one-motion transient computational fluid dynamics (CFD) method based on the simplified multi-frequency transient method is proposed. A comparison of the experimental results, two-motion transient CFD method and proposed method showcase the better accuracy of the current method in rotordynamic performance prediction. The results shows the better rotordynamic characteristics of the TOS layout for different layouts and of the HDLS type seals for three labyrinth type seals. Even though, the TOR layout cannot increase the stability of the rotor system, a clear circumferential velocity reduction in the DLS and HDLS seals can be observed in both the TOS and TOR layouts. However, the changes in leakage performance for DLS and HDLS seals are different from those for traditional LSs. Unlike TOR-LS and TOR-HDLS, which exhibit relatively large increases in leakage compared with the TOS layout, TOR-DLS achieves a maximum 1.7% leakage reduction at a 15000 rpm rotation speed. A decrease in the jet flow length and increase in the turbulence kinetic energy in TOR-DLS compared with those in TOS-DLS further explain this abnormal phenomenon.

Estimating the Impact of Biodiversity Loss in a Marine Antarctic Food Web

The consequences of climate change and anthropogenic stressors, such as habitat loss and overexploitation, are threatening the subsistence of species and communities across the planet. Therefore, it is crucial that we analyze the impact of environmental perturbations on the diversity, structure and function of ecosystems. In this study, in silico simulations of biodiversity loss were carried out on the marine food web of Caleta Potter (25 de Mayo/King George Island, Antarctica), where global warming has caused critical changes in the abundance and distribution of benthic and pelagic communities over the last 30 years. We performed species removal, considering their degree and trophic level, and including four different thresholds on the occurrence of secondary extinctions. We examined the impact of extinctions on connectance, modularity and stability of the food web. We found different responses for these properties depending on the extinction criteria used, e.g., large increase in modularity and rapid decrease in stability when the most connected and relatively high-trophic-level species were removed. Additionally, we studied the complexity–stability relationship of the food web, and found two regimes: (1) high sensitivity to small perturbations, suggesting that Potter Cove would be locally unstable, and (2) high persistence to long-range perturbations, suggesting global stability of this ecosystem.

Weakened Increase in Global Near‐Surface Water Vapor Pressure During the Last 20 Years

AbstractIt is well known that global warming increases the atmospheric water vapor content, which results in substantial changes in the hydrological cycle. Using five observational data sets, the results show that an increasing trend of near‐surface water vapor pressure (AVP) over land and ocean was significant from 1975 to 1998, while such an increasing trend in AVP subsequently weakened from 1999 to 2019. This phenomenon is associated with decreased oceanic evaporation and land surface evapotranspiration in response to recent climate variations. One consequence of such a phenomenon is a large increase in near‐surface vapor pressure deficit (VPD), which in turn increases atmospheric demand for water vapor and thus aridity and drought over land. This result emphasizes the importance of water vapor change under global warming.

The Addition of Zinc to the ICIE16-Bioactive Glass Composition Enhances Osteogenic Differentiation and Matrix Formation of Human Bone Marrow-Derived Mesenchymal Stromal Cells.

An ICIE16-bioactive glass (BG) composition (in mol%: 49.5 SiO2, 6.6 Na2O, 36.3 CaO, 1.1 P2O5, and 6.6 K2O) has demonstrated excellent in vitro cytocompatibility when cultured with human bone marrow-derived mesenchymal stromal cells (BMSCs). However, its impact on the development of an osseous extracellular matrix (ECM) is limited. Since zinc (Zn) is known to enhance ECM formation and maturation, two ICIE16-BG-based Zn-supplemented BG compositions, namely 1.5 Zn-BG and 3Zn-BG (in mol%: 49.5 SiO2, 6.6 Na2O, 34.8/33.3 CaO, 1.1 P2O5, 6.6 K2O, and 1.5/3.0 ZnO) were developed, and their influence on BMSC viability, osteogenic differentiation, and ECM formation was assessed. Compared to ICIE16-BG, the Zn-doped BGs showed improved cytocompatibility and significantly enhanced osteogenic differentiation. The expression level of the osteopontin gene was significantly higher in the presence of Zn-doped BGs. A larger increase in collagen production was observed when the BMSCs were exposed to the Zn-doped BGs compared to that of the ICIE16-BG. The calcification of the ECM was increased by all the BG compositions; however, calcification was significantly enhanced by the Zn-doped BGs in the early stages of cultivation. Zn constitutes an attractive addition to ICIE16-BG, since it improves its ability to build and calcify an ECM. Future studies should assess whether these positive properties remain in an in vivo environment.

