We reappraise the viability of asymmetric dark matter (ADM) realized as a Dirac fermion coupling dominantly to the Standard Model fermions. Treating the interactions of such a DM particle with quarks/leptons in an effective-interactions framework, we derive updated constraints using mono-jet searches from the Large Hadron Collider (LHC) and mono-photon searches at the Large Electron-Positron (LEP) collider. We carefully model the detectors used in these experiments, which is found to have significant impact. The constraint of efficient annihilation of the symmetric part of the ADM, as well as other observational constraints are synthesized to produce a global picture. Consistent with previous work, we find that ADM with mass in the range 1–100 GeV is strongly constrained, thus ruling out its best motivated mass range. However, we find that leptophilic ADM remains allowed for ≳ 10 GeV DM, including bounds from colliders, direct detection, and stellar heating. We forecast that the Future Circular Collider for electron-positron collisions (FCC-ee) will improve sensitivity to DM-lepton interactions by almost an order of magnitude.
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