Large Doses Of Testosterone Research Articles

Effect of Testosterone on Somatic Growth

SummaryNo somatic growth inhibition was observed in the rat even when treated with very large doses of testosterone, although these same doses proved sufficient to inhibit gonad development in both sexes. It has been found that doses of testosterone which suffice to inhibit the growth of the gonad in both sexes and to cause permanent vaginal dioestrus in the female do not cause hypertrophy of the hypophysis in either sex. In these respects, the effect of testosterone on somatic and hypophyseal growth differs from that of oestrone.