Accounting of value of ecosystem services in the desert: an example of the Kubuqi Desert ecosystem

Ecological products and ecosystem services are essential for human survival and development. Gross Ecosystem Product (GEP) is a method to combine the value of ecosystem services and can reflect the status of ecosystem and ecological conservation and restoration performance. The conservation and restoration of desert ecosystems play an important role in expanding global cultivated land, ensuring food security, and improving human wellbeing. However, ecosystem services and the value of GEP in deserts have been neglected. Taking the Kubuqi Desert ecosystem as an example, this study evaluated the pattens, GEP value, and its change in the Kubuqi Desert ecosystem from 2000 to 2020. Our study found that 1) over the past 20 years, the areas of wetlands, forests, grasslands, and shrubs in the Kubuqi desert ecosystem had increased by 100.65%, 6.05%, 2.24%, and 2.03%, respectively, while that of desert had decreased by 10.62%; 2) the GEP of Kubuqi in 2020 was 55.48 billion CNY, among which its sandstorm prevention value was the highest (39.39%); 3) The value of ecosystem services in the Kubuqi desert ecosystem were all increased over the 20-year period and the largest increase came from sandstorm prevention (increased by 195.09%). This study emphasizes how GEP accounting can promote desert conservation and restoration, quantifies the contribution of desert ecosystems to human wellbeing, and provides future GEP accounting suggestions for desert ecosystems. This study can provide scientific information on the conservation and restoration of global desert ecosystems.

Low Thermal Conductivity and High Thermoelectric Performance of Nb-Doped Quarternary Mixed Crystal Nb0.05W0.95-xMox(Se1-xSx)2.

Transition-metal dichalcogenide WSe2 has attracted increasing interest due to its large thermopower (S), low-cost, and environment-friendly constituents. However, its thermoelectric figure of merit, ZT, of WSe2 is limited due to its large lattice thermal conductivity (κL) and low electrical conductivity. In view of WSe2 and MoS2 having the same crystal structure, here we designed and prepared Nb-doped quarternary mixed crystal (MC) Nb0.05W0.95-xMox(Se1-xSx)2 (0 ≤ x ≤ 0.095). The results indicate that the κL of the MC can reach as low as 0.12 W m K-1 at 850 K, being 93% smaller than that of WSe2. Our analysis reveals that its low κL originates chiefly from intense scattering of both high-frequency phonons from point defects (mainly alloying elements) and mid/low-frequency phonons from MoS2 inclusions residual within MC. In addition, the alloying of WSe2 with MoS2 causes a 5-fold increase in cation vacancies (VW‴'), leading to a large increase in hole concentration and electrical conductivity, which gives rise to a ∼7.5 times increase in power factor (reaching 4.2 μ W cm-1 K-2 at 850 K). As a result, a record high ZTmax = 0.63 is achieved at 850 K for the MC sample with x = 0.076, which is 20 times larger than that of WSe2, demonstrating that MC Nb0.05W0.95-xMox(Se1-xSx)2 is a promising thermoelectric material.

On the evolution of turbulent boundary layers during flame–wall interaction investigated by highly resolved laser diagnostics

The turbulent boundary layer behavior in the presence of flame–wall interactions (FWI) has an important role on the mass and energy transfer at the gas/solid interface. Detailed experiments resolving the turbulent boundary layer evolution in the presence of FWI are lacking, which impedes knowledge. This work presents a combination of particle image velocimetry (flow field), dual-pump coherent anti-Stokes Raman spectroscopy (gas temperature), and OH laser induced fluorescence (flame topology) measurements to study the evolution of the boundary layer structure in the presence of FWI. Experiments are conducted in a side-wall quenching (SWQ) burner. Findings reveal that the reacting boundary layer flow adheres to the linear scaling law u+=y+ in the viscous sublayer until y+ = 5. Beyond y+ = 5, the flame modifies the velocity and temperature field such that the uz+ streamwise velocity deviates from the viscous sublayer and the law-of-the-wall scaling in the log-layer with uz+ being smaller than that of the non-reacting flow (the subscript z refers to the streamwise coordinate and is used throughout this manuscript). As the fluid approaches the flame impingement location at the wall, the gas temperature increases significantly, causing a threefold increase in kinematic viscosity, ν. Although the near-wall streamwise velocity gradient d〈Uz〉/dy|y=0mm decreases, the larger increase in ν reduces uz+ and leads to the deviation from the law-of-the-wall. Downstream the flame impingement location, ν is relatively constant and uz+ values begin to approach those of the law-of-the-wall. Trends are presented for SWQ and head-on quenching flame topologies, and are intended to help development of more accurate wall models.

SNOWTRAN: A Fast Radiative Transfer Model for Polar Hyperspectral Remote Sensing Applications

In this work, we develop a software suite for studies of atmosphere–underlying SNOW-spaceborne optical receiver light TRANsmission calculations (SNOWTRAN) with applications for the solution of forward and inverse radiative transfer problems in polar regions. Assuming that the aerosol load is extremely low, the proposed theory does not require the numerical procedures for the solution of the radiative transfer equation and is based on analytical equations for the spectral nadir reflectance and simple approximations for the local optical properties of atmosphere and snow. The developed model is validated using EnMAP and PRISMA spaceborne imaging spectroscopy data close to the Concordia research station in Antarctica. A new, fast technique for the determination of the snow grain size and assessment of the snowpack vertical inhomogeneity is then proposed and further demonstrated on EnMAP imagery over the Aviator Glacier and in the vicinity of the Concordia research station in Antarctica. The results revealed a large increase in precipitable water vapor at the Concordia research station in February 2023 that was linked to a warming event and a four times larger grain size at Aviator Glacier compared with Dome C.

Analisis Kelayakan Investasi Penambahan Gudang Bahan Baku Garam Beriodium Pada PT. SSD Lamongan

A warehouse is a place used to store finished goods or raw materials and is an important factor so that the production process runs optimally, therefore a company needs adequate facilities and infrastructure. PT. SSD Lamongan experiences limited storage space for raw materials in the form of krosok salt. This company wants to purchase raw materials in large quantities to avoid large increases in raw material prices in the dry, wet, and rainy seasons. However, the current warehouse capacity is insufficient to store these raw materials. So the company plans to build a new warehouse to store raw materials. The construction of this warehouse requires careful consideration and calculations so that it is profitable in the future. Therefore, the aim of this research is to analyze the feasibility of investment by considering market and financial aspects for 10 years, using the Net Present Value (NPV), Internal Rate of Return (IRR), and Payback Period (PP) methods. Based on the results and calculations carried out by researchers, the Net Present Value (NPV) value obtained with an interest rate of 9.08% was IDR 4,615,037,364.00. The Internal Rate of Return (IRR) is 64.94% (IRR&gt;9.08%) and the investment payback period (PP) will be returned for 1 year and 6 months. From the results obtained, this project is feasible. Keywords: Investment Feasibility, IRR, NPV, PP, Raw Material Warehouse

Methane uptake responses to extreme droughts regulated by seasonal timing and plant composition

Increasingly frequent and severe droughts are occurring in multiple seasons of a year in many dryland ecosystems, with unknown impacts on the role of drylands in cycling of methane (CH4), a potent greenhouse gas. In particular, there is limited understanding of how drought occurring at different times within the growing season regulates biological CH4 uptake, and how these responses are mediated by plant community composition. Here, we quantify how drought timing and plant community composition regulate CH4 uptake in a semiarid grassland. We employ a field experiment in which droughts were imposed in early, middle, or late growing season in three different communities (two graminoids, two shrubs and their mixture), respectively. All three droughts increased CH4 uptake, but the effect size and pathway varied with seasonal timing. Early and middle drought increased CH4 uptake through increasing both soil pomA abundance and diffusivity resulting from reduced soil water content (SWC), while late drought increased CH4 uptake only by reducing SWC. Overall, early drought had the least positive effects on CH4 uptake because it excluded the least precipitation and therefore had smaller impacts on SWC. Besides, plant composition did not affect CH4 uptake under normal environment but regulated CH4 uptake in response to droughts due to different response of plant composition to droughts. Early and middle drought had larger positive effects on CH4 uptake in shrub communities than the other two communities, consistent with larger reductions in SWC and larger increases in pomA abundance, respectively. In contrast, late drought had consistent effects on CH4 uptake across three communities. Our results suggest that the magnitude and pathways of extreme drought effects on CH4 uptake are strongly co-regulated by seasonal timing and plant composition.

Linking hazard intensity to impact severity: mini review of vulnerability models for volcanic impact and risk assessment

Volcanic eruptions can cause significant impacts on communities and infrastructure. There is an increasing need for effective risk assessments to inform decision-making and minimise the impact of volcanic hazards. Vulnerability models play a crucial role in these assessments, connecting the intensity of the hazard with the elements that are exposed to it, allowing for the calculation of potential impact or risk. There has been a large increase in the number of vulnerability models being developed for volcanic risk applications, and there is now a need to identify knowledge gaps for the field to take a strategic approach moving forward. This review aims to provide a high-level overview of the current state of volcanic vulnerability modelling and identify areas for future development. We evaluated 594 vulnerability models covering a range of elements and sectors, including buildings, critical infrastructure, transportation networks, agriculture, and human vulnerability. We reviewed the types of hazard intensity metrics and impact/risk metrics used in the models, modelling methodologies, underpinning data requirements, and uncertainty characterisation. A global clearinghouse for volcanic vulnerability models would be advantageous for the volcanic risk community to identify appropriate vulnerability models quickly and efficiently for their needs. As a first step towards such a clearinghouse, we have uploaded this volcano vulnerability model compilation to a repository and encourage additions/suggestions from the community on its future development. The results of this study will contribute to the advancement of the field and provide valuable insights for future research and development in volcanic risk assessment.

Перспективы применения различных органоминеральных удобрений на яровом ячмене

The results of field experiments on spring barley conducted in 2023 on the experimental fields of the Agrobiotechnopark of the Kazan State Agrarian University are presented. The purpose of the research was to assess the impact of the use of various compositions of organomineral fertilizers based on natural minerals (zeolite, diatomite, perlite), humates and food industry waste (buckwheat husk, beet molasses) developed at the Institute of Agrobiotechnologies and Land Management of Kazan State Agrarian University on the formation of the yield and grain quality of spring barley. The objectives of the research included studying the nature of changes in plant growth and development, yield and protein content in grain when using experimental organomineral fertilizers. The object of the study was spring barley of the Raushan variety. The control was the option without fertilizers; the standard was the application of 100 kg/ha of azofoska. Experimental fertilizers were applied at a rate of 120 kg/ha. All fertilizers in the experiment were applied before sowing. The studies were carried out on gray forest highly cultivated soil. The growing season conditions in 2023 were characterized by periodically severe drought phenomena, which affected the growth and development of spring barley plants. It was found that the application of experimental fertilizers contributed to the growth of the length of roots and above-ground parts of plants, and also reduced the damage to plants by root rot. Diatomite-based fertilizer had the greatest positive effect on reducing root rot damage. The largest increase in yield over the control (by 0.73 t/ha) and standard (by 0.22 t/ha) was obtained when using diatomite-based fertilizer. The use of all organomineral fertilizers (especially those based on zeolite) leads to an increase in the protein content in the grain.

Оценка влияния органоминеральных удобрений на формирование урожая картофеля

The results of field experiments on potatoes conducted in 2023 on the experimental fields of the Agrobiotechnopark of the Kazan State Agrarian University are presented. The purpose of the research was to evaluate the impact of the use of foliar application of experimental liquid organomineral fertilizers on the formation of the yield and quality of potato tubers. The objectives of the research included studying the nature of changes in the phytosanitary condition, yield and starch content in potato tubers when using a liquid organomineral fertilizer based on humic substances and food industry waste developed at Kazan State Agrarian University. The object of research was the Red Scarlet potato variety. Biosok was used as a standard humic fertilizer. The treatment was carried out in the budding phase - the beginning of flowering with a working fluid consumption of 300 l/ha. The drugs were used individually and as part of a tank mixture. The studies were carried out on gray forest highly cultivated soil. The agroclimatic conditions of the growing season in 2023 were characterized by periodically severe drought phenomena, which negatively affected the growth and development of potato plants. It was established that treatment of potato plantings with experimental organomineral fertilizer contributed to an increase in the number of tubers and their mass formed in one bush. The largest increase (by 3.2 t/ha to the control) in potato yield was obtained when using an experimental fertilizer with a consumption rate of 0.5 l/ha. When using foliar application of organomineral fertilizer, the infection of tubers of the new crop with dry rot and common scab significantly decreased. Due to the use of experimental fertilizer, there was an increase in the marketability of tubers and an increase in the starch content in them, which is important for industrial potato growing.

Anti-relapse therapy in children with chronic secondary pyelonephritis: evaluation of effectiveness and rationale for a differentiated approach

Currently, there is no unified system of anti-relapse treatment of pyelonephritis in children.Purpose. To assess the feasibility of prescribing and effectiveness of various anti-relapse therapy regimens to prevent exacerbations of the disease in children with chronic secondary pyelonephritis.Materials and Methods. The study involved 158 children with chronic secondary pyelonephritis aged 2 to 14 years, including 130 (82.3%) girls and 28 boys (17.7%). The children were divided into the following groups: Group A (n=32) — furazidine — 14 days, anti-relapse therapy after 12 months; Group B (n=34) — furazidine — 14 days, then — Canephron 1 month, anti–relapse therapy after 12 months; Group C (n=34) — Canephron 3 months, anti-relapse therapy after 12 months; Group D (n=30) — furazidine — 14 days, then — Canephron 1 month of anti–relapse therapy after 6 months; Group E (n=28) — furazidine — 14 days of anti-relapse therapy was not performed. Results. It was found that the recurrence rate of chronic secondary pyelonephritis for a 24-month follow-up in Group A was 28.1% (n=9), in Group B, 14.7% (n=5), in Group C, 20.5% (n=7), in Group D, 10% (n=3), in Group E, 42.9% (n=12). The timing of relapse of chronic secondary pyelonephritis was different, with the largest increase in the proportion of patients with exacerbations in the period from 6 to 12 months. The average recurrence rate per year in the catamnesis in all children (n=158) was 1.4 [1.2–1.6], during the prospective follow-up, a statistically significant (p=0.001) decrease in the recurrence rate to 0.36 [0.2–0.79] was noted. Conclusion. The data obtained confirm the feasibility of anti-relapse therapy in children with chronic secondary pyelonephritis.